D-alanyl-glycyl endopeptidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-alanyl-glycyl endopeptidase-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4C6_LEIMU

TriTrypDb:

LmxM.32.2850

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	17
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

E9B4C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4C6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.459
CLV_C14_Caspase3-7	243	247	PF00656	0.318
CLV_NRD_NRD_1	212	214	PF00675	0.453
CLV_NRD_NRD_1	4	6	PF00675	0.434
CLV_NRD_NRD_1	47	49	PF00675	0.528
CLV_PCSK_FUR_1	2	6	PF00082	0.442
CLV_PCSK_KEX2_1	212	214	PF00082	0.459
CLV_PCSK_KEX2_1	4	6	PF00082	0.434
CLV_PCSK_SKI1_1	186	190	PF00082	0.665
CLV_PCSK_SKI1_1	197	201	PF00082	0.622
DEG_APCC_DBOX_1	320	328	PF00400	0.287
DEG_Nend_UBRbox_1	1	4	PF02207	0.721
DEG_SPOP_SBC_1	118	122	PF00917	0.417
DEG_SPOP_SBC_1	25	29	PF00917	0.687
DEG_SPOP_SBC_1	33	37	PF00917	0.710
DOC_CKS1_1	123	128	PF01111	0.387
DOC_CYCLIN_RxL_1	342	354	PF00134	0.341
DOC_MAPK_gen_1	319	327	PF00069	0.350
DOC_MAPK_gen_1	82	91	PF00069	0.658
DOC_MAPK_MEF2A_6	346	353	PF00069	0.304
DOC_MAPK_MEF2A_6	82	91	PF00069	0.658
DOC_PP2B_LxvP_1	189	192	PF13499	0.465
DOC_PP2B_PxIxI_1	86	92	PF00149	0.462
DOC_USP7_MATH_1	119	123	PF00917	0.517
DOC_USP7_MATH_1	25	29	PF00917	0.680
DOC_USP7_MATH_1	278	282	PF00917	0.192
DOC_USP7_MATH_1	304	308	PF00917	0.522
DOC_USP7_MATH_1	33	37	PF00917	0.723
DOC_USP7_UBL2_3	200	204	PF12436	0.196
DOC_WW_Pin1_4	122	127	PF00397	0.507
DOC_WW_Pin1_4	312	317	PF00397	0.348
DOC_WW_Pin1_4	83	88	PF00397	0.637
LIG_14-3-3_CanoR_1	24	33	PF00244	0.560
LIG_Actin_WH2_2	98	115	PF00022	0.454
LIG_Clathr_ClatBox_1	350	354	PF01394	0.297
LIG_deltaCOP1_diTrp_1	329	337	PF00928	0.329
LIG_FHA_1	118	124	PF00498	0.539
LIG_FHA_1	248	254	PF00498	0.301
LIG_FHA_1	297	303	PF00498	0.340
LIG_FHA_1	96	102	PF00498	0.460
LIG_FHA_2	119	125	PF00498	0.528
LIG_FHA_2	185	191	PF00498	0.440
LIG_FHA_2	241	247	PF00498	0.305
LIG_FHA_2	334	340	PF00498	0.346
LIG_FHA_2	362	368	PF00498	0.374
LIG_FHA_2	69	75	PF00498	0.553
LIG_HP1_1	349	353	PF01393	0.303
LIG_LIR_Apic_2	334	340	PF02991	0.426
LIG_LIR_Gen_1	234	244	PF02991	0.272
LIG_LIR_Gen_1	329	340	PF02991	0.364
LIG_LIR_LC3C_4	347	352	PF02991	0.303
LIG_LIR_LC3C_4	98	103	PF02991	0.302
LIG_LIR_Nem_3	146	151	PF02991	0.379
LIG_LIR_Nem_3	234	239	PF02991	0.266
LIG_LIR_Nem_3	329	335	PF02991	0.339
LIG_LIR_Nem_3	339	344	PF02991	0.370
LIG_LIR_Nem_3	366	372	PF02991	0.296
LIG_NBox_RRM_1	225	235	PF00076	0.202
LIG_NRBOX	89	95	PF00104	0.495
LIG_Pex14_1	337	341	PF04695	0.374
LIG_SH2_GRB2like	161	164	PF00017	0.359
LIG_SH2_GRB2like	341	344	PF00017	0.380
LIG_SH2_STAP1	210	214	PF00017	0.237
LIG_SH2_STAP1	344	348	PF00017	0.332
LIG_SH2_STAP1	62	66	PF00017	0.648
LIG_SH2_STAT5	326	329	PF00017	0.411
LIG_SH2_STAT5	363	366	PF00017	0.401
LIG_SH3_3	120	126	PF00018	0.575
LIG_SH3_3	177	183	PF00018	0.392
LIG_SH3_3	19	25	PF00018	0.646
LIG_SH3_3	332	338	PF00018	0.279
LIG_SUMO_SIM_par_1	291	297	PF11976	0.184
LIG_SUMO_SIM_par_1	347	355	PF11976	0.314
LIG_TYR_ITIM	102	107	PF00017	0.619
MOD_CDK_SPK_2	312	317	PF00069	0.348
MOD_CDK_SPxxK_3	312	319	PF00069	0.335
MOD_CK1_1	122	128	PF00069	0.474
MOD_CK1_1	26	32	PF00069	0.727
MOD_CK1_1	51	57	PF00069	0.671
MOD_CK2_1	118	124	PF00069	0.501
MOD_CK2_1	44	50	PF00069	0.798
MOD_CK2_1	68	74	PF00069	0.675
MOD_GlcNHglycan	280	283	PF01048	0.505
MOD_GlcNHglycan	30	33	PF01048	0.576
MOD_GlcNHglycan	354	357	PF01048	0.519
MOD_GlcNHglycan	50	53	PF01048	0.395
MOD_GlcNHglycan	7	10	PF01048	0.588
MOD_GSK3_1	118	125	PF00069	0.495
MOD_GSK3_1	159	166	PF00069	0.346
MOD_GSK3_1	23	30	PF00069	0.677
MOD_GSK3_1	361	368	PF00069	0.408
MOD_GSK3_1	44	51	PF00069	0.658
MOD_N-GLC_1	246	251	PF02516	0.519
MOD_N-GLC_1	342	347	PF02516	0.567
MOD_NEK2_1	107	112	PF00069	0.418
MOD_NEK2_1	159	164	PF00069	0.341
MOD_NEK2_1	198	203	PF00069	0.299
MOD_NEK2_1	309	314	PF00069	0.344
MOD_OFUCOSY	164	169	PF10250	0.541
MOD_PIKK_1	125	131	PF00454	0.483
MOD_PKA_1	48	54	PF00069	0.657
MOD_PKA_2	23	29	PF00069	0.596
MOD_PKA_2	278	284	PF00069	0.394
MOD_PKB_1	46	54	PF00069	0.647
MOD_Plk_1	107	113	PF00069	0.380
MOD_Plk_1	304	310	PF00069	0.481
MOD_Plk_1	365	371	PF00069	0.392
MOD_Plk_2-3	333	339	PF00069	0.233
MOD_Plk_4	18	24	PF00069	0.635
MOD_Plk_4	240	246	PF00069	0.284
MOD_Plk_4	288	294	PF00069	0.229
MOD_Plk_4	304	310	PF00069	0.447
MOD_Plk_4	34	40	PF00069	0.597
MOD_Plk_4	85	91	PF00069	0.537
MOD_ProDKin_1	122	128	PF00069	0.498
MOD_ProDKin_1	312	318	PF00069	0.341
MOD_ProDKin_1	83	89	PF00069	0.632
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.303
TRG_ENDOCYTIC_2	104	107	PF00928	0.497
TRG_ENDOCYTIC_2	214	217	PF00928	0.289
TRG_ENDOCYTIC_2	287	290	PF00928	0.297
TRG_ER_diArg_1	1	4	PF00400	0.778
TRG_ER_diArg_1	212	214	PF00400	0.259
TRG_ER_diArg_1	318	321	PF00400	0.416
TRG_ER_diArg_1	45	48	PF00400	0.738
TRG_ER_diArg_1	81	84	PF00400	0.690
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB04	Leptomonas seymouri	57%	100%
A0A0S4ITA7	Bodo saltans	36%	100%
A0A1X0NR96	Trypanosomatidae	44%	100%
A0A3S5IRC8	Trypanosoma rangeli	42%	100%
A0A3S7WZA9	Leishmania donovani	29%	100%
A0A3S7X774	Leishmania donovani	84%	95%
A0A422NKH5	Trypanosoma rangeli	29%	100%
A4HLZ4	Leishmania braziliensis	38%	100%
A4HLZ6	Leishmania braziliensis	70%	100%
A4I1M7	Leishmania infantum	29%	100%
A4I9C4	Leishmania infantum	37%	100%
A4I9C6	Leishmania infantum	84%	95%
C9ZJ94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AXR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q3Q0	Leishmania major	87%	100%
Q4Q9R0	Leishmania major	30%	100%
V5BF57	Trypanosoma cruzi	29%	100%