VWFA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4D6_LEIMU

TriTrypDb:

LmxM.32.2940

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.502
CLV_NRD_NRD_1	256	258	PF00675	0.622
CLV_NRD_NRD_1	343	345	PF00675	0.452
CLV_NRD_NRD_1	403	405	PF00675	0.419
CLV_NRD_NRD_1	573	575	PF00675	0.413
CLV_PCSK_KEX2_1	186	188	PF00082	0.572
CLV_PCSK_KEX2_1	227	229	PF00082	0.654
CLV_PCSK_KEX2_1	256	258	PF00082	0.717
CLV_PCSK_KEX2_1	590	592	PF00082	0.489
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.572
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.643
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.558
CLV_PCSK_SKI1_1	400	404	PF00082	0.363
CLV_PCSK_SKI1_1	484	488	PF00082	0.491
CLV_PCSK_SKI1_1	500	504	PF00082	0.255
CLV_PCSK_SKI1_1	577	581	PF00082	0.412
CLV_PCSK_SKI1_1	630	634	PF00082	0.617
CLV_Separin_Metazoa	599	603	PF03568	0.410
DOC_AGCK_PIF_1	592	597	PF00069	0.496
DOC_ANK_TNKS_1	543	550	PF00023	0.463
DOC_MAPK_gen_1	256	263	PF00069	0.604
DOC_MAPK_gen_1	409	419	PF00069	0.479
DOC_MAPK_MEF2A_6	412	421	PF00069	0.466
DOC_USP7_MATH_1	141	145	PF00917	0.655
DOC_USP7_MATH_1	151	155	PF00917	0.524
DOC_USP7_MATH_1	174	178	PF00917	0.604
DOC_USP7_MATH_1	268	272	PF00917	0.708
DOC_USP7_MATH_1	280	284	PF00917	0.768
DOC_USP7_MATH_1	289	293	PF00917	0.724
DOC_USP7_MATH_1	44	48	PF00917	0.526
DOC_USP7_MATH_1	610	614	PF00917	0.458
DOC_USP7_MATH_1	71	75	PF00917	0.499
DOC_USP7_UBL2_3	258	262	PF12436	0.699
DOC_USP7_UBL2_3	303	307	PF12436	0.576
DOC_USP7_UBL2_3	341	345	PF12436	0.556
DOC_USP7_UBL2_3	500	504	PF12436	0.387
DOC_USP7_UBL2_3	641	645	PF12436	0.361
DOC_WW_Pin1_4	18	23	PF00397	0.727
DOC_WW_Pin1_4	451	456	PF00397	0.420
DOC_WW_Pin1_4	535	540	PF00397	0.519
DOC_WW_Pin1_4	635	640	PF00397	0.439
LIG_14-3-3_CanoR_1	187	197	PF00244	0.605
LIG_14-3-3_CanoR_1	256	263	PF00244	0.608
LIG_14-3-3_CanoR_1	36	41	PF00244	0.697
LIG_Actin_WH2_2	416	433	PF00022	0.469
LIG_CaM_IQ_9	392	407	PF13499	0.504
LIG_Clathr_ClatBox_1	317	321	PF01394	0.334
LIG_Clathr_ClatBox_1	461	465	PF01394	0.490
LIG_CtBP_PxDLS_1	31	35	PF00389	0.516
LIG_EH1_1	311	319	PF00400	0.359
LIG_eIF4E_1	312	318	PF01652	0.356
LIG_FHA_1	161	167	PF00498	0.638
LIG_FHA_1	345	351	PF00498	0.471
LIG_FHA_1	393	399	PF00498	0.468
LIG_FHA_2	200	206	PF00498	0.695
LIG_FHA_2	274	280	PF00498	0.737
LIG_FHA_2	322	328	PF00498	0.521
LIG_FHA_2	469	475	PF00498	0.471
LIG_FHA_2	503	509	PF00498	0.477
LIG_FHA_2	558	564	PF00498	0.243
LIG_FHA_2	594	600	PF00498	0.465
LIG_FHA_2	609	615	PF00498	0.565
LIG_FHA_2	635	641	PF00498	0.412
LIG_LIR_Nem_3	191	197	PF02991	0.724
LIG_LIR_Nem_3	594	600	PF02991	0.499
LIG_PCNA_yPIPBox_3	305	318	PF02747	0.400
LIG_REV1ctd_RIR_1	494	504	PF16727	0.340
LIG_SH2_STAP1	446	450	PF00017	0.393
LIG_SH2_STAT5	595	598	PF00017	0.586
LIG_SH3_3	25	31	PF00018	0.689
LIG_SH3_3	328	334	PF00018	0.396
LIG_SH3_3	453	459	PF00018	0.390
LIG_SH3_3	7	13	PF00018	0.669
LIG_SUMO_SIM_anti_2	316	321	PF11976	0.399
LIG_SUMO_SIM_par_1	316	321	PF11976	0.331
LIG_SUMO_SIM_par_1	460	466	PF11976	0.410
LIG_TRAF2_1	486	489	PF00917	0.597
LIG_TRAF2_1	507	510	PF00917	0.497
LIG_UBA3_1	461	467	PF00899	0.434
LIG_WRC_WIRS_1	213	218	PF05994	0.669
LIG_WRC_WIRS_1	476	481	PF05994	0.376
LIG_WW_3	582	586	PF00397	0.422
MOD_CDC14_SPxK_1	538	541	PF00782	0.491
MOD_CDC14_SPxK_1	638	641	PF00782	0.324
MOD_CDK_SPxK_1	535	541	PF00069	0.511
MOD_CDK_SPxK_1	635	641	PF00069	0.318
MOD_CK1_1	188	194	PF00069	0.688
MOD_CK1_1	248	254	PF00069	0.651
MOD_CK1_1	292	298	PF00069	0.643
MOD_CK1_1	355	361	PF00069	0.468
MOD_CK2_1	273	279	PF00069	0.635
MOD_CK2_1	468	474	PF00069	0.396
MOD_CK2_1	502	508	PF00069	0.406
MOD_CK2_1	593	599	PF00069	0.462
MOD_CK2_1	608	614	PF00069	0.488
MOD_CK2_1	634	640	PF00069	0.502
MOD_Cter_Amidation	225	228	PF01082	0.650
MOD_Cter_Amidation	342	345	PF01082	0.563
MOD_GlcNHglycan	191	194	PF01048	0.793
MOD_GlcNHglycan	224	227	PF01048	0.580
MOD_GlcNHglycan	264	267	PF01048	0.807
MOD_GlcNHglycan	268	271	PF01048	0.658
MOD_GlcNHglycan	357	360	PF01048	0.539
MOD_GlcNHglycan	380	383	PF01048	0.387
MOD_GlcNHglycan	554	557	PF01048	0.392
MOD_GlcNHglycan	585	588	PF01048	0.458
MOD_GlcNHglycan	608	611	PF01048	0.493
MOD_GlcNHglycan	62	65	PF01048	0.601
MOD_GlcNHglycan	90	93	PF01048	0.714
MOD_GSK3_1	112	119	PF00069	0.619
MOD_GSK3_1	185	192	PF00069	0.655
MOD_GSK3_1	242	249	PF00069	0.682
MOD_GSK3_1	262	269	PF00069	0.540
MOD_GSK3_1	280	287	PF00069	0.653
MOD_GSK3_1	362	369	PF00069	0.390
MOD_GSK3_1	470	477	PF00069	0.443
MOD_GSK3_1	498	505	PF00069	0.474
MOD_GSK3_1	606	613	PF00069	0.513
MOD_GSK3_1	635	642	PF00069	0.530
MOD_GSK3_1	99	106	PF00069	0.575
MOD_N-GLC_1	174	179	PF02516	0.627
MOD_N-GLC_1	246	251	PF02516	0.664
MOD_N-GLC_1	412	417	PF02516	0.286
MOD_NEK2_1	103	108	PF00069	0.686
MOD_NEK2_1	116	121	PF00069	0.672
MOD_NEK2_1	421	426	PF00069	0.347
MOD_NEK2_1	450	455	PF00069	0.395
MOD_NEK2_1	557	562	PF00069	0.251
MOD_NEK2_1	60	65	PF00069	0.569
MOD_NEK2_2	141	146	PF00069	0.642
MOD_NEK2_2	151	156	PF00069	0.583
MOD_PIKK_1	116	122	PF00454	0.545
MOD_PIKK_1	180	186	PF00454	0.726
MOD_PIKK_1	392	398	PF00454	0.478
MOD_PIKK_1	639	645	PF00454	0.320
MOD_PKA_1	256	262	PF00069	0.685
MOD_PKA_1	344	350	PF00069	0.469
MOD_PKA_2	188	194	PF00069	0.609
MOD_PKA_2	256	262	PF00069	0.633
MOD_PKB_1	187	195	PF00069	0.476
MOD_Plk_1	174	180	PF00069	0.706
MOD_Plk_1	199	205	PF00069	0.745
MOD_Plk_1	246	252	PF00069	0.804
MOD_Plk_1	326	332	PF00069	0.607
MOD_Plk_1	421	427	PF00069	0.338
MOD_Plk_1	593	599	PF00069	0.501
MOD_Plk_2-3	212	218	PF00069	0.444
MOD_Plk_2-3	327	333	PF00069	0.379
MOD_Plk_4	120	126	PF00069	0.648
MOD_Plk_4	129	135	PF00069	0.618
MOD_Plk_4	141	147	PF00069	0.627
MOD_Plk_4	151	157	PF00069	0.593
MOD_Plk_4	313	319	PF00069	0.340
MOD_Plk_4	333	339	PF00069	0.529
MOD_Plk_4	362	368	PF00069	0.355
MOD_Plk_4	423	429	PF00069	0.434
MOD_Plk_4	99	105	PF00069	0.598
MOD_ProDKin_1	18	24	PF00069	0.729
MOD_ProDKin_1	451	457	PF00069	0.420
MOD_ProDKin_1	535	541	PF00069	0.522
MOD_ProDKin_1	635	641	PF00069	0.447
MOD_SUMO_for_1	486	489	PF00179	0.565
MOD_SUMO_rev_2	259	263	PF00179	0.695
MOD_SUMO_rev_2	278	283	PF00179	0.654
MOD_SUMO_rev_2	463	468	PF00179	0.331
MOD_SUMO_rev_2	568	576	PF00179	0.429
MOD_SUMO_rev_2	608	617	PF00179	0.531
MOD_SUMO_rev_2	626	635	PF00179	0.393
TRG_DiLeu_BaEn_4	508	514	PF01217	0.537
TRG_ENDOCYTIC_2	104	107	PF00928	0.609
TRG_ENDOCYTIC_2	194	197	PF00928	0.737
TRG_ENDOCYTIC_2	446	449	PF00928	0.381
TRG_ENDOCYTIC_2	45	48	PF00928	0.704
TRG_ENDOCYTIC_2	597	600	PF00928	0.499
TRG_ENDOCYTIC_2	65	68	PF00928	0.747
TRG_ENDOCYTIC_2	72	75	PF00928	0.601
TRG_ENDOCYTIC_2	79	82	PF00928	0.565
TRG_ENDOCYTIC_2	93	96	PF00928	0.713
TRG_ER_diArg_1	187	190	PF00400	0.482
TRG_ER_diArg_1	255	257	PF00400	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF45	Leptomonas seymouri	62%	75%
A0A1X0NRD1	Trypanosomatidae	42%	79%
A0A1X0NST4	Trypanosomatidae	31%	79%
A0A3Q8II25	Leishmania donovani	34%	100%
A0A3S7X791	Leishmania donovani	90%	99%
A4HM05	Leishmania braziliensis	77%	99%
A4HM06	Leishmania braziliensis	34%	100%
A4I9D6	Leishmania infantum	89%	99%
A4I9D8	Leishmania infantum	33%	100%
C9ZJQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	85%
E9B4D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q3P0	Leishmania major	34%	100%
Q4Q3P1	Leishmania major	91%	100%
V5B7N5	Trypanosoma cruzi	25%	100%
V5D844	Trypanosoma cruzi	37%	100%