Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4C9_LEIMU

TriTrypDb:

LmxM.32.2880

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4C9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.723
CLV_C14_Caspase3-7	401	405	PF00656	0.691
CLV_NRD_NRD_1	110	112	PF00675	0.678
CLV_NRD_NRD_1	136	138	PF00675	0.661
CLV_NRD_NRD_1	227	229	PF00675	0.668
CLV_NRD_NRD_1	25	27	PF00675	0.626
CLV_NRD_NRD_1	317	319	PF00675	0.699
CLV_NRD_NRD_1	383	385	PF00675	0.667
CLV_NRD_NRD_1	386	388	PF00675	0.699
CLV_NRD_NRD_1	389	391	PF00675	0.713
CLV_PCSK_FUR_1	227	231	PF00082	0.633
CLV_PCSK_FUR_1	384	388	PF00082	0.685
CLV_PCSK_KEX2_1	136	138	PF00082	0.661
CLV_PCSK_KEX2_1	187	189	PF00082	0.671
CLV_PCSK_KEX2_1	194	196	PF00082	0.646
CLV_PCSK_KEX2_1	227	229	PF00082	0.665
CLV_PCSK_KEX2_1	317	319	PF00082	0.682
CLV_PCSK_KEX2_1	334	336	PF00082	0.380
CLV_PCSK_KEX2_1	382	384	PF00082	0.660
CLV_PCSK_KEX2_1	386	388	PF00082	0.699
CLV_PCSK_KEX2_1	389	391	PF00082	0.713
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.671
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.646
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.645
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.559
CLV_PCSK_PC7_1	190	196	PF00082	0.468
CLV_PCSK_PC7_1	382	388	PF00082	0.679
CLV_PCSK_SKI1_1	261	265	PF00082	0.606
CLV_Separin_Metazoa	262	266	PF03568	0.642
DOC_ANK_TNKS_1	388	395	PF00023	0.662
DOC_PP1_RVXF_1	332	339	PF00149	0.649
DOC_PP4_FxxP_1	385	388	PF00568	0.795
DOC_USP7_MATH_1	193	197	PF00917	0.708
DOC_USP7_MATH_1	2	6	PF00917	0.795
DOC_USP7_MATH_1	220	224	PF00917	0.565
DOC_USP7_MATH_1	288	292	PF00917	0.501
DOC_USP7_MATH_1	355	359	PF00917	0.682
DOC_USP7_MATH_1	64	68	PF00917	0.705
DOC_WW_Pin1_4	11	16	PF00397	0.779
DOC_WW_Pin1_4	122	127	PF00397	0.691
DOC_WW_Pin1_4	91	96	PF00397	0.742
LIG_14-3-3_CanoR_1	111	116	PF00244	0.651
LIG_14-3-3_CanoR_1	298	303	PF00244	0.560
LIG_14-3-3_CanoR_1	317	323	PF00244	0.729
LIG_BIR_II_1	1	5	PF00653	0.697
LIG_BIR_III_3	1	5	PF00653	0.794
LIG_DLG_GKlike_1	298	306	PF00625	0.488
LIG_FHA_1	130	136	PF00498	0.643
LIG_FHA_1	236	242	PF00498	0.447
LIG_FHA_1	274	280	PF00498	0.556
LIG_FHA_1	284	290	PF00498	0.528
LIG_FHA_1	302	308	PF00498	0.697
LIG_FHA_1	371	377	PF00498	0.401
LIG_FHA_1	79	85	PF00498	0.735
LIG_FHA_1	86	92	PF00498	0.590
LIG_FHA_2	112	118	PF00498	0.487
LIG_FHA_2	242	248	PF00498	0.642
LIG_FHA_2	255	261	PF00498	0.626
LIG_LIR_Gen_1	67	77	PF02991	0.618
LIG_LIR_Nem_3	158	164	PF02991	0.611
LIG_LIR_Nem_3	56	62	PF02991	0.621
LIG_LIR_Nem_3	67	72	PF02991	0.615
LIG_LIR_Nem_3	94	99	PF02991	0.637
LIG_LYPXL_yS_3	59	62	PF13949	0.617
LIG_PCNA_PIPBox_1	326	335	PF02747	0.566
LIG_PCNA_yPIPBox_3	326	337	PF02747	0.580
LIG_RPA_C_Fungi	132	144	PF08784	0.677
LIG_SH2_CRK	69	73	PF00017	0.612
LIG_SH2_NCK_1	104	108	PF00017	0.679
LIG_SH2_NCK_1	253	257	PF00017	0.681
LIG_SH2_NCK_1	37	41	PF00017	0.760
LIG_SH2_SRC	104	107	PF00017	0.678
LIG_SH2_STAT5	243	246	PF00017	0.645
LIG_SH2_STAT5	332	335	PF00017	0.556
LIG_SH3_3	112	118	PF00018	0.701
LIG_SH3_3	39	45	PF00018	0.646
LIG_Sin3_3	140	147	PF02671	0.650
LIG_SUMO_SIM_par_1	297	306	PF11976	0.602
LIG_TRAF2_1	203	206	PF00917	0.504
LIG_TRAF2_1	256	259	PF00917	0.625
LIG_TRAF2_1	290	293	PF00917	0.765
LIG_TRAF2_1	319	322	PF00917	0.730
LIG_TYR_ITIM	241	246	PF00017	0.480
LIG_ULM_U2AF65_1	334	339	PF00076	0.548
LIG_WW_3	14	18	PF00397	0.767
MOD_CDC14_SPxK_1	14	17	PF00782	0.770
MOD_CDK_SPxK_1	11	17	PF00069	0.778
MOD_CK1_1	125	131	PF00069	0.682
MOD_CK1_1	254	260	PF00069	0.634
MOD_CK1_1	271	277	PF00069	0.689
MOD_CK1_1	291	297	PF00069	0.628
MOD_CK1_1	301	307	PF00069	0.635
MOD_CK1_1	358	364	PF00069	0.583
MOD_CK1_1	9	15	PF00069	0.696
MOD_CK1_1	94	100	PF00069	0.449
MOD_CK2_1	241	247	PF00069	0.644
MOD_CK2_1	254	260	PF00069	0.634
MOD_CK2_1	316	322	PF00069	0.747
MOD_GlcNHglycan	197	200	PF01048	0.599
MOD_GlcNHglycan	2	5	PF01048	0.785
MOD_GlcNHglycan	253	256	PF01048	0.655
MOD_GlcNHglycan	312	315	PF01048	0.627
MOD_GlcNHglycan	357	360	PF01048	0.722
MOD_GlcNHglycan	96	99	PF01048	0.545
MOD_GSK3_1	125	132	PF00069	0.703
MOD_GSK3_1	2	9	PF00069	0.669
MOD_GSK3_1	241	248	PF00069	0.598
MOD_GSK3_1	268	275	PF00069	0.610
MOD_GSK3_1	294	301	PF00069	0.524
MOD_GSK3_1	302	309	PF00069	0.520
MOD_GSK3_1	338	345	PF00069	0.553
MOD_GSK3_1	44	51	PF00069	0.667
MOD_N-GLC_1	211	216	PF02516	0.746
MOD_N-GLC_1	271	276	PF02516	0.592
MOD_N-GLC_1	343	348	PF02516	0.406
MOD_NEK2_1	246	251	PF00069	0.589
MOD_NEK2_1	302	307	PF00069	0.516
MOD_NEK2_1	7	12	PF00069	0.607
MOD_NEK2_2	64	69	PF00069	0.712
MOD_PIKK_1	254	260	PF00454	0.703
MOD_PIKK_1	288	294	PF00454	0.766
MOD_PIKK_1	338	344	PF00454	0.548
MOD_PKA_1	111	117	PF00069	0.594
MOD_PKA_2	316	322	PF00069	0.758
MOD_Plk_1	211	217	PF00069	0.686
MOD_Plk_1	220	226	PF00069	0.673
MOD_Plk_1	246	252	PF00069	0.452
MOD_Plk_4	206	212	PF00069	0.639
MOD_Plk_4	246	252	PF00069	0.618
MOD_Plk_4	298	304	PF00069	0.631
MOD_ProDKin_1	11	17	PF00069	0.778
MOD_ProDKin_1	122	128	PF00069	0.684
MOD_ProDKin_1	91	97	PF00069	0.741
MOD_SUMO_for_1	371	374	PF00179	0.585
MOD_SUMO_rev_2	254	263	PF00179	0.629
TRG_DiLeu_BaEn_4	259	265	PF01217	0.630
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.613
TRG_ENDOCYTIC_2	104	107	PF00928	0.678
TRG_ENDOCYTIC_2	243	246	PF00928	0.645
TRG_ENDOCYTIC_2	37	40	PF00928	0.655
TRG_ENDOCYTIC_2	59	62	PF00928	0.617
TRG_ENDOCYTIC_2	69	72	PF00928	0.618
TRG_ER_diArg_1	135	137	PF00400	0.574
TRG_ER_diArg_1	226	228	PF00400	0.659
TRG_ER_diArg_1	316	318	PF00400	0.581
TRG_ER_diArg_1	335	338	PF00400	0.491
TRG_ER_diArg_1	382	384	PF00400	0.658
TRG_ER_diArg_1	385	387	PF00400	0.691
TRG_ER_diArg_1	388	390	PF00400	0.707
TRG_NLS_Bipartite_1	317	338	PF00514	0.687
TRG_NLS_MonoExtC_3	227	233	PF00514	0.622
TRG_NLS_MonoExtN_4	227	232	PF00514	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L6	Leptomonas seymouri	55%	100%
A0A3S7X784	Leishmania donovani	88%	100%
A4HLZ9	Leishmania braziliensis	78%	100%
A4I9C9	Leishmania infantum	88%	100%
Q4Q3P7	Leishmania major	87%	100%