Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B4E3_LEIMU

TriTrypDb:

LmxM.32.3020

Length:

974

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4E3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.527
CLV_C14_Caspase3-7	88	92	PF00656	0.814
CLV_C14_Caspase3-7	914	918	PF00656	0.766
CLV_NRD_NRD_1	179	181	PF00675	0.588
CLV_NRD_NRD_1	221	223	PF00675	0.534
CLV_NRD_NRD_1	237	239	PF00675	0.747
CLV_NRD_NRD_1	460	462	PF00675	0.612
CLV_NRD_NRD_1	579	581	PF00675	0.810
CLV_NRD_NRD_1	587	589	PF00675	0.672
CLV_NRD_NRD_1	797	799	PF00675	0.630
CLV_NRD_NRD_1	893	895	PF00675	0.848
CLV_NRD_NRD_1	923	925	PF00675	0.698
CLV_PCSK_FUR_1	672	676	PF00082	0.566
CLV_PCSK_KEX2_1	179	181	PF00082	0.588
CLV_PCSK_KEX2_1	221	223	PF00082	0.534
CLV_PCSK_KEX2_1	237	239	PF00082	0.747
CLV_PCSK_KEX2_1	354	356	PF00082	0.812
CLV_PCSK_KEX2_1	460	462	PF00082	0.624
CLV_PCSK_KEX2_1	579	581	PF00082	0.812
CLV_PCSK_KEX2_1	586	588	PF00082	0.685
CLV_PCSK_KEX2_1	665	667	PF00082	0.838
CLV_PCSK_KEX2_1	671	673	PF00082	0.708
CLV_PCSK_KEX2_1	674	676	PF00082	0.673
CLV_PCSK_KEX2_1	893	895	PF00082	0.746
CLV_PCSK_KEX2_1	923	925	PF00082	0.745
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.812
CLV_PCSK_PC1ET2_1	665	667	PF00082	0.762
CLV_PCSK_PC1ET2_1	671	673	PF00082	0.708
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.673
CLV_PCSK_SKI1_1	33	37	PF00082	0.746
CLV_PCSK_SKI1_1	447	451	PF00082	0.836
CLV_PCSK_SKI1_1	630	634	PF00082	0.523
CLV_PCSK_SKI1_1	820	824	PF00082	0.840
CLV_PCSK_SKI1_1	893	897	PF00082	0.750
CLV_PCSK_SKI1_1	903	907	PF00082	0.619
DEG_APCC_DBOX_1	178	186	PF00400	0.539
DEG_SCF_FBW7_1	133	140	PF00400	0.752
DEG_SCF_FBW7_1	814	821	PF00400	0.528
DEG_SPOP_SBC_1	250	254	PF00917	0.835
DOC_CKS1_1	29	34	PF01111	0.765
DOC_CKS1_1	823	828	PF01111	0.675
DOC_CYCLIN_RxL_1	635	646	PF00134	0.734
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.552
DOC_MAPK_gen_1	179	186	PF00069	0.607
DOC_MAPK_gen_1	221	229	PF00069	0.536
DOC_MAPK_gen_1	235	244	PF00069	0.537
DOC_MAPK_gen_1	941	948	PF00069	0.525
DOC_MAPK_MEF2A_6	179	186	PF00069	0.611
DOC_MAPK_MEF2A_6	237	246	PF00069	0.543
DOC_MAPK_MEF2A_6	941	948	PF00069	0.556
DOC_PP1_RVXF_1	636	643	PF00149	0.817
DOC_PP2B_LxvP_1	35	38	PF13499	0.547
DOC_PP2B_LxvP_1	449	452	PF13499	0.569
DOC_PP2B_LxvP_1	829	832	PF13499	0.755
DOC_PP2B_LxvP_1	952	955	PF13499	0.537
DOC_PP4_FxxP_1	603	606	PF00568	0.641
DOC_PP4_FxxP_1	823	826	PF00568	0.769
DOC_PP4_FxxP_1	880	883	PF00568	0.628
DOC_USP7_MATH_1	137	141	PF00917	0.747
DOC_USP7_MATH_1	208	212	PF00917	0.585
DOC_USP7_MATH_1	24	28	PF00917	0.725
DOC_USP7_MATH_1	259	263	PF00917	0.745
DOC_USP7_MATH_1	301	305	PF00917	0.717
DOC_USP7_MATH_1	405	409	PF00917	0.800
DOC_USP7_MATH_1	472	476	PF00917	0.710
DOC_USP7_MATH_1	547	551	PF00917	0.848
DOC_USP7_MATH_1	568	572	PF00917	0.829
DOC_USP7_MATH_1	593	597	PF00917	0.601
DOC_USP7_MATH_1	606	610	PF00917	0.748
DOC_USP7_MATH_1	695	699	PF00917	0.570
DOC_USP7_MATH_1	756	760	PF00917	0.626
DOC_USP7_MATH_1	862	866	PF00917	0.637
DOC_USP7_MATH_1	927	931	PF00917	0.544
DOC_USP7_MATH_2	606	612	PF00917	0.719
DOC_USP7_MATH_2	884	890	PF00917	0.661
DOC_USP7_UBL2_3	443	447	PF12436	0.773
DOC_USP7_UBL2_3	659	663	PF12436	0.848
DOC_USP7_UBL2_3	664	668	PF12436	0.787
DOC_USP7_UBL2_3	670	674	PF12436	0.687
DOC_WW_Pin1_4	133	138	PF00397	0.758
DOC_WW_Pin1_4	191	196	PF00397	0.744
DOC_WW_Pin1_4	274	279	PF00397	0.599
DOC_WW_Pin1_4	28	33	PF00397	0.768
DOC_WW_Pin1_4	424	429	PF00397	0.748
DOC_WW_Pin1_4	484	489	PF00397	0.839
DOC_WW_Pin1_4	497	502	PF00397	0.612
DOC_WW_Pin1_4	645	650	PF00397	0.683
DOC_WW_Pin1_4	724	729	PF00397	0.751
DOC_WW_Pin1_4	752	757	PF00397	0.735
DOC_WW_Pin1_4	792	797	PF00397	0.683
DOC_WW_Pin1_4	814	819	PF00397	0.725
DOC_WW_Pin1_4	822	827	PF00397	0.820
DOC_WW_Pin1_4	884	889	PF00397	0.835
DOC_WW_Pin1_4	960	965	PF00397	0.533
LIG_14-3-3_CanoR_1	170	174	PF00244	0.657
LIG_14-3-3_CanoR_1	179	185	PF00244	0.645
LIG_14-3-3_CanoR_1	190	194	PF00244	0.633
LIG_14-3-3_CanoR_1	355	360	PF00244	0.807
LIG_14-3-3_CanoR_1	370	377	PF00244	0.603
LIG_14-3-3_CanoR_1	421	425	PF00244	0.543
LIG_14-3-3_CanoR_1	473	477	PF00244	0.641
LIG_14-3-3_CanoR_1	599	604	PF00244	0.779
LIG_14-3-3_CanoR_1	614	621	PF00244	0.647
LIG_14-3-3_CanoR_1	638	643	PF00244	0.816
LIG_14-3-3_CanoR_1	893	898	PF00244	0.844
LIG_14-3-3_CanoR_1	934	938	PF00244	0.809
LIG_Actin_WH2_2	405	423	PF00022	0.730
LIG_APCC_ABBA_1	946	951	PF00400	0.529
LIG_APCC_ABBAyCdc20_2	329	335	PF00400	0.635
LIG_APCC_Cbox_2	561	567	PF00515	0.540
LIG_BRCT_BRCA1_1	182	186	PF00533	0.667
LIG_BRCT_BRCA1_1	261	265	PF00533	0.576
LIG_BRCT_BRCA1_1	269	273	PF00533	0.607
LIG_BRCT_BRCA1_1	308	312	PF00533	0.645
LIG_BRCT_BRCA1_1	463	467	PF00533	0.564
LIG_BRCT_BRCA1_1	473	477	PF00533	0.525
LIG_EVH1_2	80	84	PF00568	0.533
LIG_FHA_1	237	243	PF00498	0.536
LIG_FHA_1	252	258	PF00498	0.829
LIG_FHA_1	34	40	PF00498	0.841
LIG_FHA_1	466	472	PF00498	0.749
LIG_FHA_1	823	829	PF00498	0.820
LIG_FHA_1	904	910	PF00498	0.563
LIG_FHA_1	963	969	PF00498	0.545
LIG_FHA_2	129	135	PF00498	0.835
LIG_FHA_2	20	26	PF00498	0.790
LIG_FHA_2	29	35	PF00498	0.737
LIG_FHA_2	533	539	PF00498	0.736
LIG_FHA_2	649	655	PF00498	0.853
LIG_FHA_2	81	87	PF00498	0.738
LIG_FHA_2	912	918	PF00498	0.769
LIG_HCF-1_HBM_1	335	338	PF13415	0.547
LIG_LIR_Apic_2	601	606	PF02991	0.636
LIG_LIR_Apic_2	821	826	PF02991	0.764
LIG_LIR_Apic_2	878	883	PF02991	0.627
LIG_LIR_Gen_1	116	122	PF02991	0.719
LIG_LIR_Gen_1	309	317	PF02991	0.632
LIG_LIR_Gen_1	520	528	PF02991	0.532
LIG_LIR_Gen_1	82	91	PF02991	0.762
LIG_LIR_Gen_1	875	885	PF02991	0.838
LIG_LIR_Nem_3	116	121	PF02991	0.719
LIG_LIR_Nem_3	140	144	PF02991	0.734
LIG_LIR_Nem_3	413	419	PF02991	0.764
LIG_LIR_Nem_3	520	526	PF02991	0.535
LIG_LIR_Nem_3	82	87	PF02991	0.758
LIG_LIR_Nem_3	875	880	PF02991	0.839
LIG_MAD2	811	819	PF02301	0.533
LIG_MLH1_MIPbox_1	474	478	PF16413	0.546
LIG_Rb_pABgroove_1	180	188	PF01858	0.620
LIG_SH2_SRC	144	147	PF00017	0.755
LIG_SH2_SRC	333	336	PF00017	0.551
LIG_SH2_STAP1	118	122	PF00017	0.733
LIG_SH2_STAP1	949	953	PF00017	0.530
LIG_SH2_STAT5	122	125	PF00017	0.618
LIG_SH3_3	275	281	PF00018	0.599
LIG_SH3_3	750	756	PF00018	0.831
LIG_SH3_3	934	940	PF00018	0.753
LIG_SH3_3	961	967	PF00018	0.657
LIG_Sin3_3	225	232	PF02671	0.539
LIG_SUMO_SIM_par_1	36	42	PF11976	0.551
LIG_TRAF2_1	147	150	PF00917	0.736
LIG_WRC_WIRS_1	118	123	PF05994	0.734
LIG_WRC_WIRS_1	639	644	PF05994	0.660
LIG_WW_3	487	491	PF00397	0.562
LIG_WW_3	817	821	PF00397	0.524
MOD_CDC14_SPxK_1	487	490	PF00782	0.558
MOD_CDC14_SPxK_1	727	730	PF00782	0.641
MOD_CDC14_SPxK_1	795	798	PF00782	0.550
MOD_CDC14_SPxK_1	963	966	PF00782	0.547
MOD_CDK_SPK_2	28	33	PF00069	0.671
MOD_CDK_SPxK_1	484	490	PF00069	0.758
MOD_CDK_SPxK_1	724	730	PF00069	0.642
MOD_CDK_SPxK_1	792	798	PF00069	0.553
MOD_CDK_SPxK_1	814	820	PF00069	0.526
MOD_CDK_SPxK_1	960	966	PF00069	0.538
MOD_CDK_SPxxK_3	191	198	PF00069	0.668
MOD_CDK_SPxxK_3	792	799	PF00069	0.556
MOD_CK1_1	111	117	PF00069	0.736
MOD_CK1_1	120	126	PF00069	0.582
MOD_CK1_1	17	23	PF00069	0.593
MOD_CK1_1	172	178	PF00069	0.668
MOD_CK1_1	189	195	PF00069	0.693
MOD_CK1_1	204	210	PF00069	0.762
MOD_CK1_1	233	239	PF00069	0.687
MOD_CK1_1	274	280	PF00069	0.734
MOD_CK1_1	3	9	PF00069	0.744
MOD_CK1_1	318	324	PF00069	0.645
MOD_CK1_1	427	433	PF00069	0.695
MOD_CK1_1	437	443	PF00069	0.653
MOD_CK1_1	465	471	PF00069	0.821
MOD_CK1_1	518	524	PF00069	0.819
MOD_CK1_1	573	579	PF00069	0.633
MOD_CK1_1	598	604	PF00069	0.573
MOD_CK1_1	615	621	PF00069	0.731
MOD_CK1_1	754	760	PF00069	0.646
MOD_CK1_1	899	905	PF00069	0.753
MOD_CK1_1	915	921	PF00069	0.584
MOD_CK1_1	960	966	PF00069	0.635
MOD_CK2_1	144	150	PF00069	0.728
MOD_CK2_1	19	25	PF00069	0.792
MOD_CK2_1	28	34	PF00069	0.734
MOD_CK2_1	338	344	PF00069	0.747
MOD_CK2_1	391	397	PF00069	0.643
MOD_CK2_1	532	538	PF00069	0.866
MOD_CK2_1	568	574	PF00069	0.704
MOD_CK2_1	638	644	PF00069	0.813
MOD_CK2_1	648	654	PF00069	0.683
MOD_Cter_Amidation	352	355	PF01082	0.523
MOD_Cter_Amidation	458	461	PF01082	0.583
MOD_Cter_Amidation	577	580	PF01082	0.724
MOD_DYRK1A_RPxSP_1	752	756	PF00069	0.654
MOD_GlcNHglycan	103	106	PF01048	0.678
MOD_GlcNHglycan	11	14	PF01048	0.652
MOD_GlcNHglycan	112	116	PF01048	0.570
MOD_GlcNHglycan	206	209	PF01048	0.734
MOD_GlcNHglycan	214	217	PF01048	0.657
MOD_GlcNHglycan	267	270	PF01048	0.708
MOD_GlcNHglycan	274	277	PF01048	0.633
MOD_GlcNHglycan	292	295	PF01048	0.726
MOD_GlcNHglycan	403	406	PF01048	0.627
MOD_GlcNHglycan	431	434	PF01048	0.563
MOD_GlcNHglycan	436	439	PF01048	0.621
MOD_GlcNHglycan	494	497	PF01048	0.702
MOD_GlcNHglycan	51	54	PF01048	0.599
MOD_GlcNHglycan	576	579	PF01048	0.826
MOD_GlcNHglycan	589	592	PF01048	0.644
MOD_GlcNHglycan	61	64	PF01048	0.628
MOD_GlcNHglycan	617	620	PF01048	0.847
MOD_GlcNHglycan	756	759	PF01048	0.704
MOD_GlcNHglycan	837	840	PF01048	0.753
MOD_GlcNHglycan	864	867	PF01048	0.609
MOD_GlcNHglycan	888	891	PF01048	0.723
MOD_GlcNHglycan	898	901	PF01048	0.631
MOD_GlcNHglycan	95	98	PF01048	0.765
MOD_GSK3_1	113	120	PF00069	0.638
MOD_GSK3_1	129	136	PF00069	0.507
MOD_GSK3_1	144	151	PF00069	0.575
MOD_GSK3_1	169	176	PF00069	0.639
MOD_GSK3_1	204	211	PF00069	0.737
MOD_GSK3_1	212	219	PF00069	0.606
MOD_GSK3_1	24	31	PF00069	0.729
MOD_GSK3_1	261	268	PF00069	0.760
MOD_GSK3_1	306	313	PF00069	0.733
MOD_GSK3_1	371	378	PF00069	0.630
MOD_GSK3_1	401	408	PF00069	0.691
MOD_GSK3_1	420	427	PF00069	0.565
MOD_GSK3_1	432	439	PF00069	0.773
MOD_GSK3_1	461	468	PF00069	0.726
MOD_GSK3_1	564	571	PF00069	0.830
MOD_GSK3_1	589	596	PF00069	0.634
MOD_GSK3_1	608	615	PF00069	0.701
MOD_GSK3_1	752	759	PF00069	0.730
MOD_GSK3_1	788	795	PF00069	0.553
MOD_GSK3_1	814	821	PF00069	0.631
MOD_GSK3_1	827	834	PF00069	0.766
MOD_GSK3_1	884	891	PF00069	0.676
MOD_GSK3_1	89	96	PF00069	0.804
MOD_GSK3_1	899	906	PF00069	0.666
MOD_GSK3_1	911	918	PF00069	0.776
MOD_GSK3_1	97	104	PF00069	0.672
MOD_LATS_1	529	535	PF00433	0.854
MOD_N-GLC_1	180	185	PF02516	0.752
MOD_N-GLC_1	250	255	PF02516	0.548
MOD_N-GLC_1	259	264	PF02516	0.567
MOD_N-GLC_1	306	311	PF02516	0.759
MOD_N-GLC_1	465	470	PF02516	0.761
MOD_N-GLC_1	64	69	PF02516	0.734
MOD_N-GLC_1	835	840	PF02516	0.770
MOD_N-GLC_1	912	917	PF02516	0.652
MOD_N-GLC_2	76	78	PF02516	0.544
MOD_NEK2_1	121	126	PF00069	0.731
MOD_NEK2_1	14	19	PF00069	0.840
MOD_NEK2_1	186	191	PF00069	0.770
MOD_NEK2_1	227	232	PF00069	0.752
MOD_NEK2_1	261	266	PF00069	0.743
MOD_NEK2_1	267	272	PF00069	0.675
MOD_NEK2_1	310	315	PF00069	0.751
MOD_NEK2_1	412	417	PF00069	0.709
MOD_NEK2_1	420	425	PF00069	0.635
MOD_NEK2_1	589	594	PF00069	0.596
MOD_NEK2_2	117	122	PF00069	0.732
MOD_NEK2_2	472	477	PF00069	0.537
MOD_NEK2_2	888	893	PF00069	0.764
MOD_NEK2_2	957	962	PF00069	0.750
MOD_OFUCOSY	744	750	PF10250	0.740
MOD_PIKK_1	310	316	PF00454	0.825
MOD_PIKK_1	64	70	PF00454	0.691
MOD_PIKK_1	928	934	PF00454	0.611
MOD_PK_1	180	186	PF00069	0.755
MOD_PKA_1	587	593	PF00069	0.829
MOD_PKA_1	664	670	PF00069	0.793
MOD_PKA_1	893	899	PF00069	0.840
MOD_PKA_2	169	175	PF00069	0.622
MOD_PKA_2	189	195	PF00069	0.728
MOD_PKA_2	236	242	PF00069	0.618
MOD_PKA_2	369	375	PF00069	0.697
MOD_PKA_2	420	426	PF00069	0.545
MOD_PKA_2	462	468	PF00069	0.610
MOD_PKA_2	472	478	PF00069	0.616
MOD_PKA_2	508	514	PF00069	0.516
MOD_PKA_2	568	574	PF00069	0.802
MOD_PKA_2	587	593	PF00069	0.657
MOD_PKA_2	598	604	PF00069	0.691
MOD_PKA_2	606	612	PF00069	0.522
MOD_PKA_2	751	757	PF00069	0.666
MOD_PKA_2	893	899	PF00069	0.840
MOD_PKA_2	9	15	PF00069	0.749
MOD_PKA_2	933	939	PF00069	0.759
MOD_Plk_1	129	135	PF00069	0.761
MOD_Plk_1	180	186	PF00069	0.573
MOD_Plk_1	24	30	PF00069	0.738
MOD_Plk_1	259	265	PF00069	0.532
MOD_Plk_1	306	312	PF00069	0.759
MOD_Plk_1	412	418	PF00069	0.713
MOD_Plk_1	515	521	PF00069	0.739
MOD_Plk_1	612	618	PF00069	0.558
MOD_Plk_1	64	70	PF00069	0.832
MOD_Plk_1	957	963	PF00069	0.635
MOD_Plk_2-3	396	402	PF00069	0.741
MOD_Plk_2-3	608	614	PF00069	0.553
MOD_Plk_2-3	864	870	PF00069	0.666
MOD_Plk_4	117	123	PF00069	0.690
MOD_Plk_4	14	20	PF00069	0.599
MOD_Plk_4	180	186	PF00069	0.657
MOD_Plk_4	208	214	PF00069	0.535
MOD_Plk_4	261	267	PF00069	0.700
MOD_Plk_4	357	363	PF00069	0.833
MOD_Plk_4	415	421	PF00069	0.798
MOD_Plk_4	472	478	PF00069	0.631
MOD_Plk_4	80	86	PF00069	0.653
MOD_Plk_4	933	939	PF00069	0.655
MOD_ProDKin_1	133	139	PF00069	0.753
MOD_ProDKin_1	191	197	PF00069	0.748
MOD_ProDKin_1	274	280	PF00069	0.601
MOD_ProDKin_1	28	34	PF00069	0.767
MOD_ProDKin_1	424	430	PF00069	0.750
MOD_ProDKin_1	484	490	PF00069	0.843
MOD_ProDKin_1	497	503	PF00069	0.609
MOD_ProDKin_1	645	651	PF00069	0.686
MOD_ProDKin_1	724	730	PF00069	0.754
MOD_ProDKin_1	752	758	PF00069	0.738
MOD_ProDKin_1	792	798	PF00069	0.686
MOD_ProDKin_1	814	820	PF00069	0.729
MOD_ProDKin_1	822	828	PF00069	0.821
MOD_ProDKin_1	884	890	PF00069	0.836
MOD_ProDKin_1	960	966	PF00069	0.538
MOD_SUMO_rev_2	393	399	PF00179	0.791
MOD_SUMO_rev_2	42	52	PF00179	0.540
MOD_SUMO_rev_2	534	542	PF00179	0.754
TRG_DiLeu_BaEn_3	155	161	PF01217	0.653
TRG_DiLeu_BaLyEn_6	635	640	PF01217	0.815
TRG_ENDOCYTIC_2	118	121	PF00928	0.646
TRG_ENDOCYTIC_2	949	952	PF00928	0.659
TRG_ER_diArg_1	237	240	PF00400	0.736
TRG_ER_diArg_1	579	581	PF00400	0.813
TRG_ER_diArg_1	585	588	PF00400	0.689
TRG_ER_diArg_1	892	894	PF00400	0.849
TRG_ER_diArg_1	923	926	PF00400	0.744
TRG_NLS_MonoCore_2	662	667	PF00514	0.687
TRG_NLS_MonoExtC_3	663	668	PF00514	0.814
TRG_NLS_MonoExtC_3	670	675	PF00514	0.765
TRG_NLS_MonoExtN_4	663	668	PF00514	0.815
TRG_NLS_MonoExtN_4	670	675	PF00514	0.699
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7V4	Leishmania donovani	73%	100%
A4HM12	Leishmania braziliensis	44%	97%
A4I9E3	Leishmania infantum	73%	100%
Q4Q3N4	Leishmania major	72%	100%