Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania mexicana

UniProt:

E9B4F9_LEIMU

TriTrypDb:

LmxM.32.3200

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	35
GO:0110165	cellular anatomical entity	1	35
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	4

Expansion

Sequence features

E9B4F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4F9

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	4
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	4
GO:0006812	monoatomic cation transport	5	4
GO:0006829	zinc ion transport	8	4
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006882	intracellular zinc ion homeostasis	7	1
GO:0009987	cellular process	1	4
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	4
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0034220	monoatomic ion transmembrane transport	3	4
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055069	obsolete zinc ion homeostasis	8	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	4
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071577	zinc ion transmembrane transport	6	4
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098655	monoatomic cation transmembrane transport	4	4
GO:0098660	inorganic ion transmembrane transport	4	4
GO:0098662	inorganic cation transmembrane transport	5	4
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	35
GO:0008324	monoatomic cation transmembrane transporter activity	4	35
GO:0015075	monoatomic ion transmembrane transporter activity	3	35
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	35
GO:0022857	transmembrane transporter activity	2	35
GO:0022890	inorganic cation transmembrane transporter activity	4	35
GO:0046873	metal ion transmembrane transporter activity	5	35
GO:0005385	zinc ion transmembrane transporter activity	7	4
GO:0046915	transition metal ion transmembrane transporter activity	6	4
GO:0005381	iron ion transmembrane transporter activity	7	1
GO:0015093	ferrous iron transmembrane transporter activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	45	51	PF00089	0.168
CLV_PCSK_KEX2_1	47	49	PF00082	0.247
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.247
CLV_PCSK_SKI1_1	122	126	PF00082	0.350
CLV_PCSK_SKI1_1	310	314	PF00082	0.275
DEG_APCC_DBOX_1	309	317	PF00400	0.511
DEG_APCC_KENBOX_2	16	20	PF00400	0.250
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.279
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.151
DOC_PP1_RVXF_1	120	126	PF00149	0.191
DOC_PP2B_LxvP_1	132	135	PF13499	0.483
DOC_PP2B_LxvP_1	243	246	PF13499	0.447
DOC_PP4_FxxP_1	52	55	PF00568	0.524
DOC_USP7_MATH_1	113	117	PF00917	0.360
DOC_USP7_MATH_1	135	139	PF00917	0.609
DOC_USP7_MATH_1	219	223	PF00917	0.317
DOC_USP7_MATH_1	322	326	PF00917	0.210
DOC_USP7_MATH_1	82	86	PF00917	0.302
DOC_WW_Pin1_4	3	8	PF00397	0.352
LIG_14-3-3_CanoR_1	300	304	PF00244	0.494
LIG_14-3-3_CanoR_1	48	55	PF00244	0.413
LIG_Actin_WH2_2	66	82	PF00022	0.452
LIG_APCC_ABBA_1	121	126	PF00400	0.373
LIG_BRCT_BRCA1_1	243	247	PF00533	0.313
LIG_BRCT_BRCA1_1	308	312	PF00533	0.395
LIG_Clathr_ClatBox_1	290	294	PF01394	0.351
LIG_CSL_BTD_1	7	10	PF09270	0.316
LIG_eIF4E_1	285	291	PF01652	0.295
LIG_FHA_1	204	210	PF00498	0.182
LIG_FHA_1	231	237	PF00498	0.559
LIG_FHA_1	269	275	PF00498	0.266
LIG_FHA_1	65	71	PF00498	0.346
LIG_FHA_2	13	19	PF00498	0.416
LIG_LIR_Apic_2	50	55	PF02991	0.371
LIG_LIR_Gen_1	21	32	PF02991	0.185
LIG_LIR_Gen_1	210	219	PF02991	0.243
LIG_LIR_Gen_1	234	245	PF02991	0.224
LIG_LIR_Gen_1	294	303	PF02991	0.497
LIG_LIR_Nem_3	187	192	PF02991	0.318
LIG_LIR_Nem_3	21	27	PF02991	0.234
LIG_LIR_Nem_3	210	214	PF02991	0.278
LIG_LIR_Nem_3	234	240	PF02991	0.247
LIG_PCNA_PIPBox_1	289	298	PF02747	0.210
LIG_PCNA_yPIPBox_3	289	300	PF02747	0.159
LIG_PDZ_Class_2	329	334	PF00595	0.141
LIG_Pex14_2	124	128	PF04695	0.371
LIG_Pex14_2	211	215	PF04695	0.345
LIG_Pex14_2	237	241	PF04695	0.237
LIG_SH2_SRC	57	60	PF00017	0.473
LIG_SH2_STAP1	20	24	PF00017	0.343
LIG_SH2_STAP1	57	61	PF00017	0.387
LIG_SH2_STAT5	104	107	PF00017	0.315
LIG_SH2_STAT5	203	206	PF00017	0.300
LIG_SH2_STAT5	235	238	PF00017	0.410
LIG_SH2_STAT5	268	271	PF00017	0.282
LIG_SH2_STAT5	285	288	PF00017	0.271
LIG_SH3_3	4	10	PF00018	0.530
LIG_SUMO_SIM_par_1	289	294	PF11976	0.169
LIG_TRAF2_1	137	140	PF00917	0.526
LIG_UBA3_1	75	80	PF00899	0.440
MOD_CK1_1	138	144	PF00069	0.409
MOD_CK1_1	184	190	PF00069	0.308
MOD_CK1_1	302	308	PF00069	0.380
MOD_CK1_1	64	70	PF00069	0.375
MOD_CK1_1	85	91	PF00069	0.249
MOD_CK1_1	96	102	PF00069	0.257
MOD_CK2_1	12	18	PF00069	0.433
MOD_CK2_1	94	100	PF00069	0.206
MOD_Cter_Amidation	45	48	PF01082	0.293
MOD_GlcNHglycan	166	170	PF01048	0.238
MOD_GlcNHglycan	174	177	PF01048	0.311
MOD_GlcNHglycan	243	246	PF01048	0.327
MOD_GlcNHglycan	3	6	PF01048	0.653
MOD_GlcNHglycan	49	52	PF01048	0.171
MOD_GSK3_1	203	210	PF00069	0.222
MOD_GSK3_1	298	305	PF00069	0.422
MOD_GSK3_1	33	40	PF00069	0.269
MOD_GSK3_1	8	15	PF00069	0.382
MOD_N-GLC_1	18	23	PF02516	0.431
MOD_N-GLC_1	33	38	PF02516	0.146
MOD_N-GLC_1	82	87	PF02516	0.567
MOD_NEK2_1	1	6	PF00069	0.350
MOD_NEK2_1	145	150	PF00069	0.391
MOD_NEK2_1	181	186	PF00069	0.306
MOD_NEK2_1	241	246	PF00069	0.306
MOD_NEK2_1	260	265	PF00069	0.237
MOD_NEK2_1	299	304	PF00069	0.535
MOD_NEK2_1	33	38	PF00069	0.285
MOD_NEK2_2	207	212	PF00069	0.454
MOD_NEK2_2	227	232	PF00069	0.396
MOD_PIKK_1	138	144	PF00454	0.506
MOD_PIKK_1	145	151	PF00454	0.374
MOD_PIKK_1	268	274	PF00454	0.246
MOD_PKA_1	47	53	PF00069	0.371
MOD_PKA_2	299	305	PF00069	0.533
MOD_PKA_2	306	312	PF00069	0.525
MOD_PKA_2	47	53	PF00069	0.371
MOD_Plk_1	18	24	PF00069	0.347
MOD_Plk_1	33	39	PF00069	0.274
MOD_Plk_1	82	88	PF00069	0.216
MOD_Plk_4	184	190	PF00069	0.296
MOD_Plk_4	263	269	PF00069	0.290
MOD_Plk_4	322	328	PF00069	0.268
MOD_Plk_4	33	39	PF00069	0.297
MOD_ProDKin_1	3	9	PF00069	0.345
TRG_DiLeu_BaEn_1	140	145	PF01217	0.387
TRG_ENDOCYTIC_2	285	288	PF00928	0.300
TRG_ENDOCYTIC_2	296	299	PF00928	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	34%	100%
A0A0N0P5K7	Leptomonas seymouri	59%	100%
A0A1X0NR51	Trypanosomatidae	41%	90%
A0A1X0NSB9	Trypanosomatidae	36%	82%
A0A1X0NSI7	Trypanosomatidae	36%	88%
A0A3R7LZX6	Trypanosoma rangeli	38%	95%
A0A3S7X1N7	Leishmania donovani	34%	72%
A0A3S7X501	Leishmania donovani	35%	77%
A0A3S7X7B0	Leishmania donovani	86%	100%
A0A422MUI2	Trypanosoma rangeli	34%	90%
A4HGP7	Leishmania braziliensis	36%	100%
A4HJU6	Leishmania braziliensis	41%	100%
A4HJU9	Leishmania braziliensis	33%	100%
A4HJV0	Leishmania braziliensis	33%	100%
A4HM27	Leishmania braziliensis	73%	100%
A4I3R9	Leishmania infantum	34%	72%
A4I7B1	Leishmania infantum	35%	77%
A4I9G1	Leishmania infantum	86%	100%
D0A885	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	85%
D0A886	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	85%
D0A887	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	85%
D0A888	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	85%
D0A889	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	87%
E9B012	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B2A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B2A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
O23039	Arabidopsis thaliana	25%	93%
O64738	Arabidopsis thaliana	26%	98%
O81123	Arabidopsis thaliana	27%	94%
O81850	Arabidopsis thaliana	26%	95%
O82643	Arabidopsis thaliana	26%	97%
O94639	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	82%
P32804	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	89%
Q38856	Arabidopsis thaliana	26%	96%
Q4Q3L6	Leishmania major	85%	100%
Q4Q5V0	Leishmania major	35%	100%
Q4Q5V1	Leishmania major	35%	100%
Q4Q873	Leishmania major	35%	100%
Q6L8G0	Oryza sativa subsp. japonica	32%	95%
Q6L8G1	Oryza sativa subsp. japonica	28%	90%
Q75HB1	Oryza sativa subsp. japonica	27%	89%
Q7XLD4	Oryza sativa subsp. japonica	27%	92%
Q852F6	Oryza sativa subsp. japonica	25%	93%
Q8S3W4	Arabidopsis thaliana	26%	96%
Q8W245	Arabidopsis thaliana	28%	92%
Q8W246	Arabidopsis thaliana	25%	92%
Q94DG6	Oryza sativa subsp. japonica	24%	95%
Q9FIS2	Arabidopsis thaliana	25%	94%
Q9SLG3	Arabidopsis thaliana	24%	99%
V5AWN3	Trypanosoma cruzi	36%	90%
V5BC34	Trypanosoma cruzi	33%	90%
V5DCU2	Trypanosoma cruzi	40%	90%