Peptidase C51 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4C7_LEIMU

TriTrypDb:

LmxM.32.2860

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9B4C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4C7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	413	417	PF00656	0.612
CLV_C14_Caspase3-7	425	429	PF00656	0.610
CLV_NRD_NRD_1	184	186	PF00675	0.310
CLV_NRD_NRD_1	216	218	PF00675	0.505
CLV_NRD_NRD_1	364	366	PF00675	0.552
CLV_NRD_NRD_1	432	434	PF00675	0.552
CLV_NRD_NRD_1	442	444	PF00675	0.547
CLV_PCSK_KEX2_1	184	186	PF00082	0.310
CLV_PCSK_KEX2_1	216	218	PF00082	0.505
CLV_PCSK_KEX2_1	364	366	PF00082	0.552
CLV_PCSK_KEX2_1	422	424	PF00082	0.548
CLV_PCSK_KEX2_1	442	444	PF00082	0.526
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.533
CLV_PCSK_SKI1_1	269	273	PF00082	0.434
CLV_PCSK_SKI1_1	337	341	PF00082	0.451
CLV_PCSK_SKI1_1	355	359	PF00082	0.522
CLV_PCSK_SKI1_1	410	414	PF00082	0.372
CLV_PCSK_SKI1_1	443	447	PF00082	0.491
CLV_PCSK_SKI1_1	449	453	PF00082	0.411
CLV_Separin_Metazoa	382	386	PF03568	0.629
DOC_CYCLIN_RxL_1	334	344	PF00134	0.642
DOC_CYCLIN_RxL_1	447	461	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.649
DOC_MAPK_DCC_7	25	33	PF00069	0.561
DOC_MAPK_gen_1	216	227	PF00069	0.669
DOC_MAPK_gen_1	25	33	PF00069	0.563
DOC_MAPK_gen_1	447	456	PF00069	0.567
DOC_PP2B_LxvP_1	122	125	PF13499	0.641
DOC_PP2B_LxvP_1	233	236	PF13499	0.625
DOC_PP2B_PxIxI_1	89	95	PF00149	0.485
DOC_PP4_FxxP_1	234	237	PF00568	0.586
DOC_USP7_MATH_1	282	286	PF00917	0.690
DOC_USP7_MATH_1	302	306	PF00917	0.462
DOC_WW_Pin1_4	130	135	PF00397	0.609
DOC_WW_Pin1_4	349	354	PF00397	0.693
DOC_WW_Pin1_4	86	91	PF00397	0.493
LIG_14-3-3_CanoR_1	130	134	PF00244	0.497
LIG_14-3-3_CanoR_1	220	225	PF00244	0.732
LIG_14-3-3_CanoR_1	337	347	PF00244	0.648
LIG_14-3-3_CanoR_1	385	390	PF00244	0.501
LIG_14-3-3_CanoR_1	423	427	PF00244	0.626
LIG_14-3-3_CanoR_1	75	80	PF00244	0.563
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_deltaCOP1_diTrp_1	398	406	PF00928	0.543
LIG_FHA_1	106	112	PF00498	0.411
LIG_FHA_1	188	194	PF00498	0.637
LIG_FHA_1	450	456	PF00498	0.636
LIG_FHA_2	356	362	PF00498	0.799
LIG_FHA_2	411	417	PF00498	0.762
LIG_FHA_2	423	429	PF00498	0.700
LIG_FHA_2	430	436	PF00498	0.608
LIG_GBD_Chelix_1	103	111	PF00786	0.411
LIG_Integrin_isoDGR_2	214	216	PF01839	0.470
LIG_Integrin_isoDGR_2	73	75	PF01839	0.595
LIG_LIR_Apic_2	231	237	PF02991	0.571
LIG_LIR_Apic_2	459	463	PF02991	0.611
LIG_LIR_Gen_1	161	171	PF02991	0.606
LIG_LIR_Gen_1	175	182	PF02991	0.552
LIG_LIR_Gen_1	228	237	PF02991	0.617
LIG_LIR_Gen_1	404	412	PF02991	0.728
LIG_LIR_Nem_3	115	120	PF02991	0.411
LIG_LIR_Nem_3	132	138	PF02991	0.576
LIG_LIR_Nem_3	161	166	PF02991	0.568
LIG_LIR_Nem_3	175	180	PF02991	0.559
LIG_LIR_Nem_3	183	189	PF02991	0.530
LIG_LIR_Nem_3	194	198	PF02991	0.512
LIG_LIR_Nem_3	228	233	PF02991	0.676
LIG_LIR_Nem_3	312	318	PF02991	0.660
LIG_LIR_Nem_3	36	42	PF02991	0.637
LIG_LIR_Nem_3	388	394	PF02991	0.584
LIG_LIR_Nem_3	404	409	PF02991	0.632
LIG_NRBOX	102	108	PF00104	0.378
LIG_NRBOX	188	194	PF00104	0.651
LIG_PCNA_yPIPBox_3	473	481	PF02747	0.552
LIG_PDZ_Class_1	481	486	PF00595	0.612
LIG_Pex14_1	401	405	PF04695	0.576
LIG_Pex14_2	116	120	PF04695	0.513
LIG_SH2_CRK	230	234	PF00017	0.676
LIG_SH2_CRK	39	43	PF00017	0.556
LIG_SH2_CRK	460	464	PF00017	0.648
LIG_SH2_GRB2like	148	151	PF00017	0.589
LIG_SH2_GRB2like	230	233	PF00017	0.558
LIG_SH2_GRB2like	460	463	PF00017	0.689
LIG_SH2_STAP1	182	186	PF00017	0.552
LIG_SH2_STAP1	230	234	PF00017	0.604
LIG_SH2_STAT5	117	120	PF00017	0.411
LIG_SH2_STAT5	172	175	PF00017	0.556
LIG_SH2_STAT5	182	185	PF00017	0.536
LIG_SH2_STAT5	230	233	PF00017	0.585
LIG_SH2_STAT5	411	414	PF00017	0.771
LIG_SH3_3	193	199	PF00018	0.588
LIG_SH3_3	2	8	PF00018	0.590
LIG_SH3_3	20	26	PF00018	0.465
LIG_SH3_3	296	302	PF00018	0.611
LIG_SH3_3	325	331	PF00018	0.730
LIG_SH3_3	348	354	PF00018	0.746
LIG_SUMO_SIM_anti_2	108	115	PF11976	0.513
LIG_SUMO_SIM_anti_2	452	459	PF11976	0.584
LIG_SUMO_SIM_par_1	108	115	PF11976	0.436
LIG_SUMO_SIM_par_1	452	459	PF11976	0.584
LIG_TRAF2_1	376	379	PF00917	0.588
LIG_TYR_ITIM	389	394	PF00017	0.576
LIG_WRC_WIRS_1	113	118	PF05994	0.513
MOD_CDK_SPxK_1	349	355	PF00069	0.692
MOD_CK1_1	14	20	PF00069	0.473
MOD_CK1_1	191	197	PF00069	0.536
MOD_CK1_1	21	27	PF00069	0.436
MOD_CK1_1	341	347	PF00069	0.574
MOD_CK2_1	372	378	PF00069	0.793
MOD_CK2_1	401	407	PF00069	0.629
MOD_CK2_1	429	435	PF00069	0.713
MOD_Cter_Amidation	214	217	PF01082	0.479
MOD_GlcNHglycan	122	125	PF01048	0.441
MOD_GlcNHglycan	15	19	PF01048	0.663
MOD_GlcNHglycan	259	262	PF01048	0.516
MOD_GlcNHglycan	289	292	PF01048	0.496
MOD_GlcNHglycan	321	324	PF01048	0.387
MOD_GlcNHglycan	347	350	PF01048	0.494
MOD_GlcNHglycan	367	370	PF01048	0.571
MOD_GlcNHglycan	435	439	PF01048	0.543
MOD_GlcNHglycan	54	57	PF01048	0.764
MOD_GSK3_1	130	137	PF00069	0.582
MOD_GSK3_1	14	21	PF00069	0.509
MOD_GSK3_1	187	194	PF00069	0.521
MOD_GSK3_1	204	211	PF00069	0.440
MOD_GSK3_1	341	348	PF00069	0.715
MOD_GSK3_1	355	362	PF00069	0.792
MOD_GSK3_1	401	408	PF00069	0.594
MOD_GSK3_1	410	417	PF00069	0.697
MOD_GSK3_1	418	425	PF00069	0.758
MOD_GSK3_1	429	436	PF00069	0.748
MOD_GSK3_1	82	89	PF00069	0.477
MOD_N-GLC_1	241	246	PF02516	0.544
MOD_N-GLC_1	257	262	PF02516	0.330
MOD_N-GLC_1	319	324	PF02516	0.502
MOD_N-GLC_1	355	360	PF02516	0.577
MOD_N-GLC_1	372	377	PF02516	0.483
MOD_N-GLC_1	418	423	PF02516	0.534
MOD_N-GLC_1	429	434	PF02516	0.540
MOD_N-GLC_1	449	454	PF02516	0.403
MOD_NEK2_1	112	117	PF00069	0.353
MOD_NEK2_1	120	125	PF00069	0.476
MOD_NEK2_1	139	144	PF00069	0.598
MOD_NEK2_1	180	185	PF00069	0.513
MOD_NEK2_1	206	211	PF00069	0.596
MOD_NEK2_1	259	264	PF00069	0.717
MOD_NEK2_1	468	473	PF00069	0.594
MOD_NEK2_1	66	71	PF00069	0.529
MOD_NEK2_2	405	410	PF00069	0.514
MOD_PIKK_1	172	178	PF00454	0.439
MOD_PIKK_1	338	344	PF00454	0.763
MOD_PK_1	220	226	PF00069	0.727
MOD_PK_1	385	391	PF00069	0.563
MOD_PKA_1	422	428	PF00069	0.646
MOD_PKA_1	433	439	PF00069	0.683
MOD_PKA_2	129	135	PF00069	0.500
MOD_PKA_2	21	27	PF00069	0.519
MOD_PKA_2	219	225	PF00069	0.694
MOD_PKA_2	228	234	PF00069	0.564
MOD_PKA_2	422	428	PF00069	0.713
MOD_PKA_2	480	486	PF00069	0.612
MOD_PKA_2	61	67	PF00069	0.613
MOD_PKA_2	74	80	PF00069	0.435
MOD_PKB_1	447	455	PF00069	0.598
MOD_Plk_1	35	41	PF00069	0.463
MOD_Plk_1	401	407	PF00069	0.583
MOD_Plk_1	449	455	PF00069	0.645
MOD_Plk_4	105	111	PF00069	0.397
MOD_Plk_4	112	118	PF00069	0.360
MOD_Plk_4	134	140	PF00069	0.565
MOD_Plk_4	188	194	PF00069	0.563
MOD_Plk_4	220	226	PF00069	0.727
MOD_Plk_4	385	391	PF00069	0.629
MOD_Plk_4	401	407	PF00069	0.604
MOD_ProDKin_1	130	136	PF00069	0.608
MOD_ProDKin_1	349	355	PF00069	0.692
MOD_ProDKin_1	86	92	PF00069	0.490
TRG_DiLeu_BaEn_1	63	68	PF01217	0.403
TRG_DiLeu_BaEn_2	311	317	PF01217	0.732
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.644
TRG_ENDOCYTIC_2	117	120	PF00928	0.411
TRG_ENDOCYTIC_2	186	189	PF00928	0.562
TRG_ENDOCYTIC_2	230	233	PF00928	0.600
TRG_ENDOCYTIC_2	39	42	PF00928	0.566
TRG_ENDOCYTIC_2	391	394	PF00928	0.570
TRG_ER_diArg_1	184	186	PF00400	0.510
TRG_ER_diArg_1	263	266	PF00400	0.683
TRG_ER_diArg_1	364	366	PF00400	0.752
TRG_NES_CRM1_1	158	169	PF08389	0.617
TRG_Pf-PMV_PEXEL_1	337	342	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRT1	Leptomonas seymouri	52%	100%
A0A3S7X756	Leishmania donovani	86%	100%
A4HLZ7	Leishmania braziliensis	67%	97%
A4I9C7	Leishmania infantum	86%	100%
Q4Q3P9	Leishmania major	86%	100%