LeishMANIAdb
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GOLD domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
GOLD domain-containing protein
Gene product:
emp24/gp25L/p24 family/GOLD, putative
Species:
Leishmania mexicana
UniProt:
E9B4J0_LEIMU
TriTrypDb:
LmxM.33.0220
Length:
352

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein. Probable receptor for ER-Golgi trafficking of GPI-anchored proteins. Related to metazoan Tmed10.. Localization: ER (by homology) / Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 7, no: 1
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005783 endoplasmic reticulum 5 1
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 5 1
GO:0005794 Golgi apparatus 5 1
GO:0030134 COPII-coated ER to Golgi transport vesicle 8 1
GO:0030135 coated vesicle 7 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

E9B4J0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4J0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006886 intracellular protein transport 4 1
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 4 1
GO:0006996 organelle organization 4 1
GO:0007030 Golgi organization 5 1
GO:0008104 protein localization 4 1
GO:0009987 cellular process 1 1
GO:0015031 protein transport 4 1
GO:0016043 cellular component organization 3 1
GO:0016192 vesicle-mediated transport 4 1
GO:0033036 macromolecule localization 2 1
GO:0045184 establishment of protein localization 3 1
GO:0046907 intracellular transport 3 1
GO:0048193 Golgi vesicle transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0070727 cellular macromolecule localization 3 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 106 110 PF00656 0.683
CLV_NRD_NRD_1 133 135 PF00675 0.441
CLV_NRD_NRD_1 263 265 PF00675 0.245
CLV_PCSK_KEX2_1 133 135 PF00082 0.441
CLV_PCSK_SKI1_1 252 256 PF00082 0.274
CLV_PCSK_SKI1_1 264 268 PF00082 0.276
CLV_PCSK_SKI1_1 290 294 PF00082 0.275
CLV_PCSK_SKI1_1 8 12 PF00082 0.601
CLV_Separin_Metazoa 130 134 PF03568 0.597
DEG_MDM2_SWIB_1 317 325 PF02201 0.516
DEG_Nend_Nbox_1 1 3 PF02207 0.491
DOC_CYCLIN_RxL_1 249 259 PF00134 0.467
DOC_MAPK_MEF2A_6 319 328 PF00069 0.220
DOC_USP7_MATH_1 226 230 PF00917 0.549
DOC_USP7_MATH_1 236 240 PF00917 0.396
DOC_USP7_MATH_1 272 276 PF00917 0.448
DOC_USP7_MATH_1 74 78 PF00917 0.543
DOC_USP7_MATH_1 95 99 PF00917 0.664
DOC_USP7_UBL2_3 42 46 PF12436 0.436
LIG_14-3-3_CanoR_1 115 120 PF00244 0.567
LIG_14-3-3_CanoR_1 212 222 PF00244 0.467
LIG_14-3-3_CanoR_1 256 266 PF00244 0.467
LIG_14-3-3_CanoR_1 308 317 PF00244 0.453
LIG_14-3-3_CanoR_1 319 325 PF00244 0.284
LIG_14-3-3_CanoR_1 72 82 PF00244 0.586
LIG_Clathr_ClatBox_1 60 64 PF01394 0.323
LIG_FHA_1 258 264 PF00498 0.464
LIG_FHA_1 340 346 PF00498 0.289
LIG_FHA_1 4 10 PF00498 0.475
LIG_LIR_Gen_1 195 206 PF02991 0.467
LIG_LIR_Gen_1 244 255 PF02991 0.518
LIG_LIR_Gen_1 303 313 PF02991 0.458
LIG_LIR_Gen_1 314 325 PF02991 0.486
LIG_LIR_Gen_1 47 52 PF02991 0.437
LIG_LIR_Nem_3 195 201 PF02991 0.488
LIG_LIR_Nem_3 314 320 PF02991 0.473
LIG_LIR_Nem_3 32 38 PF02991 0.540
LIG_LIR_Nem_3 334 339 PF02991 0.175
LIG_LIR_Nem_3 47 51 PF02991 0.374
LIG_NRBOX 11 17 PF00104 0.544
LIG_NRBOX 262 268 PF00104 0.481
LIG_PCNA_PIPBox_1 289 298 PF02747 0.481
LIG_PCNA_yPIPBox_3 286 296 PF02747 0.481
LIG_Pex14_2 317 321 PF04695 0.516
LIG_SH2_CRK 48 52 PF00017 0.437
LIG_SH2_GRB2like 38 41 PF00017 0.363
LIG_SH2_SRC 198 201 PF00017 0.445
LIG_SH2_STAP1 177 181 PF00017 0.481
LIG_SH2_STAP1 247 251 PF00017 0.516
LIG_SH2_STAP1 75 79 PF00017 0.602
LIG_SH2_STAT5 218 221 PF00017 0.481
LIG_SH2_STAT5 341 344 PF00017 0.267
LIG_SH3_3 30 36 PF00018 0.481
LIG_SH3_3 94 100 PF00018 0.628
LIG_SUMO_SIM_anti_2 101 106 PF11976 0.583
LIG_SUMO_SIM_anti_2 323 329 PF11976 0.299
LIG_SUMO_SIM_par_1 59 64 PF11976 0.336
LIG_TRAF2_1 118 121 PF00917 0.600
LIG_TRAF2_1 274 277 PF00917 0.484
MOD_CK1_1 152 158 PF00069 0.645
MOD_CK1_1 214 220 PF00069 0.433
MOD_CK1_1 77 83 PF00069 0.627
MOD_CK1_1 98 104 PF00069 0.617
MOD_CK2_1 115 121 PF00069 0.669
MOD_CK2_1 236 242 PF00069 0.489
MOD_CK2_1 271 277 PF00069 0.486
MOD_CK2_1 41 47 PF00069 0.457
MOD_GlcNHglycan 144 147 PF01048 0.429
MOD_GlcNHglycan 19 22 PF01048 0.657
MOD_GSK3_1 111 118 PF00069 0.612
MOD_GSK3_1 138 145 PF00069 0.688
MOD_GSK3_1 151 158 PF00069 0.622
MOD_GSK3_1 207 214 PF00069 0.504
MOD_GSK3_1 309 316 PF00069 0.460
MOD_GSK3_1 331 338 PF00069 0.342
MOD_GSK3_1 73 80 PF00069 0.631
MOD_GSK3_1 89 96 PF00069 0.746
MOD_N-GLC_1 142 147 PF02516 0.431
MOD_N-GLC_1 77 82 PF02516 0.373
MOD_N-GLC_2 56 58 PF02516 0.228
MOD_NEK2_1 1 6 PF00069 0.698
MOD_NEK2_1 11 16 PF00069 0.476
MOD_NEK2_1 183 188 PF00069 0.530
MOD_NEK2_1 250 255 PF00069 0.514
MOD_NEK2_1 331 336 PF00069 0.316
MOD_NEK2_1 339 344 PF00069 0.323
MOD_NEK2_1 73 78 PF00069 0.594
MOD_NEK2_1 89 94 PF00069 0.590
MOD_PIKK_1 226 232 PF00454 0.418
MOD_PIKK_1 3 9 PF00454 0.443
MOD_PK_1 115 121 PF00069 0.536
MOD_PKA_1 133 139 PF00069 0.607
MOD_PKA_2 133 139 PF00069 0.688
MOD_PKA_2 211 217 PF00069 0.467
MOD_PKA_2 255 261 PF00069 0.481
MOD_PKA_2 309 315 PF00069 0.478
MOD_Plk_1 313 319 PF00069 0.473
MOD_Plk_2-3 41 47 PF00069 0.397
MOD_Plk_4 11 17 PF00069 0.530
MOD_Plk_4 214 220 PF00069 0.459
MOD_Plk_4 320 326 PF00069 0.269
MOD_Plk_4 331 337 PF00069 0.269
MOD_SUMO_rev_2 194 203 PF00179 0.474
TRG_DiLeu_BaEn_4 120 126 PF01217 0.540
TRG_ENDOCYTIC_2 198 201 PF00928 0.538
TRG_ENDOCYTIC_2 247 250 PF00928 0.520
TRG_ENDOCYTIC_2 296 299 PF00928 0.524
TRG_ENDOCYTIC_2 48 51 PF00928 0.441
TRG_ER_diArg_1 132 134 PF00400 0.643
TRG_ER_diLys_1 348 352 PF00400 0.407
TRG_Pf-PMV_PEXEL_1 264 268 PF00026 0.281
TRG_Pf-PMV_PEXEL_1 286 291 PF00026 0.283

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCV9 Leptomonas seymouri 50% 100%
A0A1X0P7Z0 Trypanosomatidae 23% 100%
A0A3S7X7B6 Leishmania donovani 83% 100%
A4HAE0 Leishmania braziliensis 75% 100%
A4I9J2 Leishmania infantum 83% 100%
E9ASZ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
Q4Q3I6 Leishmania major 84% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS