Mediator of RNA polymerase II transcription subunit 15

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B4E0_LEIMU

TriTrypDb:

LmxM.32.2990

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4E0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.622
CLV_NRD_NRD_1	102	104	PF00675	0.456
CLV_NRD_NRD_1	398	400	PF00675	0.718
CLV_NRD_NRD_1	457	459	PF00675	0.587
CLV_NRD_NRD_1	463	465	PF00675	0.579
CLV_PCSK_KEX2_1	102	104	PF00082	0.456
CLV_PCSK_KEX2_1	451	453	PF00082	0.639
CLV_PCSK_KEX2_1	457	459	PF00082	0.566
CLV_PCSK_KEX2_1	463	465	PF00082	0.547
CLV_PCSK_KEX2_1	477	479	PF00082	0.494
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.664
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.645
CLV_PCSK_SKI1_1	135	139	PF00082	0.408
CLV_PCSK_SKI1_1	6	10	PF00082	0.460
DOC_CYCLIN_RxL_1	140	152	PF00134	0.433
DOC_CYCLIN_RxL_1	353	364	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	380	386	PF00134	0.477
DOC_MAPK_DCC_7	102	110	PF00069	0.431
DOC_MAPK_DCC_7	144	153	PF00069	0.444
DOC_MAPK_gen_1	102	110	PF00069	0.431
DOC_MAPK_gen_1	142	151	PF00069	0.437
DOC_MAPK_MEF2A_6	102	110	PF00069	0.431
DOC_MAPK_MEF2A_6	144	153	PF00069	0.444
DOC_PP2B_LxvP_1	129	132	PF13499	0.427
DOC_USP7_MATH_1	25	29	PF00917	0.447
DOC_WW_Pin1_4	198	203	PF00397	0.524
DOC_WW_Pin1_4	296	301	PF00397	0.470
DOC_WW_Pin1_4	401	406	PF00397	0.557
DOC_WW_Pin1_4	424	429	PF00397	0.606
LIG_14-3-3_CanoR_1	144	149	PF00244	0.427
LIG_14-3-3_CanoR_1	156	166	PF00244	0.473
LIG_14-3-3_CanoR_1	406	413	PF00244	0.557
LIG_14-3-3_CanoR_1	452	457	PF00244	0.649
LIG_14-3-3_CanoR_1	458	463	PF00244	0.682
LIG_14-3-3_CanoR_1	478	483	PF00244	0.513
LIG_14-3-3_CanoR_1	6	15	PF00244	0.458
LIG_14-3-3_CanoR_1	78	84	PF00244	0.444
LIG_CtBP_PxDLS_1	385	389	PF00389	0.472
LIG_deltaCOP1_diTrp_1	301	307	PF00928	0.509
LIG_EVH1_1	332	336	PF00568	0.480
LIG_FHA_1	29	35	PF00498	0.444
LIG_FHA_1	441	447	PF00498	0.694
LIG_LIR_Apic_2	11	17	PF02991	0.452
LIG_LIR_Apic_2	21	25	PF02991	0.435
LIG_LIR_Gen_1	121	131	PF02991	0.423
LIG_LIR_Gen_1	299	310	PF02991	0.506
LIG_LIR_Gen_1	40	50	PF02991	0.437
LIG_LIR_Nem_3	113	118	PF02991	0.444
LIG_LIR_Nem_3	121	126	PF02991	0.399
LIG_LIR_Nem_3	299	305	PF02991	0.548
LIG_LIR_Nem_3	364	369	PF02991	0.437
LIG_LIR_Nem_3	371	376	PF02991	0.443
LIG_LIR_Nem_3	40	45	PF02991	0.440
LIG_LIR_Nem_3	88	93	PF02991	0.434
LIG_LYPXL_yS_3	362	365	PF13949	0.446
LIG_PCNA_yPIPBox_3	116	126	PF02747	0.428
LIG_Pex14_2	111	115	PF04695	0.426
LIG_Pex14_2	134	138	PF04695	0.409
LIG_Pex14_2	307	311	PF04695	0.571
LIG_PTB_Apo_2	38	45	PF02174	0.443
LIG_REV1ctd_RIR_1	1	10	PF16727	0.464
LIG_REV1ctd_RIR_1	131	139	PF16727	0.415
LIG_SH2_CRK	123	127	PF00017	0.424
LIG_SH2_CRK	22	26	PF00017	0.425
LIG_SH2_CRK	355	359	PF00017	0.397
LIG_SH2_CRK	5	9	PF00017	0.463
LIG_SH2_STAP1	167	171	PF00017	0.481
LIG_SH2_STAT3	167	170	PF00017	0.647
LIG_SH2_STAT3	259	262	PF00017	0.619
LIG_SH2_STAT3	347	350	PF00017	0.432
LIG_SH2_STAT5	369	372	PF00017	0.545
LIG_SH2_STAT5	373	376	PF00017	0.490
LIG_SH2_STAT5	55	58	PF00017	0.464
LIG_SH3_3	14	20	PF00018	0.449
LIG_SH3_3	196	202	PF00018	0.570
LIG_SH3_3	330	336	PF00018	0.499
LIG_SH3_3	380	386	PF00018	0.451
LIG_SH3_3	412	418	PF00018	0.704
LIG_SH3_3	430	436	PF00018	0.681
LIG_SUMO_SIM_par_1	30	36	PF11976	0.445
LIG_TRFH_1	195	199	PF08558	0.601
LIG_TYR_ITIM	352	357	PF00017	0.455
LIG_TYR_ITIM	360	365	PF00017	0.389
LIG_TYR_ITSM	119	126	PF00017	0.420
MOD_CDK_SPK_2	401	406	PF00069	0.560
MOD_CDK_SPK_2	424	429	PF00069	0.546
MOD_CK1_1	28	34	PF00069	0.443
MOD_CK1_1	444	450	PF00069	0.636
MOD_CK2_1	318	324	PF00069	0.403
MOD_GlcNHglycan	229	232	PF01048	0.589
MOD_GlcNHglycan	446	449	PF01048	0.669
MOD_GlcNHglycan	70	73	PF01048	0.446
MOD_GSK3_1	121	128	PF00069	0.426
MOD_GSK3_1	198	205	PF00069	0.490
MOD_GSK3_1	254	261	PF00069	0.590
MOD_GSK3_1	28	35	PF00069	0.444
MOD_GSK3_1	401	408	PF00069	0.558
MOD_GSK3_1	440	447	PF00069	0.649
MOD_GSK3_1	56	63	PF00069	0.473
MOD_N-GLC_1	118	123	PF02516	0.430
MOD_N-GLC_1	266	271	PF02516	0.603
MOD_N-GLC_1	444	449	PF02516	0.621
MOD_NEK2_1	110	115	PF00069	0.435
MOD_NEK2_1	118	123	PF00069	0.431
MOD_NEK2_1	68	73	PF00069	0.447
MOD_NEK2_1	79	84	PF00069	0.426
MOD_NEK2_2	25	30	PF00069	0.446
MOD_NEK2_2	85	90	PF00069	0.443
MOD_NEK2_2	97	102	PF00069	0.407
MOD_OFUCOSY	76	81	PF10250	0.439
MOD_OFUCOSY	95	101	PF10250	0.379
MOD_PIKK_1	157	163	PF00454	0.494
MOD_PIKK_1	258	264	PF00454	0.697
MOD_PIKK_1	405	411	PF00454	0.724
MOD_PKA_1	451	457	PF00069	0.646
MOD_PKA_1	477	483	PF00069	0.528
MOD_PKA_2	254	260	PF00069	0.546
MOD_PKA_2	405	411	PF00069	0.617
MOD_PKA_2	440	446	PF00069	0.699
MOD_PKA_2	451	457	PF00069	0.517
MOD_PKA_2	477	483	PF00069	0.528
MOD_PKA_2	77	83	PF00069	0.444
MOD_PKB_1	142	150	PF00069	0.432
MOD_PKB_1	64	72	PF00069	0.460
MOD_Plk_1	118	124	PF00069	0.428
MOD_Plk_1	266	272	PF00069	0.605
MOD_Plk_4	121	127	PF00069	0.418
MOD_Plk_4	144	150	PF00069	0.471
MOD_Plk_4	85	91	PF00069	0.443
MOD_ProDKin_1	198	204	PF00069	0.527
MOD_ProDKin_1	296	302	PF00069	0.459
MOD_ProDKin_1	401	407	PF00069	0.557
MOD_ProDKin_1	424	430	PF00069	0.606
MOD_SUMO_for_1	470	473	PF00179	0.602
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.515
TRG_ENDOCYTIC_2	123	126	PF00928	0.418
TRG_ENDOCYTIC_2	354	357	PF00928	0.473
TRG_ENDOCYTIC_2	362	365	PF00928	0.446
TRG_ENDOCYTIC_2	372	375	PF00928	0.438
TRG_ENDOCYTIC_2	377	380	PF00928	0.473
TRG_ENDOCYTIC_2	5	8	PF00928	0.464
TRG_ER_diArg_1	102	104	PF00400	0.456
TRG_ER_diArg_1	141	144	PF00400	0.420
TRG_ER_diArg_1	456	458	PF00400	0.590
TRG_ER_diArg_1	462	464	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I737	Leptomonas seymouri	46%	100%
A0A3Q8IHR4	Leishmania donovani	78%	100%
A4HM09	Leishmania braziliensis	62%	100%
A4I9E1	Leishmania infantum	79%	100%
Q4Q3N7	Leishmania major	76%	100%