D-alanyl-glycyl endopeptidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-alanyl-glycyl endopeptidase-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4C3_LEIMU

TriTrypDb:

LmxM.32.2830

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 29
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	21
GO:0110165	cellular anatomical entity	1	22
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

E9B4C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4C3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.321
CLV_NRD_NRD_1	206	208	PF00675	0.426
CLV_NRD_NRD_1	95	97	PF00675	0.420
CLV_PCSK_KEX2_1	95	97	PF00082	0.420
CLV_PCSK_SKI1_1	73	77	PF00082	0.479
DEG_Nend_Nbox_1	1	3	PF02207	0.463
DEG_SCF_FBW7_1	28	35	PF00400	0.475
DOC_PP1_RVXF_1	226	233	PF00149	0.236
DOC_PP2B_LxvP_1	149	152	PF13499	0.205
DOC_PP2B_LxvP_1	63	66	PF13499	0.316
DOC_USP7_MATH_1	32	36	PF00917	0.321
DOC_WW_Pin1_4	100	105	PF00397	0.222
DOC_WW_Pin1_4	28	33	PF00397	0.450
LIG_14-3-3_CanoR_1	73	78	PF00244	0.541
LIG_BRCT_BRCA1_1	78	82	PF00533	0.334
LIG_deltaCOP1_diTrp_1	117	123	PF00928	0.264
LIG_deltaCOP1_diTrp_1	190	198	PF00928	0.310
LIG_FHA_1	131	137	PF00498	0.262
LIG_FHA_1	204	210	PF00498	0.408
LIG_FHA_1	217	223	PF00498	0.374
LIG_FHA_1	70	76	PF00498	0.589
LIG_FHA_2	219	225	PF00498	0.368
LIG_LIR_Gen_1	122	127	PF02991	0.273
LIG_LIR_Gen_1	57	68	PF02991	0.316
LIG_LIR_Nem_3	122	126	PF02991	0.267
LIG_LIR_Nem_3	199	205	PF02991	0.472
LIG_LIR_Nem_3	31	36	PF02991	0.354
LIG_LIR_Nem_3	57	63	PF02991	0.402
LIG_Pex14_1	119	123	PF04695	0.312
LIG_Pex14_1	198	202	PF04695	0.330
LIG_Pex14_2	40	44	PF04695	0.262
LIG_PTB_Apo_2	117	124	PF02174	0.221
LIG_PTB_Apo_2	38	45	PF02174	0.349
LIG_SH2_CRK	213	217	PF00017	0.458
LIG_SH2_CRK	3	7	PF00017	0.548
LIG_SH2_GRB2like	202	205	PF00017	0.353
LIG_SH2_GRB2like	46	49	PF00017	0.372
LIG_SH2_GRB2like	60	63	PF00017	0.399
LIG_SH2_PTP2	60	63	PF00017	0.536
LIG_SH2_STAP1	205	209	PF00017	0.361
LIG_SH2_STAP1	93	97	PF00017	0.209
LIG_SH2_STAT3	160	163	PF00017	0.241
LIG_SH2_STAT3	97	100	PF00017	0.346
LIG_SH2_STAT5	108	111	PF00017	0.308
LIG_SH2_STAT5	187	190	PF00017	0.309
LIG_SH2_STAT5	205	208	PF00017	0.505
LIG_SH2_STAT5	53	56	PF00017	0.464
LIG_SH2_STAT5	60	63	PF00017	0.475
LIG_SH2_STAT5	77	80	PF00017	0.517
LIG_SH3_3	22	28	PF00018	0.613
LIG_SUMO_SIM_par_1	217	224	PF11976	0.503
LIG_TYR_ITIM	211	216	PF00017	0.489
LIG_TYR_ITIM	58	63	PF00017	0.517
MOD_CK1_1	128	134	PF00069	0.344
MOD_CK1_1	19	25	PF00069	0.604
MOD_CK1_1	218	224	PF00069	0.306
MOD_CK1_1	52	58	PF00069	0.389
MOD_GlcNHglycan	100	103	PF01048	0.507
MOD_GlcNHglycan	18	21	PF01048	0.617
MOD_GlcNHglycan	199	202	PF01048	0.337
MOD_GSK3_1	12	19	PF00069	0.635
MOD_GSK3_1	193	200	PF00069	0.380
MOD_GSK3_1	214	221	PF00069	0.415
MOD_GSK3_1	28	35	PF00069	0.395
MOD_GSK3_1	49	56	PF00069	0.412
MOD_GSK3_1	69	76	PF00069	0.565
MOD_N-GLC_1	10	15	PF02516	0.651
MOD_N-GLC_1	119	124	PF02516	0.546
MOD_N-GLC_1	128	133	PF02516	0.406
MOD_N-GLC_1	203	208	PF02516	0.356
MOD_N-GLC_1	49	54	PF02516	0.400
MOD_NEK2_1	1	6	PF00069	0.609
MOD_NEK2_1	215	220	PF00069	0.384
MOD_NEK2_1	44	49	PF00069	0.354
MOD_PIKK_1	179	185	PF00454	0.245
MOD_Plk_1	119	125	PF00069	0.335
MOD_Plk_1	128	134	PF00069	0.322
MOD_Plk_1	49	55	PF00069	0.471
MOD_Plk_4	119	125	PF00069	0.303
MOD_Plk_4	193	199	PF00069	0.292
MOD_Plk_4	32	38	PF00069	0.319
MOD_Plk_4	49	55	PF00069	0.507
MOD_Plk_4	73	79	PF00069	0.522
MOD_ProDKin_1	100	106	PF00069	0.222
MOD_ProDKin_1	28	34	PF00069	0.446
MOD_SUMO_for_1	176	179	PF00179	0.326
MOD_SUMO_rev_2	223	230	PF00179	0.222
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.307
TRG_ENDOCYTIC_2	169	172	PF00928	0.272
TRG_ENDOCYTIC_2	213	216	PF00928	0.450
TRG_ENDOCYTIC_2	3	6	PF00928	0.609
TRG_ENDOCYTIC_2	60	63	PF00928	0.449
TRG_ER_diArg_1	95	97	PF00400	0.221
TRG_NES_CRM1_1	117	130	PF08389	0.235
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I309	Leptomonas seymouri	27%	79%
A0A0N1PB04	Leptomonas seymouri	40%	66%
A0A0S4IP47	Bodo saltans	29%	69%
A0A0S4ITA7	Bodo saltans	37%	76%
A0A0S4IVA9	Bodo saltans	30%	78%
A0A1X0NR96	Trypanosomatidae	50%	83%
A0A1X0NR98	Trypanosomatidae	46%	80%
A0A1X0NRB4	Trypanosomatidae	32%	69%
A0A1X0NY88	Trypanosomatidae	24%	84%
A0A1X0NYK9	Trypanosomatidae	24%	80%
A0A3R7KMG1	Trypanosoma rangeli	24%	72%
A0A3R7LYQ4	Trypanosoma rangeli	45%	76%
A0A3S5IRC8	Trypanosoma rangeli	45%	84%
A0A3S7WZA9	Leishmania donovani	29%	79%
A0A3S7X769	Leishmania donovani	86%	100%
A0A422NKH5	Trypanosoma rangeli	29%	72%
A4HEJ1	Leishmania braziliensis	29%	100%
A4HLZ4	Leishmania braziliensis	62%	100%
A4I1M7	Leishmania infantum	29%	79%
C9ZJ94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	86%
C9ZJ95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	84%
C9ZK72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	82%
D0A867	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	86%
E9AXR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q3Q2	Leishmania major	80%	98%
Q4Q9R0	Leishmania major	30%	100%
V5BF57	Trypanosoma cruzi	30%	72%
V5DB66	Trypanosoma cruzi	41%	76%
V5DIU8	Trypanosoma cruzi	27%	80%