LeishMANIAdb
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Short-chain dehydrogenase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Short-chain dehydrogenase
Gene product:
short chain dehydrogenase, putative
Species:
Leishmania mexicana
UniProt:
E9B4G7_LEIMU
TriTrypDb:
LmxM.33.0010
Length:
306

Annotations

LeishMANIAdb annotations

These proteins belong to short-chain dehydrogenases / reductases using NAD or NADP as cofactor. All homologs are used for very long fatty acid biosynthesis.. Expanded in multiple organisms, but especially Strigomonas. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9B4G7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4G7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016491 oxidoreductase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 236 238 PF00675 0.390
CLV_NRD_NRD_1 302 304 PF00675 0.380
CLV_NRD_NRD_1 64 66 PF00675 0.287
CLV_PCSK_KEX2_1 170 172 PF00082 0.275
CLV_PCSK_KEX2_1 304 306 PF00082 0.412
CLV_PCSK_KEX2_1 36 38 PF00082 0.322
CLV_PCSK_KEX2_1 64 66 PF00082 0.257
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.300
CLV_PCSK_PC1ET2_1 304 306 PF00082 0.424
CLV_PCSK_PC1ET2_1 36 38 PF00082 0.322
CLV_PCSK_SKI1_1 147 151 PF00082 0.240
CLV_PCSK_SKI1_1 295 299 PF00082 0.336
DOC_CKS1_1 263 268 PF01111 0.545
DOC_MAPK_gen_1 168 178 PF00069 0.461
DOC_MAPK_gen_1 237 246 PF00069 0.542
DOC_MAPK_gen_1 64 71 PF00069 0.457
DOC_MAPK_MEF2A_6 117 124 PF00069 0.522
DOC_PP1_RVXF_1 17 24 PF00149 0.282
DOC_PP1_RVXF_1 92 99 PF00149 0.461
DOC_USP7_UBL2_3 166 170 PF12436 0.518
DOC_USP7_UBL2_3 300 304 PF12436 0.640
DOC_WW_Pin1_4 182 187 PF00397 0.463
DOC_WW_Pin1_4 219 224 PF00397 0.443
DOC_WW_Pin1_4 262 267 PF00397 0.550
LIG_Actin_WH2_2 4 21 PF00022 0.154
LIG_BRCT_BRCA1_1 96 100 PF00533 0.486
LIG_FHA_1 158 164 PF00498 0.495
LIG_FHA_1 229 235 PF00498 0.482
LIG_FHA_1 281 287 PF00498 0.580
LIG_LIR_Apic_2 160 165 PF02991 0.461
LIG_LIR_Gen_1 105 115 PF02991 0.493
LIG_LIR_Gen_1 134 142 PF02991 0.542
LIG_LIR_Gen_1 2 12 PF02991 0.165
LIG_LIR_Gen_1 22 29 PF02991 0.404
LIG_LIR_Gen_1 241 251 PF02991 0.543
LIG_LIR_Gen_1 43 50 PF02991 0.452
LIG_LIR_Nem_3 105 111 PF02991 0.440
LIG_LIR_Nem_3 132 136 PF02991 0.481
LIG_LIR_Nem_3 2 7 PF02991 0.165
LIG_LIR_Nem_3 205 211 PF02991 0.470
LIG_LIR_Nem_3 22 26 PF02991 0.309
LIG_LIR_Nem_3 241 246 PF02991 0.555
LIG_LIR_Nem_3 43 47 PF02991 0.443
LIG_Pex14_2 199 203 PF04695 0.451
LIG_SH2_GRB2like 133 136 PF00017 0.461
LIG_SH2_PTP2 162 165 PF00017 0.500
LIG_SH2_STAP1 108 112 PF00017 0.519
LIG_SH2_STAP1 133 137 PF00017 0.461
LIG_SH2_STAP1 56 60 PF00017 0.508
LIG_SH2_STAT5 131 134 PF00017 0.452
LIG_SH2_STAT5 136 139 PF00017 0.438
LIG_SH2_STAT5 162 165 PF00017 0.500
LIG_SH3_3 260 266 PF00018 0.640
LIG_SUMO_SIM_par_1 174 180 PF11976 0.472
LIG_SUMO_SIM_par_1 217 222 PF11976 0.451
LIG_UBA3_1 111 117 PF00899 0.519
LIG_WRC_WIRS_1 20 25 PF05994 0.237
MOD_CDK_SPxxK_3 262 269 PF00069 0.491
MOD_CK1_1 102 108 PF00069 0.397
MOD_CK1_1 182 188 PF00069 0.459
MOD_CK1_1 202 208 PF00069 0.524
MOD_CK1_1 228 234 PF00069 0.461
MOD_CK2_1 74 80 PF00069 0.524
MOD_Cter_Amidation 62 65 PF01082 0.335
MOD_GlcNHglycan 101 104 PF01048 0.330
MOD_GlcNHglycan 181 184 PF01048 0.273
MOD_GlcNHglycan 204 207 PF01048 0.359
MOD_GSK3_1 153 160 PF00069 0.474
MOD_GSK3_1 189 196 PF00069 0.461
MOD_GSK3_1 228 235 PF00069 0.455
MOD_GSK3_1 258 265 PF00069 0.557
MOD_GSK3_1 280 287 PF00069 0.616
MOD_N-GLC_1 129 134 PF02516 0.270
MOD_N-GLC_1 199 204 PF02516 0.300
MOD_N-GLC_2 68 70 PF02516 0.251
MOD_NEK2_1 177 182 PF00069 0.500
MOD_NEK2_1 189 194 PF00069 0.425
MOD_NEK2_1 199 204 PF00069 0.438
MOD_NEK2_1 225 230 PF00069 0.449
MOD_NEK2_2 153 158 PF00069 0.500
MOD_PIKK_1 228 234 PF00454 0.451
MOD_PK_1 258 264 PF00069 0.596
MOD_PKA_2 157 163 PF00069 0.461
MOD_PKA_2 239 245 PF00069 0.568
MOD_Plk_1 129 135 PF00069 0.466
MOD_Plk_1 153 159 PF00069 0.509
MOD_Plk_1 199 205 PF00069 0.500
MOD_Plk_4 239 245 PF00069 0.572
MOD_Plk_4 3 9 PF00069 0.308
MOD_ProDKin_1 182 188 PF00069 0.463
MOD_ProDKin_1 219 225 PF00069 0.443
MOD_ProDKin_1 262 268 PF00069 0.547
MOD_SUMO_rev_2 205 214 PF00179 0.511
MOD_SUMO_rev_2 80 89 PF00179 0.490
TRG_DiLeu_BaLyEn_6 144 149 PF01217 0.509
TRG_DiLeu_BaLyEn_6 185 190 PF01217 0.500
TRG_ENDOCYTIC_2 108 111 PF00928 0.439
TRG_ENDOCYTIC_2 208 211 PF00928 0.508
TRG_NES_CRM1_1 141 154 PF08389 0.519
TRG_Pf-PMV_PEXEL_1 279 284 PF00026 0.337

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0E3D8L9 Penicillium crustosum 29% 100%
A0A0N1I1P8 Leptomonas seymouri 24% 89%
A0A0N1I6F8 Leptomonas seymouri 80% 99%
A0A0S4IR33 Bodo saltans 53% 90%
A0A0S4IWL0 Bodo saltans 56% 96%
A0A0S4JBE7 Bodo saltans 47% 94%
A0A0S4JNE8 Bodo saltans 28% 95%
A0A0S4JSF1 Bodo saltans 30% 76%
A0A140FAN3 Pinus massoniana 28% 86%
A0A1B2CTA9 Penicillium thymicola 30% 100%
A0A1X0NWL8 Trypanosomatidae 58% 99%
A0A1X0P1C4 Trypanosomatidae 32% 94%
A0A2I1C3T5 Aspergillus novofumigatus (strain IBT 16806) 27% 100%
A0A3Q8IE20 Leishmania donovani 92% 100%
A0A3Q8IHN8 Leishmania donovani 25% 100%
A0A3Q8IIU6 Leishmania donovani 24% 100%
A0A3S7X6T1 Leishmania donovani 29% 94%
A0A3S7X793 Leishmania donovani 90% 100%
A0A411PQN6 Paecilomyces divaricatus 28% 100%
A0A422NG64 Trypanosoma rangeli 27% 94%
A0A422NJG3 Trypanosoma rangeli 62% 99%
A0A422NNE9 Trypanosoma rangeli 27% 90%
A1C6J8 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 34% 89%
A1DH66 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 31% 89%
A2QCH3 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 32% 88%
A3LXZ3 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 32% 88%
A4HAC6 Leishmania braziliensis 86% 100%
A4HM71 Leishmania braziliensis 25% 100%
A4HME4 Leishmania braziliensis 26% 100%
A4I931 Leishmania infantum 29% 94%
A4I9G9 Leishmania infantum 91% 100%
A4IAT4 Leishmania infantum 25% 100%
A4IB16 Leishmania infantum 24% 100%
A4QTE3 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 32% 92%
A5DND6 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 37% 90%
A5E0R1 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 32% 87%
A5JYX5 Caenorhabditis elegans 27% 99%
A5PJF6 Bos taurus 32% 93%
A5WWC6 Danio rerio 25% 96%
A6RBW9 Ajellomyces capsulatus (strain NAm1 / WU24) 32% 90%
A6SG70 Botryotinia fuckeliana (strain B05.10) 32% 92%
A6ZLA1 Saccharomyces cerevisiae (strain YJM789) 31% 88%
A7F8T1 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 32% 92%
A7TMJ2 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) 32% 88%
A8N6B4 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) 31% 90%
A8Q1U2 Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) 35% 94%
B0D8R3 Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) 31% 91%
B0XSI3 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 31% 89%
B2B3L4 Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) 31% 90%
B2WMJ3 Pyrenophora tritici-repentis (strain Pt-1C-BFP) 32% 90%
B3LN00 Saccharomyces cerevisiae (strain RM11-1a) 31% 88%
C9ZNQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 98%
D0A2C4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 88%
D4A1J4 Rattus norvegicus 29% 100%
E3VWI6 Streptomyces arenae 27% 100%
E3VWK2 Streptomyces exfoliatus 28% 100%
E9AEU5 Leishmania major 25% 100%
E9B3Z6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 94%
E9B601 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
G9FRD7 Clostridium sardiniense 23% 100%
I6Y778 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 26% 67%
M2ZIX7 Pseudocercospora fijiensis (strain CIRAD86) 30% 99%
O07399 Mycobacterium avium 24% 100%
O16925 Caenorhabditis elegans 29% 100%
O17795 Caenorhabditis elegans 27% 97%
O32229 Bacillus subtilis (strain 168) 30% 100%
O34896 Bacillus subtilis (strain 168) 26% 100%
O49332 Arabidopsis thaliana 28% 100%
O54438 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 34% 100%
O54939 Rattus norvegicus 33% 100%
O57314 Anas platyrhynchos 36% 98%
O70503 Mus musculus 34% 98%
P06234 Rhizobium meliloti (strain 1021) 29% 100%
P07772 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) 26% 100%
P0CG22 Homo sapiens 25% 100%
P0CR34 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 28% 85%
P0CR35 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 28% 85%
P0DKC7 Arabidopsis thaliana 25% 100%
P0DKI3 Arabidopsis thaliana 23% 100%
P16542 Streptomyces violaceoruber 28% 100%
P17611 Azospirillum brasilense 26% 100%
P37058 Homo sapiens 31% 99%
P37959 Bacillus subtilis (strain 168) 29% 100%
P38286 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 88%
P39577 Bacillus subtilis (strain 168) 24% 100%
P40397 Bacillus subtilis (strain 168) 25% 100%
P40398 Bacillus subtilis (strain 168) 27% 100%
P50162 Datura stramonium 25% 100%
P50163 Datura stramonium 24% 100%
P50164 Hyoscyamus niger 24% 100%
P50200 Paeniclostridium sordellii 25% 100%
P50202 Agrobacterium tumefaciens (strain 15955) 28% 71%
P50941 Rickettsia prowazekii (strain Madrid E) 26% 100%
P55336 Vibrio harveyi 32% 100%
P70385 Mus musculus 32% 100%
P72332 Rhizobium sp. (strain N33) 32% 100%
P87025 Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) 25% 100%
Q06136 Homo sapiens 23% 92%
Q09517 Caenorhabditis elegans 33% 97%
Q0CY11 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 33% 87%
Q0IH28 Xenopus laevis 23% 95%
Q0U3N7 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 33% 90%
Q0VFE7 Xenopus tropicalis 22% 99%
Q10130 Caenorhabditis elegans 29% 81%
Q10245 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 90%
Q12634 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 25% 100%
Q15SS0 Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) 26% 100%
Q17703 Caenorhabditis elegans 29% 97%
Q17704 Caenorhabditis elegans 26% 97%
Q1DNC5 Coccidioides immitis (strain RS) 33% 88%
Q28IU1 Xenopus tropicalis 39% 96%
Q2H1V7 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 33% 89%
Q2KIJ5 Bos taurus 23% 92%
Q2UET3 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 33% 88%
Q3SXM5 Homo sapiens 30% 93%
Q3T0R4 Bos taurus 23% 94%
Q3U0B3 Mus musculus 25% 100%
Q42182 Arabidopsis thaliana 30% 100%
Q49117 Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) 32% 100%
Q49WS9 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 26% 100%
Q4P622 Ustilago maydis (strain 521 / FGSC 9021) 32% 87%
Q4Q3K8 Leishmania major 92% 100%
Q4R5G7 Macaca fascicularis 34% 98%
Q4V8B7 Rattus norvegicus 29% 93%
Q4X117 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 31% 89%
Q53GQ0 Homo sapiens 33% 98%
Q566S6 Danio rerio 27% 99%
Q59V93 Candida albicans (strain SC5314 / ATCC MYA-2876) 30% 88%
Q5B0R9 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 32% 88%
Q5E9H7 Bos taurus 36% 98%
Q5HLD8 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 27% 100%
Q5NVG2 Pongo abelii 24% 100%
Q5R6U1 Pongo abelii 24% 94%
Q5R7K0 Pongo abelii 31% 93%
Q5RCF8 Pongo abelii 28% 100%
Q5XG41 Xenopus laevis 37% 96%
Q5ZJG8 Gallus gallus 34% 92%
Q60V51 Caenorhabditis briggsae 32% 97%
Q68VY7 Rickettsia typhi (strain ATCC VR-144 / Wilmington) 27% 100%
Q6BIG0 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 31% 88%
Q6CHP1 Yarrowia lipolytica (strain CLIB 122 / E 150) 32% 79%
Q6CVS4 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 33% 88%
Q6F7B8 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) 25% 100%
Q6FRM0 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 32% 87%
Q6GV12 Mus musculus 22% 92%
Q6P3L6 Danio rerio 35% 96%
Q6P7R8 Rattus norvegicus 35% 98%
Q6QA32 Danio rerio 31% 100%
Q6QA33 Danio rerio 34% 98%
Q6UWP2 Homo sapiens 26% 100%
Q71R50 Gallus gallus 25% 100%
Q75A60 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 34% 87%
Q7Q732 Anopheles gambiae 27% 97%
Q7RYE5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 33% 92%
Q7TQA3 Mus musculus 23% 99%
Q7Z5P4 Homo sapiens 24% 100%
Q82IY9 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 28% 100%
Q84ST4 Oryza sativa subsp. japonica 26% 89%
Q8AVY8 Xenopus laevis 39% 96%
Q8BTX9 Mus musculus 29% 93%
Q8CN40 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 27% 100%
Q8L9C4 Arabidopsis thaliana 31% 96%
Q8LEU3 Arabidopsis thaliana 25% 88%
Q8LKV5 Sesamum indicum 23% 85%
Q8NBQ5 Homo sapiens 24% 100%
Q8SPU8 Bos taurus 26% 100%
Q988B7 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 28% 100%
Q99J47 Mus musculus 23% 95%
Q9BTZ2 Homo sapiens 28% 100%
Q9CXR1 Mus musculus 28% 91%
Q9FYL6 Arabidopsis thaliana 36% 98%
Q9GKX2 Oryctolagus cuniculus 26% 100%
Q9HK58 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 28% 100%
Q9KQH7 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 31% 100%
Q9L9F8 Streptomyces niveus 31% 100%
Q9LHT0 Arabidopsis thaliana 25% 100%
Q9LUE4 Arabidopsis thaliana 27% 89%
Q9LUF2 Arabidopsis thaliana 25% 100%
Q9N126 Bos taurus 26% 98%
Q9SQR2 Arabidopsis thaliana 27% 100%
Q9STY8 Arabidopsis thaliana 24% 99%
Q9X248 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 30% 100%
Q9X6U2 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 22% 100%
Q9Y140 Drosophila melanogaster 25% 94%
Q9ZW12 Arabidopsis thaliana 23% 95%
Q9ZW13 Arabidopsis thaliana 26% 100%
Q9ZW14 Arabidopsis thaliana 28% 100%
Q9ZW15 Arabidopsis thaliana 29% 100%
Q9ZW16 Arabidopsis thaliana 27% 100%
Q9ZW18 Arabidopsis thaliana 25% 100%
Q9ZW19 Arabidopsis thaliana 26% 100%
Q9ZW20 Arabidopsis thaliana 26% 100%
V5B6S6 Trypanosoma cruzi 57% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS