LeishMANIAdb
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Methyltranfer_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltranfer_dom domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B4I6_LEIMU
TriTrypDb:
LmxM.33.0180
Length:
767

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B4I6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4I6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 353 357 PF00656 0.538
CLV_C14_Caspase3-7 404 408 PF00656 0.489
CLV_C14_Caspase3-7 503 507 PF00656 0.418
CLV_NRD_NRD_1 156 158 PF00675 0.519
CLV_NRD_NRD_1 187 189 PF00675 0.466
CLV_NRD_NRD_1 279 281 PF00675 0.485
CLV_NRD_NRD_1 328 330 PF00675 0.518
CLV_NRD_NRD_1 388 390 PF00675 0.603
CLV_NRD_NRD_1 394 396 PF00675 0.498
CLV_NRD_NRD_1 515 517 PF00675 0.393
CLV_NRD_NRD_1 548 550 PF00675 0.508
CLV_NRD_NRD_1 580 582 PF00675 0.331
CLV_NRD_NRD_1 588 590 PF00675 0.440
CLV_NRD_NRD_1 720 722 PF00675 0.540
CLV_NRD_NRD_1 724 726 PF00675 0.505
CLV_PCSK_FUR_1 325 329 PF00082 0.577
CLV_PCSK_FUR_1 717 721 PF00082 0.510
CLV_PCSK_KEX2_1 155 157 PF00082 0.566
CLV_PCSK_KEX2_1 279 281 PF00082 0.487
CLV_PCSK_KEX2_1 325 327 PF00082 0.524
CLV_PCSK_KEX2_1 328 330 PF00082 0.515
CLV_PCSK_KEX2_1 514 516 PF00082 0.405
CLV_PCSK_KEX2_1 548 550 PF00082 0.619
CLV_PCSK_KEX2_1 588 590 PF00082 0.539
CLV_PCSK_KEX2_1 719 721 PF00082 0.538
CLV_PCSK_PC7_1 544 550 PF00082 0.482
CLV_PCSK_PC7_1 584 590 PF00082 0.491
CLV_PCSK_SKI1_1 157 161 PF00082 0.435
CLV_PCSK_SKI1_1 655 659 PF00082 0.552
CLV_PCSK_SKI1_1 726 730 PF00082 0.575
CLV_PCSK_SKI1_1 742 746 PF00082 0.500
CLV_Separin_Metazoa 459 463 PF03568 0.430
CLV_TASPASE1 504 510 PF01112 0.466
DEG_APCC_DBOX_1 720 728 PF00400 0.615
DEG_SCF_FBW7_1 299 305 PF00400 0.494
DEG_SPOP_SBC_1 214 218 PF00917 0.490
DEG_SPOP_SBC_1 315 319 PF00917 0.652
DOC_CKS1_1 299 304 PF01111 0.493
DOC_CKS1_1 492 497 PF01111 0.297
DOC_CKS1_1 648 653 PF01111 0.366
DOC_CYCLIN_RxL_1 719 733 PF00134 0.601
DOC_CYCLIN_yCln2_LP_2 410 416 PF00134 0.488
DOC_MAPK_gen_1 719 729 PF00069 0.494
DOC_MAPK_MEF2A_6 533 542 PF00069 0.371
DOC_PP2B_LxvP_1 410 413 PF13499 0.462
DOC_PP2B_LxvP_1 475 478 PF13499 0.407
DOC_PP4_FxxP_1 159 162 PF00568 0.419
DOC_USP7_MATH_1 169 173 PF00917 0.294
DOC_USP7_MATH_1 21 25 PF00917 0.428
DOC_USP7_MATH_1 214 218 PF00917 0.611
DOC_USP7_MATH_1 292 296 PF00917 0.699
DOC_USP7_MATH_1 302 306 PF00917 0.667
DOC_USP7_MATH_1 357 361 PF00917 0.601
DOC_USP7_MATH_1 430 434 PF00917 0.469
DOC_USP7_MATH_1 451 455 PF00917 0.704
DOC_USP7_MATH_1 528 532 PF00917 0.684
DOC_USP7_MATH_1 627 631 PF00917 0.552
DOC_USP7_MATH_1 96 100 PF00917 0.650
DOC_USP7_MATH_2 343 349 PF00917 0.597
DOC_USP7_UBL2_3 755 759 PF12436 0.455
DOC_USP7_UBL2_3 763 767 PF12436 0.505
DOC_WW_Pin1_4 103 108 PF00397 0.546
DOC_WW_Pin1_4 295 300 PF00397 0.727
DOC_WW_Pin1_4 491 496 PF00397 0.361
DOC_WW_Pin1_4 647 652 PF00397 0.607
DOC_WW_Pin1_4 678 683 PF00397 0.717
DOC_WW_Pin1_4 727 732 PF00397 0.589
LIG_14-3-3_CanoR_1 291 299 PF00244 0.598
LIG_14-3-3_CanoR_1 389 393 PF00244 0.496
LIG_BIR_III_2 247 251 PF00653 0.461
LIG_BRCT_BRCA1_1 215 219 PF00533 0.560
LIG_BRCT_BRCA1_1 64 68 PF00533 0.472
LIG_BRCT_BRCA1_1 704 708 PF00533 0.530
LIG_deltaCOP1_diTrp_1 77 81 PF00928 0.519
LIG_eIF4E_1 230 236 PF01652 0.315
LIG_eIF4E_1 481 487 PF01652 0.461
LIG_eIF4E_1 5 11 PF01652 0.251
LIG_eIF4E_1 738 744 PF01652 0.428
LIG_FHA_1 407 413 PF00498 0.359
LIG_FHA_1 481 487 PF00498 0.492
LIG_FHA_1 492 498 PF00498 0.327
LIG_FHA_1 593 599 PF00498 0.522
LIG_FHA_1 632 638 PF00498 0.533
LIG_FHA_1 692 698 PF00498 0.745
LIG_FHA_2 196 202 PF00498 0.686
LIG_FHA_2 257 263 PF00498 0.400
LIG_GBD_Chelix_1 42 50 PF00786 0.439
LIG_GBD_Chelix_1 7 15 PF00786 0.268
LIG_LIR_Apic_2 365 371 PF02991 0.413
LIG_LIR_Apic_2 645 651 PF02991 0.578
LIG_LIR_Apic_2 671 677 PF02991 0.677
LIG_LIR_Gen_1 112 120 PF02991 0.410
LIG_LIR_Gen_1 20 28 PF02991 0.392
LIG_LIR_Gen_1 469 478 PF02991 0.328
LIG_LIR_Gen_1 506 513 PF02991 0.365
LIG_LIR_Gen_1 571 580 PF02991 0.401
LIG_LIR_Gen_1 630 640 PF02991 0.465
LIG_LIR_Gen_1 705 716 PF02991 0.530
LIG_LIR_Gen_1 78 89 PF02991 0.492
LIG_LIR_Nem_3 112 116 PF02991 0.365
LIG_LIR_Nem_3 122 126 PF02991 0.338
LIG_LIR_Nem_3 20 25 PF02991 0.468
LIG_LIR_Nem_3 216 222 PF02991 0.395
LIG_LIR_Nem_3 26 32 PF02991 0.493
LIG_LIR_Nem_3 391 397 PF02991 0.551
LIG_LIR_Nem_3 469 475 PF02991 0.334
LIG_LIR_Nem_3 506 512 PF02991 0.368
LIG_LIR_Nem_3 571 577 PF02991 0.380
LIG_LIR_Nem_3 614 620 PF02991 0.480
LIG_LIR_Nem_3 630 636 PF02991 0.403
LIG_LIR_Nem_3 639 643 PF02991 0.408
LIG_LIR_Nem_3 705 711 PF02991 0.530
LIG_LIR_Nem_3 78 84 PF02991 0.532
LIG_NRBOX 45 51 PF00104 0.423
LIG_NRBOX 6 12 PF00104 0.387
LIG_Pex14_1 611 615 PF04695 0.522
LIG_Pex14_2 159 163 PF04695 0.424
LIG_Pex14_2 708 712 PF04695 0.579
LIG_SH2_CRK 337 341 PF00017 0.687
LIG_SH2_CRK 509 513 PF00017 0.484
LIG_SH2_CRK 674 678 PF00017 0.646
LIG_SH2_NCK_1 648 652 PF00017 0.561
LIG_SH2_PTP2 178 181 PF00017 0.340
LIG_SH2_PTP2 368 371 PF00017 0.448
LIG_SH2_PTP2 472 475 PF00017 0.404
LIG_SH2_SRC 178 181 PF00017 0.435
LIG_SH2_SRC 368 371 PF00017 0.448
LIG_SH2_STAP1 399 403 PF00017 0.294
LIG_SH2_STAP1 481 485 PF00017 0.465
LIG_SH2_STAP1 509 513 PF00017 0.337
LIG_SH2_STAT5 158 161 PF00017 0.370
LIG_SH2_STAT5 178 181 PF00017 0.211
LIG_SH2_STAT5 230 233 PF00017 0.426
LIG_SH2_STAT5 277 280 PF00017 0.450
LIG_SH2_STAT5 368 371 PF00017 0.448
LIG_SH2_STAT5 414 417 PF00017 0.482
LIG_SH2_STAT5 472 475 PF00017 0.309
LIG_SH2_STAT5 5 8 PF00017 0.454
LIG_SH2_STAT5 642 645 PF00017 0.428
LIG_SH2_STAT5 738 741 PF00017 0.433
LIG_SH3_2 299 304 PF14604 0.674
LIG_SH3_3 101 107 PF00018 0.679
LIG_SH3_3 208 214 PF00018 0.492
LIG_SH3_3 296 302 PF00018 0.679
LIG_SH3_3 34 40 PF00018 0.502
LIG_SH3_3 410 416 PF00018 0.488
LIG_SH3_3 657 663 PF00018 0.658
LIG_SH3_3 85 91 PF00018 0.615
LIG_SUMO_SIM_anti_2 576 581 PF11976 0.352
LIG_SUMO_SIM_par_1 521 526 PF11976 0.424
LIG_TRAF2_1 330 333 PF00917 0.590
LIG_TRAF2_1 343 346 PF00917 0.509
LIG_TRAF2_1 569 572 PF00917 0.482
LIG_TRFH_1 158 162 PF08558 0.341
LIG_UBA3_1 753 759 PF00899 0.489
LIG_WRC_WIRS_1 110 115 PF05994 0.426
LIG_WW_3 459 463 PF00397 0.485
MOD_CDK_SPK_2 678 683 PF00069 0.606
MOD_CDK_SPxK_1 298 304 PF00069 0.565
MOD_CDK_SPxxK_3 727 734 PF00069 0.477
MOD_CK1_1 135 141 PF00069 0.585
MOD_CK1_1 215 221 PF00069 0.434
MOD_CK1_1 295 301 PF00069 0.670
MOD_CK1_1 338 344 PF00069 0.727
MOD_CK1_1 373 379 PF00069 0.521
MOD_CK1_1 665 671 PF00069 0.617
MOD_CK2_1 14 20 PF00069 0.493
MOD_CK2_1 195 201 PF00069 0.588
MOD_CK2_1 21 27 PF00069 0.473
MOD_CK2_1 256 262 PF00069 0.397
MOD_CK2_1 318 324 PF00069 0.641
MOD_CK2_1 347 353 PF00069 0.685
MOD_CK2_1 430 436 PF00069 0.563
MOD_CK2_1 453 459 PF00069 0.686
MOD_CK2_1 566 572 PF00069 0.567
MOD_CK2_1 638 644 PF00069 0.451
MOD_CK2_1 727 733 PF00069 0.567
MOD_CMANNOS 76 79 PF00535 0.496
MOD_GlcNHglycan 100 103 PF01048 0.463
MOD_GlcNHglycan 11 14 PF01048 0.302
MOD_GlcNHglycan 137 140 PF01048 0.728
MOD_GlcNHglycan 171 174 PF01048 0.301
MOD_GlcNHglycan 191 194 PF01048 0.659
MOD_GlcNHglycan 227 230 PF01048 0.344
MOD_GlcNHglycan 304 307 PF01048 0.775
MOD_GlcNHglycan 318 321 PF01048 0.672
MOD_GlcNHglycan 337 340 PF01048 0.538
MOD_GlcNHglycan 349 352 PF01048 0.685
MOD_GlcNHglycan 353 356 PF01048 0.636
MOD_GlcNHglycan 358 362 PF01048 0.592
MOD_GlcNHglycan 372 375 PF01048 0.296
MOD_GlcNHglycan 399 402 PF01048 0.398
MOD_GlcNHglycan 432 435 PF01048 0.428
MOD_GlcNHglycan 448 452 PF01048 0.645
MOD_GlcNHglycan 455 458 PF01048 0.704
MOD_GlcNHglycan 462 465 PF01048 0.664
MOD_GlcNHglycan 554 557 PF01048 0.627
MOD_GlcNHglycan 64 67 PF01048 0.624
MOD_GlcNHglycan 651 654 PF01048 0.569
MOD_GlcNHglycan 664 667 PF01048 0.721
MOD_GlcNHglycan 704 707 PF01048 0.643
MOD_GlcNHglycan 746 749 PF01048 0.456
MOD_GSK3_1 225 232 PF00069 0.376
MOD_GSK3_1 293 300 PF00069 0.664
MOD_GSK3_1 314 321 PF00069 0.670
MOD_GSK3_1 341 348 PF00069 0.691
MOD_GSK3_1 447 454 PF00069 0.545
MOD_GSK3_1 622 629 PF00069 0.531
MOD_GSK3_1 691 698 PF00069 0.598
MOD_GSK3_1 715 722 PF00069 0.546
MOD_GSK3_1 80 87 PF00069 0.579
MOD_N-GLC_1 397 402 PF02516 0.422
MOD_NEK2_1 1 6 PF00069 0.509
MOD_NEK2_1 111 116 PF00069 0.362
MOD_NEK2_1 388 393 PF00069 0.516
MOD_NEK2_1 406 411 PF00069 0.596
MOD_NEK2_1 50 55 PF00069 0.638
MOD_NEK2_1 523 528 PF00069 0.470
MOD_NEK2_1 743 748 PF00069 0.518
MOD_NEK2_2 438 443 PF00069 0.266
MOD_PIKK_1 111 117 PF00454 0.360
MOD_PIKK_1 500 506 PF00454 0.348
MOD_PIKK_1 698 704 PF00454 0.609
MOD_PKA_1 719 725 PF00069 0.609
MOD_PKA_2 135 141 PF00069 0.543
MOD_PKA_2 285 291 PF00069 0.553
MOD_PKA_2 293 299 PF00069 0.573
MOD_PKA_2 388 394 PF00069 0.482
MOD_PKA_2 566 572 PF00069 0.406
MOD_PKA_2 592 598 PF00069 0.642
MOD_PKA_2 622 628 PF00069 0.583
MOD_PKA_2 719 725 PF00069 0.608
MOD_PKB_1 514 522 PF00069 0.352
MOD_PKB_1 717 725 PF00069 0.603
MOD_Plk_1 256 262 PF00069 0.397
MOD_Plk_1 345 351 PF00069 0.609
MOD_Plk_1 406 412 PF00069 0.394
MOD_Plk_1 611 617 PF00069 0.410
MOD_Plk_1 698 704 PF00069 0.625
MOD_Plk_2-3 493 499 PF00069 0.274
MOD_Plk_4 1 7 PF00069 0.251
MOD_Plk_4 373 379 PF00069 0.609
MOD_Plk_4 388 394 PF00069 0.444
MOD_Plk_4 406 412 PF00069 0.423
MOD_Plk_4 534 540 PF00069 0.448
MOD_Plk_4 638 644 PF00069 0.427
MOD_ProDKin_1 103 109 PF00069 0.540
MOD_ProDKin_1 295 301 PF00069 0.726
MOD_ProDKin_1 491 497 PF00069 0.351
MOD_ProDKin_1 647 653 PF00069 0.608
MOD_ProDKin_1 678 684 PF00069 0.718
MOD_ProDKin_1 727 733 PF00069 0.588
MOD_SUMO_for_1 749 752 PF00179 0.429
MOD_SUMO_rev_2 65 73 PF00179 0.509
MOD_SUMO_rev_2 736 744 PF00179 0.439
TRG_DiLeu_BaEn_1 28 33 PF01217 0.476
TRG_ENDOCYTIC_2 178 181 PF00928 0.340
TRG_ENDOCYTIC_2 337 340 PF00928 0.689
TRG_ENDOCYTIC_2 472 475 PF00928 0.309
TRG_ENDOCYTIC_2 508 511 PF00928 0.350
TRG_ENDOCYTIC_2 640 643 PF00928 0.422
TRG_ER_diArg_1 154 157 PF00400 0.561
TRG_ER_diArg_1 325 328 PF00400 0.517
TRG_ER_diArg_1 513 516 PF00400 0.392
TRG_ER_diArg_1 548 550 PF00400 0.508
TRG_ER_diArg_1 716 719 PF00400 0.512

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY62 Leptomonas seymouri 48% 89%
A0A1X0P9D5 Trypanosomatidae 29% 100%
A0A3S7X7D8 Leishmania donovani 89% 100%
A0A422N292 Trypanosoma rangeli 31% 100%
A4HAD6 Leishmania braziliensis 80% 100%
A4I9I8 Leishmania infantum 89% 100%
Q4Q3J0 Leishmania major 88% 100%
V5BM66 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS