Calx-beta domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Antimony resistance marker of 58 kDa

Species:

Leishmania mexicana

UniProt:

E9B4I8_LEIMU

TriTrypDb:

LmxM.33.0200

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4I8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	442	444	PF00675	0.367
CLV_PCSK_KEX2_1	442	444	PF00082	0.367
CLV_PCSK_SKI1_1	144	148	PF00082	0.364
CLV_PCSK_SKI1_1	270	274	PF00082	0.372
CLV_PCSK_SKI1_1	31	35	PF00082	0.396
CLV_PCSK_SKI1_1	423	427	PF00082	0.318
CLV_PCSK_SKI1_1	443	447	PF00082	0.162
CLV_PCSK_SKI1_1	59	63	PF00082	0.369
DEG_APCC_DBOX_1	30	38	PF00400	0.421
DEG_SCF_FBW7_1	365	371	PF00400	0.600
DOC_CDC14_PxL_1	341	349	PF14671	0.327
DOC_CKS1_1	365	370	PF01111	0.770
DOC_MAPK_gen_1	144	154	PF00069	0.499
DOC_MAPK_MEF2A_6	171	179	PF00069	0.307
DOC_MAPK_MEF2A_6	315	322	PF00069	0.383
DOC_PP1_RVXF_1	124	131	PF00149	0.484
DOC_PP1_RVXF_1	29	36	PF00149	0.327
DOC_PP1_RVXF_1	456	462	PF00149	0.383
DOC_PP2B_LxvP_1	195	198	PF13499	0.483
DOC_PP2B_LxvP_1	212	215	PF13499	0.271
DOC_PP2B_LxvP_1	396	399	PF13499	0.520
DOC_PP4_MxPP_1	391	394	PF00568	0.465
DOC_USP7_MATH_1	135	139	PF00917	0.257
DOC_USP7_MATH_1	309	313	PF00917	0.421
DOC_USP7_MATH_1	374	378	PF00917	0.710
DOC_WW_Pin1_4	294	299	PF00397	0.478
DOC_WW_Pin1_4	358	363	PF00397	0.632
DOC_WW_Pin1_4	364	369	PF00397	0.750
DOC_WW_Pin1_4	375	380	PF00397	0.556
LIG_14-3-3_CanoR_1	134	140	PF00244	0.249
LIG_14-3-3_CanoR_1	307	316	PF00244	0.443
LIG_14-3-3_CanoR_1	458	467	PF00244	0.428
LIG_Clathr_ClatBox_1	37	41	PF01394	0.327
LIG_FHA_1	123	129	PF00498	0.563
LIG_FHA_1	168	174	PF00498	0.387
LIG_FHA_1	192	198	PF00498	0.332
LIG_FHA_1	208	214	PF00498	0.399
LIG_FHA_1	226	232	PF00498	0.203
LIG_FHA_1	241	247	PF00498	0.598
LIG_FHA_1	309	315	PF00498	0.348
LIG_FHA_1	448	454	PF00498	0.368
LIG_FHA_1	479	485	PF00498	0.413
LIG_FHA_1	50	56	PF00498	0.398
LIG_FHA_1	506	512	PF00498	0.339
LIG_FHA_1	87	93	PF00498	0.388
LIG_FHA_2	200	206	PF00498	0.446
LIG_LIR_Gen_1	136	146	PF02991	0.302
LIG_LIR_Gen_1	206	215	PF02991	0.447
LIG_LIR_Nem_3	136	142	PF02991	0.334
LIG_LIR_Nem_3	206	212	PF02991	0.447
LIG_LIR_Nem_3	23	28	PF02991	0.355
LIG_LIR_Nem_3	266	272	PF02991	0.285
LIG_LIR_Nem_3	289	294	PF02991	0.310
LIG_LIR_Nem_3	32	38	PF02991	0.323
LIG_LIR_Nem_3	419	425	PF02991	0.353
LIG_PCNA_yPIPBox_3	144	157	PF02747	0.323
LIG_PCNA_yPIPBox_3	270	284	PF02747	0.492
LIG_PCNA_yPIPBox_3	423	437	PF02747	0.307
LIG_PCNA_yPIPBox_3	69	79	PF02747	0.181
LIG_Pex14_2	102	106	PF04695	0.394
LIG_Pex14_2	114	118	PF04695	0.317
LIG_Pex14_2	506	510	PF04695	0.367
LIG_SH2_CRK	139	143	PF00017	0.328
LIG_SH2_CRK	209	213	PF00017	0.421
LIG_SH2_NCK_1	139	143	PF00017	0.367
LIG_SH2_NCK_1	354	358	PF00017	0.401
LIG_SH2_SRC	252	255	PF00017	0.551
LIG_SH2_STAP1	139	143	PF00017	0.348
LIG_SH2_STAP1	209	213	PF00017	0.327
LIG_SH2_STAP1	229	233	PF00017	0.162
LIG_SH2_STAP1	354	358	PF00017	0.421
LIG_SH2_STAT5	209	212	PF00017	0.469
LIG_SH2_STAT5	229	232	PF00017	0.162
LIG_SH2_STAT5	252	255	PF00017	0.573
LIG_SH2_STAT5	300	303	PF00017	0.421
LIG_SH2_STAT5	405	408	PF00017	0.607
LIG_SH3_3	235	241	PF00018	0.525
LIG_SH3_3	243	249	PF00018	0.566
LIG_SH3_3	345	351	PF00018	0.478
LIG_SH3_3	359	365	PF00018	0.612
LIG_SH3_3	367	373	PF00018	0.661
LIG_SH3_3	391	397	PF00018	0.585
LIG_SH3_3	58	64	PF00018	0.418
LIG_SH3_3	76	82	PF00018	0.358
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.288
LIG_SUMO_SIM_anti_2	411	416	PF11976	0.439
LIG_SUMO_SIM_anti_2	449	458	PF11976	0.327
LIG_TRAF2_1	20	23	PF00917	0.395
LIG_TRAF2_1	245	248	PF00917	0.518
LIG_TRAF2_2	379	384	PF00917	0.526
LIG_TYR_ITIM	137	142	PF00017	0.367
LIG_TYR_ITIM	207	212	PF00017	0.327
LIG_UBA3_1	33	42	PF00899	0.331
MOD_CK1_1	133	139	PF00069	0.181
MOD_CK2_1	102	108	PF00069	0.417
MOD_CK2_1	199	205	PF00069	0.446
MOD_CK2_1	323	329	PF00069	0.379
MOD_GlcNHglycan	183	186	PF01048	0.431
MOD_GlcNHglycan	407	410	PF01048	0.473
MOD_GlcNHglycan	461	464	PF01048	0.186
MOD_GSK3_1	177	184	PF00069	0.343
MOD_GSK3_1	199	206	PF00069	0.398
MOD_GSK3_1	364	371	PF00069	0.664
MOD_GSK3_1	88	95	PF00069	0.401
MOD_N-GLC_1	167	172	PF02516	0.348
MOD_N-GLC_1	294	299	PF02516	0.332
MOD_N-GLC_1	447	452	PF02516	0.348
MOD_N-GLC_1	48	53	PF02516	0.329
MOD_NEK2_1	102	107	PF00069	0.479
MOD_NEK2_1	130	135	PF00069	0.399
MOD_NEK2_1	175	180	PF00069	0.404
MOD_NEK2_1	190	195	PF00069	0.274
MOD_NEK2_1	470	475	PF00069	0.361
MOD_PKA_2	133	139	PF00069	0.337
MOD_Plk_1	410	416	PF00069	0.509
MOD_Plk_1	92	98	PF00069	0.309
MOD_Plk_2-3	88	94	PF00069	0.421
MOD_Plk_4	102	108	PF00069	0.377
MOD_Plk_4	203	209	PF00069	0.405
MOD_Plk_4	286	292	PF00069	0.327
MOD_Plk_4	410	416	PF00069	0.509
MOD_Plk_4	470	476	PF00069	0.327
MOD_Plk_4	480	486	PF00069	0.435
MOD_Plk_4	63	69	PF00069	0.430
MOD_ProDKin_1	294	300	PF00069	0.478
MOD_ProDKin_1	358	364	PF00069	0.637
MOD_ProDKin_1	375	381	PF00069	0.560
MOD_SUMO_rev_2	104	114	PF00179	0.430
TRG_DiLeu_BaEn_2	493	499	PF01217	0.450
TRG_ENDOCYTIC_2	139	142	PF00928	0.339
TRG_ENDOCYTIC_2	143	146	PF00928	0.340
TRG_ENDOCYTIC_2	209	212	PF00928	0.421
TRG_ENDOCYTIC_2	25	28	PF00928	0.378
TRG_ENDOCYTIC_2	422	425	PF00928	0.372
TRG_ER_diArg_1	442	444	PF00400	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I505	Leptomonas seymouri	62%	96%
A0A0N1PDX2	Leptomonas seymouri	39%	100%
A0A1X0P8U8	Trypanosomatidae	41%	100%
A0A3Q8IE32	Leishmania donovani	93%	100%
A0A3S7X7C8	Leishmania donovani	40%	100%
A4HAD7	Leishmania braziliensis	40%	94%
A4HAD8	Leishmania braziliensis	81%	100%
A4I9I9	Leishmania infantum	40%	100%
A4I9J0	Leishmania infantum	93%	100%
C9ZT01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A1U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B4I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	94%
Q4Q3I8	Leishmania major	92%	100%
Q4Q3I9	Leishmania major	41%	94%
V5B262	Trypanosoma cruzi	38%	100%