VWFA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4D7_LEIMU

TriTrypDb:

LmxM.32.2960

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.504
CLV_C14_Caspase3-7	298	302	PF00656	0.746
CLV_NRD_NRD_1	393	395	PF00675	0.604
CLV_NRD_NRD_1	482	484	PF00675	0.567
CLV_NRD_NRD_1	499	501	PF00675	0.450
CLV_PCSK_KEX2_1	246	248	PF00082	0.592
CLV_PCSK_KEX2_1	252	254	PF00082	0.634
CLV_PCSK_KEX2_1	258	260	PF00082	0.643
CLV_PCSK_KEX2_1	393	395	PF00082	0.599
CLV_PCSK_KEX2_1	482	484	PF00082	0.300
CLV_PCSK_KEX2_1	587	589	PF00082	0.559
CLV_PCSK_KEX2_1	621	623	PF00082	0.431
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.504
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.494
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.486
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.607
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.431
CLV_PCSK_SKI1_1	209	213	PF00082	0.642
CLV_PCSK_SKI1_1	228	232	PF00082	0.502
CLV_PCSK_SKI1_1	243	247	PF00082	0.761
CLV_PCSK_SKI1_1	253	257	PF00082	0.612
CLV_PCSK_SKI1_1	259	263	PF00082	0.543
CLV_PCSK_SKI1_1	265	269	PF00082	0.564
CLV_PCSK_SKI1_1	290	294	PF00082	0.519
CLV_PCSK_SKI1_1	331	335	PF00082	0.527
CLV_PCSK_SKI1_1	435	439	PF00082	0.366
CLV_PCSK_SKI1_1	446	450	PF00082	0.345
CLV_PCSK_SKI1_1	482	486	PF00082	0.506
CLV_Separin_Metazoa	596	600	PF03568	0.464
DEG_Nend_UBRbox_1	1	4	PF02207	0.505
DOC_ANK_TNKS_1	23	30	PF00023	0.494
DOC_CYCLIN_RxL_1	318	329	PF00134	0.471
DOC_MAPK_gen_1	222	232	PF00069	0.558
DOC_MAPK_gen_1	328	337	PF00069	0.480
DOC_MAPK_gen_1	348	358	PF00069	0.420
DOC_MAPK_gen_1	393	400	PF00069	0.405
DOC_MAPK_gen_1	500	508	PF00069	0.465
DOC_MAPK_gen_1	621	627	PF00069	0.445
DOC_MAPK_MEF2A_6	501	510	PF00069	0.509
DOC_PP4_FxxP_1	32	35	PF00568	0.514
DOC_PP4_FxxP_1	517	520	PF00568	0.325
DOC_USP7_MATH_1	113	117	PF00917	0.670
DOC_USP7_MATH_1	124	128	PF00917	0.626
DOC_USP7_MATH_1	197	201	PF00917	0.678
DOC_USP7_MATH_1	448	452	PF00917	0.505
DOC_USP7_MATH_1	85	89	PF00917	0.601
DOC_USP7_MATH_1	96	100	PF00917	0.633
DOC_USP7_UBL2_3	218	222	PF12436	0.765
DOC_USP7_UBL2_3	285	289	PF12436	0.596
DOC_USP7_UBL2_3	295	299	PF12436	0.779
DOC_USP7_UBL2_3	334	338	PF12436	0.527
DOC_USP7_UBL2_3	497	501	PF12436	0.447
DOC_WW_Pin1_4	449	454	PF00397	0.443
LIG_14-3-3_CanoR_1	180	185	PF00244	0.571
LIG_14-3-3_CanoR_1	393	401	PF00244	0.449
LIG_14-3-3_CanoR_1	500	509	PF00244	0.408
LIG_14-3-3_CanoR_1	541	545	PF00244	0.492
LIG_FHA_1	382	388	PF00498	0.484
LIG_FHA_1	393	399	PF00498	0.515
LIG_FHA_1	407	413	PF00498	0.380
LIG_FHA_1	462	468	PF00498	0.416
LIG_FHA_1	548	554	PF00498	0.337
LIG_FHA_2	348	354	PF00498	0.435
LIG_FHA_2	424	430	PF00498	0.376
LIG_FHA_2	461	467	PF00498	0.527
LIG_FHA_2	591	597	PF00498	0.489
LIG_LIR_Apic_2	516	520	PF02991	0.320
LIG_LIR_Gen_1	170	177	PF02991	0.605
LIG_LIR_Gen_1	615	624	PF02991	0.397
LIG_LIR_Nem_3	170	174	PF02991	0.653
LIG_LIR_Nem_3	415	421	PF02991	0.508
LIG_LIR_Nem_3	492	496	PF02991	0.344
LIG_SH2_CRK	171	175	PF00017	0.564
LIG_SH2_GRB2like	418	421	PF00017	0.235
LIG_SH2_STAP1	616	620	PF00017	0.508
LIG_SH2_STAT5	404	407	PF00017	0.365
LIG_SH2_STAT5	418	421	PF00017	0.223
LIG_SH2_STAT5	422	425	PF00017	0.324
LIG_SH2_STAT5	493	496	PF00017	0.472
LIG_SH2_STAT5	509	512	PF00017	0.235
LIG_SH2_STAT5	592	595	PF00017	0.593
LIG_SH3_2	533	538	PF14604	0.415
LIG_SH3_3	358	364	PF00018	0.420
LIG_SH3_3	451	457	PF00018	0.457
LIG_SH3_3	530	536	PF00018	0.506
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.417
LIG_SUMO_SIM_par_1	383	390	PF11976	0.545
LIG_TRAF2_1	607	610	PF00917	0.578
LIG_UBA3_1	525	532	PF00899	0.368
LIG_UBA3_1	619	628	PF00899	0.428
MOD_CK1_1	106	112	PF00069	0.436
MOD_CK1_1	170	176	PF00069	0.602
MOD_CK1_1	389	395	PF00069	0.418
MOD_CK1_1	406	412	PF00069	0.238
MOD_CK1_1	605	611	PF00069	0.526
MOD_CK2_1	326	332	PF00069	0.516
MOD_CK2_1	423	429	PF00069	0.454
MOD_CK2_1	460	466	PF00069	0.510
MOD_CK2_1	554	560	PF00069	0.372
MOD_CK2_1	590	596	PF00069	0.481
MOD_CK2_1	603	609	PF00069	0.474
MOD_Cter_Amidation	610	613	PF01082	0.355
MOD_GlcNHglycan	14	17	PF01048	0.702
MOD_GlcNHglycan	212	215	PF01048	0.693
MOD_GlcNHglycan	294	298	PF01048	0.548
MOD_GlcNHglycan	315	318	PF01048	0.636
MOD_GlcNHglycan	328	331	PF01048	0.411
MOD_GlcNHglycan	414	417	PF01048	0.480
MOD_GlcNHglycan	502	505	PF01048	0.453
MOD_GlcNHglycan	52	55	PF01048	0.660
MOD_GlcNHglycan	558	564	PF01048	0.461
MOD_GlcNHglycan	582	585	PF01048	0.495
MOD_GlcNHglycan	605	608	PF01048	0.553
MOD_GlcNHglycan	79	82	PF01048	0.685
MOD_GSK3_1	176	183	PF00069	0.681
MOD_GSK3_1	315	322	PF00069	0.436
MOD_GSK3_1	36	43	PF00069	0.578
MOD_GSK3_1	50	57	PF00069	0.646
MOD_GSK3_1	509	516	PF00069	0.412
MOD_GSK3_1	576	583	PF00069	0.461
MOD_N-GLC_1	381	386	PF02516	0.453
MOD_N-GLC_1	460	465	PF02516	0.425
MOD_N-GLC_1	513	518	PF02516	0.345
MOD_NEK2_1	103	108	PF00069	0.721
MOD_NEK2_1	313	318	PF00069	0.548
MOD_NEK2_1	513	518	PF00069	0.435
MOD_NEK2_2	113	118	PF00069	0.648
MOD_NEK2_2	124	129	PF00069	0.653
MOD_NEK2_2	133	138	PF00069	0.647
MOD_NEK2_2	145	150	PF00069	0.614
MOD_NEK2_2	154	159	PF00069	0.587
MOD_NEK2_2	162	167	PF00069	0.451
MOD_NEK2_2	333	338	PF00069	0.393
MOD_NEK2_2	85	90	PF00069	0.535
MOD_NEK2_2	96	101	PF00069	0.564
MOD_OFUCOSY	402	408	PF10250	0.301
MOD_PIKK_1	392	398	PF00454	0.571
MOD_PK_1	270	276	PF00069	0.596
MOD_PKA_1	222	228	PF00069	0.597
MOD_PKA_1	270	276	PF00069	0.786
MOD_PKA_1	299	305	PF00069	0.693
MOD_PKA_1	500	506	PF00069	0.438
MOD_PKA_2	339	345	PF00069	0.387
MOD_PKA_2	347	353	PF00069	0.527
MOD_PKA_2	392	398	PF00069	0.409
MOD_PKA_2	499	505	PF00069	0.417
MOD_PKA_2	540	546	PF00069	0.484
MOD_Plk_1	381	387	PF00069	0.419
MOD_Plk_1	513	519	PF00069	0.463
MOD_Plk_4	106	112	PF00069	0.613
MOD_Plk_4	113	119	PF00069	0.597
MOD_Plk_4	124	130	PF00069	0.650
MOD_Plk_4	133	139	PF00069	0.642
MOD_Plk_4	145	151	PF00069	0.645
MOD_Plk_4	154	160	PF00069	0.532
MOD_Plk_4	162	168	PF00069	0.462
MOD_Plk_4	170	176	PF00069	0.584
MOD_Plk_4	180	186	PF00069	0.485
MOD_Plk_4	339	345	PF00069	0.603
MOD_Plk_4	381	387	PF00069	0.445
MOD_Plk_4	489	495	PF00069	0.360
MOD_Plk_4	513	519	PF00069	0.389
MOD_Plk_4	615	621	PF00069	0.519
MOD_Plk_4	85	91	PF00069	0.660
MOD_Plk_4	96	102	PF00069	0.669
MOD_ProDKin_1	449	455	PF00069	0.442
MOD_SUMO_for_1	230	233	PF00179	0.645
MOD_SUMO_for_1	245	248	PF00179	0.503
MOD_SUMO_rev_2	189	198	PF00179	0.683
MOD_SUMO_rev_2	208	214	PF00179	0.715
MOD_SUMO_rev_2	215	225	PF00179	0.585
MOD_SUMO_rev_2	238	245	PF00179	0.810
MOD_SUMO_rev_2	257	267	PF00179	0.724
MOD_SUMO_rev_2	269	279	PF00179	0.730
MOD_SUMO_rev_2	280	287	PF00179	0.707
MOD_SUMO_rev_2	294	302	PF00179	0.652
MOD_SUMO_rev_2	329	336	PF00179	0.492
MOD_SUMO_rev_2	346	352	PF00179	0.463
MOD_SUMO_rev_2	605	614	PF00179	0.547
MOD_SUMO_rev_2	631	640	PF00179	0.558
TRG_DiLeu_BaEn_4	534	540	PF01217	0.401
TRG_ENDOCYTIC_2	171	174	PF00928	0.688
TRG_ENDOCYTIC_2	41	44	PF00928	0.578
TRG_ENDOCYTIC_2	418	421	PF00928	0.356
TRG_ENDOCYTIC_2	422	425	PF00928	0.324
TRG_ENDOCYTIC_2	493	496	PF00928	0.344
TRG_ENDOCYTIC_2	616	619	PF00928	0.529
TRG_ENDOCYTIC_2	68	71	PF00928	0.702
TRG_ER_diArg_1	481	483	PF00400	0.282
TRG_ER_diArg_1	598	601	PF00400	0.441
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRB5	Trypanosomatidae	35%	76%
A0A1X0NST4	Trypanosomatidae	30%	78%
A0A3Q8II25	Leishmania donovani	87%	100%
A0A3S7X791	Leishmania donovani	31%	98%
A4HM05	Leishmania braziliensis	34%	100%
A4HM06	Leishmania braziliensis	69%	95%
A4I9D6	Leishmania infantum	31%	98%
A4I9D8	Leishmania infantum	88%	82%
E9B4D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	99%
Q4Q3P0	Leishmania major	74%	95%
Q4Q3P1	Leishmania major	34%	99%
V5D844	Trypanosoma cruzi	29%	100%