Cleft lip and palate associated transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cleft lip and palate transmembrane protein 1 (CLPTM1), putative

Species:

Leishmania mexicana

UniProt:

E9B4H1_LEIMU

TriTrypDb:

LmxM.33.0050

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B4H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4H1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.629
CLV_C14_Caspase3-7	176	180	PF00656	0.142
CLV_C14_Caspase3-7	564	568	PF00656	0.655
CLV_NRD_NRD_1	332	334	PF00675	0.278
CLV_NRD_NRD_1	413	415	PF00675	0.278
CLV_PCSK_KEX2_1	291	293	PF00082	0.436
CLV_PCSK_KEX2_1	413	415	PF00082	0.287
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.436
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.307
CLV_PCSK_SKI1_1	161	165	PF00082	0.507
CLV_PCSK_SKI1_1	262	266	PF00082	0.487
CLV_PCSK_SKI1_1	291	295	PF00082	0.461
CLV_PCSK_SKI1_1	382	386	PF00082	0.321
CLV_PCSK_SKI1_1	388	392	PF00082	0.306
DEG_SPOP_SBC_1	242	246	PF00917	0.295
DOC_CKS1_1	487	492	PF01111	0.383
DOC_CYCLIN_RxL_1	158	168	PF00134	0.327
DOC_CYCLIN_RxL_1	259	267	PF00134	0.351
DOC_CYCLIN_RxL_1	289	299	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	91	97	PF00134	0.327
DOC_MAPK_FxFP_2	199	202	PF00069	0.351
DOC_MAPK_gen_1	291	297	PF00069	0.351
DOC_MAPK_gen_1	331	341	PF00069	0.461
DOC_MAPK_gen_1	382	392	PF00069	0.551
DOC_MAPK_gen_1	432	441	PF00069	0.464
DOC_MAPK_MEF2A_6	184	193	PF00069	0.247
DOC_MAPK_MEF2A_6	26	35	PF00069	0.153
DOC_MAPK_MEF2A_6	300	307	PF00069	0.351
DOC_PP2B_LxvP_1	145	148	PF13499	0.212
DOC_PP2B_PxIxI_1	489	495	PF00149	0.498
DOC_PP4_FxxP_1	199	202	PF00568	0.261
DOC_PP4_FxxP_1	220	223	PF00568	0.351
DOC_SPAK_OSR1_1	80	84	PF12202	0.327
DOC_USP7_MATH_1	177	181	PF00917	0.340
DOC_USP7_MATH_1	406	410	PF00917	0.551
DOC_USP7_MATH_1	45	49	PF00917	0.349
DOC_USP7_MATH_1	578	582	PF00917	0.650
DOC_USP7_MATH_1	63	67	PF00917	0.173
DOC_WW_Pin1_4	191	196	PF00397	0.256
DOC_WW_Pin1_4	208	213	PF00397	0.247
DOC_WW_Pin1_4	253	258	PF00397	0.276
DOC_WW_Pin1_4	486	491	PF00397	0.370
DOC_WW_Pin1_4	56	61	PF00397	0.296
LIG_14-3-3_CanoR_1	139	144	PF00244	0.303
LIG_14-3-3_CanoR_1	337	342	PF00244	0.490
LIG_14-3-3_CanoR_1	466	472	PF00244	0.322
LIG_14-3-3_CanoR_1	80	84	PF00244	0.319
LIG_BRCT_BRCA1_1	33	37	PF00533	0.250
LIG_BRCT_BRCA1_1	346	350	PF00533	0.409
LIG_BRCT_BRCA1_1	351	355	PF00533	0.415
LIG_BRCT_BRCA1_1	481	485	PF00533	0.410
LIG_CaM_NSCaTE_8	468	475	PF13499	0.296
LIG_CtBP_PxDLS_1	554	558	PF00389	0.641
LIG_deltaCOP1_diTrp_1	19	24	PF00928	0.490
LIG_eIF4E_1	30	36	PF01652	0.380
LIG_FHA_1	129	135	PF00498	0.206
LIG_FHA_1	140	146	PF00498	0.265
LIG_FHA_1	209	215	PF00498	0.327
LIG_FHA_1	250	256	PF00498	0.278
LIG_FHA_1	306	312	PF00498	0.300
LIG_FHA_1	384	390	PF00498	0.478
LIG_FHA_1	395	401	PF00498	0.478
LIG_FHA_1	4	10	PF00498	0.776
LIG_FHA_1	445	451	PF00498	0.167
LIG_FHA_1	487	493	PF00498	0.368
LIG_FHA_1	50	56	PF00498	0.337
LIG_FHA_2	265	271	PF00498	0.327
LIG_FHA_2	514	520	PF00498	0.490
LIG_FHA_2	572	578	PF00498	0.564
LIG_GBD_Chelix_1	306	314	PF00786	0.445
LIG_Integrin_RGD_1	17	19	PF01839	0.314
LIG_Integrin_RGDW_4	17	20	PF00362	0.313
LIG_LIR_Apic_2	200	204	PF02991	0.279
LIG_LIR_Gen_1	19	28	PF02991	0.448
LIG_LIR_Gen_1	316	323	PF02991	0.303
LIG_LIR_Gen_1	34	45	PF02991	0.430
LIG_LIR_Gen_1	347	358	PF02991	0.311
LIG_LIR_Gen_1	363	374	PF02991	0.198
LIG_LIR_Gen_1	456	462	PF02991	0.297
LIG_LIR_Gen_1	482	493	PF02991	0.410
LIG_LIR_Gen_1	519	529	PF02991	0.516
LIG_LIR_Gen_1	540	548	PF02991	0.500
LIG_LIR_Gen_1	79	89	PF02991	0.278
LIG_LIR_Nem_3	180	186	PF02991	0.275
LIG_LIR_Nem_3	19	23	PF02991	0.533
LIG_LIR_Nem_3	209	213	PF02991	0.270
LIG_LIR_Nem_3	316	321	PF02991	0.315
LIG_LIR_Nem_3	335	339	PF02991	0.444
LIG_LIR_Nem_3	34	40	PF02991	0.373
LIG_LIR_Nem_3	347	353	PF02991	0.296
LIG_LIR_Nem_3	363	369	PF02991	0.198
LIG_LIR_Nem_3	379	383	PF02991	0.281
LIG_LIR_Nem_3	453	458	PF02991	0.325
LIG_LIR_Nem_3	508	514	PF02991	0.496
LIG_LIR_Nem_3	519	525	PF02991	0.506
LIG_LIR_Nem_3	540	546	PF02991	0.496
LIG_LIR_Nem_3	79	84	PF02991	0.286
LIG_MLH1_MIPbox_1	346	350	PF16413	0.399
LIG_PCNA_yPIPBox_3	512	522	PF02747	0.491
LIG_Pex14_1	20	24	PF04695	0.342
LIG_Pex14_2	37	41	PF04695	0.388
LIG_Pex14_2	377	381	PF04695	0.367
LIG_Pex14_2	479	483	PF04695	0.289
LIG_Pex14_2	97	101	PF04695	0.198
LIG_PTB_Apo_2	137	144	PF02174	0.299
LIG_PTB_Apo_2	96	103	PF02174	0.311
LIG_REV1ctd_RIR_1	150	158	PF16727	0.318
LIG_REV1ctd_RIR_1	21	28	PF16727	0.342
LIG_SH2_CRK	446	450	PF00017	0.367
LIG_SH2_CRK	458	462	PF00017	0.244
LIG_SH2_CRK	469	473	PF00017	0.223
LIG_SH2_CRK	511	515	PF00017	0.493
LIG_SH2_GRB2like	226	229	PF00017	0.247
LIG_SH2_PTP2	30	33	PF00017	0.348
LIG_SH2_SRC	421	424	PF00017	0.551
LIG_SH2_STAP1	141	145	PF00017	0.291
LIG_SH2_STAP1	446	450	PF00017	0.357
LIG_SH2_STAP1	458	462	PF00017	0.250
LIG_SH2_STAP1	469	473	PF00017	0.252
LIG_SH2_STAT5	141	144	PF00017	0.275
LIG_SH2_STAT5	162	165	PF00017	0.314
LIG_SH2_STAT5	186	189	PF00017	0.236
LIG_SH2_STAT5	226	229	PF00017	0.298
LIG_SH2_STAT5	266	269	PF00017	0.254
LIG_SH2_STAT5	30	33	PF00017	0.348
LIG_SH2_STAT5	349	352	PF00017	0.307
LIG_SH2_STAT5	357	360	PF00017	0.281
LIG_SH2_STAT5	443	446	PF00017	0.295
LIG_SH2_STAT5	455	458	PF00017	0.300
LIG_SH3_3	111	117	PF00018	0.351
LIG_SH3_3	365	371	PF00018	0.412
LIG_SH3_3	57	63	PF00018	0.306
LIG_SUMO_SIM_par_1	293	299	PF11976	0.354
LIG_SUMO_SIM_par_1	302	308	PF11976	0.275
LIG_TRAF2_1	568	571	PF00917	0.678
LIG_TYR_ITIM	28	33	PF00017	0.387
LIG_TYR_ITIM	444	449	PF00017	0.412
LIG_UBA3_1	91	96	PF00899	0.351
LIG_ULM_U2AF65_1	412	417	PF00076	0.495
LIG_WRC_WIRS_1	480	485	PF05994	0.412
MOD_CDK_SPxxK_3	253	260	PF00069	0.351
MOD_CK1_1	22	28	PF00069	0.362
MOD_CK1_1	243	249	PF00069	0.350
MOD_CK1_1	282	288	PF00069	0.260
MOD_CK1_1	340	346	PF00069	0.300
MOD_CK1_1	361	367	PF00069	0.327
MOD_CK1_1	428	434	PF00069	0.527
MOD_CK1_1	513	519	PF00069	0.569
MOD_CK1_1	64	70	PF00069	0.286
MOD_CK2_1	163	169	PF00069	0.246
MOD_CK2_1	282	288	PF00069	0.210
MOD_CK2_1	313	319	PF00069	0.412
MOD_CK2_1	571	577	PF00069	0.534
MOD_Cter_Amidation	331	334	PF01082	0.327
MOD_Cter_Amidation	410	413	PF01082	0.212
MOD_GlcNHglycan	171	174	PF01048	0.529
MOD_GlcNHglycan	179	183	PF01048	0.509
MOD_GlcNHglycan	371	374	PF01048	0.300
MOD_GlcNHglycan	408	411	PF01048	0.351
MOD_GlcNHglycan	458	461	PF01048	0.295
MOD_GlcNHglycan	563	567	PF01048	0.487
MOD_GSK3_1	126	133	PF00069	0.277
MOD_GSK3_1	139	146	PF00069	0.315
MOD_GSK3_1	165	172	PF00069	0.280
MOD_GSK3_1	249	256	PF00069	0.285
MOD_GSK3_1	305	312	PF00069	0.300
MOD_GSK3_1	340	347	PF00069	0.399
MOD_GSK3_1	358	365	PF00069	0.399
MOD_GSK3_1	45	52	PF00069	0.279
MOD_GSK3_1	467	474	PF00069	0.298
MOD_GSK3_1	63	70	PF00069	0.239
MOD_N-GLC_1	110	115	PF02516	0.480
MOD_N-GLC_1	126	131	PF02516	0.367
MOD_N-GLC_1	139	144	PF02516	0.436
MOD_N-GLC_1	240	245	PF02516	0.447
MOD_N-GLC_1	249	254	PF02516	0.447
MOD_NEK2_1	143	148	PF00069	0.343
MOD_NEK2_1	153	158	PF00069	0.305
MOD_NEK2_1	163	168	PF00069	0.228
MOD_NEK2_1	240	245	PF00069	0.259
MOD_NEK2_1	249	254	PF00069	0.210
MOD_NEK2_1	264	269	PF00069	0.234
MOD_NEK2_1	295	300	PF00069	0.263
MOD_NEK2_1	305	310	PF00069	0.269
MOD_NEK2_1	383	388	PF00069	0.445
MOD_NEK2_1	444	449	PF00069	0.269
MOD_NEK2_1	461	466	PF00069	0.418
MOD_NEK2_1	471	476	PF00069	0.294
MOD_NEK2_1	479	484	PF00069	0.202
MOD_NEK2_2	110	115	PF00069	0.328
MOD_PIKK_1	243	249	PF00454	0.351
MOD_PIKK_1	264	270	PF00454	0.327
MOD_PIKK_1	272	278	PF00454	0.327
MOD_PIKK_1	358	364	PF00454	0.431
MOD_PIKK_1	430	436	PF00454	0.527
MOD_PIKK_1	472	478	PF00454	0.300
MOD_PIKK_1	84	90	PF00454	0.344
MOD_PK_1	337	343	PF00069	0.499
MOD_PK_1	497	503	PF00069	0.540
MOD_PKA_2	153	159	PF00069	0.284
MOD_PKA_2	406	412	PF00069	0.534
MOD_PKA_2	79	85	PF00069	0.321
MOD_Plk_1	110	116	PF00069	0.282
MOD_Plk_1	126	132	PF00069	0.173
MOD_Plk_1	139	145	PF00069	0.261
MOD_Plk_1	178	184	PF00069	0.288
MOD_Plk_1	189	195	PF00069	0.303
MOD_Plk_1	249	255	PF00069	0.260
MOD_Plk_1	269	275	PF00069	0.115
MOD_Plk_1	362	368	PF00069	0.250
MOD_Plk_1	555	561	PF00069	0.653
MOD_Plk_4	130	136	PF00069	0.224
MOD_Plk_4	19	25	PF00069	0.445
MOD_Plk_4	221	227	PF00069	0.354
MOD_Plk_4	309	315	PF00069	0.356
MOD_Plk_4	31	37	PF00069	0.375
MOD_Plk_4	349	355	PF00069	0.300
MOD_Plk_4	444	450	PF00069	0.305
MOD_Plk_4	453	459	PF00069	0.292
MOD_Plk_4	467	473	PF00069	0.251
MOD_Plk_4	513	519	PF00069	0.485
MOD_ProDKin_1	191	197	PF00069	0.256
MOD_ProDKin_1	208	214	PF00069	0.247
MOD_ProDKin_1	253	259	PF00069	0.276
MOD_ProDKin_1	486	492	PF00069	0.367
MOD_ProDKin_1	56	62	PF00069	0.296
MOD_SUMO_for_1	390	393	PF00179	0.551
MOD_SUMO_for_1	95	98	PF00179	0.351
MOD_SUMO_rev_2	113	122	PF00179	0.353
MOD_SUMO_rev_2	285	293	PF00179	0.234
MOD_SUMO_rev_2	324	329	PF00179	0.461
TRG_AP2beta_CARGO_1	540	550	PF09066	0.500
TRG_DiLeu_BaEn_3	288	294	PF01217	0.295
TRG_ENDOCYTIC_2	266	269	PF00928	0.261
TRG_ENDOCYTIC_2	30	33	PF00928	0.354
TRG_ENDOCYTIC_2	446	449	PF00928	0.350
TRG_ENDOCYTIC_2	458	461	PF00928	0.234
TRG_ENDOCYTIC_2	469	472	PF00928	0.247
TRG_ENDOCYTIC_2	511	514	PF00928	0.495
TRG_ER_diLys_1	583	586	PF00400	0.740
TRG_NLS_MonoCore_2	411	416	PF00514	0.492
TRG_NLS_MonoExtC_3	412	417	PF00514	0.412
TRG_NLS_MonoExtN_4	412	418	PF00514	0.412
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I8	Leptomonas seymouri	67%	98%
A0A1X0P8S5	Trypanosomatidae	48%	100%
A0A3S7X7A7	Leishmania donovani	92%	100%
A0A422MZT4	Trypanosoma rangeli	49%	99%
A2VE61	Bos taurus	37%	100%
A4HAD0	Leishmania braziliensis	83%	100%
A4I9H3	Leishmania infantum	92%	100%
D0A1S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4Q3K4	Leishmania major	92%	100%
Q54RJ1	Dictyostelium discoideum	38%	95%
Q5R7B1	Pongo abelii	35%	100%
Q5ZKJ0	Gallus gallus	36%	100%
Q6DEL2	Danio rerio	36%	93%
Q8BXA5	Mus musculus	37%	100%
Q96KA5	Homo sapiens	35%	100%
V5DIK4	Trypanosoma cruzi	44%	100%