F-box/LRR-repeat protein 20

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B4G8_LEIMU

TriTrypDb:

LmxM.33.0020

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

E9B4G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4G8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	4
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0016310	phosphorylation	5	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.302
CLV_C14_Caspase3-7	91	95	PF00656	0.350
CLV_NRD_NRD_1	182	184	PF00675	0.226
CLV_NRD_NRD_1	213	215	PF00675	0.544
CLV_NRD_NRD_1	228	230	PF00675	0.343
CLV_NRD_NRD_1	9	11	PF00675	0.542
CLV_PCSK_KEX2_1	182	184	PF00082	0.226
CLV_PCSK_KEX2_1	228	230	PF00082	0.432
CLV_PCSK_SKI1_1	11	15	PF00082	0.446
CLV_PCSK_SKI1_1	183	187	PF00082	0.313
CLV_PCSK_SKI1_1	228	232	PF00082	0.443
CLV_PCSK_SKI1_1	275	279	PF00082	0.482
CLV_PCSK_SKI1_1	381	385	PF00082	0.494
CLV_PCSK_SKI1_1	99	103	PF00082	0.373
DEG_APCC_DBOX_1	98	106	PF00400	0.427
DEG_Nend_Nbox_1	1	3	PF02207	0.384
DEG_ODPH_VHL_1	127	139	PF01847	0.348
DEG_SCF_FBW7_1	232	239	PF00400	0.316
DOC_CYCLIN_RxL_1	179	189	PF00134	0.313
DOC_CYCLIN_RxL_1	226	235	PF00134	0.379
DOC_CYCLIN_RxL_1	272	283	PF00134	0.444
DOC_MAPK_gen_1	214	221	PF00069	0.422
DOC_MAPK_gen_1	247	256	PF00069	0.207
DOC_MAPK_MEF2A_6	317	326	PF00069	0.283
DOC_USP7_MATH_1	236	240	PF00917	0.453
DOC_USP7_UBL2_3	119	123	PF12436	0.373
DOC_WW_Pin1_4	151	156	PF00397	0.248
DOC_WW_Pin1_4	232	237	PF00397	0.497
DOC_WW_Pin1_4	59	64	PF00397	0.312
LIG_14-3-3_CanoR_1	355	362	PF00244	0.463
LIG_14-3-3_CanoR_1	369	374	PF00244	0.209
LIG_BIR_III_4	379	383	PF00653	0.319
LIG_BRCT_BRCA1_1	162	166	PF00533	0.329
LIG_BRCT_BRCA1_1	22	26	PF00533	0.408
LIG_FHA_1	176	182	PF00498	0.468
LIG_FHA_1	200	206	PF00498	0.492
LIG_FHA_1	392	398	PF00498	0.328
LIG_FHA_1	52	58	PF00498	0.354
LIG_FHA_2	374	380	PF00498	0.499
LIG_FHA_2	81	87	PF00498	0.372
LIG_GBD_Chelix_1	318	326	PF00786	0.315
LIG_LIR_Gen_1	172	181	PF02991	0.278
LIG_LIR_Gen_1	367	378	PF02991	0.459
LIG_LIR_Nem_3	222	227	PF02991	0.395
LIG_LIR_Nem_3	367	373	PF02991	0.457
LIG_NRBOX	226	232	PF00104	0.316
LIG_NRBOX	317	323	PF00104	0.331
LIG_SH2_STAT5	417	420	PF00017	0.623
LIG_SH3_3	39	45	PF00018	0.558
LIG_SUMO_SIM_anti_2	207	212	PF11976	0.305
LIG_SUMO_SIM_anti_2	344	352	PF11976	0.267
LIG_SUMO_SIM_par_1	158	164	PF11976	0.326
LIG_Vh1_VBS_1	339	357	PF01044	0.472
MOD_CK1_1	133	139	PF00069	0.409
MOD_CK1_1	151	157	PF00069	0.451
MOD_CK1_1	169	175	PF00069	0.295
MOD_CK1_1	204	210	PF00069	0.370
MOD_CK1_1	25	31	PF00069	0.434
MOD_CK1_1	341	347	PF00069	0.374
MOD_CK2_1	191	197	PF00069	0.339
MOD_CK2_1	26	32	PF00069	0.363
MOD_CK2_1	331	337	PF00069	0.316
MOD_CK2_1	341	347	PF00069	0.253
MOD_CK2_1	80	86	PF00069	0.507
MOD_GlcNHglycan	150	153	PF01048	0.424
MOD_GlcNHglycan	168	171	PF01048	0.432
MOD_GlcNHglycan	221	224	PF01048	0.388
MOD_GlcNHglycan	28	31	PF01048	0.408
MOD_GlcNHglycan	333	336	PF01048	0.375
MOD_GlcNHglycan	5	8	PF01048	0.546
MOD_GlcNHglycan	51	54	PF01048	0.594
MOD_GSK3_1	129	136	PF00069	0.341
MOD_GSK3_1	160	167	PF00069	0.365
MOD_GSK3_1	22	29	PF00069	0.471
MOD_GSK3_1	232	239	PF00069	0.377
MOD_GSK3_1	325	332	PF00069	0.459
MOD_GSK3_1	369	376	PF00069	0.461
MOD_GSK3_1	49	56	PF00069	0.640
MOD_N-GLC_1	33	38	PF02516	0.400
MOD_N-GLC_2	140	142	PF02516	0.223
MOD_NEK2_1	1	6	PF00069	0.683
MOD_NEK2_1	166	171	PF00069	0.458
MOD_NEK2_1	176	181	PF00069	0.422
MOD_NEK2_1	186	191	PF00069	0.336
MOD_NEK2_1	199	204	PF00069	0.322
MOD_NEK2_1	219	224	PF00069	0.348
MOD_NEK2_1	26	31	PF00069	0.521
MOD_NEK2_1	279	284	PF00069	0.288
MOD_NEK2_1	326	331	PF00069	0.422
MOD_NEK2_1	33	38	PF00069	0.509
MOD_NEK2_1	397	402	PF00069	0.335
MOD_NEK2_2	22	27	PF00069	0.417
MOD_NEK2_2	364	369	PF00069	0.327
MOD_PKA_2	26	32	PF00069	0.363
MOD_PKA_2	354	360	PF00069	0.442
MOD_PKA_2	80	86	PF00069	0.373
MOD_Plk_1	280	286	PF00069	0.515
MOD_Plk_1	33	39	PF00069	0.397
MOD_Plk_2-3	86	92	PF00069	0.398
MOD_Plk_4	206	212	PF00069	0.309
MOD_Plk_4	33	39	PF00069	0.327
MOD_Plk_4	341	347	PF00069	0.321
MOD_ProDKin_1	151	157	PF00069	0.241
MOD_ProDKin_1	232	238	PF00069	0.496
MOD_ProDKin_1	59	65	PF00069	0.322
TRG_DiLeu_BaEn_1	226	231	PF01217	0.245
TRG_DiLeu_LyEn_5	226	231	PF01217	0.245
TRG_ER_diArg_1	181	183	PF00400	0.229
TRG_ER_diArg_1	227	229	PF00400	0.433
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IRL6	Bodo saltans	27%	100%
A0A0S4ITQ8	Bodo saltans	23%	86%
A0A0S4KN43	Bodo saltans	27%	72%
A0A3S7X7D2	Leishmania donovani	87%	94%
A4I9H0	Leishmania infantum	87%	94%
C9ZRQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	79%
C9ZXN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	86%
Q4Q3K7	Leishmania major	87%	100%
V5BMQ2	Trypanosoma cruzi	23%	75%