Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4H6_LEIMU

TriTrypDb:

LmxM.33.0090

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	78	84	PF00089	0.365
CLV_NRD_NRD_1	252	254	PF00675	0.615
CLV_NRD_NRD_1	502	504	PF00675	0.466
CLV_NRD_NRD_1	58	60	PF00675	0.561
CLV_NRD_NRD_1	80	82	PF00675	0.664
CLV_PCSK_FUR_1	500	504	PF00082	0.634
CLV_PCSK_KEX2_1	252	254	PF00082	0.615
CLV_PCSK_KEX2_1	502	504	PF00082	0.535
CLV_PCSK_KEX2_1	79	81	PF00082	0.669
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.669
CLV_PCSK_SKI1_1	166	170	PF00082	0.570
CLV_PCSK_SKI1_1	290	294	PF00082	0.538
CLV_PCSK_SKI1_1	318	322	PF00082	0.606
CLV_PCSK_SKI1_1	462	466	PF00082	0.406
CLV_PCSK_SKI1_1	484	488	PF00082	0.524
CLV_PCSK_SKI1_1	503	507	PF00082	0.274
DEG_APCC_DBOX_1	165	173	PF00400	0.524
DEG_SPOP_SBC_1	376	380	PF00917	0.630
DOC_CYCLIN_RxL_1	312	325	PF00134	0.625
DOC_CYCLIN_RxL_1	481	488	PF00134	0.283
DOC_MAPK_gen_1	484	492	PF00069	0.281
DOC_MAPK_HePTP_8	482	494	PF00069	0.274
DOC_MAPK_MEF2A_6	208	215	PF00069	0.562
DOC_MAPK_MEF2A_6	222	229	PF00069	0.455
DOC_MAPK_MEF2A_6	485	494	PF00069	0.273
DOC_MAPK_NFAT4_5	222	230	PF00069	0.588
DOC_MAPK_RevD_3	490	503	PF00069	0.292
DOC_MIT_MIM_1	572	582	PF04212	0.649
DOC_PP1_RVXF_1	567	573	PF00149	0.717
DOC_PP2B_LxvP_1	6	9	PF13499	0.429
DOC_PP4_FxxP_1	342	345	PF00568	0.656
DOC_USP7_MATH_1	118	122	PF00917	0.694
DOC_USP7_MATH_1	228	232	PF00917	0.358
DOC_USP7_MATH_1	275	279	PF00917	0.776
DOC_USP7_MATH_1	280	284	PF00917	0.653
DOC_USP7_MATH_1	356	360	PF00917	0.574
DOC_USP7_MATH_1	376	380	PF00917	0.656
DOC_USP7_MATH_1	384	388	PF00917	0.640
DOC_USP7_MATH_1	404	408	PF00917	0.608
DOC_WW_Pin1_4	271	276	PF00397	0.714
DOC_WW_Pin1_4	32	37	PF00397	0.473
DOC_WW_Pin1_4	400	405	PF00397	0.349
LIG_14-3-3_CanoR_1	105	109	PF00244	0.473
LIG_14-3-3_CanoR_1	16	22	PF00244	0.630
LIG_14-3-3_CanoR_1	204	208	PF00244	0.554
LIG_14-3-3_CanoR_1	290	296	PF00244	0.607
LIG_14-3-3_CanoR_1	383	391	PF00244	0.746
LIG_14-3-3_CanoR_1	491	495	PF00244	0.558
LIG_14-3-3_CanoR_1	80	89	PF00244	0.686
LIG_Actin_WH2_2	422	438	PF00022	0.510
LIG_AP2alpha_2	139	141	PF02296	0.727
LIG_APCC_ABBA_1	172	177	PF00400	0.632
LIG_BRCT_BRCA1_1	295	299	PF00533	0.478
LIG_BRCT_BRCA1_1	338	342	PF00533	0.501
LIG_BRCT_BRCA1_1	492	496	PF00533	0.562
LIG_deltaCOP1_diTrp_1	137	143	PF00928	0.732
LIG_FHA_1	124	130	PF00498	0.773
LIG_FHA_1	197	203	PF00498	0.537
LIG_FHA_1	266	272	PF00498	0.697
LIG_FHA_1	397	403	PF00498	0.529
LIG_FHA_1	408	414	PF00498	0.356
LIG_FHA_1	417	423	PF00498	0.264
LIG_FHA_1	444	450	PF00498	0.571
LIG_FHA_1	46	52	PF00498	0.558
LIG_FHA_1	525	531	PF00498	0.500
LIG_FHA_1	73	79	PF00498	0.612
LIG_FHA_2	429	435	PF00498	0.629
LIG_LIR_Apic_2	339	345	PF02991	0.525
LIG_LIR_Gen_1	294	303	PF02991	0.448
LIG_LIR_Gen_1	406	416	PF02991	0.460
LIG_LIR_Gen_1	488	496	PF02991	0.493
LIG_LIR_Gen_1	571	580	PF02991	0.717
LIG_LIR_LC3C_4	409	413	PF02991	0.551
LIG_LIR_Nem_3	157	163	PF02991	0.636
LIG_LIR_Nem_3	185	191	PF02991	0.539
LIG_LIR_Nem_3	294	298	PF02991	0.461
LIG_LIR_Nem_3	392	397	PF02991	0.555
LIG_LIR_Nem_3	406	411	PF02991	0.474
LIG_LIR_Nem_3	488	492	PF02991	0.498
LIG_LIR_Nem_3	493	499	PF02991	0.553
LIG_LIR_Nem_3	571	575	PF02991	0.711
LIG_LYPXL_yS_3	337	340	PF13949	0.669
LIG_MLH1_MIPbox_1	295	299	PF16413	0.478
LIG_MYND_1	372	376	PF01753	0.647
LIG_NRBOX	37	43	PF00104	0.530
LIG_NRBOX	444	450	PF00104	0.440
LIG_SH2_CRK	14	18	PF00017	0.594
LIG_SH2_CRK	160	164	PF00017	0.698
LIG_SH2_GRB2like	201	204	PF00017	0.558
LIG_SH2_GRB2like	471	474	PF00017	0.539
LIG_SH2_PTP2	489	492	PF00017	0.273
LIG_SH2_SRC	305	308	PF00017	0.450
LIG_SH2_STAP1	295	299	PF00017	0.445
LIG_SH2_STAT5	175	178	PF00017	0.644
LIG_SH2_STAT5	201	204	PF00017	0.541
LIG_SH2_STAT5	305	308	PF00017	0.419
LIG_SH2_STAT5	390	393	PF00017	0.620
LIG_SH2_STAT5	40	43	PF00017	0.530
LIG_SH2_STAT5	471	474	PF00017	0.496
LIG_SH2_STAT5	489	492	PF00017	0.533
LIG_SH2_STAT5	498	501	PF00017	0.452
LIG_SH3_3	370	376	PF00018	0.487
LIG_SH3_3	398	404	PF00018	0.547
LIG_SUMO_SIM_anti_2	167	173	PF11976	0.634
LIG_SUMO_SIM_anti_2	409	415	PF11976	0.428
LIG_SUMO_SIM_par_1	409	415	PF11976	0.446
LIG_TRAF2_1	518	521	PF00917	0.501
LIG_TYR_ITIM	38	43	PF00017	0.548
LIG_TYR_ITIM	487	492	PF00017	0.276
LIG_UBA3_1	257	264	PF00899	0.563
LIG_WRC_WIRS_1	295	300	PF05994	0.500
MOD_CK1_1	121	127	PF00069	0.765
MOD_CK1_1	150	156	PF00069	0.709
MOD_CK1_1	278	284	PF00069	0.635
MOD_CK1_1	294	300	PF00069	0.483
MOD_CK1_1	403	409	PF00069	0.560
MOD_CK1_1	443	449	PF00069	0.495
MOD_CK1_1	45	51	PF00069	0.588
MOD_CK2_1	428	434	PF00069	0.632
MOD_CK2_1	46	52	PF00069	0.636
MOD_CK2_1	515	521	PF00069	0.504
MOD_DYRK1A_RPxSP_1	400	404	PF00069	0.351
MOD_GlcNHglycan	114	117	PF01048	0.737
MOD_GlcNHglycan	120	123	PF01048	0.779
MOD_GlcNHglycan	145	148	PF01048	0.679
MOD_GlcNHglycan	17	20	PF01048	0.560
MOD_GlcNHglycan	230	233	PF01048	0.356
MOD_GlcNHglycan	277	280	PF01048	0.683
MOD_GlcNHglycan	358	361	PF01048	0.713
MOD_GlcNHglycan	364	367	PF01048	0.744
MOD_GlcNHglycan	414	417	PF01048	0.441
MOD_GlcNHglycan	572	575	PF01048	0.667
MOD_GlcNHglycan	582	585	PF01048	0.566
MOD_GSK3_1	121	128	PF00069	0.775
MOD_GSK3_1	139	146	PF00069	0.565
MOD_GSK3_1	150	157	PF00069	0.680
MOD_GSK3_1	17	24	PF00069	0.633
MOD_GSK3_1	214	221	PF00069	0.573
MOD_GSK3_1	271	278	PF00069	0.672
MOD_GSK3_1	294	301	PF00069	0.509
MOD_GSK3_1	356	363	PF00069	0.754
MOD_GSK3_1	396	403	PF00069	0.627
MOD_GSK3_1	412	419	PF00069	0.395
MOD_GSK3_1	42	49	PF00069	0.653
MOD_GSK3_1	424	431	PF00069	0.516
MOD_GSK3_1	440	447	PF00069	0.501
MOD_GSK3_1	524	531	PF00069	0.503
MOD_GSK3_1	99	106	PF00069	0.678
MOD_LATS_1	381	387	PF00433	0.526
MOD_N-GLC_1	275	280	PF02516	0.614
MOD_N-GLC_1	46	51	PF02516	0.555
MOD_NEK2_1	143	148	PF00069	0.657
MOD_NEK2_1	17	22	PF00069	0.593
MOD_NEK2_1	218	223	PF00069	0.481
MOD_NEK2_1	291	296	PF00069	0.497
MOD_NEK2_1	298	303	PF00069	0.466
MOD_NEK2_1	42	47	PF00069	0.363
MOD_NEK2_1	570	575	PF00069	0.619
MOD_PIKK_1	147	153	PF00454	0.692
MOD_PIKK_1	360	366	PF00454	0.654
MOD_PIKK_1	424	430	PF00454	0.513
MOD_PIKK_1	80	86	PF00454	0.674
MOD_PK_1	336	342	PF00069	0.518
MOD_PKA_1	80	86	PF00069	0.674
MOD_PKA_2	104	110	PF00069	0.683
MOD_PKA_2	15	21	PF00069	0.634
MOD_PKA_2	203	209	PF00069	0.551
MOD_PKA_2	265	271	PF00069	0.762
MOD_PKA_2	382	388	PF00069	0.756
MOD_PKA_2	490	496	PF00069	0.558
MOD_PKA_2	80	86	PF00069	0.674
MOD_PKB_1	85	93	PF00069	0.707
MOD_Plk_1	218	224	PF00069	0.573
MOD_Plk_1	443	449	PF00069	0.573
MOD_Plk_1	562	568	PF00069	0.648
MOD_Plk_1	72	78	PF00069	0.567
MOD_Plk_4	104	110	PF00069	0.469
MOD_Plk_4	125	131	PF00069	0.668
MOD_Plk_4	167	173	PF00069	0.556
MOD_Plk_4	17	23	PF00069	0.544
MOD_Plk_4	2	8	PF00069	0.599
MOD_Plk_4	294	300	PF00069	0.466
MOD_Plk_4	366	372	PF00069	0.747
MOD_Plk_4	407	413	PF00069	0.557
MOD_Plk_4	444	450	PF00069	0.469
MOD_Plk_4	478	484	PF00069	0.415
MOD_ProDKin_1	271	277	PF00069	0.713
MOD_ProDKin_1	32	38	PF00069	0.467
MOD_ProDKin_1	400	406	PF00069	0.345
MOD_SUMO_for_1	560	563	PF00179	0.738
MOD_SUMO_rev_2	553	562	PF00179	0.725
TRG_DiLeu_BaEn_1	167	172	PF01217	0.634
TRG_DiLeu_BaEn_1	444	449	PF01217	0.435
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.539
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.347
TRG_ENDOCYTIC_2	14	17	PF00928	0.601
TRG_ENDOCYTIC_2	160	163	PF00928	0.711
TRG_ENDOCYTIC_2	175	178	PF00928	0.644
TRG_ENDOCYTIC_2	288	291	PF00928	0.481
TRG_ENDOCYTIC_2	295	298	PF00928	0.455
TRG_ENDOCYTIC_2	337	340	PF00928	0.669
TRG_ENDOCYTIC_2	40	43	PF00928	0.555
TRG_ENDOCYTIC_2	489	492	PF00928	0.433
TRG_ENDOCYTIC_2	498	501	PF00928	0.586
TRG_ER_diArg_1	251	253	PF00400	0.612
TRG_ER_diArg_1	499	502	PF00400	0.486
TRG_ER_diArg_1	80	82	PF00400	0.664
TRG_ER_diArg_1	85	88	PF00400	0.621
TRG_NLS_Bipartite_1	68	83	PF00514	0.577
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	484	488	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU5	Leptomonas seymouri	43%	99%
A0A3Q8IF64	Leishmania donovani	90%	100%
A4HAC5	Leishmania braziliensis	77%	100%
A4I9H8	Leishmania infantum	90%	100%
Q4Q3J9	Leishmania major	89%	100%