Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1935), putative

Species:

Leishmania mexicana

UniProt:

E9B4I7_LEIMU

TriTrypDb:

LmxM.33.0190

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4I7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.259
CLV_MEL_PAP_1	61	67	PF00089	0.288
CLV_NRD_NRD_1	382	384	PF00675	0.288
CLV_NRD_NRD_1	483	485	PF00675	0.577
CLV_PCSK_KEX2_1	444	446	PF00082	0.233
CLV_PCSK_KEX2_1	482	484	PF00082	0.624
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.177
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.594
CLV_PCSK_SKI1_1	148	152	PF00082	0.341
CLV_PCSK_SKI1_1	27	31	PF00082	0.387
CLV_PCSK_SKI1_1	272	276	PF00082	0.349
CLV_PCSK_SKI1_1	292	296	PF00082	0.202
CLV_PCSK_SKI1_1	352	356	PF00082	0.288
CLV_PCSK_SKI1_1	47	51	PF00082	0.315
CLV_PCSK_SKI1_1	473	477	PF00082	0.288
DEG_APCC_KENBOX_2	274	278	PF00400	0.288
DEG_SIAH_1	319	327	PF03145	0.259
DOC_MAPK_gen_1	30	38	PF00069	0.294
DOC_MAPK_gen_1	352	360	PF00069	0.288
DOC_MAPK_gen_1	76	84	PF00069	0.401
DOC_PP1_RVXF_1	305	311	PF00149	0.344
DOC_USP7_MATH_1	182	186	PF00917	0.369
DOC_USP7_MATH_1	258	262	PF00917	0.354
DOC_WW_Pin1_4	322	327	PF00397	0.337
DOC_WW_Pin1_4	370	375	PF00397	0.460
DOC_WW_Pin1_4	486	491	PF00397	0.550
DOC_WW_Pin1_4	63	68	PF00397	0.328
LIG_14-3-3_CanoR_1	179	185	PF00244	0.479
LIG_14-3-3_CanoR_1	39	48	PF00244	0.206
LIG_14-3-3_CanoR_1	428	432	PF00244	0.410
LIG_14-3-3_CanoR_1	483	488	PF00244	0.538
LIG_14-3-3_CanoR_1	76	84	PF00244	0.276
LIG_BIR_III_4	432	436	PF00653	0.401
LIG_BRCT_BRCA1_1	372	376	PF00533	0.572
LIG_CaM_IQ_9	465	480	PF13499	0.401
LIG_FHA_1	121	127	PF00498	0.533
LIG_FHA_1	179	185	PF00498	0.349
LIG_FHA_1	196	202	PF00498	0.301
LIG_FHA_1	331	337	PF00498	0.296
LIG_FHA_1	418	424	PF00498	0.353
LIG_FHA_1	451	457	PF00498	0.396
LIG_FHA_1	96	102	PF00498	0.355
LIG_FHA_2	366	372	PF00498	0.549
LIG_FHA_2	441	447	PF00498	0.286
LIG_LIR_Gen_1	19	29	PF02991	0.344
LIG_LIR_Gen_1	389	399	PF02991	0.401
LIG_LIR_Gen_1	91	101	PF02991	0.274
LIG_LIR_Nem_3	144	150	PF02991	0.342
LIG_LIR_Nem_3	166	172	PF02991	0.296
LIG_LIR_Nem_3	19	25	PF02991	0.332
LIG_LIR_Nem_3	389	395	PF02991	0.330
LIG_LIR_Nem_3	91	96	PF02991	0.290
LIG_PCNA_yPIPBox_3	27	41	PF02747	0.305
LIG_PCNA_yPIPBox_3	272	286	PF02747	0.415
LIG_PDZ_Class_1	486	491	PF00595	0.550
LIG_Pex14_2	117	121	PF04695	0.294
LIG_Pex14_2	425	429	PF04695	0.401
LIG_Pex14_2	475	479	PF04695	0.344
LIG_REV1ctd_RIR_1	156	164	PF16727	0.380
LIG_REV1ctd_RIR_1	422	432	PF16727	0.288
LIG_SH2_CRK	143	147	PF00017	0.305
LIG_SH2_CRK	388	392	PF00017	0.344
LIG_SH2_GRB2like	171	174	PF00017	0.344
LIG_SH2_GRB2like	253	256	PF00017	0.533
LIG_SH2_NCK_1	143	147	PF00017	0.344
LIG_SH2_NCK_1	22	26	PF00017	0.344
LIG_SH2_NCK_1	388	392	PF00017	0.344
LIG_SH2_SRC	22	25	PF00017	0.366
LIG_SH2_SRC	253	256	PF00017	0.533
LIG_SH2_STAP1	143	147	PF00017	0.324
LIG_SH2_STAP1	22	26	PF00017	0.344
LIG_SH2_STAP1	356	360	PF00017	0.401
LIG_SH2_STAP1	388	392	PF00017	0.309
LIG_SH2_STAT5	253	256	PF00017	0.558
LIG_SH2_STAT5	302	305	PF00017	0.415
LIG_SH2_STAT5	455	458	PF00017	0.383
LIG_SH3_3	181	187	PF00018	0.410
LIG_SH3_3	314	320	PF00018	0.454
LIG_SH3_3	335	341	PF00018	0.413
LIG_SH3_3	454	460	PF00018	0.288
LIG_SH3_3	484	490	PF00018	0.531
LIG_SH3_3	5	11	PF00018	0.634
LIG_SUMO_SIM_anti_2	357	364	PF11976	0.401
LIG_SUMO_SIM_par_1	94	100	PF11976	0.333
LIG_TRAF2_1	328	331	PF00917	0.288
LIG_TYR_ITIM	386	391	PF00017	0.380
LIG_UBA3_1	157	165	PF00899	0.344
LIG_UBA3_1	281	289	PF00899	0.405
MOD_CDK_SPxxK_3	63	70	PF00069	0.288
MOD_CK1_1	185	191	PF00069	0.262
MOD_CK1_1	477	483	PF00069	0.353
MOD_CK2_1	185	191	PF00069	0.374
MOD_CK2_1	365	371	PF00069	0.556
MOD_CK2_1	440	446	PF00069	0.326
MOD_Cter_Amidation	480	483	PF01082	0.476
MOD_GlcNHglycan	187	190	PF01048	0.419
MOD_GSK3_1	178	185	PF00069	0.353
MOD_GSK3_1	228	235	PF00069	0.281
MOD_GSK3_1	361	368	PF00069	0.542
MOD_GSK3_1	446	453	PF00069	0.389
MOD_GSK3_1	482	489	PF00069	0.688
MOD_N-GLC_1	172	177	PF02516	0.324
MOD_N-GLC_1	296	301	PF02516	0.309
MOD_N-GLC_1	365	370	PF02516	0.365
MOD_N-GLC_1	41	46	PF02516	0.314
MOD_N-GLC_1	417	422	PF02516	0.347
MOD_N-GLC_1	450	455	PF02516	0.391
MOD_N-GLC_1	51	56	PF02516	0.306
MOD_NEK2_1	178	183	PF00069	0.397
MOD_NEK2_1	40	45	PF00069	0.288
MOD_NEK2_1	406	411	PF00069	0.420
MOD_NEK2_1	440	445	PF00069	0.294
MOD_NEK2_1	92	97	PF00069	0.384
MOD_PIKK_1	263	269	PF00454	0.288
MOD_PIKK_1	41	47	PF00454	0.205
MOD_PIKK_1	474	480	PF00454	0.327
MOD_PIKK_1	77	83	PF00454	0.389
MOD_PK_1	483	489	PF00069	0.501
MOD_PKA_1	482	488	PF00069	0.527
MOD_PKA_2	178	184	PF00069	0.288
MOD_PKA_2	427	433	PF00069	0.401
MOD_PKA_2	482	488	PF00069	0.498
MOD_PKA_2	77	83	PF00069	0.414
MOD_Plk_1	258	264	PF00069	0.284
MOD_Plk_1	330	336	PF00069	0.436
MOD_Plk_1	356	362	PF00069	0.417
MOD_Plk_1	365	371	PF00069	0.599
MOD_Plk_2-3	446	452	PF00069	0.288
MOD_Plk_4	258	264	PF00069	0.285
MOD_Plk_4	356	362	PF00069	0.316
MOD_Plk_4	54	60	PF00069	0.338
MOD_Plk_4	92	98	PF00069	0.360
MOD_ProDKin_1	322	328	PF00069	0.337
MOD_ProDKin_1	370	376	PF00069	0.452
MOD_ProDKin_1	63	69	PF00069	0.328
MOD_SUMO_for_1	150	153	PF00179	0.374
MOD_SUMO_for_1	354	357	PF00179	0.288
MOD_SUMO_rev_2	124	134	PF00179	0.421
MOD_SUMO_rev_2	185	195	PF00179	0.468
MOD_SUMO_rev_2	242	251	PF00179	0.541
MOD_SUMO_rev_2	380	386	PF00179	0.288
MOD_SUMO_rev_2	432	437	PF00179	0.401
MOD_SUMO_rev_2	66	71	PF00179	0.413
TRG_DiLeu_BaEn_1	452	457	PF01217	0.259
TRG_DiLeu_BaEn_2	343	349	PF01217	0.288
TRG_DiLeu_BaEn_3	371	377	PF01217	0.423
TRG_ENDOCYTIC_2	143	146	PF00928	0.315
TRG_ENDOCYTIC_2	147	150	PF00928	0.317
TRG_ENDOCYTIC_2	22	25	PF00928	0.345
TRG_ENDOCYTIC_2	271	274	PF00928	0.321
TRG_ENDOCYTIC_2	388	391	PF00928	0.339
TRG_ER_diArg_1	136	139	PF00400	0.575
TRG_ER_diArg_1	61	64	PF00400	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I505	Leptomonas seymouri	37%	91%
A0A0N1PDX2	Leptomonas seymouri	57%	100%
A0A1X0P8U8	Trypanosomatidae	41%	100%
A0A3Q8IE32	Leishmania donovani	39%	95%
A0A3S7X7C8	Leishmania donovani	96%	100%
A4HAD7	Leishmania braziliensis	83%	100%
A4HAD8	Leishmania braziliensis	37%	99%
A4I9I9	Leishmania infantum	96%	100%
A4I9J0	Leishmania infantum	39%	95%
C9ZT01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A1U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	95%
Q4Q3I8	Leishmania major	39%	100%
Q4Q3I9	Leishmania major	95%	100%
V5B262	Trypanosoma cruzi	40%	100%