TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9B4E7_LEIMU

TriTrypDb:

Length:

835

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.555
CLV_NRD_NRD_1	246	248	PF00675	0.552
CLV_NRD_NRD_1	392	394	PF00675	0.598
CLV_NRD_NRD_1	551	553	PF00675	0.716
CLV_NRD_NRD_1	560	562	PF00675	0.801
CLV_NRD_NRD_1	622	624	PF00675	0.627
CLV_NRD_NRD_1	631	633	PF00675	0.573
CLV_NRD_NRD_1	693	695	PF00675	0.624
CLV_NRD_NRD_1	761	763	PF00675	0.589
CLV_NRD_NRD_1	770	772	PF00675	0.539
CLV_NRD_NRD_1	795	797	PF00675	0.563
CLV_NRD_NRD_1	814	816	PF00675	0.629
CLV_NRD_NRD_1	821	823	PF00675	0.695
CLV_NRD_NRD_1	833	835	PF00675	0.643
CLV_PCSK_FUR_1	792	796	PF00082	0.559
CLV_PCSK_FUR_1	819	823	PF00082	0.527
CLV_PCSK_KEX2_1	100	102	PF00082	0.555
CLV_PCSK_KEX2_1	246	248	PF00082	0.552
CLV_PCSK_KEX2_1	392	394	PF00082	0.598
CLV_PCSK_KEX2_1	48	50	PF00082	0.528
CLV_PCSK_KEX2_1	551	553	PF00082	0.716
CLV_PCSK_KEX2_1	560	562	PF00082	0.801
CLV_PCSK_KEX2_1	622	624	PF00082	0.627
CLV_PCSK_KEX2_1	631	633	PF00082	0.573
CLV_PCSK_KEX2_1	693	695	PF00082	0.624
CLV_PCSK_KEX2_1	761	763	PF00082	0.589
CLV_PCSK_KEX2_1	794	796	PF00082	0.563
CLV_PCSK_KEX2_1	814	816	PF00082	0.629
CLV_PCSK_KEX2_1	821	823	PF00082	0.531
CLV_PCSK_KEX2_1	832	834	PF00082	0.487
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.528
CLV_PCSK_PC7_1	757	763	PF00082	0.567
CLV_PCSK_PC7_1	828	834	PF00082	0.519
CLV_PCSK_SKI1_1	158	162	PF00082	0.419
CLV_PCSK_SKI1_1	304	308	PF00082	0.507
CLV_PCSK_SKI1_1	450	454	PF00082	0.492
CLV_PCSK_SKI1_1	573	577	PF00082	0.682
CLV_PCSK_SKI1_1	644	648	PF00082	0.590
DEG_Nend_UBRbox_2	1	3	PF02207	0.557
DEG_SCF_FBW7_1	553	559	PF00400	0.613
DEG_SCF_FBW7_1	624	630	PF00400	0.614
DOC_ANK_TNKS_1	793	800	PF00023	0.562
DOC_CKS1_1	102	107	PF01111	0.520
DOC_CKS1_1	248	253	PF01111	0.523
DOC_CKS1_1	394	399	PF01111	0.573
DOC_CKS1_1	553	558	PF01111	0.613
DOC_CKS1_1	574	579	PF01111	0.580
DOC_CKS1_1	624	629	PF01111	0.615
DOC_CKS1_1	645	650	PF01111	0.584
DOC_CKS1_1	695	700	PF01111	0.610
DOC_CYCLIN_RxL_1	533	544	PF00134	0.585
DOC_CYCLIN_RxL_1	604	615	PF00134	0.583
DOC_CYCLIN_RxL_1	675	686	PF00134	0.582
DOC_CYCLIN_RxL_1	804	813	PF00134	0.559
DOC_MAPK_gen_1	774	784	PF00069	0.543
DOC_PP1_RVXF_1	805	812	PF00149	0.560
DOC_USP7_MATH_1	30	34	PF00917	0.567
DOC_USP7_MATH_1	52	56	PF00917	0.540
DOC_USP7_MATH_1	556	560	PF00917	0.610
DOC_USP7_MATH_1	627	631	PF00917	0.609
DOC_USP7_UBL2_3	180	184	PF12436	0.386
DOC_USP7_UBL2_3	326	330	PF12436	0.399
DOC_USP7_UBL2_3	472	476	PF12436	0.386
DOC_WW_Pin1_4	101	106	PF00397	0.530
DOC_WW_Pin1_4	186	191	PF00397	0.434
DOC_WW_Pin1_4	204	209	PF00397	0.475
DOC_WW_Pin1_4	210	215	PF00397	0.559
DOC_WW_Pin1_4	247	252	PF00397	0.530
DOC_WW_Pin1_4	332	337	PF00397	0.586
DOC_WW_Pin1_4	350	355	PF00397	0.556
DOC_WW_Pin1_4	356	361	PF00397	0.653
DOC_WW_Pin1_4	393	398	PF00397	0.579
DOC_WW_Pin1_4	478	483	PF00397	0.413
DOC_WW_Pin1_4	496	501	PF00397	0.771
DOC_WW_Pin1_4	502	507	PF00397	0.725
DOC_WW_Pin1_4	552	557	PF00397	0.627
DOC_WW_Pin1_4	573	578	PF00397	0.643
DOC_WW_Pin1_4	61	66	PF00397	0.501
DOC_WW_Pin1_4	623	628	PF00397	0.616
DOC_WW_Pin1_4	644	649	PF00397	0.589
DOC_WW_Pin1_4	694	699	PF00397	0.614
LIG_14-3-3_CanoR_1	111	121	PF00244	0.402
LIG_14-3-3_CanoR_1	158	167	PF00244	0.410
LIG_14-3-3_CanoR_1	257	267	PF00244	0.398
LIG_14-3-3_CanoR_1	304	313	PF00244	0.378
LIG_14-3-3_CanoR_1	403	413	PF00244	0.377
LIG_14-3-3_CanoR_1	450	459	PF00244	0.416
LIG_14-3-3_CanoR_1	49	57	PF00244	0.534
LIG_14-3-3_CanoR_1	5	9	PF00244	0.532
LIG_14-3-3_CanoR_1	814	823	PF00244	0.523
LIG_BIR_III_4	740	744	PF00653	0.485
LIG_BRCT_BRCA1_1	583	587	PF00533	0.578
LIG_BRCT_BRCA1_1	654	658	PF00533	0.585
LIG_deltaCOP1_diTrp_1	124	133	PF00928	0.355
LIG_deltaCOP1_diTrp_1	270	279	PF00928	0.368
LIG_deltaCOP1_diTrp_1	416	425	PF00928	0.505
LIG_deltaCOP1_diTrp_1	717	726	PF00928	0.445
LIG_FHA_1	114	120	PF00498	0.373
LIG_FHA_1	140	146	PF00498	0.339
LIG_FHA_1	192	198	PF00498	0.393
LIG_FHA_1	260	266	PF00498	0.376
LIG_FHA_1	286	292	PF00498	0.350
LIG_FHA_1	338	344	PF00498	0.425
LIG_FHA_1	406	412	PF00498	0.485
LIG_FHA_1	432	438	PF00498	0.466
LIG_FHA_1	484	490	PF00498	0.397
LIG_FHA_1	564	570	PF00498	0.614
LIG_FHA_1	635	641	PF00498	0.611
LIG_FHA_1	733	739	PF00498	0.439
LIG_FHA_2	102	108	PF00498	0.518
LIG_FHA_2	248	254	PF00498	0.565
LIG_FHA_2	35	41	PF00498	0.555
LIG_FHA_2	394	400	PF00498	0.537
LIG_FHA_2	5	11	PF00498	0.531
LIG_FHA_2	539	545	PF00498	0.588
LIG_FHA_2	553	559	PF00498	0.547
LIG_FHA_2	610	616	PF00498	0.588
LIG_FHA_2	624	630	PF00498	0.548
LIG_FHA_2	681	687	PF00498	0.809
LIG_FHA_2	695	701	PF00498	0.600
LIG_LIR_Gen_1	11	20	PF02991	0.499
LIG_LIR_Gen_1	222	232	PF02991	0.704
LIG_LIR_Gen_1	368	378	PF02991	0.565
LIG_LIR_Gen_1	514	524	PF02991	0.577
LIG_LIR_Gen_1	584	595	PF02991	0.579
LIG_LIR_Gen_1	655	666	PF02991	0.580
LIG_LIR_Gen_1	67	76	PF02991	0.508
LIG_LIR_Gen_1	77	86	PF02991	0.486
LIG_LIR_Nem_3	11	17	PF02991	0.498
LIG_LIR_Nem_3	124	129	PF02991	0.351
LIG_LIR_Nem_3	131	136	PF02991	0.387
LIG_LIR_Nem_3	192	198	PF02991	0.393
LIG_LIR_Nem_3	222	227	PF02991	0.705
LIG_LIR_Nem_3	270	275	PF02991	0.589
LIG_LIR_Nem_3	277	282	PF02991	0.531
LIG_LIR_Nem_3	338	344	PF02991	0.450
LIG_LIR_Nem_3	368	373	PF02991	0.564
LIG_LIR_Nem_3	415	421	PF02991	0.396
LIG_LIR_Nem_3	423	428	PF02991	0.438
LIG_LIR_Nem_3	484	490	PF02991	0.397
LIG_LIR_Nem_3	514	519	PF02991	0.580
LIG_LIR_Nem_3	584	590	PF02991	0.577
LIG_LIR_Nem_3	655	661	PF02991	0.581
LIG_LIR_Nem_3	67	72	PF02991	0.515
LIG_LIR_Nem_3	717	722	PF02991	0.447
LIG_LIR_Nem_3	724	729	PF02991	0.412
LIG_LIR_Nem_3	75	81	PF02991	0.481
LIG_Pex14_2	191	195	PF04695	0.393
LIG_Pex14_2	337	341	PF04695	0.357
LIG_Pex14_2	483	487	PF04695	0.398
LIG_PTB_Apo_2	185	192	PF02174	0.414
LIG_PTB_Apo_2	331	338	PF02174	0.382
LIG_PTB_Apo_2	477	484	PF02174	0.416
LIG_SH2_NCK_1	198	202	PF00017	0.421
LIG_SH2_NCK_1	344	348	PF00017	0.521
LIG_SH2_NCK_1	490	494	PF00017	0.426
LIG_SH2_STAP1	198	202	PF00017	0.421
LIG_SH2_STAP1	344	348	PF00017	0.385
LIG_SH2_STAP1	490	494	PF00017	0.426
LIG_SH2_STAT5	28	31	PF00017	0.569
LIG_SH2_STAT5	68	71	PF00017	0.529
LIG_SH3_3	227	233	PF00018	0.561
LIG_SH3_3	245	251	PF00018	0.524
LIG_SH3_3	373	379	PF00018	0.601
LIG_SH3_3	391	397	PF00018	0.612
LIG_SH3_3	519	525	PF00018	0.572
LIG_SH3_3	550	556	PF00018	0.611
LIG_SH3_3	571	577	PF00018	0.595
LIG_SH3_3	590	596	PF00018	0.491
LIG_SH3_3	621	627	PF00018	0.616
LIG_SH3_3	642	648	PF00018	0.596
LIG_SH3_3	661	667	PF00018	0.596
LIG_SH3_3	692	698	PF00018	0.616
LIG_SH3_3	81	87	PF00018	0.525
LIG_SH3_3	99	105	PF00018	0.515
LIG_SUMO_SIM_anti_2	80	85	PF11976	0.515
LIG_TRAF2_1	530	533	PF00917	0.569
LIG_TRAF2_1	542	545	PF00917	0.534
LIG_TRAF2_1	555	558	PF00917	0.550
LIG_TRAF2_1	601	604	PF00917	0.575
LIG_TRAF2_1	613	616	PF00917	0.531
LIG_TRAF2_1	626	629	PF00917	0.550
LIG_TRAF2_1	672	675	PF00917	0.704
LIG_TRAF2_1	684	687	PF00917	0.730
LIG_TRAF2_1	697	700	PF00917	0.592
MOD_CDK_SPxxK_3	186	193	PF00069	0.438
MOD_CDK_SPxxK_3	204	211	PF00069	0.490
MOD_CDK_SPxxK_3	332	339	PF00069	0.383
MOD_CDK_SPxxK_3	350	357	PF00069	0.488
MOD_CDK_SPxxK_3	478	485	PF00069	0.417
MOD_CDK_SPxxK_3	496	503	PF00069	0.574
MOD_CK1_1	13	19	PF00069	0.487
MOD_CK1_1	189	195	PF00069	0.420
MOD_CK1_1	22	28	PF00069	0.519
MOD_CK1_1	223	229	PF00069	0.795
MOD_CK1_1	335	341	PF00069	0.506
MOD_CK1_1	34	40	PF00069	0.526
MOD_CK1_1	369	375	PF00069	0.681
MOD_CK1_1	481	487	PF00069	0.434
MOD_CK1_1	51	57	PF00069	0.497
MOD_CK1_1	515	521	PF00069	0.575
MOD_CK1_1	586	592	PF00069	0.750
MOD_CK1_1	657	663	PF00069	0.592
MOD_CK1_1	74	80	PF00069	0.496
MOD_CK2_1	101	107	PF00069	0.526
MOD_CK2_1	13	19	PF00069	0.487
MOD_CK2_1	247	253	PF00069	0.571
MOD_CK2_1	393	399	PF00069	0.544
MOD_CK2_1	538	544	PF00069	0.589
MOD_CK2_1	552	558	PF00069	0.549
MOD_CK2_1	609	615	PF00069	0.587
MOD_CK2_1	623	629	PF00069	0.551
MOD_CK2_1	680	686	PF00069	0.808
MOD_CK2_1	694	700	PF00069	0.606
MOD_CMANNOS	820	823	PF00535	0.530
MOD_DYRK1A_RPxSP_1	101	105	PF00069	0.535
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.535
MOD_DYRK1A_RPxSP_1	393	397	PF00069	0.583
MOD_DYRK1A_RPxSP_1	552	556	PF00069	0.611
MOD_DYRK1A_RPxSP_1	573	577	PF00069	0.589
MOD_DYRK1A_RPxSP_1	623	627	PF00069	0.614
MOD_DYRK1A_RPxSP_1	644	648	PF00069	0.590
MOD_DYRK1A_RPxSP_1	694	698	PF00069	0.615
MOD_GlcNHglycan	40	45	PF01048	0.555
MOD_GlcNHglycan	50	53	PF01048	0.521
MOD_GSK3_1	22	29	PF00069	0.501
MOD_GSK3_1	30	37	PF00069	0.544
MOD_GSK3_1	4	11	PF00069	0.533
MOD_GSK3_1	48	55	PF00069	0.489
MOD_GSK3_1	552	559	PF00069	0.625
MOD_GSK3_1	623	630	PF00069	0.615
MOD_GSK3_1	810	817	PF00069	0.715
MOD_N-GLC_1	22	27	PF02516	0.534
MOD_N-GLC_1	31	36	PF02516	0.545
MOD_NEK2_1	112	117	PF00069	0.383
MOD_NEK2_1	159	164	PF00069	0.419
MOD_NEK2_1	170	175	PF00069	0.328
MOD_NEK2_1	191	196	PF00069	0.392
MOD_NEK2_1	258	263	PF00069	0.459
MOD_NEK2_1	305	310	PF00069	0.490
MOD_NEK2_1	316	321	PF00069	0.415
MOD_NEK2_1	337	342	PF00069	0.491
MOD_NEK2_1	404	409	PF00069	0.585
MOD_NEK2_1	42	47	PF00069	0.549
MOD_NEK2_1	451	456	PF00069	0.552
MOD_NEK2_1	462	467	PF00069	0.512
MOD_NEK2_1	483	488	PF00069	0.396
MOD_NEK2_1	564	569	PF00069	0.789
MOD_NEK2_1	635	640	PF00069	0.798
MOD_NEK2_1	705	710	PF00069	0.542
MOD_PKA_1	48	54	PF00069	0.531
MOD_PKA_1	814	820	PF00069	0.519
MOD_PKA_1	821	827	PF00069	0.526
MOD_PKA_2	4	10	PF00069	0.533
MOD_PKA_2	48	54	PF00069	0.531
MOD_PKA_2	581	587	PF00069	0.580
MOD_PKA_2	652	658	PF00069	0.589
MOD_PKA_2	803	809	PF00069	0.570
MOD_PKA_2	814	820	PF00069	0.479
MOD_PKA_2	821	827	PF00069	0.614
MOD_PKB_1	410	418	PF00069	0.348
MOD_PKB_1	819	827	PF00069	0.525
MOD_Plk_1	146	152	PF00069	0.376
MOD_Plk_1	292	298	PF00069	0.544
MOD_Plk_1	438	444	PF00069	0.396
MOD_Plk_1	564	570	PF00069	0.649
MOD_Plk_1	635	641	PF00069	0.611
MOD_Plk_4	10	16	PF00069	0.520
MOD_Plk_4	162	168	PF00069	0.396
MOD_Plk_4	308	314	PF00069	0.361
MOD_Plk_4	454	460	PF00069	0.633
MOD_Plk_4	52	58	PF00069	0.539
MOD_Plk_4	565	571	PF00069	0.612
MOD_Plk_4	636	642	PF00069	0.611
MOD_ProDKin_1	101	107	PF00069	0.526
MOD_ProDKin_1	186	192	PF00069	0.437
MOD_ProDKin_1	204	210	PF00069	0.482
MOD_ProDKin_1	247	253	PF00069	0.527
MOD_ProDKin_1	332	338	PF00069	0.588
MOD_ProDKin_1	350	356	PF00069	0.565
MOD_ProDKin_1	393	399	PF00069	0.576
MOD_ProDKin_1	478	484	PF00069	0.416
MOD_ProDKin_1	496	502	PF00069	0.779
MOD_ProDKin_1	552	558	PF00069	0.628
MOD_ProDKin_1	573	579	PF00069	0.645
MOD_ProDKin_1	61	67	PF00069	0.502
MOD_ProDKin_1	623	629	PF00069	0.616
MOD_ProDKin_1	644	650	PF00069	0.591
MOD_ProDKin_1	694	700	PF00069	0.613
MOD_SUMO_for_1	178	181	PF00179	0.401
MOD_SUMO_for_1	324	327	PF00179	0.415
MOD_SUMO_for_1	470	473	PF00179	0.402
MOD_SUMO_rev_2	13	22	PF00179	0.497
MOD_SUMO_rev_2	199	207	PF00179	0.483
MOD_SUMO_rev_2	345	353	PF00179	0.444
MOD_SUMO_rev_2	491	499	PF00179	0.488
TRG_DiLeu_BaEn_1	132	137	PF01217	0.364
TRG_DiLeu_BaEn_1	278	283	PF01217	0.379
TRG_DiLeu_BaEn_1	424	429	PF01217	0.415
TRG_DiLeu_BaEn_1	725	730	PF01217	0.432
TRG_DiLeu_BaEn_4	545	551	PF01217	0.594
TRG_DiLeu_BaEn_4	616	622	PF01217	0.595
TRG_DiLeu_BaEn_4	687	693	PF01217	0.602
TRG_DiLeu_BaEn_4	94	100	PF01217	0.546
TRG_ENDOCYTIC_2	198	201	PF00928	0.419
TRG_ENDOCYTIC_2	344	347	PF00928	0.458
TRG_ENDOCYTIC_2	490	493	PF00928	0.423
TRG_ER_diArg_1	118	121	PF00400	0.351
TRG_ER_diArg_1	245	247	PF00400	0.659
TRG_ER_diArg_1	264	267	PF00400	0.449
TRG_ER_diArg_1	391	393	PF00400	0.602
TRG_ER_diArg_1	410	413	PF00400	0.292
TRG_ER_diArg_1	550	552	PF00400	0.708
TRG_ER_diArg_1	621	623	PF00400	0.621
TRG_ER_diArg_1	692	694	PF00400	0.623
TRG_ER_diArg_1	711	714	PF00400	0.479
TRG_ER_diArg_1	761	763	PF00400	0.587
TRG_ER_diArg_1	791	794	PF00400	0.556
TRG_ER_diArg_1	820	822	PF00400	0.527
TRG_ER_diArg_1	832	834	PF00400	0.484
TRG_ER_diArg_1	99	101	PF00400	0.559
TRG_NLS_Bipartite_1	761	775	PF00514	0.562
TRG_NLS_MonoExtN_4	769	775	PF00514	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E8NHN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%