Importin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4F3_LEIMU

TriTrypDb:

LmxM.32.3140

Length:

1005

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4F3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.549
CLV_NRD_NRD_1	107	109	PF00675	0.614
CLV_NRD_NRD_1	200	202	PF00675	0.433
CLV_NRD_NRD_1	26	28	PF00675	0.434
CLV_NRD_NRD_1	710	712	PF00675	0.254
CLV_NRD_NRD_1	794	796	PF00675	0.581
CLV_NRD_NRD_1	926	928	PF00675	0.537
CLV_PCSK_KEX2_1	710	712	PF00082	0.254
CLV_PCSK_KEX2_1	92	94	PF00082	0.508
CLV_PCSK_KEX2_1	926	928	PF00082	0.537
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.555
CLV_PCSK_SKI1_1	194	198	PF00082	0.428
CLV_PCSK_SKI1_1	264	268	PF00082	0.505
CLV_PCSK_SKI1_1	667	671	PF00082	0.494
CLV_PCSK_SKI1_1	711	715	PF00082	0.344
CLV_PCSK_SKI1_1	906	910	PF00082	0.413
CLV_PCSK_SKI1_1	92	96	PF00082	0.539
DEG_APCC_DBOX_1	193	201	PF00400	0.427
DEG_APCC_DBOX_1	880	888	PF00400	0.406
DEG_ODPH_VHL_1	850	862	PF01847	0.499
DEG_SPOP_SBC_1	244	248	PF00917	0.383
DOC_CYCLIN_RxL_1	645	657	PF00134	0.516
DOC_CYCLIN_RxL_1	664	673	PF00134	0.239
DOC_CYCLIN_RxL_1	87	101	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	767	773	PF00134	0.529
DOC_MAPK_gen_1	27	34	PF00069	0.433
DOC_MAPK_MEF2A_6	116	124	PF00069	0.434
DOC_MAPK_MEF2A_6	189	197	PF00069	0.410
DOC_MAPK_MEF2A_6	635	643	PF00069	0.519
DOC_USP7_MATH_1	147	151	PF00917	0.316
DOC_USP7_MATH_1	204	208	PF00917	0.516
DOC_USP7_MATH_1	244	248	PF00917	0.555
DOC_USP7_MATH_1	260	264	PF00917	0.535
DOC_USP7_MATH_1	424	428	PF00917	0.470
DOC_USP7_MATH_1	647	651	PF00917	0.532
DOC_USP7_MATH_1	685	689	PF00917	0.355
DOC_USP7_MATH_1	722	726	PF00917	0.492
DOC_USP7_MATH_1	971	975	PF00917	0.526
DOC_WW_Pin1_4	407	412	PF00397	0.549
DOC_WW_Pin1_4	55	60	PF00397	0.575
DOC_WW_Pin1_4	643	648	PF00397	0.495
DOC_WW_Pin1_4	728	733	PF00397	0.291
DOC_WW_Pin1_4	811	816	PF00397	0.508
DOC_WW_Pin1_4	969	974	PF00397	0.464
LIG_14-3-3_CanoR_1	189	193	PF00244	0.453
LIG_14-3-3_CanoR_1	27	35	PF00244	0.528
LIG_14-3-3_CanoR_1	277	283	PF00244	0.417
LIG_14-3-3_CanoR_1	285	290	PF00244	0.442
LIG_14-3-3_CanoR_1	461	465	PF00244	0.500
LIG_14-3-3_CanoR_1	710	716	PF00244	0.439
LIG_14-3-3_CanoR_1	749	758	PF00244	0.359
LIG_14-3-3_CanoR_1	87	91	PF00244	0.465
LIG_14-3-3_CanoR_1	881	885	PF00244	0.410
LIG_Actin_WH2_2	176	191	PF00022	0.550
LIG_Actin_WH2_2	394	410	PF00022	0.550
LIG_Actin_WH2_2	448	463	PF00022	0.522
LIG_Actin_WH2_2	586	602	PF00022	0.499
LIG_APCC_ABBA_1	193	198	PF00400	0.521
LIG_APCC_ABBA_1	316	321	PF00400	0.432
LIG_APCC_ABBA_1	385	390	PF00400	0.480
LIG_APCC_ABBA_1	850	855	PF00400	0.427
LIG_BIR_II_1	1	5	PF00653	0.440
LIG_BIR_III_4	146	150	PF00653	0.266
LIG_BIR_III_4	554	558	PF00653	0.503
LIG_BRCT_BRCA1_1	247	251	PF00533	0.598
LIG_BRCT_BRCA1_1	272	276	PF00533	0.444
LIG_BRCT_BRCA1_1	278	282	PF00533	0.422
LIG_BRCT_BRCA1_1	354	358	PF00533	0.248
LIG_Clathr_ClatBox_1	66	70	PF01394	0.514
LIG_Clathr_ClatBox_1	945	949	PF01394	0.532
LIG_deltaCOP1_diTrp_1	130	134	PF00928	0.507
LIG_deltaCOP1_diTrp_1	75	84	PF00928	0.403
LIG_EH1_1	804	812	PF00400	0.488
LIG_eIF4E_1	519	525	PF01652	0.370
LIG_FHA_1	183	189	PF00498	0.533
LIG_FHA_1	214	220	PF00498	0.494
LIG_FHA_1	416	422	PF00498	0.442
LIG_FHA_1	487	493	PF00498	0.517
LIG_FHA_1	605	611	PF00498	0.434
LIG_FHA_1	664	670	PF00498	0.472
LIG_FHA_1	761	767	PF00498	0.417
LIG_FHA_1	864	870	PF00498	0.512
LIG_FHA_1	89	95	PF00498	0.556
LIG_FHA_2	265	271	PF00498	0.537
LIG_GBD_Chelix_1	520	528	PF00786	0.497
LIG_GBD_Chelix_1	602	610	PF00786	0.454
LIG_Integrin_RGD_1	348	350	PF01839	0.535
LIG_Integrin_RGD_1	671	673	PF01839	0.624
LIG_KLC1_Yacidic_2	386	390	PF13176	0.511
LIG_LIR_Gen_1	279	286	PF02991	0.301
LIG_LIR_Gen_1	31	42	PF02991	0.445
LIG_LIR_Gen_1	539	550	PF02991	0.519
LIG_LIR_Gen_1	714	723	PF02991	0.503
LIG_LIR_Gen_1	947	955	PF02991	0.499
LIG_LIR_Gen_1	963	973	PF02991	0.426
LIG_LIR_Nem_3	159	164	PF02991	0.483
LIG_LIR_Nem_3	279	283	PF02991	0.441
LIG_LIR_Nem_3	31	37	PF02991	0.454
LIG_LIR_Nem_3	355	361	PF02991	0.364
LIG_LIR_Nem_3	539	545	PF02991	0.505
LIG_LIR_Nem_3	554	559	PF02991	0.432
LIG_LIR_Nem_3	714	718	PF02991	0.490
LIG_LIR_Nem_3	947	951	PF02991	0.466
LIG_LIR_Nem_3	963	969	PF02991	0.465
LIG_LYPXL_S_1	318	322	PF13949	0.546
LIG_LYPXL_yS_3	319	322	PF13949	0.539
LIG_NRBOX	229	235	PF00104	0.531
LIG_NRBOX	402	408	PF00104	0.492
LIG_NRBOX	490	496	PF00104	0.487
LIG_NRBOX	564	570	PF00104	0.474
LIG_NRBOX	62	68	PF00104	0.521
LIG_NRBOX	950	956	PF00104	0.520
LIG_PCNA_yPIPBox_3	162	170	PF02747	0.488
LIG_PCNA_yPIPBox_3	226	234	PF02747	0.532
LIG_Pex14_2	276	280	PF04695	0.229
LIG_Pex14_2	358	362	PF04695	0.254
LIG_Pex14_2	944	948	PF04695	0.251
LIG_SH2_CRK	515	519	PF00017	0.424
LIG_SH2_CRK	800	804	PF00017	0.470
LIG_SH2_NCK_1	515	519	PF00017	0.424
LIG_SH2_PTP2	893	896	PF00017	0.529
LIG_SH2_SRC	388	391	PF00017	0.526
LIG_SH2_STAP1	515	519	PF00017	0.424
LIG_SH2_STAP1	698	702	PF00017	0.531
LIG_SH2_STAT3	480	483	PF00017	0.528
LIG_SH2_STAT3	744	747	PF00017	0.510
LIG_SH2_STAT3	750	753	PF00017	0.479
LIG_SH2_STAT5	164	167	PF00017	0.516
LIG_SH2_STAT5	338	341	PF00017	0.535
LIG_SH2_STAT5	361	364	PF00017	0.491
LIG_SH2_STAT5	388	391	PF00017	0.526
LIG_SH2_STAT5	519	522	PF00017	0.467
LIG_SH2_STAT5	861	864	PF00017	0.342
LIG_SH2_STAT5	893	896	PF00017	0.465
LIG_SH3_3	679	685	PF00018	0.633
LIG_SH3_3	871	877	PF00018	0.498
LIG_SUMO_SIM_anti_2	808	814	PF11976	0.501
LIG_SUMO_SIM_par_1	120	125	PF11976	0.467
LIG_SUMO_SIM_par_1	604	609	PF11976	0.510
LIG_SUMO_SIM_par_1	65	71	PF11976	0.520
LIG_SUMO_SIM_par_1	808	814	PF11976	0.480
LIG_TYR_ITIM	336	341	PF00017	0.383
LIG_TYR_ITIM	513	518	PF00017	0.430
LIG_UBA3_1	195	202	PF00899	0.530
LIG_UBA3_1	605	611	PF00899	0.486
LIG_WRC_WIRS_1	166	171	PF05994	0.468
LIG_WRC_WIRS_1	712	717	PF05994	0.489
LIG_WRC_WIRS_1	945	950	PF05994	0.362
MOD_CDC14_SPxK_1	648	651	PF00782	0.539
MOD_CDK_SPxK_1	645	651	PF00069	0.533
MOD_CDK_SPxxK_3	55	62	PF00069	0.561
MOD_CK1_1	2	8	PF00069	0.391
MOD_CK1_1	486	492	PF00069	0.517
MOD_CK1_1	560	566	PF00069	0.459
MOD_CK1_1	614	620	PF00069	0.557
MOD_CK1_1	622	628	PF00069	0.602
MOD_CK1_1	730	736	PF00069	0.259
MOD_CK1_1	85	91	PF00069	0.484
MOD_CK1_1	863	869	PF00069	0.379
MOD_CK1_1	947	953	PF00069	0.413
MOD_CK1_1	959	965	PF00069	0.412
MOD_CK2_1	124	130	PF00069	0.397
MOD_CK2_1	264	270	PF00069	0.500
MOD_CK2_1	498	504	PF00069	0.480
MOD_CK2_1	678	684	PF00069	0.652
MOD_CK2_1	947	953	PF00069	0.474
MOD_CK2_1	969	975	PF00069	0.463
MOD_CMANNOS	131	134	PF00535	0.494
MOD_Cter_Amidation	793	796	PF01082	0.627
MOD_GlcNHglycan	149	152	PF01048	0.285
MOD_GlcNHglycan	153	156	PF01048	0.290
MOD_GlcNHglycan	213	216	PF01048	0.585
MOD_GlcNHglycan	221	224	PF01048	0.466
MOD_GlcNHglycan	270	273	PF01048	0.486
MOD_GlcNHglycan	28	31	PF01048	0.481
MOD_GlcNHglycan	313	316	PF01048	0.266
MOD_GlcNHglycan	326	330	PF01048	0.355
MOD_GlcNHglycan	354	357	PF01048	0.502
MOD_GlcNHglycan	373	376	PF01048	0.362
MOD_GlcNHglycan	392	395	PF01048	0.428
MOD_GlcNHglycan	54	58	PF01048	0.557
MOD_GlcNHglycan	559	562	PF01048	0.429
MOD_GlcNHglycan	613	616	PF01048	0.494
MOD_GlcNHglycan	735	738	PF01048	0.463
MOD_GlcNHglycan	820	823	PF01048	0.546
MOD_GlcNHglycan	826	830	PF01048	0.624
MOD_GlcNHglycan	862	865	PF01048	0.207
MOD_GlcNHglycan	896	899	PF01048	0.570
MOD_GSK3_1	147	154	PF00069	0.368
MOD_GSK3_1	260	267	PF00069	0.466
MOD_GSK3_1	479	486	PF00069	0.496
MOD_GSK3_1	498	505	PF00069	0.276
MOD_GSK3_1	557	564	PF00069	0.425
MOD_GSK3_1	614	621	PF00069	0.615
MOD_GSK3_1	643	650	PF00069	0.530
MOD_GSK3_1	680	687	PF00069	0.572
MOD_GSK3_1	722	729	PF00069	0.584
MOD_GSK3_1	749	756	PF00069	0.293
MOD_GSK3_1	82	89	PF00069	0.518
MOD_GSK3_1	902	909	PF00069	0.437
MOD_GSK3_1	956	963	PF00069	0.452
MOD_GSK3_1	969	976	PF00069	0.402
MOD_N-GLC_1	483	488	PF02516	0.532
MOD_N-GLC_2	163	165	PF02516	0.536
MOD_NEK2_1	124	129	PF00069	0.332
MOD_NEK2_1	188	193	PF00069	0.458
MOD_NEK2_1	243	248	PF00069	0.591
MOD_NEK2_1	276	281	PF00069	0.386
MOD_NEK2_1	479	484	PF00069	0.454
MOD_NEK2_1	498	503	PF00069	0.468
MOD_NEK2_1	53	58	PF00069	0.483
MOD_NEK2_1	606	611	PF00069	0.450
MOD_NEK2_1	805	810	PF00069	0.432
MOD_NEK2_1	818	823	PF00069	0.527
MOD_NEK2_1	860	865	PF00069	0.472
MOD_NEK2_1	960	965	PF00069	0.476
MOD_NEK2_2	68	73	PF00069	0.513
MOD_OFUCOSY	630	637	PF10250	0.491
MOD_OFUCOSY	757	764	PF10250	0.485
MOD_PIKK_1	450	456	PF00454	0.525
MOD_PIKK_1	479	485	PF00454	0.500
MOD_PIKK_1	486	492	PF00454	0.486
MOD_PIKK_1	536	542	PF00454	0.486
MOD_PIKK_1	749	755	PF00454	0.525
MOD_PIKK_1	765	771	PF00454	0.261
MOD_PKA_1	926	932	PF00069	0.574
MOD_PKA_2	147	153	PF00069	0.255
MOD_PKA_2	188	194	PF00069	0.481
MOD_PKA_2	204	210	PF00069	0.428
MOD_PKA_2	26	32	PF00069	0.517
MOD_PKA_2	276	282	PF00069	0.388
MOD_PKA_2	460	466	PF00069	0.538
MOD_PKA_2	86	92	PF00069	0.509
MOD_PKA_2	880	886	PF00069	0.406
MOD_PKA_2	926	932	PF00069	0.546
MOD_Plk_1	483	489	PF00069	0.535
MOD_Plk_1	85	91	PF00069	0.489
MOD_Plk_4	100	106	PF00069	0.507
MOD_Plk_4	188	194	PF00069	0.501
MOD_Plk_4	270	276	PF00069	0.449
MOD_Plk_4	564	570	PF00069	0.380
MOD_Plk_4	68	74	PF00069	0.420
MOD_Plk_4	805	811	PF00069	0.377
MOD_Plk_4	947	953	PF00069	0.504
MOD_ProDKin_1	407	413	PF00069	0.545
MOD_ProDKin_1	55	61	PF00069	0.566
MOD_ProDKin_1	643	649	PF00069	0.502
MOD_ProDKin_1	728	734	PF00069	0.282
MOD_ProDKin_1	811	817	PF00069	0.512
MOD_ProDKin_1	969	975	PF00069	0.465
MOD_SUMO_rev_2	207	213	PF00179	0.403
TRG_DiLeu_BaEn_1	224	229	PF01217	0.384
TRG_DiLeu_BaEn_2	939	945	PF01217	0.538
TRG_DiLeu_BaEn_4	238	244	PF01217	0.621
TRG_DiLeu_BaLyEn_6	402	407	PF01217	0.244
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.539
TRG_DiLeu_BaLyEn_6	903	908	PF01217	0.305
TRG_ENDOCYTIC_2	319	322	PF00928	0.527
TRG_ENDOCYTIC_2	338	341	PF00928	0.391
TRG_ENDOCYTIC_2	515	518	PF00928	0.423
TRG_ENDOCYTIC_2	800	803	PF00928	0.472
TRG_ENDOCYTIC_2	952	955	PF00928	0.458
TRG_ER_diArg_1	710	712	PF00400	0.254
TRG_ER_diArg_1	926	928	PF00400	0.537
TRG_NES_CRM1_1	306	321	PF08389	0.460
TRG_NES_CRM1_1	450	464	PF08389	0.504
TRG_NES_CRM1_1	490	504	PF08389	0.534
TRG_NES_CRM1_1	684	697	PF08389	0.501
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I500	Leptomonas seymouri	54%	100%
A0A1X0NRQ6	Trypanosomatidae	29%	98%
A0A3Q8IF54	Leishmania donovani	89%	100%
A0A3R7JX66	Trypanosoma rangeli	29%	100%
A4I9F5	Leishmania infantum	89%	100%
C9ZJS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	93%
Q4Q3M2	Leishmania major	90%	100%
V5AVU3	Trypanosoma cruzi	29%	99%