Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4F0_LEIMU

TriTrypDb:

LmxM.32.3100

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4F0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.654
CLV_C14_Caspase3-7	401	405	PF00656	0.594
CLV_NRD_NRD_1	170	172	PF00675	0.515
CLV_NRD_NRD_1	212	214	PF00675	0.455
CLV_NRD_NRD_1	3	5	PF00675	0.665
CLV_NRD_NRD_1	444	446	PF00675	0.579
CLV_PCSK_KEX2_1	170	172	PF00082	0.552
CLV_PCSK_KEX2_1	211	213	PF00082	0.477
CLV_PCSK_KEX2_1	250	252	PF00082	0.620
CLV_PCSK_KEX2_1	258	260	PF00082	0.664
CLV_PCSK_KEX2_1	3	5	PF00082	0.672
CLV_PCSK_KEX2_1	93	95	PF00082	0.561
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.656
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.689
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.630
CLV_PCSK_SKI1_1	179	183	PF00082	0.510
CLV_PCSK_SKI1_1	307	311	PF00082	0.750
CLV_PCSK_SKI1_1	373	377	PF00082	0.593
CLV_PCSK_SKI1_1	4	8	PF00082	0.693
CLV_PCSK_SKI1_1	69	73	PF00082	0.537
CLV_PCSK_SKI1_1	83	87	PF00082	0.616
DEG_APCC_DBOX_1	2	10	PF00400	0.691
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DOC_CKS1_1	278	283	PF01111	0.759
DOC_CYCLIN_RxL_1	176	185	PF00134	0.329
DOC_MAPK_gen_1	170	176	PF00069	0.493
DOC_MAPK_gen_1	211	220	PF00069	0.554
DOC_MAPK_gen_1	3	9	PF00069	0.666
DOC_MAPK_MEF2A_6	213	222	PF00069	0.487
DOC_MAPK_MEF2A_6	69	78	PF00069	0.562
DOC_PP2B_LxvP_1	273	276	PF13499	0.769
DOC_USP7_MATH_1	15	19	PF00917	0.407
DOC_USP7_UBL2_3	402	406	PF12436	0.557
DOC_USP7_UBL2_3	411	415	PF12436	0.493
DOC_USP7_UBL2_3	452	456	PF12436	0.548
DOC_USP7_UBL2_3	89	93	PF12436	0.682
DOC_WW_Pin1_4	102	107	PF00397	0.428
DOC_WW_Pin1_4	277	282	PF00397	0.768
DOC_WW_Pin1_4	62	67	PF00397	0.564
LIG_14-3-3_CanoR_1	11	20	PF00244	0.547
LIG_14-3-3_CanoR_1	110	119	PF00244	0.513
LIG_14-3-3_CanoR_1	219	223	PF00244	0.395
LIG_14-3-3_CanoR_1	291	297	PF00244	0.561
LIG_14-3-3_CanoR_1	33	39	PF00244	0.461
LIG_CSL_BTD_1	103	106	PF09270	0.438
LIG_CtBP_PxDLS_1	437	441	PF00389	0.678
LIG_deltaCOP1_diTrp_1	187	194	PF00928	0.414
LIG_DLG_GKlike_1	279	287	PF00625	0.499
LIG_FHA_1	124	130	PF00498	0.443
LIG_FHA_1	146	152	PF00498	0.543
LIG_FHA_1	196	202	PF00498	0.555
LIG_FHA_1	278	284	PF00498	0.720
LIG_FHA_1	391	397	PF00498	0.422
LIG_FHA_1	420	426	PF00498	0.678
LIG_FHA_2	157	163	PF00498	0.434
LIG_FHA_2	329	335	PF00498	0.690
LIG_FHA_2	63	69	PF00498	0.651
LIG_FHA_2	79	85	PF00498	0.540
LIG_HCF-1_HBM_1	42	45	PF13415	0.275
LIG_LIR_Apic_2	203	207	PF02991	0.408
LIG_LIR_Gen_1	148	156	PF02991	0.430
LIG_LIR_Gen_1	397	407	PF02991	0.528
LIG_LIR_Gen_1	42	52	PF02991	0.475
LIG_LIR_Nem_3	148	153	PF02991	0.433
LIG_LIR_Nem_3	30	35	PF02991	0.492
LIG_LIR_Nem_3	338	342	PF02991	0.531
LIG_LIR_Nem_3	347	353	PF02991	0.537
LIG_LIR_Nem_3	397	403	PF02991	0.536
LIG_LIR_Nem_3	42	48	PF02991	0.410
LIG_LIR_Nem_3	82	88	PF02991	0.554
LIG_MAD2	110	118	PF02301	0.522
LIG_PCNA_PIPBox_1	290	299	PF02747	0.560
LIG_Pex14_1	190	194	PF04695	0.421
LIG_SH2_CRK	350	354	PF00017	0.607
LIG_SH2_GRB2like	152	155	PF00017	0.434
LIG_SH2_PTP2	204	207	PF00017	0.302
LIG_SH2_STAP1	137	141	PF00017	0.491
LIG_SH2_STAT3	342	345	PF00017	0.550
LIG_SH2_STAT5	152	155	PF00017	0.361
LIG_SH2_STAT5	204	207	PF00017	0.570
LIG_SH2_STAT5	75	78	PF00017	0.463
LIG_SH3_3	112	118	PF00018	0.492
LIG_SH3_3	138	144	PF00018	0.561
LIG_SH3_3	17	23	PF00018	0.408
LIG_SH3_3	171	177	PF00018	0.424
LIG_SH3_3	269	275	PF00018	0.711
LIG_SH3_3	286	292	PF00018	0.718
LIG_SUMO_SIM_par_1	34	42	PF11976	0.520
LIG_UBA3_1	352	357	PF00899	0.580
LIG_WRC_WIRS_1	293	298	PF05994	0.689
MOD_CDK_SPxxK_3	62	69	PF00069	0.562
MOD_CK1_1	18	24	PF00069	0.464
MOD_CK2_1	34	40	PF00069	0.453
MOD_CK2_1	391	397	PF00069	0.678
MOD_CK2_1	78	84	PF00069	0.521
MOD_Cter_Amidation	168	171	PF01082	0.581
MOD_Cter_Amidation	248	251	PF01082	0.487
MOD_GlcNHglycan	13	16	PF01048	0.464
MOD_GlcNHglycan	184	187	PF01048	0.407
MOD_GlcNHglycan	304	307	PF01048	0.734
MOD_GlcNHglycan	322	325	PF01048	0.627
MOD_GlcNHglycan	361	364	PF01048	0.647
MOD_GSK3_1	11	18	PF00069	0.573
MOD_GSK3_1	373	380	PF00069	0.671
MOD_GSK3_1	457	464	PF00069	0.670
MOD_N-GLC_1	207	212	PF02516	0.580
MOD_N-GLC_1	302	307	PF02516	0.747
MOD_NEK2_1	156	161	PF00069	0.405
MOD_NEK2_1	218	223	PF00069	0.399
MOD_NEK2_1	359	364	PF00069	0.600
MOD_NEK2_1	375	380	PF00069	0.574
MOD_NEK2_1	391	396	PF00069	0.434
MOD_NEK2_1	424	429	PF00069	0.656
MOD_NEK2_1	440	445	PF00069	0.531
MOD_PIKK_1	430	436	PF00454	0.726
MOD_PKA_1	373	379	PF00069	0.678
MOD_PKA_2	218	224	PF00069	0.418
MOD_PKA_2	440	446	PF00069	0.608
MOD_PKB_1	211	219	PF00069	0.559
MOD_Plk_1	15	21	PF00069	0.446
MOD_Plk_1	241	247	PF00069	0.572
MOD_Plk_1	268	274	PF00069	0.567
MOD_Plk_1	376	382	PF00069	0.693
MOD_Plk_1	46	52	PF00069	0.550
MOD_Plk_2-3	377	383	PF00069	0.712
MOD_Plk_4	104	110	PF00069	0.399
MOD_Plk_4	15	21	PF00069	0.386
MOD_Plk_4	156	162	PF00069	0.418
MOD_Plk_4	200	206	PF00069	0.493
MOD_Plk_4	268	274	PF00069	0.470
MOD_Plk_4	292	298	PF00069	0.656
MOD_Plk_4	55	61	PF00069	0.576
MOD_ProDKin_1	102	108	PF00069	0.422
MOD_ProDKin_1	277	283	PF00069	0.771
MOD_ProDKin_1	62	68	PF00069	0.562
MOD_SUMO_rev_2	401	407	PF00179	0.537
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.651
TRG_ENDOCYTIC_2	152	155	PF00928	0.361
TRG_ENDOCYTIC_2	350	353	PF00928	0.602
TRG_ENDOCYTIC_2	45	48	PF00928	0.501
TRG_ENDOCYTIC_2	75	78	PF00928	0.460
TRG_ER_diArg_1	2	4	PF00400	0.682
TRG_ER_diArg_1	211	213	PF00400	0.470
TRG_NLS_MonoExtC_3	371	377	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD27	Leptomonas seymouri	76%	99%
A0A0S4JDR9	Bodo saltans	41%	75%
A0A1X0NSW5	Trypanosomatidae	52%	100%
A0A3S7X787	Leishmania donovani	95%	100%
A4HM19	Leishmania braziliensis	86%	100%
A4I9F2	Leishmania infantum	95%	100%
C9ZJS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	90%
Q4Q3M6	Leishmania major	93%	100%
V5AFA6	Trypanosoma cruzi	55%	100%