Peptidase S1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trypsin-like peptidase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4F2_LEIMU

TriTrypDb:

LmxM.32.3130

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B4F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4F2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004175	endopeptidase activity	4	2
GO:0004252	serine-type endopeptidase activity	5	2
GO:0008233	peptidase activity	3	2
GO:0008236	serine-type peptidase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0017171	serine hydrolase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.445
CLV_C14_Caspase3-7	233	237	PF00656	0.459
CLV_NRD_NRD_1	226	228	PF00675	0.531
CLV_PCSK_KEX2_1	226	228	PF00082	0.456
CLV_PCSK_KEX2_1	302	304	PF00082	0.556
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.501
CLV_PCSK_SKI1_1	211	215	PF00082	0.578
CLV_PCSK_SKI1_1	226	230	PF00082	0.577
CLV_PCSK_SKI1_1	38	42	PF00082	0.341
DOC_ANK_TNKS_1	109	116	PF00023	0.436
DOC_CYCLIN_RxL_1	38	49	PF00134	0.430
DOC_MAPK_gen_1	224	234	PF00069	0.519
DOC_MAPK_gen_1	93	103	PF00069	0.419
DOC_MAPK_JIP1_4	41	47	PF00069	0.430
DOC_MAPK_MEF2A_6	38	47	PF00069	0.319
DOC_PP1_RVXF_1	98	104	PF00149	0.390
DOC_PP2B_LxvP_1	33	36	PF13499	0.357
DOC_PP2B_LxvP_1	92	95	PF13499	0.414
DOC_SPAK_OSR1_1	102	106	PF12202	0.427
DOC_USP7_MATH_1	17	21	PF00917	0.439
DOC_USP7_MATH_1	176	180	PF00917	0.520
DOC_USP7_MATH_1	68	72	PF00917	0.619
DOC_USP7_MATH_1	76	80	PF00917	0.351
DOC_USP7_UBL2_3	96	100	PF12436	0.467
DOC_WW_Pin1_4	153	158	PF00397	0.619
DOC_WW_Pin1_4	281	286	PF00397	0.370
DOC_WW_Pin1_4	78	83	PF00397	0.446
LIG_14-3-3_CanoR_1	116	125	PF00244	0.334
LIG_14-3-3_CanoR_1	226	235	PF00244	0.569
LIG_BIR_III_4	112	116	PF00653	0.453
LIG_BIR_III_4	121	125	PF00653	0.321
LIG_BIR_III_4	236	240	PF00653	0.453
LIG_BIR_III_4	276	280	PF00653	0.533
LIG_Clathr_ClatBox_1	138	142	PF01394	0.428
LIG_CtBP_PxDLS_1	160	164	PF00389	0.343
LIG_FHA_1	118	124	PF00498	0.513
LIG_FHA_1	227	233	PF00498	0.463
LIG_FHA_2	109	115	PF00498	0.476
LIG_LIR_Gen_1	31	40	PF02991	0.374
LIG_LIR_Gen_1	97	105	PF02991	0.393
LIG_LIR_Nem_3	145	149	PF02991	0.395
LIG_LIR_Nem_3	31	35	PF02991	0.343
LIG_LIR_Nem_3	97	101	PF02991	0.393
LIG_LYPXL_SIV_4	174	182	PF13949	0.413
LIG_SH2_CRK	98	102	PF00017	0.542
LIG_SH2_STAP1	85	89	PF00017	0.515
LIG_SH2_STAT5	283	286	PF00017	0.318
LIG_SH2_STAT5	300	303	PF00017	0.387
LIG_SH2_STAT5	85	88	PF00017	0.508
LIG_SH3_3	138	144	PF00018	0.257
LIG_SH3_3	154	160	PF00018	0.377
LIG_SH3_3	272	278	PF00018	0.458
LIG_SUMO_SIM_anti_2	135	140	PF11976	0.378
LIG_SUMO_SIM_anti_2	229	236	PF11976	0.465
LIG_SUMO_SIM_par_1	229	236	PF11976	0.469
LIG_UBA3_1	29	38	PF00899	0.494
LIG_WRC_WIRS_1	29	34	PF05994	0.362
MOD_CDC14_SPxK_1	156	159	PF00782	0.396
MOD_CDK_SPxK_1	153	159	PF00069	0.405
MOD_CK1_1	20	26	PF00069	0.298
MOD_GlcNHglycan	22	25	PF01048	0.364
MOD_GlcNHglycan	254	257	PF01048	0.354
MOD_GSK3_1	194	201	PF00069	0.551
MOD_GSK3_1	226	233	PF00069	0.541
MOD_GSK3_1	68	75	PF00069	0.419
MOD_GSK3_1	83	90	PF00069	0.513
MOD_NEK2_1	259	264	PF00069	0.475
MOD_NEK2_1	46	51	PF00069	0.320
MOD_NEK2_1	72	77	PF00069	0.332
MOD_PIKK_1	17	23	PF00454	0.546
MOD_PIKK_1	87	93	PF00454	0.577
MOD_PKA_1	226	232	PF00069	0.443
MOD_PKA_2	226	232	PF00069	0.570
MOD_PKA_2	298	304	PF00069	0.381
MOD_Plk_1	87	93	PF00069	0.563
MOD_Plk_2-3	194	200	PF00069	0.469
MOD_Plk_4	198	204	PF00069	0.510
MOD_Plk_4	230	236	PF00069	0.508
MOD_Plk_4	28	34	PF00069	0.347
MOD_Plk_4	68	74	PF00069	0.503
MOD_ProDKin_1	153	159	PF00069	0.618
MOD_ProDKin_1	281	287	PF00069	0.375
MOD_ProDKin_1	78	84	PF00069	0.457
TRG_DiLeu_BaEn_1	210	215	PF01217	0.529
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.456
TRG_ENDOCYTIC_2	251	254	PF00928	0.415
TRG_ENDOCYTIC_2	98	101	PF00928	0.383
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6J2	Leptomonas seymouri	61%	100%
A0A0S4J2F7	Bodo saltans	37%	100%
A0A0S4JI53	Bodo saltans	37%	100%
A0A1X0NRD6	Trypanosomatidae	43%	100%
A0A3Q8IHS3	Leishmania donovani	90%	100%
A4HM21	Leishmania braziliensis	81%	100%
A4I9F4	Leishmania infantum	89%	100%
C9ZJS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q3M3	Leishmania major	92%	100%
V5D3Q6	Trypanosoma cruzi	43%	100%