Tyrosyl-DNA phosphodiesterase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosyl-DNA phosphodiesterase-like protein

Species:

Leishmania mexicana

UniProt:

E9B4E6_LEIMU

TriTrypDb:

LmxM.32.3050

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0020023	kinetoplast	2	1

Expansion

Sequence features

E9B4E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4E6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000012	single strand break repair	6	1
GO:0006302	double-strand break repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	5	1
GO:0070259	tyrosyl-DNA phosphodiesterase activity	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.506
CLV_NRD_NRD_1	320	322	PF00675	0.292
CLV_NRD_NRD_1	512	514	PF00675	0.324
CLV_NRD_NRD_1	603	605	PF00675	0.418
CLV_NRD_NRD_1	675	677	PF00675	0.680
CLV_NRD_NRD_1	98	100	PF00675	0.315
CLV_PCSK_FUR_1	601	605	PF00082	0.335
CLV_PCSK_KEX2_1	320	322	PF00082	0.283
CLV_PCSK_KEX2_1	428	430	PF00082	0.299
CLV_PCSK_KEX2_1	603	605	PF00082	0.416
CLV_PCSK_KEX2_1	677	679	PF00082	0.583
CLV_PCSK_KEX2_1	98	100	PF00082	0.315
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.348
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.609
CLV_PCSK_SKI1_1	161	165	PF00082	0.272
CLV_PCSK_SKI1_1	200	204	PF00082	0.299
CLV_PCSK_SKI1_1	321	325	PF00082	0.345
CLV_PCSK_SKI1_1	42	46	PF00082	0.306
CLV_PCSK_SKI1_1	428	432	PF00082	0.240
CLV_PCSK_SKI1_1	433	437	PF00082	0.233
CLV_PCSK_SKI1_1	494	498	PF00082	0.335
CLV_PCSK_SKI1_1	565	569	PF00082	0.310
CLV_PCSK_SKI1_1	69	73	PF00082	0.300
CLV_Separin_Metazoa	317	321	PF03568	0.510
DEG_APCC_DBOX_1	140	148	PF00400	0.470
DEG_APCC_DBOX_1	308	316	PF00400	0.510
DEG_APCC_DBOX_1	68	76	PF00400	0.418
DEG_Nend_UBRbox_3	1	3	PF02207	0.582
DEG_SCF_FBW7_1	589	596	PF00400	0.470
DEG_SPOP_SBC_1	219	223	PF00917	0.433
DOC_CDC14_PxL_1	72	80	PF14671	0.447
DOC_CKS1_1	569	574	PF01111	0.496
DOC_CKS1_1	582	587	PF01111	0.418
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	582	588	PF00134	0.447
DOC_MAPK_gen_1	633	642	PF00069	0.508
DOC_MAPK_MEF2A_6	395	404	PF00069	0.447
DOC_PP2B_LxvP_1	147	150	PF13499	0.426
DOC_PP2B_LxvP_1	628	631	PF13499	0.517
DOC_PP4_FxxP_1	431	434	PF00568	0.418
DOC_PP4_FxxP_1	475	478	PF00568	0.470
DOC_USP7_MATH_1	219	223	PF00917	0.436
DOC_USP7_MATH_1	440	444	PF00917	0.479
DOC_USP7_MATH_1	488	492	PF00917	0.568
DOC_USP7_MATH_1	507	511	PF00917	0.419
DOC_USP7_MATH_1	542	546	PF00917	0.542
DOC_USP7_MATH_1	561	565	PF00917	0.500
DOC_USP7_MATH_1	593	597	PF00917	0.491
DOC_USP7_MATH_1	645	649	PF00917	0.584
DOC_WW_Pin1_4	103	108	PF00397	0.514
DOC_WW_Pin1_4	109	114	PF00397	0.536
DOC_WW_Pin1_4	257	262	PF00397	0.508
DOC_WW_Pin1_4	367	372	PF00397	0.372
DOC_WW_Pin1_4	568	573	PF00397	0.498
DOC_WW_Pin1_4	581	586	PF00397	0.535
DOC_WW_Pin1_4	589	594	PF00397	0.558
DOC_WW_Pin1_4	648	653	PF00397	0.425
LIG_14-3-3_CanoR_1	130	139	PF00244	0.392
LIG_14-3-3_CanoR_1	31	41	PF00244	0.494
LIG_14-3-3_CanoR_1	320	326	PF00244	0.524
LIG_14-3-3_CanoR_1	388	392	PF00244	0.472
LIG_14-3-3_CanoR_1	98	104	PF00244	0.418
LIG_Actin_WH2_2	159	174	PF00022	0.539
LIG_BIR_III_4	636	640	PF00653	0.406
LIG_BRCT_BRCA1_1	544	548	PF00533	0.442
LIG_deltaCOP1_diTrp_1	182	187	PF00928	0.487
LIG_EH_1	118	122	PF12763	0.510
LIG_eIF4E_1	583	589	PF01652	0.470
LIG_FHA_1	109	115	PF00498	0.553
LIG_FHA_1	130	136	PF00498	0.470
LIG_FHA_1	175	181	PF00498	0.474
LIG_FHA_1	260	266	PF00498	0.462
LIG_FHA_1	274	280	PF00498	0.476
LIG_FHA_1	460	466	PF00498	0.427
LIG_FHA_1	575	581	PF00498	0.436
LIG_FHA_1	595	601	PF00498	0.370
LIG_FHA_1	664	670	PF00498	0.654
LIG_FHA_1	80	86	PF00498	0.497
LIG_FHA_1	92	98	PF00498	0.504
LIG_FHA_2	381	387	PF00498	0.429
LIG_FHA_2	552	558	PF00498	0.368
LIG_FHA_2	72	78	PF00498	0.531
LIG_FHA_2	98	104	PF00498	0.470
LIG_FXI_DFP_1	194	198	PF00024	0.188
LIG_LIR_Gen_1	23	32	PF02991	0.482
LIG_LIR_Gen_1	482	488	PF02991	0.416
LIG_LIR_Gen_1	54	64	PF02991	0.428
LIG_LIR_Gen_1	545	556	PF02991	0.470
LIG_LIR_Gen_1	584	594	PF02991	0.418
LIG_LIR_LC3C_4	82	87	PF02991	0.418
LIG_LIR_Nem_3	23	27	PF02991	0.448
LIG_LIR_Nem_3	298	304	PF02991	0.468
LIG_LIR_Nem_3	482	486	PF02991	0.423
LIG_LIR_Nem_3	54	59	PF02991	0.428
LIG_LIR_Nem_3	545	551	PF02991	0.514
LIG_LIR_Nem_3	584	589	PF02991	0.496
LIG_NRBOX	67	73	PF00104	0.460
LIG_Pex14_2	274	278	PF04695	0.510
LIG_Pex14_2	642	646	PF04695	0.250
LIG_SH2_CRK	483	487	PF00017	0.436
LIG_SH2_CRK	586	590	PF00017	0.447
LIG_SH2_NCK_1	483	487	PF00017	0.470
LIG_SH2_STAP1	483	487	PF00017	0.470
LIG_SH2_STAP1	594	598	PF00017	0.405
LIG_SH2_STAT3	246	249	PF00017	0.492
LIG_SH2_STAT3	339	342	PF00017	0.472
LIG_SH2_STAT5	108	111	PF00017	0.517
LIG_SH2_STAT5	193	196	PF00017	0.416
LIG_SH2_STAT5	246	249	PF00017	0.458
LIG_SH2_STAT5	583	586	PF00017	0.470
LIG_SH2_STAT5	64	67	PF00017	0.440
LIG_SH3_3	101	107	PF00018	0.384
LIG_SH3_3	143	149	PF00018	0.446
LIG_SH3_3	376	382	PF00018	0.447
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.510
LIG_SUMO_SIM_anti_2	360	367	PF11976	0.418
LIG_SUMO_SIM_par_1	84	89	PF11976	0.483
LIG_TRAF2_1	382	385	PF00917	0.470
LIG_TRAF2_1	420	423	PF00917	0.392
LIG_WRC_WIRS_1	21	26	PF05994	0.383
LIG_WW_2	149	152	PF00397	0.472
MOD_CDK_SPK_2	367	372	PF00069	0.341
MOD_CK1_1	106	112	PF00069	0.486
MOD_CK1_1	174	180	PF00069	0.489
MOD_CK1_1	221	227	PF00069	0.441
MOD_CK1_1	23	29	PF00069	0.507
MOD_CK1_1	253	259	PF00069	0.441
MOD_CK1_1	322	328	PF00069	0.470
MOD_CK1_1	34	40	PF00069	0.262
MOD_CK1_1	341	347	PF00069	0.459
MOD_CK1_1	367	373	PF00069	0.390
MOD_CK1_1	543	549	PF00069	0.436
MOD_CK1_1	63	69	PF00069	0.487
MOD_CK1_1	648	654	PF00069	0.422
MOD_CK1_1	79	85	PF00069	0.510
MOD_CK2_1	360	366	PF00069	0.468
MOD_CK2_1	380	386	PF00069	0.429
MOD_CK2_1	417	423	PF00069	0.427
MOD_CK2_1	551	557	PF00069	0.527
MOD_CK2_1	71	77	PF00069	0.517
MOD_CMANNOS	391	394	PF00535	0.270
MOD_GlcNHglycan	132	135	PF01048	0.352
MOD_GlcNHglycan	265	268	PF01048	0.344
MOD_GlcNHglycan	283	287	PF01048	0.243
MOD_GlcNHglycan	321	324	PF01048	0.299
MOD_GlcNHglycan	366	369	PF01048	0.289
MOD_GlcNHglycan	499	502	PF01048	0.225
MOD_GlcNHglycan	537	540	PF01048	0.311
MOD_GlcNHglycan	542	545	PF01048	0.315
MOD_GlcNHglycan	559	562	PF01048	0.280
MOD_GlcNHglycan	77	81	PF01048	0.257
MOD_GlcNHglycan	88	91	PF01048	0.181
MOD_GSK3_1	102	109	PF00069	0.481
MOD_GSK3_1	130	137	PF00069	0.534
MOD_GSK3_1	211	218	PF00069	0.557
MOD_GSK3_1	227	234	PF00069	0.435
MOD_GSK3_1	253	260	PF00069	0.479
MOD_GSK3_1	273	280	PF00069	0.500
MOD_GSK3_1	291	298	PF00069	0.362
MOD_GSK3_1	325	332	PF00069	0.409
MOD_GSK3_1	333	340	PF00069	0.445
MOD_GSK3_1	360	367	PF00069	0.368
MOD_GSK3_1	459	466	PF00069	0.457
MOD_GSK3_1	497	504	PF00069	0.423
MOD_GSK3_1	542	549	PF00069	0.550
MOD_GSK3_1	557	564	PF00069	0.510
MOD_GSK3_1	589	596	PF00069	0.561
MOD_GSK3_1	59	66	PF00069	0.484
MOD_GSK3_1	615	622	PF00069	0.443
MOD_GSK3_1	648	655	PF00069	0.428
MOD_GSK3_1	93	100	PF00069	0.489
MOD_N-GLC_1	227	232	PF02516	0.270
MOD_N-GLC_1	501	506	PF02516	0.216
MOD_N-GLC_1	652	657	PF02516	0.504
MOD_N-GLC_2	579	581	PF02516	0.141
MOD_NEK2_1	135	140	PF00069	0.565
MOD_NEK2_1	171	176	PF00069	0.470
MOD_NEK2_1	291	296	PF00069	0.466
MOD_NEK2_1	319	324	PF00069	0.464
MOD_NEK2_1	349	354	PF00069	0.518
MOD_NEK2_1	465	470	PF00069	0.470
MOD_NEK2_1	496	501	PF00069	0.473
MOD_NEK2_1	60	65	PF00069	0.514
MOD_NEK2_1	646	651	PF00069	0.446
MOD_NEK2_1	71	76	PF00069	0.438
MOD_NEK2_1	97	102	PF00069	0.561
MOD_NEK2_2	93	98	PF00069	0.510
MOD_PIKK_1	186	192	PF00454	0.432
MOD_PIKK_1	338	344	PF00454	0.416
MOD_PIKK_1	501	507	PF00454	0.466
MOD_PIKK_1	574	580	PF00454	0.436
MOD_PKA_1	676	682	PF00069	0.521
MOD_PKA_1	98	104	PF00069	0.436
MOD_PKA_2	129	135	PF00069	0.392
MOD_PKA_2	171	177	PF00069	0.510
MOD_PKA_2	319	325	PF00069	0.436
MOD_PKA_2	387	393	PF00069	0.447
MOD_PKA_2	517	523	PF00069	0.557
MOD_PKA_2	561	567	PF00069	0.392
MOD_PKA_2	97	103	PF00069	0.489
MOD_Plk_1	333	339	PF00069	0.498
MOD_Plk_1	488	494	PF00069	0.510
MOD_Plk_1	646	652	PF00069	0.357
MOD_Plk_1	76	82	PF00069	0.510
MOD_Plk_2-3	360	366	PF00069	0.375
MOD_Plk_4	211	217	PF00069	0.568
MOD_Plk_4	34	40	PF00069	0.365
MOD_Plk_4	360	366	PF00069	0.421
MOD_Plk_4	543	549	PF00069	0.441
MOD_Plk_4	60	66	PF00069	0.506
MOD_ProDKin_1	103	109	PF00069	0.514
MOD_ProDKin_1	257	263	PF00069	0.508
MOD_ProDKin_1	367	373	PF00069	0.372
MOD_ProDKin_1	568	574	PF00069	0.498
MOD_ProDKin_1	581	587	PF00069	0.535
MOD_ProDKin_1	589	595	PF00069	0.558
MOD_ProDKin_1	648	654	PF00069	0.422
TRG_ENDOCYTIC_2	301	304	PF00928	0.378
TRG_ENDOCYTIC_2	472	475	PF00928	0.452
TRG_ENDOCYTIC_2	483	486	PF00928	0.392
TRG_ENDOCYTIC_2	586	589	PF00928	0.429
TRG_ER_diArg_1	319	321	PF00400	0.470
TRG_ER_diArg_1	39	42	PF00400	0.470
TRG_ER_diArg_1	600	603	PF00400	0.498
TRG_ER_diArg_1	659	662	PF00400	0.539
TRG_ER_diArg_1	675	678	PF00400	0.550
TRG_ER_diArg_1	97	99	PF00400	0.514
TRG_ER_FFAT_1	636	648	PF00635	0.243
TRG_NES_CRM1_1	77	91	PF08389	0.510
TRG_NLS_MonoExtC_3	675	680	PF00514	0.708
TRG_NLS_MonoExtN_4	675	680	PF00514	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C9	Leptomonas seymouri	50%	98%
A0A0S4JE96	Bodo saltans	31%	97%
A0A1X0NRE8	Trypanosomatidae	34%	100%
A0A3Q8IMS2	Leishmania donovani	89%	100%
A0A3R7RCR4	Trypanosoma rangeli	32%	100%
A4HM15	Leishmania braziliensis	74%	100%
A4I9E7	Leishmania infantum	88%	100%
C9ZJR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q3N1	Leishmania major	87%	100%
Q8H1D9	Arabidopsis thaliana	26%	100%