J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4E2_LEIMU

TriTrypDb:

LmxM.32.3010

Length:

1041

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4E2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.710
CLV_C14_Caspase3-7	139	143	PF00656	0.660
CLV_C14_Caspase3-7	370	374	PF00656	0.646
CLV_C14_Caspase3-7	555	559	PF00656	0.642
CLV_C14_Caspase3-7	693	697	PF00656	0.528
CLV_C14_Caspase3-7	702	706	PF00656	0.445
CLV_NRD_NRD_1	1009	1011	PF00675	0.433
CLV_NRD_NRD_1	148	150	PF00675	0.763
CLV_NRD_NRD_1	390	392	PF00675	0.613
CLV_NRD_NRD_1	41	43	PF00675	0.545
CLV_NRD_NRD_1	425	427	PF00675	0.535
CLV_NRD_NRD_1	435	437	PF00675	0.529
CLV_NRD_NRD_1	446	448	PF00675	0.492
CLV_NRD_NRD_1	467	469	PF00675	0.623
CLV_NRD_NRD_1	492	494	PF00675	0.674
CLV_NRD_NRD_1	516	518	PF00675	0.625
CLV_NRD_NRD_1	55	57	PF00675	0.591
CLV_NRD_NRD_1	945	947	PF00675	0.451
CLV_PCSK_FUR_1	514	518	PF00082	0.607
CLV_PCSK_KEX2_1	1009	1011	PF00082	0.409
CLV_PCSK_KEX2_1	148	150	PF00082	0.763
CLV_PCSK_KEX2_1	209	211	PF00082	0.530
CLV_PCSK_KEX2_1	390	392	PF00082	0.600
CLV_PCSK_KEX2_1	41	43	PF00082	0.539
CLV_PCSK_KEX2_1	424	426	PF00082	0.514
CLV_PCSK_KEX2_1	448	450	PF00082	0.581
CLV_PCSK_KEX2_1	466	468	PF00082	0.637
CLV_PCSK_KEX2_1	516	518	PF00082	0.625
CLV_PCSK_KEX2_1	55	57	PF00082	0.555
CLV_PCSK_KEX2_1	983	985	PF00082	0.407
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.530
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.467
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.555
CLV_PCSK_PC1ET2_1	466	468	PF00082	0.549
CLV_PCSK_PC1ET2_1	983	985	PF00082	0.383
CLV_PCSK_PC7_1	386	392	PF00082	0.599
CLV_PCSK_PC7_1	462	468	PF00082	0.564
CLV_PCSK_PC7_1	512	518	PF00082	0.629
CLV_PCSK_SKI1_1	437	441	PF00082	0.544
CLV_PCSK_SKI1_1	775	779	PF00082	0.403
CLV_PCSK_SKI1_1	807	811	PF00082	0.361
CLV_PCSK_SKI1_1	984	988	PF00082	0.415
DEG_APCC_DBOX_1	40	48	PF00400	0.556
DEG_SPOP_SBC_1	211	215	PF00917	0.696
DEG_SPOP_SBC_1	326	330	PF00917	0.667
DEG_SPOP_SBC_1	851	855	PF00917	0.482
DEG_SPOP_SBC_1	94	98	PF00917	0.520
DOC_CDC14_PxL_1	263	271	PF14671	0.641
DOC_CYCLIN_RxL_1	680	693	PF00134	0.503
DOC_CYCLIN_RxL_1	772	782	PF00134	0.383
DOC_MAPK_gen_1	983	991	PF00069	0.465
DOC_PP2B_LxvP_1	292	295	PF13499	0.520
DOC_PP2B_LxvP_1	815	818	PF13499	0.390
DOC_PP4_FxxP_1	762	765	PF00568	0.379
DOC_USP7_MATH_1	161	165	PF00917	0.666
DOC_USP7_MATH_1	185	189	PF00917	0.655
DOC_USP7_MATH_1	211	215	PF00917	0.671
DOC_USP7_MATH_1	285	289	PF00917	0.563
DOC_USP7_MATH_1	346	350	PF00917	0.612
DOC_USP7_MATH_1	610	614	PF00917	0.737
DOC_USP7_MATH_1	636	640	PF00917	0.719
DOC_USP7_MATH_1	741	745	PF00917	0.444
DOC_USP7_MATH_1	83	87	PF00917	0.744
DOC_USP7_MATH_1	864	868	PF00917	0.335
DOC_USP7_MATH_1	907	911	PF00917	0.384
DOC_USP7_MATH_1	94	98	PF00917	0.623
DOC_USP7_MATH_2	664	670	PF00917	0.646
DOC_USP7_UBL2_3	159	163	PF12436	0.675
DOC_USP7_UBL2_3	424	428	PF12436	0.402
DOC_USP7_UBL2_3	803	807	PF12436	0.461
DOC_USP7_UBL2_3	983	987	PF12436	0.382
DOC_WW_Pin1_4	162	167	PF00397	0.686
DOC_WW_Pin1_4	588	593	PF00397	0.686
DOC_WW_Pin1_4	598	603	PF00397	0.581
DOC_WW_Pin1_4	615	620	PF00397	0.742
DOC_WW_Pin1_4	647	652	PF00397	0.694
DOC_WW_Pin1_4	761	766	PF00397	0.373
DOC_WW_Pin1_4	824	829	PF00397	0.385
LIG_14-3-3_CanoR_1	256	262	PF00244	0.609
LIG_14-3-3_CanoR_1	352	357	PF00244	0.600
LIG_14-3-3_CanoR_1	586	592	PF00244	0.647
LIG_14-3-3_CanoR_1	596	602	PF00244	0.542
LIG_14-3-3_CanoR_1	609	619	PF00244	0.623
LIG_14-3-3_CanoR_1	624	632	PF00244	0.544
LIG_14-3-3_CanoR_1	772	778	PF00244	0.397
LIG_14-3-3_CanoR_1	858	865	PF00244	0.493
LIG_Actin_WH2_2	681	697	PF00022	0.454
LIG_Actin_WH2_2	962	980	PF00022	0.377
LIG_BIR_III_4	20	24	PF00653	0.553
LIG_BRCT_BRCA1_1	53	57	PF00533	0.525
LIG_BRCT_BRCA1_1	62	66	PF00533	0.570
LIG_Clathr_ClatBox_1	688	692	PF01394	0.471
LIG_CtBP_PxDLS_1	681	685	PF00389	0.332
LIG_deltaCOP1_diTrp_1	58	66	PF00928	0.582
LIG_FHA_1	253	259	PF00498	0.660
LIG_FHA_1	685	691	PF00498	0.416
LIG_FHA_1	712	718	PF00498	0.457
LIG_FHA_1	793	799	PF00498	0.229
LIG_FHA_1	851	857	PF00498	0.489
LIG_FHA_1	867	873	PF00498	0.282
LIG_FHA_2	116	122	PF00498	0.535
LIG_FHA_2	439	445	PF00498	0.521
LIG_FHA_2	498	504	PF00498	0.510
LIG_FHA_2	543	549	PF00498	0.632
LIG_FHA_2	553	559	PF00498	0.649
LIG_FHA_2	599	605	PF00498	0.671
LIG_FHA_2	700	706	PF00498	0.388
LIG_FHA_2	720	726	PF00498	0.562
LIG_FHA_2	809	815	PF00498	0.507
LIG_FHA_2	844	850	PF00498	0.294
LIG_FHA_2	898	904	PF00498	0.450
LIG_FHA_2	913	919	PF00498	0.351
LIG_LIR_Gen_1	764	774	PF02991	0.354
LIG_LIR_Gen_1	816	826	PF02991	0.410
LIG_LIR_Gen_1	838	847	PF02991	0.485
LIG_LIR_Gen_1	918	927	PF02991	0.369
LIG_LIR_LC3C_4	894	898	PF02991	0.431
LIG_LIR_Nem_3	1025	1030	PF02991	0.370
LIG_LIR_Nem_3	58	64	PF02991	0.546
LIG_LIR_Nem_3	764	770	PF02991	0.351
LIG_LIR_Nem_3	816	822	PF02991	0.419
LIG_LIR_Nem_3	838	842	PF02991	0.591
LIG_LIR_Nem_3	846	851	PF02991	0.468
LIG_LIR_Nem_3	918	922	PF02991	0.380
LIG_PCNA_yPIPBox_3	771	784	PF02747	0.343
LIG_PCNA_yPIPBox_3	956	968	PF02747	0.418
LIG_PDZ_Class_3	1036	1041	PF00595	0.424
LIG_Pex14_2	53	57	PF04695	0.525
LIG_PTB_Apo_2	833	840	PF02174	0.394
LIG_PTB_Phospho_1	833	839	PF10480	0.392
LIG_Rb_LxCxE_1	1032	1041	PF01857	0.391
LIG_SH2_CRK	1027	1031	PF00017	0.382
LIG_SH2_CRK	839	843	PF00017	0.544
LIG_SH2_CRK	919	923	PF00017	0.380
LIG_SH2_NCK_1	839	843	PF00017	0.401
LIG_SH2_NCK_1	919	923	PF00017	0.366
LIG_SH2_PTP2	988	991	PF00017	0.467
LIG_SH2_STAP1	919	923	PF00017	0.380
LIG_SH2_STAT3	710	713	PF00017	0.439
LIG_SH2_STAT5	1015	1018	PF00017	0.396
LIG_SH2_STAT5	587	590	PF00017	0.531
LIG_SH2_STAT5	800	803	PF00017	0.353
LIG_SH2_STAT5	892	895	PF00017	0.365
LIG_SH2_STAT5	988	991	PF00017	0.387
LIG_SH3_3	309	315	PF00018	0.604
LIG_SH3_3	335	341	PF00018	0.702
LIG_SH3_3	356	362	PF00018	0.735
LIG_SH3_3	528	534	PF00018	0.646
LIG_SH3_3	639	645	PF00018	0.605
LIG_SH3_3	750	756	PF00018	0.439
LIG_SH3_3	839	845	PF00018	0.380
LIG_SH3_4	159	166	PF00018	0.642
LIG_SUMO_SIM_anti_2	687	693	PF11976	0.480
LIG_SUMO_SIM_par_1	686	693	PF11976	0.483
LIG_SUMO_SIM_par_1	713	719	PF11976	0.502
LIG_SUMO_SIM_par_1	749	754	PF11976	0.549
LIG_TRAF2_2	531	536	PF00917	0.605
LIG_TYR_ITIM	837	842	PF00017	0.429
LIG_TYR_ITIM	986	991	PF00017	0.465
LIG_UBA3_1	439	448	PF00899	0.520
LIG_UBA3_1	87	93	PF00899	0.667
MOD_CK1_1	164	170	PF00069	0.662
MOD_CK1_1	193	199	PF00069	0.661
MOD_CK1_1	310	316	PF00069	0.642
MOD_CK1_1	328	334	PF00069	0.521
MOD_CK1_1	351	357	PF00069	0.610
MOD_CK1_1	554	560	PF00069	0.699
MOD_CK1_1	613	619	PF00069	0.790
MOD_CK1_1	637	643	PF00069	0.642
MOD_CK1_1	647	653	PF00069	0.686
MOD_CK1_1	656	662	PF00069	0.710
MOD_CK1_1	676	682	PF00069	0.470
MOD_CK1_1	857	863	PF00069	0.424
MOD_CK1_1	910	916	PF00069	0.433
MOD_CK2_1	115	121	PF00069	0.703
MOD_CK2_1	185	191	PF00069	0.723
MOD_CK2_1	354	360	PF00069	0.574
MOD_CK2_1	497	503	PF00069	0.529
MOD_CK2_1	554	560	PF00069	0.545
MOD_CK2_1	598	604	PF00069	0.670
MOD_CK2_1	719	725	PF00069	0.546
MOD_CK2_1	808	814	PF00069	0.489
MOD_CK2_1	843	849	PF00069	0.470
MOD_CK2_1	864	870	PF00069	0.394
MOD_CK2_1	912	918	PF00069	0.429
MOD_DYRK1A_RPxSP_1	615	619	PF00069	0.732
MOD_GlcNHglycan	125	128	PF01048	0.655
MOD_GlcNHglycan	149	152	PF01048	0.770
MOD_GlcNHglycan	172	175	PF01048	0.715
MOD_GlcNHglycan	201	205	PF01048	0.840
MOD_GlcNHglycan	48	51	PF01048	0.591
MOD_GlcNHglycan	508	511	PF01048	0.749
MOD_GlcNHglycan	627	630	PF01048	0.727
MOD_GlcNHglycan	658	661	PF01048	0.602
MOD_GlcNHglycan	666	671	PF01048	0.698
MOD_GlcNHglycan	676	679	PF01048	0.542
MOD_GlcNHglycan	743	746	PF01048	0.552
MOD_GlcNHglycan	80	83	PF01048	0.766
MOD_GlcNHglycan	811	814	PF01048	0.496
MOD_GlcNHglycan	90	93	PF01048	0.680
MOD_GlcNHglycan	909	912	PF01048	0.437
MOD_GlcNHglycan	969	972	PF01048	0.451
MOD_GlcNHglycan	978	981	PF01048	0.352
MOD_GSK3_1	161	168	PF00069	0.673
MOD_GSK3_1	186	193	PF00069	0.664
MOD_GSK3_1	196	203	PF00069	0.771
MOD_GSK3_1	32	39	PF00069	0.532
MOD_GSK3_1	322	329	PF00069	0.657
MOD_GSK3_1	348	355	PF00069	0.730
MOD_GSK3_1	5	12	PF00069	0.680
MOD_GSK3_1	508	515	PF00069	0.681
MOD_GSK3_1	517	524	PF00069	0.683
MOD_GSK3_1	56	63	PF00069	0.559
MOD_GSK3_1	630	637	PF00069	0.661
MOD_GSK3_1	643	650	PF00069	0.633
MOD_GSK3_1	711	718	PF00069	0.437
MOD_GSK3_1	761	768	PF00069	0.367
MOD_GSK3_1	850	857	PF00069	0.404
MOD_N-GLC_1	637	642	PF02516	0.570
MOD_N-GLC_1	647	652	PF02516	0.658
MOD_N-GLC_1	835	840	PF02516	0.482
MOD_N-GLC_1	88	93	PF02516	0.729
MOD_NEK2_1	37	42	PF00069	0.490
MOD_NEK2_1	551	556	PF00069	0.624
MOD_NEK2_1	684	689	PF00069	0.390
MOD_NEK2_1	694	699	PF00069	0.450
MOD_NEK2_1	792	797	PF00069	0.454
MOD_NEK2_1	852	857	PF00069	0.397
MOD_NEK2_1	88	93	PF00069	0.662
MOD_NEK2_1	991	996	PF00069	0.378
MOD_NEK2_2	11	16	PF00069	0.590
MOD_NEK2_2	5	10	PF00069	0.633
MOD_NEK2_2	72	77	PF00069	0.487
MOD_NEK2_2	930	935	PF00069	0.335
MOD_PIKK_1	212	218	PF00454	0.728
MOD_PIKK_1	221	227	PF00454	0.612
MOD_PIKK_1	610	616	PF00454	0.731
MOD_PIKK_1	650	656	PF00454	0.701
MOD_PIKK_1	659	665	PF00454	0.782
MOD_PK_1	978	984	PF00069	0.369
MOD_PKA_1	209	215	PF00069	0.536
MOD_PKA_1	516	522	PF00069	0.650
MOD_PKA_2	147	153	PF00069	0.764
MOD_PKA_2	209	215	PF00069	0.536
MOD_PKA_2	351	357	PF00069	0.599
MOD_PKA_2	516	522	PF00069	0.751
MOD_PKA_2	585	591	PF00069	0.605
MOD_PKA_2	608	614	PF00069	0.538
MOD_PKA_2	694	700	PF00069	0.445
MOD_PKA_2	832	838	PF00069	0.392
MOD_PKA_2	857	863	PF00069	0.487
MOD_PKA_2	882	888	PF00069	0.421
MOD_PKB_1	514	522	PF00069	0.653
MOD_Plk_1	704	710	PF00069	0.537
MOD_Plk_1	835	841	PF00069	0.410
MOD_Plk_1	902	908	PF00069	0.404
MOD_Plk_1	951	957	PF00069	0.503
MOD_Plk_4	285	291	PF00069	0.500
MOD_Plk_4	354	360	PF00069	0.632
MOD_Plk_4	5	11	PF00069	0.634
MOD_Plk_4	684	690	PF00069	0.438
MOD_Plk_4	72	78	PF00069	0.564
MOD_Plk_4	730	736	PF00069	0.431
MOD_Plk_4	83	89	PF00069	0.624
MOD_Plk_4	843	849	PF00069	0.294
MOD_Plk_4	892	898	PF00069	0.356
MOD_Plk_4	918	924	PF00069	0.406
MOD_Plk_4	95	101	PF00069	0.630
MOD_ProDKin_1	162	168	PF00069	0.686
MOD_ProDKin_1	588	594	PF00069	0.684
MOD_ProDKin_1	598	604	PF00069	0.583
MOD_ProDKin_1	615	621	PF00069	0.742
MOD_ProDKin_1	647	653	PF00069	0.694
MOD_ProDKin_1	761	767	PF00069	0.369
MOD_ProDKin_1	824	830	PF00069	0.385
MOD_SUMO_for_1	296	299	PF00179	0.623
MOD_SUMO_rev_2	214	224	PF00179	0.692
MOD_SUMO_rev_2	465	475	PF00179	0.516
MOD_SUMO_rev_2	476	481	PF00179	0.596
MOD_SUMO_rev_2	498	507	PF00179	0.588
MOD_SUMO_rev_2	662	670	PF00179	0.722
MOD_SUMO_rev_2	716	722	PF00179	0.525
MOD_SUMO_rev_2	884	889	PF00179	0.441
TRG_DiLeu_BaEn_1	1018	1023	PF01217	0.378
TRG_DiLeu_BaLyEn_6	1025	1030	PF01217	0.451
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.642
TRG_DiLeu_BaLyEn_6	616	621	PF01217	0.541
TRG_DiLeu_LyEn_5	1018	1023	PF01217	0.378
TRG_ENDOCYTIC_2	1027	1030	PF00928	0.371
TRG_ENDOCYTIC_2	839	842	PF00928	0.430
TRG_ENDOCYTIC_2	919	922	PF00928	0.384
TRG_ENDOCYTIC_2	988	991	PF00928	0.467
TRG_ER_diArg_1	147	149	PF00400	0.576
TRG_ER_diArg_1	341	344	PF00400	0.651
TRG_ER_diArg_1	467	469	PF00400	0.680
TRG_ER_diArg_1	514	517	PF00400	0.639
TRG_ER_diArg_1	55	57	PF00400	0.534
TRG_NES_CRM1_1	953	967	PF08389	0.287
TRG_NLS_MonoExtC_3	423	428	PF00514	0.401
TRG_Pf-PMV_PEXEL_1	1014	1018	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	1021	1025	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	1028	1032	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	493	498	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	775	780	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILP3	Leptomonas seymouri	50%	99%
A0A3S7X763	Leishmania donovani	87%	99%
A4HM11	Leishmania braziliensis	68%	100%
A4I9E2	Leishmania infantum	87%	94%
Q4Q3N5	Leishmania major	85%	99%