Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PrimPol-like protein 2, putative

Species:

Leishmania mexicana

UniProt:

E9B4H7_LEIMU

TriTrypDb:

LmxM.33.0100

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4H7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003887	DNA-directed DNA polymerase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0034061	DNA polymerase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	645	649	PF00656	0.529
CLV_NRD_NRD_1	213	215	PF00675	0.443
CLV_NRD_NRD_1	238	240	PF00675	0.533
CLV_NRD_NRD_1	684	686	PF00675	0.476
CLV_PCSK_FUR_1	303	307	PF00082	0.519
CLV_PCSK_KEX2_1	213	215	PF00082	0.443
CLV_PCSK_KEX2_1	238	240	PF00082	0.583
CLV_PCSK_KEX2_1	305	307	PF00082	0.563
CLV_PCSK_KEX2_1	401	403	PF00082	0.501
CLV_PCSK_KEX2_1	684	686	PF00082	0.476
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.503
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.501
CLV_PCSK_PC7_1	397	403	PF00082	0.390
CLV_PCSK_SKI1_1	203	207	PF00082	0.343
CLV_PCSK_SKI1_1	265	269	PF00082	0.543
CLV_PCSK_SKI1_1	408	412	PF00082	0.310
CLV_PCSK_SKI1_1	494	498	PF00082	0.755
CLV_PCSK_SKI1_1	540	544	PF00082	0.452
CLV_PCSK_SKI1_1	670	674	PF00082	0.367
CLV_PCSK_SKI1_1	85	89	PF00082	0.485
CLV_Separin_Metazoa	681	685	PF03568	0.497
DEG_APCC_DBOX_1	264	272	PF00400	0.581
DEG_APCC_DBOX_1	407	415	PF00400	0.280
DEG_APCC_DBOX_1	539	547	PF00400	0.287
DEG_Nend_UBRbox_3	1	3	PF02207	0.520
DEG_SPOP_SBC_1	229	233	PF00917	0.355
DEG_SPOP_SBC_1	291	295	PF00917	0.572
DEG_SPOP_SBC_1	447	451	PF00917	0.396
DOC_CKS1_1	240	245	PF01111	0.506
DOC_CKS1_1	47	52	PF01111	0.458
DOC_CYCLIN_RxL_1	200	210	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	432	435	PF00134	0.359
DOC_MAPK_gen_1	600	608	PF00069	0.541
DOC_MAPK_MEF2A_6	85	92	PF00069	0.503
DOC_MAPK_NFAT4_5	85	93	PF00069	0.401
DOC_PP1_RVXF_1	251	257	PF00149	0.331
DOC_PP1_RVXF_1	316	323	PF00149	0.455
DOC_PP2B_LxvP_1	432	435	PF13499	0.359
DOC_PP2B_LxvP_1	56	59	PF13499	0.509
DOC_PP2B_LxvP_1	673	676	PF13499	0.389
DOC_PP4_FxxP_1	331	334	PF00568	0.359
DOC_PP4_FxxP_1	409	412	PF00568	0.331
DOC_PP4_FxxP_1	428	431	PF00568	0.370
DOC_PP4_FxxP_1	519	522	PF00568	0.580
DOC_USP7_MATH_1	342	346	PF00917	0.643
DOC_USP7_MATH_1	347	351	PF00917	0.655
DOC_USP7_MATH_1	376	380	PF00917	0.441
DOC_USP7_MATH_1	447	451	PF00917	0.688
DOC_USP7_MATH_1	501	505	PF00917	0.580
DOC_USP7_MATH_1	507	511	PF00917	0.601
DOC_USP7_MATH_1	578	582	PF00917	0.399
DOC_WW_Pin1_4	239	244	PF00397	0.554
DOC_WW_Pin1_4	26	31	PF00397	0.631
DOC_WW_Pin1_4	292	297	PF00397	0.539
DOC_WW_Pin1_4	427	432	PF00397	0.476
DOC_WW_Pin1_4	43	48	PF00397	0.675
DOC_WW_Pin1_4	514	519	PF00397	0.638
DOC_WW_Pin1_4	574	579	PF00397	0.403
LIG_14-3-3_CanoR_1	108	116	PF00244	0.547
LIG_14-3-3_CanoR_1	310	317	PF00244	0.376
LIG_14-3-3_CanoR_1	421	429	PF00244	0.557
LIG_14-3-3_CanoR_1	685	691	PF00244	0.348
LIG_Actin_WH2_2	205	223	PF00022	0.501
LIG_APCC_ABBA_1	158	163	PF00400	0.364
LIG_BRCT_BRCA1_1	489	493	PF00533	0.630
LIG_BRCT_BRCA1_1	515	519	PF00533	0.625
LIG_BRCT_BRCA1_1	99	103	PF00533	0.523
LIG_FHA_1	220	226	PF00498	0.374
LIG_FHA_1	229	235	PF00498	0.330
LIG_FHA_1	677	683	PF00498	0.588
LIG_FHA_1	686	692	PF00498	0.501
LIG_FHA_2	221	227	PF00498	0.479
LIG_FHA_2	69	75	PF00498	0.432
LIG_LIR_Apic_2	24	30	PF02991	0.532
LIG_LIR_Apic_2	427	431	PF02991	0.431
LIG_LIR_Apic_2	516	522	PF02991	0.618
LIG_LIR_Apic_2	553	557	PF02991	0.437
LIG_LIR_Gen_1	100	111	PF02991	0.505
LIG_LIR_Gen_1	568	578	PF02991	0.504
LIG_LIR_Gen_1	6	17	PF02991	0.557
LIG_LIR_Gen_1	615	623	PF02991	0.485
LIG_LIR_Nem_3	100	106	PF02991	0.493
LIG_LIR_Nem_3	13	19	PF02991	0.505
LIG_LIR_Nem_3	159	164	PF02991	0.337
LIG_LIR_Nem_3	321	325	PF02991	0.366
LIG_LIR_Nem_3	326	331	PF02991	0.428
LIG_LIR_Nem_3	404	410	PF02991	0.329
LIG_LIR_Nem_3	490	496	PF02991	0.622
LIG_LIR_Nem_3	545	550	PF02991	0.377
LIG_LIR_Nem_3	568	573	PF02991	0.526
LIG_LIR_Nem_3	6	12	PF02991	0.519
LIG_LIR_Nem_3	615	619	PF02991	0.428
LIG_LIR_Nem_3	622	626	PF02991	0.429
LIG_Pex14_2	162	166	PF04695	0.467
LIG_Pex14_2	256	260	PF04695	0.307
LIG_PTAP_UEV_1	242	247	PF05743	0.428
LIG_PTB_Apo_2	668	675	PF02174	0.445
LIG_RPA_C_Fungi	90	102	PF08784	0.491
LIG_SH2_CRK	554	558	PF00017	0.454
LIG_SH2_GRB2like	631	634	PF00017	0.486
LIG_SH2_NCK_1	149	153	PF00017	0.445
LIG_SH2_SRC	588	591	PF00017	0.451
LIG_SH2_STAP1	588	592	PF00017	0.521
LIG_SH2_STAP1	663	667	PF00017	0.487
LIG_SH2_STAT3	393	396	PF00017	0.356
LIG_SH2_STAT3	596	599	PF00017	0.360
LIG_SH2_STAT5	161	164	PF00017	0.449
LIG_SH2_STAT5	325	328	PF00017	0.484
LIG_SH2_STAT5	398	401	PF00017	0.452
LIG_SH2_STAT5	596	599	PF00017	0.428
LIG_SH2_STAT5	604	607	PF00017	0.509
LIG_SH2_STAT5	620	623	PF00017	0.279
LIG_SH3_1	44	50	PF00018	0.597
LIG_SH3_3	154	160	PF00018	0.463
LIG_SH3_3	16	22	PF00018	0.526
LIG_SH3_3	237	243	PF00018	0.585
LIG_SH3_3	409	415	PF00018	0.309
LIG_SH3_3	428	434	PF00018	0.336
LIG_SH3_3	44	50	PF00018	0.657
LIG_SH3_3	441	447	PF00018	0.447
LIG_SH3_3	512	518	PF00018	0.587
LIG_SH3_3	519	525	PF00018	0.575
LIG_SH3_3	55	61	PF00018	0.488
LIG_SH3_3	644	650	PF00018	0.491
LIG_SUMO_SIM_anti_2	48	55	PF11976	0.517
LIG_SUMO_SIM_par_1	88	93	PF11976	0.476
LIG_TRAF2_1	483	486	PF00917	0.610
LIG_TRAF2_1	678	681	PF00917	0.473
LIG_WRC_WIRS_1	620	625	PF05994	0.486
MOD_CDC14_SPxK_1	300	303	PF00782	0.560
MOD_CDK_SPxK_1	297	303	PF00069	0.574
MOD_CK1_1	233	239	PF00069	0.432
MOD_CK1_1	297	303	PF00069	0.615
MOD_CK1_1	340	346	PF00069	0.539
MOD_CK1_1	448	454	PF00069	0.580
MOD_CK1_1	487	493	PF00069	0.707
MOD_CK1_1	574	580	PF00069	0.436
MOD_CK2_1	116	122	PF00069	0.587
MOD_CK2_1	180	186	PF00069	0.436
MOD_CK2_1	220	226	PF00069	0.502
MOD_CK2_1	267	273	PF00069	0.496
MOD_CK2_1	675	681	PF00069	0.496
MOD_CK2_1	68	74	PF00069	0.522
MOD_Cter_Amidation	236	239	PF01082	0.426
MOD_DYRK1A_RPxSP_1	239	243	PF00069	0.499
MOD_GlcNHglycan	109	112	PF01048	0.490
MOD_GlcNHglycan	117	121	PF01048	0.730
MOD_GlcNHglycan	122	126	PF01048	0.669
MOD_GlcNHglycan	130	133	PF01048	0.458
MOD_GlcNHglycan	137	140	PF01048	0.467
MOD_GlcNHglycan	173	178	PF01048	0.284
MOD_GlcNHglycan	196	199	PF01048	0.439
MOD_GlcNHglycan	243	246	PF01048	0.532
MOD_GlcNHglycan	312	315	PF01048	0.501
MOD_GlcNHglycan	345	348	PF01048	0.648
MOD_GlcNHglycan	349	352	PF01048	0.593
MOD_GlcNHglycan	36	40	PF01048	0.691
MOD_GlcNHglycan	452	455	PF01048	0.456
MOD_GlcNHglycan	458	461	PF01048	0.390
MOD_GlcNHglycan	471	475	PF01048	0.388
MOD_GlcNHglycan	503	506	PF01048	0.579
MOD_GlcNHglycan	510	513	PF01048	0.632
MOD_GlcNHglycan	573	576	PF01048	0.572
MOD_GlcNHglycan	651	654	PF01048	0.684
MOD_GlcNHglycan	95	98	PF01048	0.526
MOD_GSK3_1	116	123	PF00069	0.596
MOD_GSK3_1	215	222	PF00069	0.508
MOD_GSK3_1	229	236	PF00069	0.336
MOD_GSK3_1	241	248	PF00069	0.503
MOD_GSK3_1	276	283	PF00069	0.538
MOD_GSK3_1	290	297	PF00069	0.478
MOD_GSK3_1	343	350	PF00069	0.663
MOD_GSK3_1	376	383	PF00069	0.545
MOD_GSK3_1	445	452	PF00069	0.552
MOD_GSK3_1	45	52	PF00069	0.611
MOD_GSK3_1	484	491	PF00069	0.559
MOD_GSK3_1	574	581	PF00069	0.539
MOD_GSK3_1	64	71	PF00069	0.338
MOD_GSK3_1	93	100	PF00069	0.563
MOD_N-GLC_2	633	635	PF02516	0.489
MOD_NEK2_1	180	185	PF00069	0.433
MOD_NEK2_1	220	225	PF00069	0.429
MOD_NEK2_1	228	233	PF00069	0.292
MOD_NEK2_1	252	257	PF00069	0.492
MOD_NEK2_1	34	39	PF00069	0.522
MOD_NEK2_1	420	425	PF00069	0.247
MOD_NEK2_1	619	624	PF00069	0.397
MOD_NEK2_1	64	69	PF00069	0.412
MOD_NEK2_2	588	593	PF00069	0.516
MOD_PIKK_1	276	282	PF00454	0.388
MOD_PIKK_1	340	346	PF00454	0.463
MOD_PKA_2	107	113	PF00069	0.420
MOD_PKA_2	420	426	PF00069	0.246
MOD_Plk_1	116	122	PF00069	0.478
MOD_Plk_1	164	170	PF00069	0.512
MOD_Plk_1	4	10	PF00069	0.510
MOD_Plk_1	470	476	PF00069	0.603
MOD_Plk_1	588	594	PF00069	0.507
MOD_Plk_4	204	210	PF00069	0.448
MOD_Plk_4	220	226	PF00069	0.313
MOD_Plk_4	376	382	PF00069	0.405
MOD_Plk_4	4	10	PF00069	0.587
MOD_Plk_4	49	55	PF00069	0.625
MOD_Plk_4	64	70	PF00069	0.380
MOD_Plk_4	686	692	PF00069	0.509
MOD_ProDKin_1	239	245	PF00069	0.551
MOD_ProDKin_1	26	32	PF00069	0.632
MOD_ProDKin_1	292	298	PF00069	0.546
MOD_ProDKin_1	427	433	PF00069	0.471
MOD_ProDKin_1	43	49	PF00069	0.674
MOD_ProDKin_1	514	520	PF00069	0.640
MOD_ProDKin_1	574	580	PF00069	0.397
MOD_SUMO_rev_2	183	190	PF00179	0.454
TRG_DiLeu_BaEn_2	272	278	PF01217	0.378
TRG_DiLeu_BaLyEn_6	491	496	PF01217	0.672
TRG_ENDOCYTIC_2	149	152	PF00928	0.396
TRG_ENDOCYTIC_2	161	164	PF00928	0.360
TRG_ENDOCYTIC_2	595	598	PF00928	0.464
TRG_ENDOCYTIC_2	620	623	PF00928	0.379
TRG_ENDOCYTIC_2	663	666	PF00928	0.378
TRG_ER_diArg_1	212	214	PF00400	0.439
TRG_ER_diArg_1	238	240	PF00400	0.566
TRG_ER_diArg_1	281	284	PF00400	0.459
TRG_ER_diArg_1	530	533	PF00400	0.597
TRG_ER_diArg_1	683	685	PF00400	0.461
TRG_NES_CRM1_1	250	264	PF08389	0.409
TRG_NES_CRM1_1	355	370	PF08389	0.500
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	540	545	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZS4	Leptomonas seymouri	53%	89%
A0A1X0P8G3	Trypanosomatidae	34%	94%
A0A3R7N6P4	Trypanosoma rangeli	36%	94%
A0A3S7X7B7	Leishmania donovani	91%	100%
A4HAC4	Leishmania braziliensis	80%	100%
A4I9H9	Leishmania infantum	91%	100%
D0A1T6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	95%
Q4Q3J8	Leishmania major	88%	100%