CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CS domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4I9_LEIMU

TriTrypDb:

LmxM.33.0210

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4I9

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0051131	chaperone-mediated protein complex assembly	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0031072	heat shock protein binding	3	10
GO:0051879	Hsp90 protein binding	4	10
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.697
CLV_NRD_NRD_1	83	85	PF00675	0.297
DOC_MAPK_gen_1	108	116	PF00069	0.378
DOC_MAPK_gen_1	75	83	PF00069	0.497
DOC_MAPK_MEF2A_6	108	116	PF00069	0.443
DOC_MAPK_MEF2A_6	16	24	PF00069	0.413
DOC_MAPK_MEF2A_6	75	83	PF00069	0.497
DOC_PIKK_1	126	134	PF02985	0.519
DOC_PP1_RVXF_1	39	46	PF00149	0.413
DOC_PP2B_LxvP_1	7	10	PF13499	0.470
DOC_PP2B_PxIxI_1	111	117	PF00149	0.420
DOC_USP7_MATH_1	165	169	PF00917	0.596
DOC_USP7_MATH_1	178	182	PF00917	0.399
DOC_USP7_MATH_1	64	68	PF00917	0.444
DOC_USP7_UBL2_3	106	110	PF12436	0.525
DOC_USP7_UBL2_3	37	41	PF12436	0.386
DOC_USP7_UBL2_3	82	86	PF12436	0.430
DOC_WW_Pin1_4	2	7	PF00397	0.347
DOC_WW_Pin1_4	46	51	PF00397	0.428
LIG_14-3-3_CanoR_1	44	50	PF00244	0.342
LIG_Actin_WH2_2	29	46	PF00022	0.342
LIG_BIR_II_1	1	5	PF00653	0.514
LIG_deltaCOP1_diTrp_1	117	121	PF00928	0.394
LIG_FHA_1	171	177	PF00498	0.391
LIG_FHA_1	21	27	PF00498	0.477
LIG_LIR_Gen_1	146	157	PF02991	0.537
LIG_LIR_Gen_1	18	26	PF02991	0.432
LIG_LIR_Nem_3	18	22	PF02991	0.432
LIG_LIR_Nem_3	98	104	PF02991	0.444
LIG_LYPXL_yS_3	111	114	PF13949	0.421
LIG_MYND_3	202	206	PF01753	0.533
LIG_SH2_CRK	62	66	PF00017	0.447
LIG_SH2_PTP2	19	22	PF00017	0.456
LIG_SH2_STAP1	149	153	PF00017	0.528
LIG_SH2_STAP1	55	59	PF00017	0.501
LIG_SH2_STAT5	19	22	PF00017	0.456
LIG_SH3_3	106	112	PF00018	0.372
LIG_SH3_3	3	9	PF00018	0.411
LIG_SH3_3	70	76	PF00018	0.432
LIG_SH3_3	96	102	PF00018	0.466
LIG_TRAF2_1	204	207	PF00917	0.578
LIG_TRAF2_1	66	69	PF00917	0.449
LIG_TYR_ITIM	109	114	PF00017	0.318
MOD_CDK_SPxxK_3	46	53	PF00069	0.428
MOD_CK1_1	2	8	PF00069	0.339
MOD_CK1_1	67	73	PF00069	0.430
MOD_CK2_1	45	51	PF00069	0.498
MOD_CK2_1	63	69	PF00069	0.439
MOD_CMANNOS	118	121	PF00535	0.410
MOD_GlcNHglycan	139	142	PF01048	0.522
MOD_GlcNHglycan	166	170	PF01048	0.509
MOD_GlcNHglycan	180	183	PF01048	0.599
MOD_GlcNHglycan	191	194	PF01048	0.684
MOD_GSK3_1	112	119	PF00069	0.417
MOD_GSK3_1	147	154	PF00069	0.536
MOD_GSK3_1	185	192	PF00069	0.757
MOD_GSK3_1	63	70	PF00069	0.439
MOD_N-GLC_1	112	117	PF02516	0.498
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	137	142	PF00069	0.520
MOD_NEK2_1	26	31	PF00069	0.499
MOD_NEK2_1	45	50	PF00069	0.432
MOD_NEK2_2	55	60	PF00069	0.497
MOD_PIKK_1	151	157	PF00454	0.521
MOD_PIKK_1	67	73	PF00454	0.497
MOD_PKA_1	85	91	PF00069	0.446
MOD_PKA_2	102	108	PF00069	0.383
MOD_Plk_1	112	118	PF00069	0.377
MOD_Plk_1	27	33	PF00069	0.342
MOD_ProDKin_1	2	8	PF00069	0.339
MOD_ProDKin_1	46	52	PF00069	0.428
MOD_SUMO_for_1	36	39	PF00179	0.497
MOD_SUMO_rev_2	35	43	PF00179	0.377
TRG_DiLeu_BaEn_4	166	172	PF01217	0.553
TRG_ENDOCYTIC_2	111	114	PF00928	0.421
TRG_ENDOCYTIC_2	149	152	PF00928	0.474
TRG_ENDOCYTIC_2	19	22	PF00928	0.456
TRG_ENDOCYTIC_2	62	65	PF00928	0.447
TRG_ER_diArg_1	74	77	PF00400	0.497
TRG_NLS_MonoExtN_4	82	88	PF00514	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I2	Leptomonas seymouri	65%	100%
A0A0S4JQC8	Bodo saltans	31%	100%
A0A1X0P8I0	Trypanosomatidae	34%	100%
A0A3Q8II57	Leishmania donovani	93%	100%
A0A3S5H807	Leishmania donovani	28%	100%
A0A422N770	Trypanosoma rangeli	43%	100%
A4HAD9	Leishmania braziliensis	84%	100%
A4HNB5	Leishmania braziliensis	27%	100%
A4I9J1	Leishmania infantum	92%	100%
A4IBY7	Leishmania infantum	28%	100%
D0A1U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AFS4	Leishmania major	25%	100%
E9B6X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
G1TGF1	Oryctolagus cuniculus	28%	100%
P28707	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	97%
P83868	Rattus norvegicus	28%	100%
Q11118	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q15185	Homo sapiens	28%	100%
Q3ZBF7	Bos taurus	28%	100%
Q4Q3I7	Leishmania major	92%	100%
Q5NVM4	Pongo abelii	28%	100%
Q6PWL5	Macaca fascicularis	28%	100%
Q9FR62	Brassica napus	29%	100%
Q9R0Q7	Mus musculus	28%	100%
V5B2A2	Trypanosoma cruzi	42%	100%