IFT81_CH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 81, putative

Species:

Leishmania mexicana

UniProt:

E9B4J1_LEIMU

TriTrypDb:

LmxM.33.0230

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0030992	intraciliary transport particle B	2	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0031514	motile cilium	5	2

Expansion

Sequence features

E9B4J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4J1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006996	organelle organization	4	12
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0010970	transport along microtubule	4	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0030705	cytoskeleton-dependent intracellular transport	4	12
GO:0031503	protein-containing complex localization	2	12
GO:0042073	intraciliary transport	3	12
GO:0044782	cilium organization	5	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0099111	microtubule-based transport	4	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:0035721	intraciliary retrograde transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.386
CLV_C14_Caspase3-7	280	284	PF00656	0.409
CLV_NRD_NRD_1	199	201	PF00675	0.426
CLV_NRD_NRD_1	266	268	PF00675	0.453
CLV_NRD_NRD_1	278	280	PF00675	0.345
CLV_NRD_NRD_1	291	293	PF00675	0.385
CLV_NRD_NRD_1	339	341	PF00675	0.525
CLV_NRD_NRD_1	378	380	PF00675	0.380
CLV_NRD_NRD_1	650	652	PF00675	0.517
CLV_PCSK_KEX2_1	140	142	PF00082	0.241
CLV_PCSK_KEX2_1	199	201	PF00082	0.454
CLV_PCSK_KEX2_1	266	268	PF00082	0.462
CLV_PCSK_KEX2_1	278	280	PF00082	0.345
CLV_PCSK_KEX2_1	291	293	PF00082	0.385
CLV_PCSK_KEX2_1	605	607	PF00082	0.559
CLV_PCSK_KEX2_1	649	651	PF00082	0.509
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.241
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.455
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.490
CLV_PCSK_SKI1_1	165	169	PF00082	0.472
CLV_PCSK_SKI1_1	175	179	PF00082	0.368
CLV_PCSK_SKI1_1	189	193	PF00082	0.459
CLV_PCSK_SKI1_1	229	233	PF00082	0.385
CLV_PCSK_SKI1_1	291	295	PF00082	0.465
CLV_PCSK_SKI1_1	434	438	PF00082	0.434
CLV_PCSK_SKI1_1	671	675	PF00082	0.390
DEG_APCC_DBOX_1	440	448	PF00400	0.412
DEG_APCC_DBOX_1	526	534	PF00400	0.395
DEG_APCC_DBOX_1	57	65	PF00400	0.305
DEG_SPOP_SBC_1	12	16	PF00917	0.454
DOC_ANK_TNKS_1	278	285	PF00023	0.416
DOC_MAPK_gen_1	199	207	PF00069	0.330
DOC_MAPK_gen_1	240	249	PF00069	0.261
DOC_MAPK_gen_1	592	600	PF00069	0.513
DOC_MAPK_MEF2A_6	199	207	PF00069	0.270
DOC_PP1_RVXF_1	660	667	PF00149	0.454
DOC_PP1_RVXF_1	89	96	PF00149	0.300
DOC_PP1_SILK_1	364	369	PF00149	0.425
DOC_PP2B_LxvP_1	151	154	PF13499	0.392
DOC_PP4_FxxP_1	147	150	PF00568	0.386
DOC_PP4_FxxP_1	192	195	PF00568	0.505
DOC_USP7_MATH_1	12	16	PF00917	0.528
DOC_USP7_MATH_1	235	239	PF00917	0.395
DOC_USP7_MATH_1	259	263	PF00917	0.456
DOC_USP7_MATH_1	553	557	PF00917	0.388
DOC_USP7_MATH_2	20	26	PF00917	0.581
DOC_USP7_MATH_2	309	315	PF00917	0.458
DOC_WW_Pin1_4	2	7	PF00397	0.634
LIG_14-3-3_CanoR_1	266	274	PF00244	0.409
LIG_14-3-3_CanoR_1	46	51	PF00244	0.241
LIG_14-3-3_CanoR_1	541	547	PF00244	0.384
LIG_14-3-3_CanoR_1	592	600	PF00244	0.496
LIG_Actin_WH2_2	160	177	PF00022	0.414
LIG_Actin_WH2_2	394	409	PF00022	0.527
LIG_Actin_WH2_2	657	673	PF00022	0.402
LIG_BIR_II_1	1	5	PF00653	0.793
LIG_BIR_III_2	118	122	PF00653	0.215
LIG_BRCT_BRCA1_1	419	423	PF00533	0.552
LIG_Clathr_ClatBox_1	50	54	PF01394	0.241
LIG_CtBP_PxDLS_1	329	333	PF00389	0.537
LIG_deltaCOP1_diTrp_1	450	456	PF00928	0.396
LIG_FAT_LD_1	93	101	PF03623	0.386
LIG_FHA_1	12	18	PF00498	0.695
LIG_FHA_1	413	419	PF00498	0.557
LIG_FHA_1	518	524	PF00498	0.382
LIG_FHA_1	564	570	PF00498	0.506
LIG_FHA_1	593	599	PF00498	0.445
LIG_FHA_1	634	640	PF00498	0.439
LIG_FHA_1	709	715	PF00498	0.541
LIG_FHA_2	131	137	PF00498	0.386
LIG_FHA_2	334	340	PF00498	0.505
LIG_FHA_2	453	459	PF00498	0.393
LIG_FHA_2	506	512	PF00498	0.433
LIG_FHA_2	541	547	PF00498	0.384
LIG_FHA_2	582	588	PF00498	0.574
LIG_FHA_2	625	631	PF00498	0.507
LIG_FHA_2	694	700	PF00498	0.716
LIG_GBD_Chelix_1	64	72	PF00786	0.334
LIG_LIR_Apic_2	190	195	PF02991	0.508
LIG_LIR_Gen_1	45	56	PF02991	0.241
LIG_LIR_Gen_1	463	472	PF02991	0.479
LIG_LIR_Gen_1	587	598	PF02991	0.379
LIG_LIR_Gen_1	665	674	PF02991	0.410
LIG_LIR_Gen_1	67	76	PF02991	0.343
LIG_LIR_LC3C_4	120	124	PF02991	0.305
LIG_LIR_Nem_3	127	132	PF02991	0.316
LIG_LIR_Nem_3	166	171	PF02991	0.485
LIG_LIR_Nem_3	420	426	PF02991	0.399
LIG_LIR_Nem_3	449	454	PF02991	0.367
LIG_LIR_Nem_3	45	51	PF02991	0.241
LIG_LIR_Nem_3	463	468	PF02991	0.375
LIG_LIR_Nem_3	52	56	PF02991	0.241
LIG_LIR_Nem_3	587	593	PF02991	0.367
LIG_LIR_Nem_3	627	631	PF02991	0.441
LIG_LIR_Nem_3	665	670	PF02991	0.376
LIG_LIR_Nem_3	67	72	PF02991	0.249
LIG_LYPXL_S_1	124	128	PF13949	0.241
LIG_LYPXL_yS_3	125	128	PF13949	0.241
LIG_NRBOX	92	98	PF00104	0.386
LIG_PALB2_WD40_1	662	670	PF16756	0.382
LIG_PCNA_PIPBox_1	89	98	PF02747	0.305
LIG_PCNA_yPIPBox_3	316	326	PF02747	0.384
LIG_Pex14_2	112	116	PF04695	0.270
LIG_PTB_Apo_2	63	70	PF02174	0.275
LIG_RPA_C_Fungi	238	250	PF08784	0.504
LIG_SH2_CRK	102	106	PF00017	0.241
LIG_SH2_CRK	171	175	PF00017	0.429
LIG_SH2_CRK	590	594	PF00017	0.381
LIG_SH2_NCK_1	48	52	PF00017	0.241
LIG_SH2_SRC	215	218	PF00017	0.490
LIG_SH2_SRC	560	563	PF00017	0.380
LIG_SH2_STAP1	484	488	PF00017	0.424
LIG_SH2_STAT3	558	561	PF00017	0.368
LIG_SH2_STAT5	143	146	PF00017	0.241
LIG_SH2_STAT5	215	218	PF00017	0.360
LIG_SH2_STAT5	631	634	PF00017	0.525
LIG_SH3_3	120	126	PF00018	0.256
LIG_SH3_3	14	20	PF00018	0.596
LIG_SH3_3	323	329	PF00018	0.542
LIG_SUMO_SIM_par_1	149	156	PF11976	0.525
LIG_SUMO_SIM_par_1	201	206	PF11976	0.250
LIG_SUMO_SIM_par_1	518	525	PF11976	0.475
LIG_SUMO_SIM_par_1	711	718	PF11976	0.559
LIG_TRAF2_1	242	245	PF00917	0.355
LIG_TRAF2_1	460	463	PF00917	0.512
LIG_TRAF2_1	500	503	PF00917	0.449
LIG_TRAF2_1	508	511	PF00917	0.399
LIG_TRAF2_1	607	610	PF00917	0.472
LIG_TRAF2_1	84	87	PF00917	0.326
LIG_UBA3_1	131	140	PF00899	0.343
LIG_UBA3_1	289	294	PF00899	0.531
LIG_UBA3_1	68	77	PF00899	0.368
LIG_UBA3_1	92	98	PF00899	0.243
MOD_CK1_1	2	8	PF00069	0.595
MOD_CK1_1	25	31	PF00069	0.511
MOD_CK1_1	563	569	PF00069	0.504
MOD_CK1_1	617	623	PF00069	0.384
MOD_CK2_1	130	136	PF00069	0.374
MOD_CK2_1	452	458	PF00069	0.395
MOD_CK2_1	46	52	PF00069	0.252
MOD_CK2_1	505	511	PF00069	0.437
MOD_CK2_1	540	546	PF00069	0.384
MOD_CK2_1	553	559	PF00069	0.381
MOD_CK2_1	581	587	PF00069	0.476
MOD_Cter_Amidation	647	650	PF01082	0.425
MOD_GlcNHglycan	1	4	PF01048	0.652
MOD_GlcNHglycan	189	192	PF01048	0.449
MOD_GlcNHglycan	27	30	PF01048	0.472
MOD_GlcNHglycan	412	415	PF01048	0.544
MOD_GlcNHglycan	550	554	PF01048	0.394
MOD_GSK3_1	108	115	PF00069	0.357
MOD_GSK3_1	265	272	PF00069	0.493
MOD_GSK3_1	406	413	PF00069	0.534
MOD_GSK3_1	446	453	PF00069	0.472
MOD_GSK3_1	549	556	PF00069	0.452
MOD_GSK3_1	581	588	PF00069	0.459
MOD_GSK3_1	653	660	PF00069	0.453
MOD_GSK3_1	685	692	PF00069	0.685
MOD_N-GLC_1	617	622	PF02516	0.457
MOD_N-GLC_1	693	698	PF02516	0.411
MOD_NEK2_1	1	6	PF00069	0.676
MOD_NEK2_1	178	183	PF00069	0.377
MOD_NEK2_1	233	238	PF00069	0.457
MOD_NEK2_1	406	411	PF00069	0.491
MOD_NEK2_1	585	590	PF00069	0.351
MOD_NEK2_2	235	240	PF00069	0.394
MOD_PIKK_1	22	28	PF00454	0.561
MOD_PIKK_1	406	412	PF00454	0.480
MOD_PIKK_1	553	559	PF00454	0.400
MOD_PIKK_1	592	598	PF00454	0.450
MOD_PK_1	243	249	PF00069	0.268
MOD_PK_1	677	683	PF00069	0.529
MOD_PKA_2	265	271	PF00069	0.393
MOD_PKA_2	406	412	PF00069	0.440
MOD_PKA_2	540	546	PF00069	0.453
MOD_PKB_1	691	699	PF00069	0.579
MOD_Plk_1	22	28	PF00069	0.565
MOD_Plk_1	243	249	PF00069	0.304
MOD_Plk_1	385	391	PF00069	0.526
MOD_Plk_1	457	463	PF00069	0.511
MOD_Plk_1	510	516	PF00069	0.401
MOD_Plk_1	517	523	PF00069	0.377
MOD_Plk_1	574	580	PF00069	0.437
MOD_Plk_1	581	587	PF00069	0.379
MOD_Plk_1	609	615	PF00069	0.429
MOD_Plk_1	617	623	PF00069	0.608
MOD_Plk_1	657	663	PF00069	0.533
MOD_Plk_1	693	699	PF00069	0.530
MOD_Plk_2-3	581	587	PF00069	0.473
MOD_Plk_4	124	130	PF00069	0.260
MOD_Plk_4	362	368	PF00069	0.545
MOD_Plk_4	46	52	PF00069	0.241
MOD_Plk_4	560	566	PF00069	0.422
MOD_Plk_4	585	591	PF00069	0.385
MOD_ProDKin_1	2	8	PF00069	0.634
MOD_SUMO_for_1	293	296	PF00179	0.535
MOD_SUMO_for_1	315	318	PF00179	0.403
MOD_SUMO_for_1	579	582	PF00179	0.494
MOD_SUMO_rev_2	339	349	PF00179	0.495
MOD_SUMO_rev_2	474	479	PF00179	0.436
TRG_DiLeu_BaEn_1	228	233	PF01217	0.518
TRG_DiLeu_BaEn_1	321	326	PF01217	0.407
TRG_DiLeu_BaEn_4	244	250	PF01217	0.367
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.394
TRG_ENDOCYTIC_2	125	128	PF00928	0.241
TRG_ENDOCYTIC_2	129	132	PF00928	0.241
TRG_ENDOCYTIC_2	171	174	PF00928	0.339
TRG_ENDOCYTIC_2	465	468	PF00928	0.514
TRG_ENDOCYTIC_2	48	51	PF00928	0.241
TRG_ENDOCYTIC_2	590	593	PF00928	0.382
TRG_ER_diArg_1	277	279	PF00400	0.414
TRG_ER_diArg_1	290	292	PF00400	0.389
TRG_ER_diArg_1	440	443	PF00400	0.532
TRG_ER_diArg_1	527	530	PF00400	0.534
TRG_NES_CRM1_1	510	525	PF08389	0.389
TRG_NES_CRM1_1	54	67	PF08389	0.386
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	651	655	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.254
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.207

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W4	Leptomonas seymouri	82%	100%
A0A0S4ITV8	Bodo saltans	48%	95%
A0A1X0P8Q2	Trypanosomatidae	54%	92%
A0A3Q8IHU5	Leishmania donovani	96%	100%
A0A3R7NE32	Trypanosoma rangeli	54%	88%
A4HAE1	Leishmania braziliensis	90%	100%
A4I9J3	Leishmania infantum	96%	100%
D0A1V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	94%
O35594	Mus musculus	30%	100%
P83829	Rattus norvegicus	30%	100%
Q4Q3I5	Leishmania major	96%	100%
Q68RJ5	Chlamydomonas reinhardtii	25%	100%
Q8WYA0	Homo sapiens	29%	100%
V5BM72	Trypanosoma cruzi	55%	89%