Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4F6_LEIMU

TriTrypDb:

LmxM.32.3170

Length:

529

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4F6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.518
CLV_NRD_NRD_1	512	514	PF00675	0.575
CLV_PCSK_KEX2_1	120	122	PF00082	0.548
CLV_PCSK_KEX2_1	289	291	PF00082	0.514
CLV_PCSK_KEX2_1	296	298	PF00082	0.551
CLV_PCSK_KEX2_1	300	302	PF00082	0.620
CLV_PCSK_KEX2_1	512	514	PF00082	0.606
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.593
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.620
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.620
CLV_PCSK_PC7_1	285	291	PF00082	0.572
CLV_PCSK_SKI1_1	120	124	PF00082	0.629
CLV_PCSK_SKI1_1	225	229	PF00082	0.448
CLV_PCSK_SKI1_1	230	234	PF00082	0.471
CLV_PCSK_SKI1_1	289	293	PF00082	0.498
CLV_PCSK_SKI1_1	297	301	PF00082	0.534
CLV_PCSK_SKI1_1	343	347	PF00082	0.515
CLV_PCSK_SKI1_1	355	359	PF00082	0.370
CLV_PCSK_SKI1_1	73	77	PF00082	0.631
DEG_APCC_DBOX_1	354	362	PF00400	0.465
DEG_MDM2_SWIB_1	28	36	PF02201	0.526
DEG_Nend_UBRbox_1	1	4	PF02207	0.748
DEG_SPOP_SBC_1	405	409	PF00917	0.470
DOC_CDC14_PxL_1	515	523	PF14671	0.635
DOC_CYCLIN_RxL_1	117	127	PF00134	0.590
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.642
DOC_MAPK_gen_1	296	307	PF00069	0.460
DOC_MAPK_gen_1	309	317	PF00069	0.548
DOC_MAPK_MEF2A_6	217	224	PF00069	0.519
DOC_PP2B_LxvP_1	315	318	PF13499	0.643
DOC_PP4_FxxP_1	411	414	PF00568	0.475
DOC_SPAK_OSR1_1	98	102	PF12202	0.386
DOC_USP7_MATH_1	349	353	PF00917	0.569
DOC_USP7_MATH_1	404	408	PF00917	0.555
DOC_USP7_MATH_1	430	434	PF00917	0.661
DOC_USP7_MATH_1	464	468	PF00917	0.774
DOC_USP7_MATH_1	486	490	PF00917	0.736
DOC_USP7_MATH_1	504	508	PF00917	0.433
DOC_USP7_MATH_1	59	63	PF00917	0.532
DOC_USP7_UBL2_3	292	296	PF12436	0.606
DOC_WW_Pin1_4	215	220	PF00397	0.611
DOC_WW_Pin1_4	480	485	PF00397	0.740
DOC_WW_Pin1_4	493	498	PF00397	0.550
DOC_WW_Pin1_4	76	81	PF00397	0.439
LIG_14-3-3_CanoR_1	130	134	PF00244	0.555
LIG_14-3-3_CanoR_1	158	168	PF00244	0.561
LIG_14-3-3_CanoR_1	235	240	PF00244	0.561
LIG_14-3-3_CanoR_1	406	412	PF00244	0.754
LIG_14-3-3_CanoR_1	513	519	PF00244	0.703
LIG_14-3-3_CanoR_1	70	80	PF00244	0.544
LIG_Actin_WH2_2	115	132	PF00022	0.552
LIG_Actin_WH2_2	221	239	PF00022	0.319
LIG_Actin_WH2_2	277	294	PF00022	0.351
LIG_BRCT_BRCA1_1	243	247	PF00533	0.589
LIG_BRCT_BRCA1_1	407	411	PF00533	0.475
LIG_CaM_IQ_9	277	292	PF13499	0.644
LIG_Clathr_ClatBox_1	13	17	PF01394	0.639
LIG_FHA_1	107	113	PF00498	0.589
LIG_FHA_1	135	141	PF00498	0.606
LIG_FHA_1	16	22	PF00498	0.512
LIG_FHA_1	170	176	PF00498	0.504
LIG_FHA_1	192	198	PF00498	0.791
LIG_FHA_1	231	237	PF00498	0.568
LIG_FHA_1	275	281	PF00498	0.584
LIG_FHA_1	72	78	PF00498	0.478
LIG_FHA_1	90	96	PF00498	0.611
LIG_FHA_2	179	185	PF00498	0.591
LIG_FHA_2	325	331	PF00498	0.443
LIG_FHA_2	455	461	PF00498	0.779
LIG_LIR_Apic_2	408	414	PF02991	0.476
LIG_LIR_Apic_2	459	464	PF02991	0.683
LIG_LIR_Gen_1	172	182	PF02991	0.587
LIG_LIR_Gen_1	302	312	PF02991	0.555
LIG_LIR_Nem_3	302	307	PF02991	0.558
LIG_LIR_Nem_3	352	357	PF02991	0.450
LIG_Pex14_2	28	32	PF04695	0.529
LIG_REV1ctd_RIR_1	221	229	PF16727	0.318
LIG_SH2_CRK	437	441	PF00017	0.689
LIG_SH2_CRK	461	465	PF00017	0.694
LIG_SH2_GRB2like	67	70	PF00017	0.414
LIG_SH2_STAP1	502	506	PF00017	0.562
LIG_SH2_STAT5	267	270	PF00017	0.641
LIG_SH3_3	516	522	PF00018	0.555
LIG_SH3_3	74	80	PF00018	0.519
LIG_UBA3_1	228	237	PF00899	0.400
LIG_WRC_WIRS_1	60	65	PF05994	0.556
MOD_CDK_SPK_2	480	485	PF00069	0.708
MOD_CK1_1	132	138	PF00069	0.633
MOD_CK1_1	141	147	PF00069	0.579
MOD_CK1_1	201	207	PF00069	0.698
MOD_CK1_1	210	216	PF00069	0.581
MOD_CK1_1	407	413	PF00069	0.530
MOD_CK1_1	443	449	PF00069	0.721
MOD_CK1_1	5	11	PF00069	0.713
MOD_CK2_1	16	22	PF00069	0.512
MOD_CK2_1	201	207	PF00069	0.574
MOD_CK2_1	272	278	PF00069	0.491
MOD_CK2_1	324	330	PF00069	0.537
MOD_CK2_1	415	421	PF00069	0.701
MOD_CK2_1	454	460	PF00069	0.780
MOD_CK2_1	5	11	PF00069	0.659
MOD_CK2_1	76	82	PF00069	0.510
MOD_GlcNHglycan	134	137	PF01048	0.615
MOD_GlcNHglycan	164	167	PF01048	0.601
MOD_GlcNHglycan	188	192	PF01048	0.636
MOD_GlcNHglycan	198	201	PF01048	0.707
MOD_GlcNHglycan	272	275	PF01048	0.575
MOD_GlcNHglycan	4	7	PF01048	0.686
MOD_GlcNHglycan	430	433	PF01048	0.632
MOD_GlcNHglycan	445	448	PF01048	0.688
MOD_GlcNHglycan	454	457	PF01048	0.720
MOD_GlcNHglycan	466	469	PF01048	0.556
MOD_GlcNHglycan	89	92	PF01048	0.629
MOD_GSK3_1	1	8	PF00069	0.725
MOD_GSK3_1	134	141	PF00069	0.601
MOD_GSK3_1	158	165	PF00069	0.519
MOD_GSK3_1	16	23	PF00069	0.406
MOD_GSK3_1	187	194	PF00069	0.649
MOD_GSK3_1	198	205	PF00069	0.595
MOD_GSK3_1	270	277	PF00069	0.568
MOD_GSK3_1	357	364	PF00069	0.553
MOD_GSK3_1	424	431	PF00069	0.666
MOD_GSK3_1	439	446	PF00069	0.639
MOD_GSK3_1	452	459	PF00069	0.653
MOD_GSK3_1	504	511	PF00069	0.674
MOD_GSK3_1	59	66	PF00069	0.546
MOD_N-GLC_1	105	110	PF02516	0.540
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	129	134	PF00069	0.408
MOD_NEK2_1	16	21	PF00069	0.400
MOD_NEK2_1	167	172	PF00069	0.476
MOD_NEK2_1	196	201	PF00069	0.759
MOD_NEK2_1	247	252	PF00069	0.518
MOD_NEK2_1	280	285	PF00069	0.595
MOD_NEK2_1	357	362	PF00069	0.609
MOD_NEK2_1	440	445	PF00069	0.736
MOD_NEK2_1	63	68	PF00069	0.561
MOD_NEK2_1	89	94	PF00069	0.597
MOD_PIKK_1	159	165	PF00454	0.492
MOD_PIKK_1	361	367	PF00454	0.585
MOD_PIKK_1	38	44	PF00454	0.321
MOD_PIKK_1	430	436	PF00454	0.678
MOD_PIKK_1	454	460	PF00454	0.779
MOD_PIKK_1	495	501	PF00454	0.601
MOD_PIKK_1	89	95	PF00454	0.594
MOD_PK_1	235	241	PF00069	0.583
MOD_PKA_2	1	7	PF00069	0.737
MOD_PKA_2	129	135	PF00069	0.584
MOD_PKA_2	366	372	PF00069	0.481
MOD_PKA_2	393	399	PF00069	0.779
MOD_PKA_2	405	411	PF00069	0.526
MOD_Plk_1	16	22	PF00069	0.580
MOD_Plk_1	486	492	PF00069	0.691
MOD_Plk_2-3	207	213	PF00069	0.715
MOD_Plk_4	16	22	PF00069	0.495
MOD_Plk_4	192	198	PF00069	0.776
MOD_Plk_4	210	216	PF00069	0.608
MOD_Plk_4	235	241	PF00069	0.492
MOD_Plk_4	303	309	PF00069	0.576
MOD_Plk_4	311	317	PF00069	0.596
MOD_Plk_4	393	399	PF00069	0.740
MOD_Plk_4	486	492	PF00069	0.730
MOD_Plk_4	59	65	PF00069	0.559
MOD_ProDKin_1	215	221	PF00069	0.606
MOD_ProDKin_1	480	486	PF00069	0.737
MOD_ProDKin_1	493	499	PF00069	0.545
MOD_ProDKin_1	76	82	PF00069	0.442
MOD_SUMO_rev_2	30	39	PF00179	0.385
TRG_DiLeu_BaEn_1	282	287	PF01217	0.347
TRG_DiLeu_BaEn_1	303	308	PF01217	0.546
TRG_DiLeu_BaEn_1	353	358	PF01217	0.559
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.589
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.559
TRG_DiLeu_LyEn_5	282	287	PF01217	0.347
TRG_ENDOCYTIC_2	437	440	PF00928	0.690
TRG_ENDOCYTIC_2	502	505	PF00928	0.604
TRG_ER_diArg_1	120	122	PF00400	0.512
TRG_NES_CRM1_1	169	184	PF08389	0.571
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K5	Leptomonas seymouri	47%	96%
A0A1X0NRF9	Trypanosomatidae	25%	93%
A0A3Q8IMT0	Leishmania donovani	84%	100%
A0A422N0Y7	Trypanosoma rangeli	26%	100%
A4HM24	Leishmania braziliensis	66%	100%
A4I9F8	Leishmania infantum	85%	100%
C9ZJT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
Q4Q3L9	Leishmania major	85%	100%