TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tyrosine phosphatase family/Tyrosine phosphatase family C-terminal region, putative

Species:

Leishmania mexicana

UniProt:

E9B4C5_LEIMU

TriTrypDb:

LmxM.32.2840

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4C5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016311	dephosphorylation	5	9
GO:0044237	cellular metabolic process	2	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004721	phosphoprotein phosphatase activity	3	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.312
CLV_C14_Caspase3-7	68	72	PF00656	0.162
CLV_NRD_NRD_1	9	11	PF00675	0.384
CLV_PCSK_FUR_1	7	11	PF00082	0.400
CLV_PCSK_KEX2_1	179	181	PF00082	0.278
CLV_PCSK_KEX2_1	78	80	PF00082	0.316
CLV_PCSK_KEX2_1	9	11	PF00082	0.427
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.312
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.316
CLV_PCSK_SKI1_1	236	240	PF00082	0.460
DEG_APCC_DBOX_1	78	86	PF00400	0.316
DOC_ANK_TNKS_1	9	16	PF00023	0.316
DOC_CYCLIN_RxL_1	250	258	PF00134	0.186
DOC_MAPK_gen_1	236	244	PF00069	0.316
DOC_MAPK_MEF2A_6	126	134	PF00069	0.246
DOC_MAPK_MEF2A_6	87	94	PF00069	0.279
LIG_14-3-3_CanoR_1	79	83	PF00244	0.405
LIG_14-3-3_CanoR_1	87	91	PF00244	0.328
LIG_CtBP_PxDLS_1	91	95	PF00389	0.433
LIG_eIF4E_1	166	172	PF01652	0.312
LIG_FHA_1	129	135	PF00498	0.365
LIG_FHA_2	168	174	PF00498	0.338
LIG_FHA_2	243	249	PF00498	0.312
LIG_LIR_Gen_1	182	190	PF02991	0.207
LIG_LIR_Gen_1	211	221	PF02991	0.268
LIG_LIR_Nem_3	119	124	PF02991	0.312
LIG_LIR_Nem_3	161	166	PF02991	0.312
LIG_LIR_Nem_3	188	192	PF02991	0.348
LIG_LIR_Nem_3	211	217	PF02991	0.305
LIG_LIR_Nem_3	33	39	PF02991	0.306
LIG_NRBOX	167	173	PF00104	0.316
LIG_Pex14_1	36	40	PF04695	0.259
LIG_SH2_CRK	80	84	PF00017	0.277
LIG_SH2_PTP2	166	169	PF00017	0.370
LIG_SH2_SRC	220	223	PF00017	0.343
LIG_SH2_STAT5	166	169	PF00017	0.312
LIG_SH2_STAT5	183	186	PF00017	0.268
LIG_SH2_STAT5	220	223	PF00017	0.370
LIG_SUMO_SIM_par_1	167	173	PF11976	0.312
LIG_TRAF2_1	175	178	PF00917	0.372
LIG_UBA3_1	135	143	PF00899	0.316
LIG_WRC_WIRS_1	186	191	PF05994	0.162
MOD_CK1_1	30	36	PF00069	0.460
MOD_CK2_1	172	178	PF00069	0.387
MOD_GlcNHglycan	74	78	PF01048	0.409
MOD_GSK3_1	124	131	PF00069	0.355
MOD_GSK3_1	208	215	PF00069	0.232
MOD_GSK3_1	24	31	PF00069	0.453
MOD_N-GLC_1	27	32	PF02516	0.316
MOD_NEK2_1	185	190	PF00069	0.368
MOD_NEK2_1	85	90	PF00069	0.316
MOD_NEK2_2	212	217	PF00069	0.318
MOD_PKA_1	78	84	PF00069	0.316
MOD_PKA_2	78	84	PF00069	0.405
MOD_PKA_2	86	92	PF00069	0.328
MOD_Plk_2-3	203	209	PF00069	0.246
MOD_Plk_4	167	173	PF00069	0.313
MOD_Plk_4	78	84	PF00069	0.387
MOD_SUMO_rev_2	103	110	PF00179	0.169
MOD_SUMO_rev_2	173	181	PF00179	0.259
TRG_ENDOCYTIC_2	121	124	PF00928	0.298
TRG_ENDOCYTIC_2	166	169	PF00928	0.303
TRG_ENDOCYTIC_2	183	186	PF00928	0.203
TRG_ENDOCYTIC_2	80	83	PF00928	0.382
TRG_ER_diArg_1	7	10	PF00400	0.417
TRG_NES_CRM1_1	247	258	PF08389	0.314
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4V5	Leptomonas seymouri	27%	100%
A0A0N1HYX0	Leptomonas seymouri	49%	100%
A0A0N1PC37	Leptomonas seymouri	53%	100%
A0A0N1PFC3	Leptomonas seymouri	36%	100%
A0A3S7WWX6	Leishmania donovani	28%	100%
A0A3S7X743	Leishmania donovani	86%	100%
A4HZQ2	Leishmania infantum	29%	100%
A4I9C5	Leishmania infantum	86%	100%
E9AVK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P40289	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	28%	95%
Q4Q3Q1	Leishmania major	90%	100%
Q4QBX1	Leishmania major	27%	100%