Ribosomal_L7Ae domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B4E1_LEIMU

TriTrypDb:

LmxM.32.3000

Length:

1055

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1032	1036	PF00656	0.527
CLV_MEL_PAP_1	389	395	PF00089	0.738
CLV_NRD_NRD_1	1037	1039	PF00675	0.495
CLV_NRD_NRD_1	16	18	PF00675	0.638
CLV_NRD_NRD_1	3	5	PF00675	0.832
CLV_NRD_NRD_1	396	398	PF00675	0.548
CLV_NRD_NRD_1	58	60	PF00675	0.695
CLV_NRD_NRD_1	90	92	PF00675	0.817
CLV_NRD_NRD_1	984	986	PF00675	0.665
CLV_NRD_NRD_1	992	994	PF00675	0.491
CLV_PCSK_FUR_1	3	7	PF00082	0.745
CLV_PCSK_KEX2_1	16	18	PF00082	0.638
CLV_PCSK_KEX2_1	3	5	PF00082	0.832
CLV_PCSK_KEX2_1	58	60	PF00082	0.695
CLV_PCSK_KEX2_1	878	880	PF00082	0.717
CLV_PCSK_KEX2_1	90	92	PF00082	0.780
CLV_PCSK_KEX2_1	984	986	PF00082	0.665
CLV_PCSK_KEX2_1	992	994	PF00082	0.491
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.749
CLV_PCSK_PC1ET2_1	878	880	PF00082	0.717
CLV_PCSK_SKI1_1	1038	1042	PF00082	0.494
CLV_PCSK_SKI1_1	189	193	PF00082	0.749
CLV_PCSK_SKI1_1	610	614	PF00082	0.672
CLV_PCSK_SKI1_1	733	737	PF00082	0.540
CLV_PCSK_SKI1_1	999	1003	PF00082	0.619
DEG_APCC_DBOX_1	1037	1045	PF00400	0.472
DEG_ODPH_VHL_1	320	331	PF01847	0.533
DEG_SPOP_SBC_1	509	513	PF00917	0.563
DEG_SPOP_SBC_1	555	559	PF00917	0.539
DOC_CKS1_1	256	261	PF01111	0.768
DOC_CYCLIN_yCln2_LP_2	693	699	PF00134	0.541
DOC_MAPK_gen_1	23	30	PF00069	0.579
DOC_MAPK_MEF2A_6	467	475	PF00069	0.557
DOC_PP1_RVXF_1	187	193	PF00149	0.747
DOC_PP1_RVXF_1	214	221	PF00149	0.560
DOC_PP4_FxxP_1	110	113	PF00568	0.644
DOC_PP4_FxxP_1	89	92	PF00568	0.784
DOC_PP4_FxxP_1	949	952	PF00568	0.586
DOC_PP4_MxPP_1	263	266	PF00568	0.778
DOC_USP7_MATH_1	207	211	PF00917	0.761
DOC_USP7_MATH_1	322	326	PF00917	0.580
DOC_USP7_MATH_1	33	37	PF00917	0.561
DOC_USP7_MATH_1	351	355	PF00917	0.551
DOC_USP7_MATH_1	462	466	PF00917	0.755
DOC_USP7_MATH_1	478	482	PF00917	0.571
DOC_USP7_MATH_1	509	513	PF00917	0.635
DOC_USP7_MATH_1	521	525	PF00917	0.608
DOC_USP7_MATH_1	542	546	PF00917	0.763
DOC_USP7_MATH_1	555	559	PF00917	0.706
DOC_USP7_MATH_1	699	703	PF00917	0.587
DOC_USP7_MATH_1	802	806	PF00917	0.581
DOC_USP7_MATH_1	812	816	PF00917	0.475
DOC_USP7_MATH_1	899	903	PF00917	0.715
DOC_USP7_MATH_1	922	926	PF00917	0.348
DOC_USP7_UBL2_3	691	695	PF12436	0.517
DOC_USP7_UBL2_3	747	751	PF12436	0.350
DOC_WW_Pin1_4	208	213	PF00397	0.836
DOC_WW_Pin1_4	255	260	PF00397	0.784
DOC_WW_Pin1_4	273	278	PF00397	0.635
DOC_WW_Pin1_4	29	34	PF00397	0.568
DOC_WW_Pin1_4	315	320	PF00397	0.742
DOC_WW_Pin1_4	335	340	PF00397	0.503
DOC_WW_Pin1_4	474	479	PF00397	0.748
DOC_WW_Pin1_4	538	543	PF00397	0.850
LIG_14-3-3_CanoR_1	1048	1052	PF00244	0.660
LIG_14-3-3_CanoR_1	392	397	PF00244	0.751
LIG_14-3-3_CanoR_1	510	516	PF00244	0.567
LIG_14-3-3_CanoR_1	531	537	PF00244	0.561
LIG_14-3-3_CanoR_1	610	616	PF00244	0.510
LIG_14-3-3_CanoR_1	659	665	PF00244	0.571
LIG_14-3-3_CanoR_1	761	770	PF00244	0.396
LIG_14-3-3_CanoR_1	801	809	PF00244	0.620
LIG_14-3-3_CanoR_1	84	90	PF00244	0.694
LIG_14-3-3_CanoR_1	993	1001	PF00244	0.535
LIG_Actin_WH2_2	625	640	PF00022	0.541
LIG_BRCT_BRCA1_1	235	239	PF00533	0.654
LIG_BRCT_BRCA1_1	457	461	PF00533	0.737
LIG_BRCT_BRCA1_1	666	670	PF00533	0.319
LIG_BRCT_BRCA1_1	731	735	PF00533	0.523
LIG_BRCT_BRCA1_1	787	791	PF00533	0.318
LIG_EH1_1	649	657	PF00400	0.417
LIG_EH1_1	767	775	PF00400	0.597
LIG_eIF4E_1	768	774	PF01652	0.586
LIG_EVH1_1	250	254	PF00568	0.764
LIG_FHA_1	1000	1006	PF00498	0.621
LIG_FHA_1	144	150	PF00498	0.543
LIG_FHA_1	384	390	PF00498	0.724
LIG_FHA_1	515	521	PF00498	0.735
LIG_FHA_1	560	566	PF00498	0.638
LIG_FHA_1	577	583	PF00498	0.571
LIG_FHA_1	590	596	PF00498	0.632
LIG_FHA_1	625	631	PF00498	0.587
LIG_FHA_1	808	814	PF00498	0.531
LIG_FHA_1	850	856	PF00498	0.556
LIG_FHA_1	928	934	PF00498	0.547
LIG_FHA_1	953	959	PF00498	0.578
LIG_FHA_2	365	371	PF00498	0.650
LIG_FHA_2	644	650	PF00498	0.638
LIG_FHA_2	661	667	PF00498	0.367
LIG_FHA_2	962	968	PF00498	0.549
LIG_GBD_Chelix_1	182	190	PF00786	0.539
LIG_HP1_1	471	475	PF01393	0.638
LIG_Integrin_isoDGR_2	187	189	PF01839	0.537
LIG_LIR_Apic_2	107	113	PF02991	0.649
LIG_LIR_Apic_2	87	92	PF02991	0.784
LIG_LIR_Apic_2	946	952	PF02991	0.590
LIG_LIR_Gen_1	667	678	PF02991	0.300
LIG_LIR_Gen_1	741	750	PF02991	0.579
LIG_LIR_Gen_1	845	855	PF02991	0.286
LIG_LIR_Nem_3	667	673	PF02991	0.306
LIG_LIR_Nem_3	741	745	PF02991	0.544
LIG_LIR_Nem_3	799	803	PF02991	0.607
LIG_LIR_Nem_3	845	851	PF02991	0.298
LIG_NRBOX	448	454	PF00104	0.645
LIG_PCNA_yPIPBox_3	708	716	PF02747	0.372
LIG_PCNA_yPIPBox_3	842	851	PF02747	0.597
LIG_Pex14_2	736	740	PF04695	0.565
LIG_Pex14_2	945	949	PF04695	0.597
LIG_RPA_C_Fungi	631	643	PF08784	0.339
LIG_SH2_CRK	281	285	PF00017	0.544
LIG_SH2_CRK	800	804	PF00017	0.617
LIG_SH2_CRK	954	958	PF00017	0.577
LIG_SH2_NCK_1	768	772	PF00017	0.509
LIG_SH2_SRC	605	608	PF00017	0.584
LIG_SH2_STAP1	1030	1034	PF00017	0.523
LIG_SH2_STAP1	214	218	PF00017	0.559
LIG_SH2_STAP1	681	685	PF00017	0.554
LIG_SH2_STAP1	726	730	PF00017	0.674
LIG_SH2_STAP1	954	958	PF00017	0.577
LIG_SH2_STAT3	323	326	PF00017	0.534
LIG_SH2_STAT5	233	236	PF00017	0.733
LIG_SH2_STAT5	255	258	PF00017	0.716
LIG_SH2_STAT5	269	272	PF00017	0.616
LIG_SH2_STAT5	954	957	PF00017	0.576
LIG_SH3_1	248	254	PF00018	0.769
LIG_SH3_3	1012	1018	PF00018	0.604
LIG_SH3_3	124	130	PF00018	0.581
LIG_SH3_3	206	212	PF00018	0.635
LIG_SH3_3	226	232	PF00018	0.811
LIG_SH3_3	248	254	PF00018	0.744
LIG_SH3_3	27	33	PF00018	0.571
LIG_SH3_3	313	319	PF00018	0.763
LIG_SH3_3	333	339	PF00018	0.502
LIG_SH3_3	341	347	PF00018	0.743
LIG_SH3_3	490	496	PF00018	0.746
LIG_SH3_3	579	585	PF00018	0.732
LIG_SUMO_SIM_anti_2	769	777	PF11976	0.527
LIG_SUMO_SIM_par_1	684	690	PF11976	0.561
LIG_SUMO_SIM_par_1	954	960	PF11976	0.580
LIG_TRAF2_1	130	133	PF00917	0.557
LIG_TRAF2_1	197	200	PF00917	0.759
LIG_TRAF2_1	409	412	PF00917	0.490
LIG_TRAF2_1	444	447	PF00917	0.422
LIG_TRAF2_1	523	526	PF00917	0.779
LIG_TRAF2_1	864	867	PF00917	0.643
LIG_TYR_ITIM	798	803	PF00017	0.603
LIG_UBA3_1	711	720	PF00899	0.471
LIG_WRC_WIRS_1	393	398	PF05994	0.751
LIG_WW_1	266	269	PF00397	0.605
LIG_WW_2	251	254	PF00397	0.763
MOD_CDC14_SPxK_1	32	35	PF00782	0.563
MOD_CDK_SPK_2	474	479	PF00069	0.748
MOD_CDK_SPxK_1	29	35	PF00069	0.570
MOD_CK1_1	354	360	PF00069	0.721
MOD_CK1_1	477	483	PF00069	0.764
MOD_CK1_1	508	514	PF00069	0.824
MOD_CK1_1	524	530	PF00069	0.618
MOD_CK1_1	545	551	PF00069	0.766
MOD_CK1_1	559	565	PF00069	0.586
MOD_CK1_1	576	582	PF00069	0.531
MOD_CK1_1	684	690	PF00069	0.561
MOD_CK1_1	724	730	PF00069	0.668
MOD_CK1_1	807	813	PF00069	0.531
MOD_CK1_1	85	91	PF00069	0.711
MOD_CK1_1	9	15	PF00069	0.577
MOD_CK1_1	907	913	PF00069	0.603
MOD_CK1_1	968	974	PF00069	0.600
MOD_CK1_1	976	982	PF00069	0.551
MOD_CK2_1	296	302	PF00069	0.569
MOD_CK2_1	520	526	PF00069	0.571
MOD_CK2_1	643	649	PF00069	0.649
MOD_CK2_1	660	666	PF00069	0.376
MOD_CK2_1	802	808	PF00069	0.626
MOD_CK2_1	861	867	PF00069	0.645
MOD_CK2_1	885	891	PF00069	0.747
MOD_CK2_1	961	967	PF00069	0.629
MOD_Cter_Amidation	1	4	PF01082	0.825
MOD_GlcNHglycan	1015	1018	PF01048	0.584
MOD_GlcNHglycan	1051	1054	PF01048	0.780
MOD_GlcNHglycan	161	165	PF01048	0.636
MOD_GlcNHglycan	176	180	PF01048	0.798
MOD_GlcNHglycan	46	49	PF01048	0.647
MOD_GlcNHglycan	507	510	PF01048	0.566
MOD_GlcNHglycan	558	561	PF01048	0.823
MOD_GlcNHglycan	571	574	PF01048	0.610
MOD_GlcNHglycan	681	684	PF01048	0.555
MOD_GlcNHglycan	697	700	PF01048	0.338
MOD_GlcNHglycan	701	704	PF01048	0.256
MOD_GlcNHglycan	748	751	PF01048	0.577
MOD_GlcNHglycan	8	11	PF01048	0.611
MOD_GlcNHglycan	814	817	PF01048	0.610
MOD_GlcNHglycan	84	87	PF01048	0.832
MOD_GlcNHglycan	906	909	PF01048	0.652
MOD_GlcNHglycan	967	970	PF01048	0.651
MOD_GlcNHglycan	975	978	PF01048	0.492
MOD_GlcNHglycan	989	992	PF01048	0.375
MOD_GSK3_1	1040	1047	PF00069	0.581
MOD_GSK3_1	29	36	PF00069	0.777
MOD_GSK3_1	335	342	PF00069	0.791
MOD_GSK3_1	474	481	PF00069	0.756
MOD_GSK3_1	482	489	PF00069	0.710
MOD_GSK3_1	50	57	PF00069	0.665
MOD_GSK3_1	504	511	PF00069	0.690
MOD_GSK3_1	520	527	PF00069	0.577
MOD_GSK3_1	538	545	PF00069	0.803
MOD_GSK3_1	555	562	PF00069	0.633
MOD_GSK3_1	569	576	PF00069	0.585
MOD_GSK3_1	660	667	PF00069	0.569
MOD_GSK3_1	695	702	PF00069	0.411
MOD_GSK3_1	72	79	PF00069	0.667
MOD_GSK3_1	756	763	PF00069	0.736
MOD_GSK3_1	849	856	PF00069	0.558
MOD_GSK3_1	880	887	PF00069	0.701
MOD_GSK3_1	940	947	PF00069	0.497
MOD_GSK3_1	957	964	PF00069	0.562
MOD_GSK3_1	995	1002	PF00069	0.615
MOD_N-GLC_1	104	109	PF02516	0.638
MOD_N-GLC_1	150	155	PF02516	0.817
MOD_N-GLC_1	168	173	PF02516	0.548
MOD_N-GLC_1	218	223	PF02516	0.676
MOD_N-GLC_1	39	44	PF02516	0.713
MOD_N-GLC_1	486	491	PF02516	0.689
MOD_N-GLC_1	756	761	PF02516	0.595
MOD_N-GLC_1	987	992	PF02516	0.619
MOD_NEK2_1	1049	1054	PF00069	0.777
MOD_NEK2_1	119	124	PF00069	0.560
MOD_NEK2_1	150	155	PF00069	0.633
MOD_NEK2_1	190	195	PF00069	0.547
MOD_NEK2_1	218	223	PF00069	0.565
MOD_NEK2_1	554	559	PF00069	0.734
MOD_NEK2_1	632	637	PF00069	0.632
MOD_NEK2_1	664	669	PF00069	0.541
MOD_NEK2_1	715	720	PF00069	0.482
MOD_NEK2_1	722	727	PF00069	0.516
MOD_NEK2_1	785	790	PF00069	0.326
MOD_NEK2_1	933	938	PF00069	0.516
MOD_NEK2_1	944	949	PF00069	0.574
MOD_NEK2_1	987	992	PF00069	0.619
MOD_NEK2_1	994	999	PF00069	0.497
MOD_PIKK_1	111	117	PF00454	0.757
MOD_PIKK_1	195	201	PF00454	0.553
MOD_PIKK_1	219	225	PF00454	0.836
MOD_PIKK_1	322	328	PF00454	0.529
MOD_PIKK_1	383	389	PF00454	0.724
MOD_PIKK_1	521	527	PF00454	0.643
MOD_PIKK_1	589	595	PF00454	0.677
MOD_PIKK_1	761	767	PF00454	0.663
MOD_PIKK_1	971	977	PF00454	0.628
MOD_PK_1	385	391	PF00069	0.810
MOD_PK_1	39	45	PF00069	0.572
MOD_PKA_1	58	64	PF00069	0.695
MOD_PKA_1	746	752	PF00069	0.506
MOD_PKA_2	1047	1053	PF00069	0.669
MOD_PKA_2	24	30	PF00069	0.811
MOD_PKA_2	391	397	PF00069	0.790
MOD_PKA_2	481	487	PF00069	0.651
MOD_PKA_2	509	515	PF00069	0.630
MOD_PKA_2	548	554	PF00069	0.762
MOD_PKA_2	58	64	PF00069	0.707
MOD_PKA_2	760	766	PF00069	0.446
MOD_PKA_2	995	1001	PF00069	0.532
MOD_PKB_1	4	12	PF00069	0.575
MOD_Plk_1	104	110	PF00069	0.571
MOD_Plk_1	1044	1050	PF00069	0.418
MOD_Plk_1	39	45	PF00069	0.736
MOD_Plk_1	623	629	PF00069	0.562
MOD_Plk_1	842	848	PF00069	0.337
MOD_Plk_4	235	241	PF00069	0.526
MOD_Plk_4	339	345	PF00069	0.812
MOD_Plk_4	385	391	PF00069	0.810
MOD_Plk_4	598	604	PF00069	0.493
MOD_Plk_4	660	666	PF00069	0.574
MOD_Plk_4	681	687	PF00069	0.554
MOD_Plk_4	776	782	PF00069	0.440
MOD_Plk_4	785	791	PF00069	0.349
MOD_Plk_4	843	849	PF00069	0.609
MOD_Plk_4	940	946	PF00069	0.561
MOD_Plk_4	952	958	PF00069	0.430
MOD_Plk_4	968	974	PF00069	0.369
MOD_ProDKin_1	208	214	PF00069	0.838
MOD_ProDKin_1	255	261	PF00069	0.773
MOD_ProDKin_1	273	279	PF00069	0.641
MOD_ProDKin_1	29	35	PF00069	0.570
MOD_ProDKin_1	315	321	PF00069	0.741
MOD_ProDKin_1	335	341	PF00069	0.503
MOD_ProDKin_1	474	480	PF00069	0.748
MOD_ProDKin_1	538	544	PF00069	0.849
MOD_SUMO_rev_2	662	670	PF00179	0.337
MOD_SUMO_rev_2	684	693	PF00179	0.463
TRG_DiLeu_BaEn_1	769	774	PF01217	0.500
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.710
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.483
TRG_DiLeu_BaLyEn_6	990	995	PF01217	0.527
TRG_ENDOCYTIC_2	768	771	PF00928	0.595
TRG_ENDOCYTIC_2	800	803	PF00928	0.605
TRG_ENDOCYTIC_2	954	957	PF00928	0.576
TRG_ER_diArg_1	15	17	PF00400	0.622
TRG_ER_diArg_1	3	6	PF00400	0.748
TRG_ER_diArg_1	427	430	PF00400	0.699
TRG_ER_diArg_1	636	639	PF00400	0.314
TRG_ER_diArg_1	89	91	PF00400	0.802
TRG_ER_diArg_1	984	986	PF00400	0.665
TRG_ER_diArg_1	992	994	PF00400	0.491
TRG_ER_FFAT_1	729	741	PF00635	0.465
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	801	806	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF45	Leishmania donovani	80%	100%
A4HM10	Leishmania braziliensis	56%	100%
A4I9E4	Leishmania infantum	80%	100%
Q4Q3N6	Leishmania major	81%	100%