Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4F1_LEIMU

TriTrypDb:

LmxM.32.3110

Length:

947

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4F1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.533
CLV_NRD_NRD_1	270	272	PF00675	0.409
CLV_NRD_NRD_1	369	371	PF00675	0.534
CLV_NRD_NRD_1	396	398	PF00675	0.544
CLV_NRD_NRD_1	908	910	PF00675	0.671
CLV_PCSK_KEX2_1	163	165	PF00082	0.494
CLV_PCSK_KEX2_1	369	371	PF00082	0.534
CLV_PCSK_KEX2_1	396	398	PF00082	0.544
CLV_PCSK_KEX2_1	639	641	PF00082	0.575
CLV_PCSK_KEX2_1	908	910	PF00082	0.671
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.489
CLV_PCSK_PC7_1	904	910	PF00082	0.699
CLV_PCSK_SKI1_1	265	269	PF00082	0.493
CLV_PCSK_SKI1_1	396	400	PF00082	0.525
CLV_PCSK_SKI1_1	756	760	PF00082	0.291
CLV_PCSK_SKI1_1	844	848	PF00082	0.439
CLV_PCSK_SKI1_1	879	883	PF00082	0.529
DEG_APCC_DBOX_1	594	602	PF00400	0.528
DEG_APCC_DBOX_1	843	851	PF00400	0.321
DEG_Nend_UBRbox_2	1	3	PF02207	0.610
DOC_ANK_TNKS_1	104	111	PF00023	0.393
DOC_CDC14_PxL_1	72	80	PF14671	0.579
DOC_CKS1_1	157	162	PF01111	0.288
DOC_CKS1_1	387	392	PF01111	0.384
DOC_CYCLIN_RxL_1	391	404	PF00134	0.531
DOC_CYCLIN_RxL_1	753	761	PF00134	0.286
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	223	226	PF00134	0.594
DOC_MAPK_DCC_7	557	565	PF00069	0.461
DOC_MAPK_gen_1	746	754	PF00069	0.280
DOC_MAPK_MEF2A_6	136	144	PF00069	0.480
DOC_MAPK_MEF2A_6	557	565	PF00069	0.504
DOC_MAPK_MEF2A_6	879	887	PF00069	0.685
DOC_MAPK_RevD_3	354	370	PF00069	0.562
DOC_PP1_RVXF_1	378	385	PF00149	0.529
DOC_PP1_RVXF_1	871	877	PF00149	0.630
DOC_PP2B_LxvP_1	175	178	PF13499	0.620
DOC_PP2B_LxvP_1	223	226	PF13499	0.594
DOC_PP2B_LxvP_1	400	403	PF13499	0.415
DOC_PP4_FxxP_1	157	160	PF00568	0.307
DOC_PP4_FxxP_1	625	628	PF00568	0.503
DOC_SPAK_OSR1_1	656	660	PF12202	0.433
DOC_USP7_MATH_1	302	306	PF00917	0.405
DOC_USP7_MATH_1	403	407	PF00917	0.493
DOC_USP7_MATH_1	512	516	PF00917	0.460
DOC_USP7_MATH_1	865	869	PF00917	0.712
DOC_USP7_MATH_1	903	907	PF00917	0.673
DOC_USP7_UBL2_3	422	426	PF12436	0.580
DOC_WW_Pin1_4	156	161	PF00397	0.290
DOC_WW_Pin1_4	386	391	PF00397	0.505
DOC_WW_Pin1_4	508	513	PF00397	0.431
DOC_WW_Pin1_4	764	769	PF00397	0.596
DOC_WW_Pin1_4	787	792	PF00397	0.487
DOC_WW_Pin1_4	811	816	PF00397	0.612
LIG_14-3-3_CanoR_1	105	113	PF00244	0.464
LIG_14-3-3_CanoR_1	216	224	PF00244	0.562
LIG_14-3-3_CanoR_1	254	262	PF00244	0.587
LIG_14-3-3_CanoR_1	462	472	PF00244	0.308
LIG_14-3-3_CanoR_1	557	561	PF00244	0.556
LIG_14-3-3_CanoR_1	629	638	PF00244	0.359
LIG_14-3-3_CanoR_1	67	73	PF00244	0.318
LIG_14-3-3_CanoR_1	676	686	PF00244	0.561
LIG_14-3-3_CanoR_1	695	704	PF00244	0.492
LIG_14-3-3_CanoR_1	706	713	PF00244	0.481
LIG_14-3-3_CanoR_1	821	830	PF00244	0.363
LIG_14-3-3_CanoR_1	904	908	PF00244	0.655
LIG_BIR_III_2	323	327	PF00653	0.410
LIG_Clathr_ClatBox_1	142	146	PF01394	0.557
LIG_Clathr_ClatBox_1	798	802	PF01394	0.549
LIG_deltaCOP1_diTrp_1	47	54	PF00928	0.543
LIG_FHA_1	312	318	PF00498	0.504
LIG_FHA_1	373	379	PF00498	0.457
LIG_FHA_1	459	465	PF00498	0.550
LIG_FHA_1	588	594	PF00498	0.475
LIG_FHA_1	645	651	PF00498	0.520
LIG_FHA_1	713	719	PF00498	0.447
LIG_FHA_1	788	794	PF00498	0.562
LIG_FHA_1	854	860	PF00498	0.542
LIG_FHA_2	113	119	PF00498	0.547
LIG_FHA_2	258	264	PF00498	0.539
LIG_FHA_2	314	320	PF00498	0.486
LIG_FHA_2	387	393	PF00498	0.599
LIG_FHA_2	471	477	PF00498	0.303
LIG_FHA_2	631	637	PF00498	0.410
LIG_FHA_2	811	817	PF00498	0.633
LIG_FHA_2	87	93	PF00498	0.568
LIG_GBD_Chelix_1	309	317	PF00786	0.541
LIG_LIR_Gen_1	121	132	PF02991	0.479
LIG_LIR_Gen_1	212	222	PF02991	0.477
LIG_LIR_Gen_1	435	444	PF02991	0.523
LIG_LIR_Gen_1	498	507	PF02991	0.440
LIG_LIR_Gen_1	539	547	PF02991	0.398
LIG_LIR_Gen_1	633	643	PF02991	0.450
LIG_LIR_Gen_1	699	708	PF02991	0.360
LIG_LIR_Gen_1	92	100	PF02991	0.491
LIG_LIR_Nem_3	121	127	PF02991	0.417
LIG_LIR_Nem_3	212	217	PF02991	0.346
LIG_LIR_Nem_3	435	441	PF02991	0.520
LIG_LIR_Nem_3	498	502	PF02991	0.484
LIG_LIR_Nem_3	539	543	PF02991	0.427
LIG_LIR_Nem_3	566	571	PF02991	0.428
LIG_LIR_Nem_3	63	69	PF02991	0.321
LIG_LIR_Nem_3	633	638	PF02991	0.498
LIG_LIR_Nem_3	699	704	PF02991	0.367
LIG_LIR_Nem_3	840	846	PF02991	0.493
LIG_LIR_Nem_3	92	97	PF02991	0.494
LIG_LYPXL_yS_3	6	9	PF13949	0.622
LIG_NRBOX	143	149	PF00104	0.459
LIG_NRBOX	248	254	PF00104	0.490
LIG_NRBOX	362	368	PF00104	0.432
LIG_PCNA_yPIPBox_3	136	148	PF02747	0.444
LIG_PCNA_yPIPBox_3	80	94	PF02747	0.347
LIG_Pex14_2	17	21	PF04695	0.666
LIG_PTB_Apo_2	340	347	PF02174	0.540
LIG_PTB_Phospho_1	340	346	PF10480	0.550
LIG_Rb_pABgroove_1	716	724	PF01858	0.502
LIG_RPA_C_Fungi	365	377	PF08784	0.558
LIG_SH2_CRK	346	350	PF00017	0.603
LIG_SH2_CRK	66	70	PF00017	0.331
LIG_SH2_SRC	900	903	PF00017	0.570
LIG_SH2_STAP1	346	350	PF00017	0.315
LIG_SH2_STAP1	915	919	PF00017	0.663
LIG_SH2_STAT5	584	587	PF00017	0.489
LIG_SH2_STAT5	940	943	PF00017	0.478
LIG_SH3_3	287	293	PF00018	0.492
LIG_SH3_3	529	535	PF00018	0.346
LIG_SH3_3	691	697	PF00018	0.493
LIG_SH3_3	762	768	PF00018	0.473
LIG_Sin3_3	682	689	PF02671	0.542
LIG_SUMO_SIM_par_1	141	146	PF11976	0.487
LIG_SUMO_SIM_par_1	797	804	PF11976	0.477
LIG_SUMO_SIM_par_1	855	862	PF11976	0.512
LIG_TRAF2_1	119	122	PF00917	0.555
LIG_TYR_ITIM	64	69	PF00017	0.319
LIG_TYR_ITSM	631	638	PF00017	0.354
LIG_UBA3_1	78	84	PF00899	0.391
LIG_Vh1_VBS_1	876	894	PF01044	0.406
LIG_WRC_WIRS_1	537	542	PF05994	0.557
MOD_CDK_SPxxK_3	156	163	PF00069	0.290
MOD_CK1_1	112	118	PF00069	0.547
MOD_CK1_1	242	248	PF00069	0.335
MOD_CK1_1	255	261	PF00069	0.452
MOD_CK1_1	357	363	PF00069	0.435
MOD_CK1_1	372	378	PF00069	0.410
MOD_CK1_1	460	466	PF00069	0.551
MOD_CK1_1	614	620	PF00069	0.259
MOD_CK1_1	631	637	PF00069	0.258
MOD_CK1_1	661	667	PF00069	0.613
MOD_CK1_1	730	736	PF00069	0.371
MOD_CK1_1	742	748	PF00069	0.279
MOD_CK1_1	787	793	PF00069	0.519
MOD_CK2_1	112	118	PF00069	0.507
MOD_CK2_1	386	392	PF00069	0.481
MOD_CK2_1	630	636	PF00069	0.514
MOD_CK2_1	810	816	PF00069	0.631
MOD_CK2_1	86	92	PF00069	0.511
MOD_CK2_1	883	889	PF00069	0.574
MOD_CMANNOS	46	49	PF00535	0.567
MOD_GlcNHglycan	106	109	PF01048	0.566
MOD_GlcNHglycan	148	151	PF01048	0.483
MOD_GlcNHglycan	220	223	PF01048	0.647
MOD_GlcNHglycan	257	260	PF01048	0.668
MOD_GlcNHglycan	356	359	PF01048	0.489
MOD_GlcNHglycan	363	366	PF01048	0.484
MOD_GlcNHglycan	371	374	PF01048	0.492
MOD_GlcNHglycan	527	530	PF01048	0.412
MOD_GlcNHglycan	630	633	PF01048	0.306
MOD_GlcNHglycan	698	701	PF01048	0.450
MOD_GlcNHglycan	729	732	PF01048	0.442
MOD_GlcNHglycan	734	737	PF01048	0.584
MOD_GlcNHglycan	786	789	PF01048	0.503
MOD_GlcNHglycan	915	918	PF01048	0.588
MOD_GlcNHglycan	929	932	PF01048	0.612
MOD_GSK3_1	112	119	PF00069	0.545
MOD_GSK3_1	126	133	PF00069	0.389
MOD_GSK3_1	253	260	PF00069	0.638
MOD_GSK3_1	357	364	PF00069	0.554
MOD_GSK3_1	453	460	PF00069	0.461
MOD_GSK3_1	508	515	PF00069	0.408
MOD_GSK3_1	571	578	PF00069	0.478
MOD_GSK3_1	712	719	PF00069	0.568
MOD_GSK3_1	742	749	PF00069	0.558
MOD_GSK3_1	783	790	PF00069	0.615
MOD_GSK3_1	801	808	PF00069	0.487
MOD_GSK3_1	810	817	PF00069	0.709
MOD_GSK3_1	853	860	PF00069	0.423
MOD_GSK3_1	923	930	PF00069	0.672
MOD_N-GLC_1	302	307	PF02516	0.524
MOD_N-GLC_1	453	458	PF02516	0.565
MOD_N-GLC_1	86	91	PF02516	0.354
MOD_N-GLC_2	57	59	PF02516	0.551
MOD_NEK2_1	19	24	PF00069	0.668
MOD_NEK2_1	252	257	PF00069	0.617
MOD_NEK2_1	301	306	PF00069	0.481
MOD_NEK2_1	354	359	PF00069	0.497
MOD_NEK2_1	453	458	PF00069	0.490
MOD_NEK2_1	491	496	PF00069	0.438
MOD_NEK2_1	563	568	PF00069	0.454
MOD_NEK2_1	630	635	PF00069	0.433
MOD_NEK2_1	658	663	PF00069	0.465
MOD_NEK2_1	724	729	PF00069	0.351
MOD_NEK2_1	732	737	PF00069	0.651
MOD_NEK2_1	747	752	PF00069	0.375
MOD_NEK2_1	758	763	PF00069	0.524
MOD_NEK2_1	857	862	PF00069	0.520
MOD_NEK2_1	883	888	PF00069	0.566
MOD_NEK2_1	893	898	PF00069	0.554
MOD_NEK2_2	805	810	PF00069	0.389
MOD_NEK2_2	903	908	PF00069	0.682
MOD_PIKK_1	170	176	PF00454	0.473
MOD_PIKK_1	215	221	PF00454	0.581
MOD_PKA_1	369	375	PF00069	0.470
MOD_PKA_2	104	110	PF00069	0.486
MOD_PKA_2	215	221	PF00069	0.600
MOD_PKA_2	253	259	PF00069	0.533
MOD_PKA_2	369	375	PF00069	0.470
MOD_PKA_2	556	562	PF00069	0.476
MOD_PKA_2	571	577	PF00069	0.529
MOD_PKA_2	628	634	PF00069	0.452
MOD_PKA_2	747	753	PF00069	0.460
MOD_PKA_2	903	909	PF00069	0.652
MOD_Plk_1	170	176	PF00069	0.473
MOD_Plk_1	447	453	PF00069	0.453
MOD_Plk_1	563	569	PF00069	0.470
MOD_Plk_1	86	92	PF00069	0.565
MOD_Plk_2-3	470	476	PF00069	0.311
MOD_Plk_4	112	118	PF00069	0.556
MOD_Plk_4	403	409	PF00069	0.332
MOD_Plk_4	448	454	PF00069	0.501
MOD_Plk_4	470	476	PF00069	0.473
MOD_Plk_4	563	569	PF00069	0.427
MOD_Plk_4	611	617	PF00069	0.371
MOD_Plk_4	747	753	PF00069	0.435
MOD_Plk_4	776	782	PF00069	0.563
MOD_Plk_4	853	859	PF00069	0.488
MOD_Plk_4	893	899	PF00069	0.598
MOD_ProDKin_1	156	162	PF00069	0.285
MOD_ProDKin_1	386	392	PF00069	0.521
MOD_ProDKin_1	508	514	PF00069	0.434
MOD_ProDKin_1	764	770	PF00069	0.544
MOD_ProDKin_1	787	793	PF00069	0.479
MOD_ProDKin_1	811	817	PF00069	0.609
MOD_SUMO_for_1	421	424	PF00179	0.502
MOD_SUMO_for_1	601	604	PF00179	0.575
MOD_SUMO_rev_2	232	242	PF00179	0.439
MOD_SUMO_rev_2	258	267	PF00179	0.520
TRG_DiLeu_BaEn_1	121	126	PF01217	0.536
TRG_DiLeu_BaEn_1	889	894	PF01217	0.652
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.670
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.321
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.545
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.523
TRG_DiLeu_BaLyEn_6	750	755	PF01217	0.466
TRG_ENDOCYTIC_2	346	349	PF00928	0.549
TRG_ENDOCYTIC_2	6	9	PF00928	0.622
TRG_ENDOCYTIC_2	635	638	PF00928	0.506
TRG_ENDOCYTIC_2	66	69	PF00928	0.332
TRG_ER_diArg_1	163	165	PF00400	0.533
TRG_ER_diArg_1	395	397	PF00400	0.541
TRG_ER_diArg_1	907	909	PF00400	0.664
TRG_NLS_MonoExtC_3	270	276	PF00514	0.403
TRG_Pf-PMV_PEXEL_1	462	467	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS9	Leptomonas seymouri	46%	91%
A0A3Q8II36	Leishmania donovani	88%	93%
A4HM20	Leishmania braziliensis	70%	100%
A4I9F3	Leishmania infantum	88%	100%
V5AN04	Trypanosoma cruzi	24%	95%