LeishMANIAdb
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ABC transporter family-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ABC transporter family-like protein
Gene product:
ABC transporter family-like protein
Species:
Leishmania mexicana
UniProt:
E9B4G5_LEIMU
TriTrypDb:
LmxM.32.3260
Length:
949

Annotations

LeishMANIAdb annotations

Publication identifier(s): 23716044
ABC superfamily protein. Involved in the efflux of toxic antimony species and porphyrin derivatives. Dimeric.. Most closely related to bacterial ABC transporters (e.g. A0A557ZZI4_9PSEU, A0A2Z6DZW4_HYDTE, G6XIG1_9PROT) with lipid flippase activity. Localization: Cell surface (experimental) / Mitochondrial (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005739 mitochondrion 5 1
GO:0005886 plasma membrane 3 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9B4G5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4G5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0006812 monoatomic cation transport 5 1
GO:0009987 cellular process 1 1
GO:0030001 metal ion transport 6 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 9
GO:0005488 binding 1 9
GO:0005524 ATP binding 5 9
GO:0017076 purine nucleotide binding 4 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0035639 purine ribonucleoside triphosphate binding 4 9
GO:0036094 small molecule binding 2 9
GO:0043167 ion binding 2 9
GO:0043168 anion binding 3 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9
GO:0005215 transporter activity 1 1
GO:0008324 monoatomic cation transmembrane transporter activity 4 1
GO:0015075 monoatomic ion transmembrane transporter activity 3 1
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 1
GO:0015399 primary active transmembrane transporter activity 4 1
GO:0022804 active transmembrane transporter activity 3 1
GO:0022857 transmembrane transporter activity 2 1
GO:0022890 inorganic cation transmembrane transporter activity 4 1
GO:0042626 ATPase-coupled transmembrane transporter activity 2 1
GO:0046873 metal ion transmembrane transporter activity 5 1
GO:0140657 ATP-dependent activity 1 1
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.678
CLV_C14_Caspase3-7 499 503 PF00656 0.536
CLV_C14_Caspase3-7 605 609 PF00656 0.351
CLV_NRD_NRD_1 195 197 PF00675 0.526
CLV_NRD_NRD_1 276 278 PF00675 0.678
CLV_NRD_NRD_1 31 33 PF00675 0.471
CLV_NRD_NRD_1 317 319 PF00675 0.634
CLV_NRD_NRD_1 539 541 PF00675 0.768
CLV_NRD_NRD_1 777 779 PF00675 0.277
CLV_NRD_NRD_1 83 85 PF00675 0.458
CLV_PCSK_KEX2_1 276 278 PF00082 0.678
CLV_PCSK_KEX2_1 31 33 PF00082 0.513
CLV_PCSK_KEX2_1 317 319 PF00082 0.634
CLV_PCSK_KEX2_1 539 541 PF00082 0.764
CLV_PCSK_KEX2_1 776 778 PF00082 0.277
CLV_PCSK_KEX2_1 83 85 PF00082 0.458
CLV_PCSK_PC7_1 773 779 PF00082 0.277
CLV_PCSK_SKI1_1 180 184 PF00082 0.532
CLV_PCSK_SKI1_1 188 192 PF00082 0.479
CLV_PCSK_SKI1_1 20 24 PF00082 0.424
CLV_PCSK_SKI1_1 224 228 PF00082 0.403
CLV_PCSK_SKI1_1 850 854 PF00082 0.390
CLV_Separin_Metazoa 836 840 PF03568 0.575
DEG_APCC_DBOX_1 393 401 PF00400 0.515
DEG_COP1_1 244 253 PF00400 0.538
DEG_Nend_UBRbox_1 1 4 PF02207 0.507
DEG_SPOP_SBC_1 175 179 PF00917 0.563
DEG_SPOP_SBC_1 575 579 PF00917 0.488
DOC_ANK_TNKS_1 539 546 PF00023 0.564
DOC_CKS1_1 183 188 PF01111 0.695
DOC_CKS1_1 498 503 PF01111 0.349
DOC_CKS1_1 683 688 PF01111 0.529
DOC_CYCLIN_RxL_1 185 193 PF00134 0.744
DOC_MAPK_FxFP_2 709 712 PF00069 0.405
DOC_MAPK_gen_1 276 282 PF00069 0.333
DOC_MAPK_gen_1 317 323 PF00069 0.389
DOC_MAPK_gen_1 891 900 PF00069 0.610
DOC_MAPK_MEF2A_6 317 325 PF00069 0.389
DOC_MAPK_MEF2A_6 445 454 PF00069 0.445
DOC_MAPK_MEF2A_6 742 749 PF00069 0.413
DOC_MAPK_NFAT4_5 318 326 PF00069 0.387
DOC_MAPK_NFAT4_5 742 750 PF00069 0.413
DOC_PP1_RVXF_1 699 705 PF00149 0.322
DOC_PP1_RVXF_1 91 98 PF00149 0.484
DOC_PP2B_LxvP_1 172 175 PF13499 0.700
DOC_PP2B_LxvP_1 546 549 PF13499 0.489
DOC_PP4_FxxP_1 439 442 PF00568 0.365
DOC_PP4_FxxP_1 547 550 PF00568 0.510
DOC_PP4_FxxP_1 626 629 PF00568 0.461
DOC_PP4_FxxP_1 709 712 PF00568 0.405
DOC_PP4_FxxP_1 857 860 PF00568 0.525
DOC_PP4_FxxP_1 9 12 PF00568 0.459
DOC_SPAK_OSR1_1 277 281 PF12202 0.334
DOC_USP7_MATH_1 137 141 PF00917 0.712
DOC_USP7_MATH_1 146 150 PF00917 0.670
DOC_USP7_MATH_1 175 179 PF00917 0.759
DOC_USP7_MATH_1 249 253 PF00917 0.351
DOC_USP7_MATH_1 298 302 PF00917 0.440
DOC_USP7_MATH_1 464 468 PF00917 0.510
DOC_USP7_MATH_1 64 68 PF00917 0.579
DOC_USP7_MATH_1 740 744 PF00917 0.391
DOC_USP7_MATH_1 829 833 PF00917 0.527
DOC_WW_Pin1_4 182 187 PF00397 0.746
DOC_WW_Pin1_4 217 222 PF00397 0.553
DOC_WW_Pin1_4 456 461 PF00397 0.527
DOC_WW_Pin1_4 480 485 PF00397 0.460
DOC_WW_Pin1_4 497 502 PF00397 0.427
DOC_WW_Pin1_4 518 523 PF00397 0.528
DOC_WW_Pin1_4 682 687 PF00397 0.536
LIG_14-3-3_CanoR_1 20 28 PF00244 0.459
LIG_14-3-3_CanoR_1 240 250 PF00244 0.539
LIG_14-3-3_CanoR_1 289 299 PF00244 0.497
LIG_14-3-3_CanoR_1 318 324 PF00244 0.387
LIG_14-3-3_CanoR_1 347 355 PF00244 0.522
LIG_14-3-3_CanoR_1 376 381 PF00244 0.488
LIG_14-3-3_CanoR_1 438 442 PF00244 0.474
LIG_14-3-3_CanoR_1 489 495 PF00244 0.468
LIG_14-3-3_CanoR_1 496 501 PF00244 0.519
LIG_14-3-3_CanoR_1 632 637 PF00244 0.510
LIG_14-3-3_CanoR_1 701 705 PF00244 0.318
LIG_14-3-3_CanoR_1 891 900 PF00244 0.518
LIG_14-3-3_CanoR_1 903 908 PF00244 0.565
LIG_14-3-3_CanoR_1 91 96 PF00244 0.651
LIG_Actin_WH2_2 21 39 PF00022 0.604
LIG_APCC_ABBA_1 866 871 PF00400 0.502
LIG_BRCT_BRCA1_1 300 304 PF00533 0.486
LIG_BRCT_BRCA1_1 638 642 PF00533 0.548
LIG_deltaCOP1_diTrp_1 398 404 PF00928 0.511
LIG_DLG_GKlike_1 91 99 PF00625 0.673
LIG_EH1_1 382 390 PF00400 0.325
LIG_eIF4E_1 448 454 PF01652 0.502
LIG_FHA_1 167 173 PF00498 0.628
LIG_FHA_1 21 27 PF00498 0.399
LIG_FHA_1 409 415 PF00498 0.508
LIG_FHA_1 489 495 PF00498 0.521
LIG_FHA_1 533 539 PF00498 0.549
LIG_FHA_1 599 605 PF00498 0.545
LIG_FHA_1 644 650 PF00498 0.563
LIG_FHA_1 721 727 PF00498 0.364
LIG_FHA_1 742 748 PF00498 0.325
LIG_FHA_1 787 793 PF00498 0.542
LIG_FHA_1 813 819 PF00498 0.575
LIG_FHA_1 871 877 PF00498 0.485
LIG_FHA_1 893 899 PF00498 0.479
LIG_FHA_1 926 932 PF00498 0.575
LIG_FHA_2 112 118 PF00498 0.681
LIG_FHA_2 218 224 PF00498 0.267
LIG_FHA_2 330 336 PF00498 0.472
LIG_FHA_2 712 718 PF00498 0.463
LIG_FHA_2 72 78 PF00498 0.629
LIG_Integrin_RGD_1 932 934 PF01839 0.274
LIG_LIR_Apic_2 339 345 PF02991 0.503
LIG_LIR_Apic_2 379 384 PF02991 0.522
LIG_LIR_Apic_2 436 442 PF02991 0.390
LIG_LIR_Apic_2 544 550 PF02991 0.514
LIG_LIR_Apic_2 708 712 PF02991 0.356
LIG_LIR_Gen_1 122 131 PF02991 0.561
LIG_LIR_Gen_1 332 340 PF02991 0.505
LIG_LIR_Gen_1 359 367 PF02991 0.521
LIG_LIR_Gen_1 703 712 PF02991 0.391
LIG_LIR_Gen_1 926 931 PF02991 0.549
LIG_LIR_Gen_1 936 947 PF02991 0.516
LIG_LIR_Nem_3 122 127 PF02991 0.562
LIG_LIR_Nem_3 274 278 PF02991 0.462
LIG_LIR_Nem_3 332 337 PF02991 0.461
LIG_LIR_Nem_3 359 363 PF02991 0.518
LIG_LIR_Nem_3 551 555 PF02991 0.514
LIG_LIR_Nem_3 703 707 PF02991 0.322
LIG_LIR_Nem_3 926 930 PF02991 0.563
LIG_LIR_Nem_3 936 942 PF02991 0.548
LIG_LIR_Nem_3 94 100 PF02991 0.519
LIG_NRBOX 225 231 PF00104 0.459
LIG_NRBOX 449 455 PF00104 0.429
LIG_NRBOX 744 750 PF00104 0.358
LIG_Pex14_1 700 704 PF04695 0.316
LIG_PTB_Apo_2 231 238 PF02174 0.660
LIG_PTB_Apo_2 354 361 PF02174 0.516
LIG_PTB_Apo_2 570 577 PF02174 0.485
LIG_PTB_Phospho_1 231 237 PF10480 0.660
LIG_Rb_pABgroove_1 97 105 PF01858 0.680
LIG_RPA_C_Fungi 898 910 PF08784 0.448
LIG_SH2_CRK 349 353 PF00017 0.617
LIG_SH2_CRK 512 516 PF00017 0.696
LIG_SH2_CRK 683 687 PF00017 0.703
LIG_SH2_CRK 803 807 PF00017 0.393
LIG_SH2_NCK_1 683 687 PF00017 0.703
LIG_SH2_SRC 651 654 PF00017 0.624
LIG_SH2_STAP1 256 260 PF00017 0.671
LIG_SH2_STAP1 657 661 PF00017 0.638
LIG_SH2_STAT3 448 451 PF00017 0.630
LIG_SH2_STAT3 943 946 PF00017 0.507
LIG_SH2_STAT5 138 141 PF00017 0.597
LIG_SH2_STAT5 237 240 PF00017 0.704
LIG_SH2_STAT5 256 259 PF00017 0.390
LIG_SH2_STAT5 867 870 PF00017 0.193
LIG_SH3_3 478 484 PF00018 0.559
LIG_SH3_3 495 501 PF00018 0.590
LIG_SH3_3 547 553 PF00018 0.655
LIG_SH3_3 624 630 PF00018 0.645
LIG_SH3_3 749 755 PF00018 0.413
LIG_SUMO_SIM_anti_2 743 750 PF11976 0.413
LIG_SUMO_SIM_anti_2 911 917 PF11976 0.363
LIG_SUMO_SIM_par_1 326 332 PF11976 0.573
LIG_SUMO_SIM_par_1 743 750 PF11976 0.413
LIG_TRAF2_1 522 525 PF00917 0.546
LIG_TYR_ITIM 801 806 PF00017 0.413
LIG_WRC_WIRS_1 410 415 PF05994 0.571
LIG_WRC_WIRS_1 637 642 PF05994 0.705
LIG_WW_3 185 189 PF00397 0.695
LIG_WW_3 770 774 PF00397 0.413
MOD_CDK_SPK_2 480 485 PF00069 0.626
MOD_CDK_SPxK_1 182 188 PF00069 0.701
MOD_CDK_SPxxK_3 217 224 PF00069 0.389
MOD_CK1_1 142 148 PF00069 0.541
MOD_CK1_1 465 471 PF00069 0.656
MOD_CK1_1 551 557 PF00069 0.594
MOD_CK1_1 603 609 PF00069 0.616
MOD_CK1_1 660 666 PF00069 0.681
MOD_CK1_1 841 847 PF00069 0.459
MOD_CK2_1 217 223 PF00069 0.267
MOD_CK2_1 303 309 PF00069 0.589
MOD_CK2_1 518 524 PF00069 0.694
MOD_CK2_1 841 847 PF00069 0.288
MOD_CK2_1 875 881 PF00069 0.508
MOD_GlcNHglycan 139 142 PF01048 0.628
MOD_GlcNHglycan 144 147 PF01048 0.618
MOD_GlcNHglycan 246 249 PF01048 0.730
MOD_GlcNHglycan 251 254 PF01048 0.660
MOD_GlcNHglycan 284 287 PF01048 0.679
MOD_GlcNHglycan 292 295 PF01048 0.598
MOD_GlcNHglycan 305 308 PF01048 0.439
MOD_GlcNHglycan 349 352 PF01048 0.545
MOD_GlcNHglycan 464 467 PF01048 0.634
MOD_GlcNHglycan 541 544 PF01048 0.648
MOD_GlcNHglycan 605 608 PF01048 0.430
MOD_GlcNHglycan 621 624 PF01048 0.713
MOD_GlcNHglycan 695 699 PF01048 0.592
MOD_GlcNHglycan 737 740 PF01048 0.338
MOD_GlcNHglycan 831 834 PF01048 0.389
MOD_GlcNHglycan 842 846 PF01048 0.294
MOD_GSK3_1 142 149 PF00069 0.593
MOD_GSK3_1 298 305 PF00069 0.480
MOD_GSK3_1 456 463 PF00069 0.638
MOD_GSK3_1 588 595 PF00069 0.661
MOD_GSK3_1 598 605 PF00069 0.657
MOD_GSK3_1 632 639 PF00069 0.737
MOD_GSK3_1 681 688 PF00069 0.679
MOD_GSK3_1 934 941 PF00069 0.454
MOD_N-GLC_1 233 238 PF02516 0.677
MOD_N-GLC_1 26 31 PF02516 0.626
MOD_N-GLC_1 356 361 PF02516 0.593
MOD_N-GLC_1 693 698 PF02516 0.593
MOD_N-GLC_1 78 83 PF02516 0.637
MOD_N-GLC_1 893 898 PF02516 0.541
MOD_N-GLC_1 934 939 PF02516 0.282
MOD_N-GLC_2 217 219 PF02516 0.389
MOD_N-GLC_2 888 890 PF02516 0.316
MOD_NEK2_1 1 6 PF00069 0.602
MOD_NEK2_1 176 181 PF00069 0.656
MOD_NEK2_1 241 246 PF00069 0.669
MOD_NEK2_1 290 295 PF00069 0.617
MOD_NEK2_1 303 308 PF00069 0.528
MOD_NEK2_1 319 324 PF00069 0.524
MOD_NEK2_1 329 334 PF00069 0.536
MOD_NEK2_1 409 414 PF00069 0.518
MOD_NEK2_1 488 493 PF00069 0.574
MOD_NEK2_1 532 537 PF00069 0.705
MOD_NEK2_1 576 581 PF00069 0.600
MOD_NEK2_1 636 641 PF00069 0.655
MOD_NEK2_1 747 752 PF00069 0.329
MOD_NEK2_1 78 83 PF00069 0.570
MOD_NEK2_1 938 943 PF00069 0.437
MOD_PIKK_1 488 494 PF00454 0.465
MOD_PIKK_1 85 91 PF00454 0.426
MOD_PIKK_1 925 931 PF00454 0.538
MOD_PK_1 903 909 PF00069 0.549
MOD_PKA_1 539 545 PF00069 0.654
MOD_PKA_2 1 7 PF00069 0.634
MOD_PKA_2 254 260 PF00069 0.633
MOD_PKA_2 437 443 PF00069 0.699
MOD_PKA_2 488 494 PF00069 0.616
MOD_PKA_2 539 545 PF00069 0.654
MOD_PKA_2 700 706 PF00069 0.384
MOD_PKA_2 786 792 PF00069 0.459
MOD_PKA_2 829 835 PF00069 0.348
MOD_PKA_2 838 844 PF00069 0.373
MOD_PKA_2 892 898 PF00069 0.284
MOD_PKA_2 923 929 PF00069 0.495
MOD_PKB_1 35 43 PF00069 0.593
MOD_PKB_1 691 699 PF00069 0.487
MOD_PKB_1 891 899 PF00069 0.484
MOD_PKB_1 91 99 PF00069 0.484
MOD_Plk_1 233 239 PF00069 0.694
MOD_Plk_1 356 362 PF00069 0.590
MOD_Plk_1 475 481 PF00069 0.601
MOD_Plk_1 720 726 PF00069 0.388
MOD_Plk_1 893 899 PF00069 0.513
MOD_Plk_1 934 940 PF00069 0.536
MOD_Plk_2-3 793 799 PF00069 0.413
MOD_Plk_4 324 330 PF00069 0.603
MOD_Plk_4 409 415 PF00069 0.536
MOD_Plk_4 45 51 PF00069 0.535
MOD_Plk_4 551 557 PF00069 0.505
MOD_Plk_4 660 666 PF00069 0.691
MOD_Plk_4 685 691 PF00069 0.669
MOD_Plk_4 741 747 PF00069 0.346
MOD_Plk_4 934 940 PF00069 0.490
MOD_ProDKin_1 182 188 PF00069 0.701
MOD_ProDKin_1 217 223 PF00069 0.429
MOD_ProDKin_1 456 462 PF00069 0.675
MOD_ProDKin_1 480 486 PF00069 0.578
MOD_ProDKin_1 497 503 PF00069 0.525
MOD_ProDKin_1 518 524 PF00069 0.676
MOD_ProDKin_1 682 688 PF00069 0.681
MOD_SUMO_rev_2 877 885 PF00179 0.514
TRG_DiLeu_BaEn_1 847 852 PF01217 0.459
TRG_DiLeu_BaLyEn_6 177 182 PF01217 0.644
TRG_DiLeu_BaLyEn_6 210 215 PF01217 0.550
TRG_DiLeu_BaLyEn_6 362 367 PF01217 0.600
TRG_ENDOCYTIC_2 349 352 PF00928 0.619
TRG_ENDOCYTIC_2 512 515 PF00928 0.692
TRG_ENDOCYTIC_2 803 806 PF00928 0.413
TRG_ER_diArg_1 275 277 PF00400 0.607
TRG_ER_diArg_1 316 318 PF00400 0.551
TRG_ER_diArg_1 34 37 PF00400 0.632
TRG_ER_diArg_1 538 540 PF00400 0.736
TRG_ER_diArg_1 690 693 PF00400 0.495
TRG_ER_diArg_1 775 778 PF00400 0.323
TRG_ER_diArg_1 83 85 PF00400 0.571
TRG_Pf-PMV_PEXEL_1 188 193 PF00026 0.699
TRG_Pf-PMV_PEXEL_1 887 892 PF00026 0.443

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I508 Leptomonas seymouri 45% 99%
A0A1X0NRF7 Trypanosomatidae 24% 94%
A0A3R7LPT9 Trypanosoma rangeli 27% 100%
A0A3S7X7B4 Leishmania donovani 91% 100%
A4HM34 Leishmania braziliensis 77% 100%
A4I9G7 Leishmania infantum 91% 100%
Q4Q3L0 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS