PWWP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PWWP domain/TFIIS helical bundle-like domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4C2_LEIMU

TriTrypDb:

LmxM.32.2820

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9B4C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4C2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006351	DNA-templated transcription	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0009059	macromolecule biosynthetic process	4	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0018130	heterocycle biosynthetic process	4	3
GO:0019438	aromatic compound biosynthetic process	4	3
GO:0032774	RNA biosynthetic process	5	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034654	nucleobase-containing compound biosynthetic process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:0097659	nucleic acid-templated transcription	6	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901362	organic cyclic compound biosynthetic process	4	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.628
CLV_C14_Caspase3-7	395	399	PF00656	0.733
CLV_C14_Caspase3-7	421	425	PF00656	0.497
CLV_C14_Caspase3-7	516	520	PF00656	0.722
CLV_NRD_NRD_1	170	172	PF00675	0.726
CLV_NRD_NRD_1	188	190	PF00675	0.685
CLV_NRD_NRD_1	191	193	PF00675	0.681
CLV_NRD_NRD_1	234	236	PF00675	0.633
CLV_NRD_NRD_1	279	281	PF00675	0.585
CLV_NRD_NRD_1	286	288	PF00675	0.541
CLV_NRD_NRD_1	444	446	PF00675	0.538
CLV_NRD_NRD_1	469	471	PF00675	0.455
CLV_NRD_NRD_1	498	500	PF00675	0.658
CLV_PCSK_FUR_1	496	500	PF00082	0.637
CLV_PCSK_KEX2_1	170	172	PF00082	0.681
CLV_PCSK_KEX2_1	234	236	PF00082	0.666
CLV_PCSK_KEX2_1	286	288	PF00082	0.535
CLV_PCSK_KEX2_1	444	446	PF00082	0.538
CLV_PCSK_KEX2_1	469	471	PF00082	0.455
CLV_PCSK_KEX2_1	498	500	PF00082	0.657
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.666
CLV_PCSK_PC7_1	494	500	PF00082	0.633
CLV_PCSK_SKI1_1	246	250	PF00082	0.650
CLV_PCSK_SKI1_1	327	331	PF00082	0.368
CLV_PCSK_SKI1_1	353	357	PF00082	0.342
CLV_PCSK_SKI1_1	469	473	PF00082	0.510
DEG_SCF_FBW7_1	113	120	PF00400	0.834
DOC_CKS1_1	354	359	PF01111	0.550
DOC_CYCLIN_RxL_1	466	474	PF00134	0.495
DOC_MAPK_DCC_7	353	362	PF00069	0.542
DOC_MAPK_gen_1	327	336	PF00069	0.560
DOC_MAPK_gen_1	496	505	PF00069	0.704
DOC_MAPK_MEF2A_6	327	336	PF00069	0.560
DOC_MAPK_MEF2A_6	353	362	PF00069	0.562
DOC_PP4_FxxP_1	354	357	PF00568	0.561
DOC_PP4_FxxP_1	541	544	PF00568	0.707
DOC_USP7_MATH_1	10	14	PF00917	0.529
DOC_USP7_MATH_1	100	104	PF00917	0.608
DOC_USP7_MATH_1	117	121	PF00917	0.644
DOC_USP7_MATH_1	214	218	PF00917	0.696
DOC_USP7_MATH_1	238	242	PF00917	0.758
DOC_USP7_MATH_1	3	7	PF00917	0.667
DOC_USP7_MATH_1	347	351	PF00917	0.542
DOC_USP7_MATH_1	40	44	PF00917	0.550
DOC_USP7_MATH_1	51	55	PF00917	0.510
DOC_USP7_MATH_1	563	567	PF00917	0.497
DOC_USP7_MATH_1	572	576	PF00917	0.569
DOC_USP7_MATH_1	83	87	PF00917	0.566
DOC_USP7_UBL2_3	160	164	PF12436	0.665
DOC_USP7_UBL2_3	166	170	PF12436	0.662
DOC_WW_Pin1_4	104	109	PF00397	0.748
DOC_WW_Pin1_4	113	118	PF00397	0.786
DOC_WW_Pin1_4	267	272	PF00397	0.691
DOC_WW_Pin1_4	353	358	PF00397	0.550
DOC_WW_Pin1_4	506	511	PF00397	0.715
DOC_WW_Pin1_4	517	522	PF00397	0.634
DOC_WW_Pin1_4	526	531	PF00397	0.537
DOC_WW_Pin1_4	535	540	PF00397	0.745
LIG_14-3-3_CanoR_1	235	245	PF00244	0.470
LIG_14-3-3_CanoR_1	286	294	PF00244	0.512
LIG_14-3-3_CanoR_1	295	304	PF00244	0.470
LIG_14-3-3_CanoR_1	547	556	PF00244	0.646
LIG_Actin_WH2_2	315	332	PF00022	0.534
LIG_BIR_II_1	1	5	PF00653	0.710
LIG_BIR_III_2	105	109	PF00653	0.792
LIG_BRCT_BRCA1_1	537	541	PF00533	0.728
LIG_CSL_BTD_1	23	26	PF09270	0.483
LIG_FHA_1	114	120	PF00498	0.545
LIG_FHA_1	144	150	PF00498	0.478
LIG_FHA_1	296	302	PF00498	0.512
LIG_FHA_1	354	360	PF00498	0.560
LIG_FHA_1	486	492	PF00498	0.530
LIG_FHA_1	547	553	PF00498	0.611
LIG_FHA_1	586	592	PF00498	0.483
LIG_FHA_2	105	111	PF00498	0.596
LIG_FHA_2	189	195	PF00498	0.718
LIG_FHA_2	206	212	PF00498	0.701
LIG_FHA_2	263	269	PF00498	0.716
LIG_FHA_2	3	9	PF00498	0.679
LIG_FHA_2	312	318	PF00498	0.521
LIG_FHA_2	393	399	PF00498	0.651
LIG_FHA_2	416	422	PF00498	0.468
LIG_LIR_Apic_2	538	544	PF02991	0.683
LIG_LIR_Apic_2	550	556	PF02991	0.408
LIG_LIR_Gen_1	13	22	PF02991	0.525
LIG_LIR_Gen_1	136	144	PF02991	0.710
LIG_LIR_Nem_3	13	17	PF02991	0.525
LIG_LIR_Nem_3	136	142	PF02991	0.713
LIG_LIR_Nem_3	522	528	PF02991	0.792
LIG_NRBOX	467	473	PF00104	0.577
LIG_PALB2_WD40_1	366	374	PF16756	0.483
LIG_PTB_Apo_2	365	372	PF02174	0.560
LIG_SH2_CRK	279	283	PF00017	0.637
LIG_SH2_CRK	553	557	PF00017	0.502
LIG_SH2_STAP1	568	572	PF00017	0.582
LIG_SH2_STAT3	250	253	PF00017	0.667
LIG_SH2_STAT3	568	571	PF00017	0.578
LIG_SH2_STAT5	478	481	PF00017	0.595
LIG_SH3_3	20	26	PF00018	0.494
LIG_SH3_3	504	510	PF00018	0.745
LIG_SH3_3	518	524	PF00018	0.661
LIG_SUMO_SIM_anti_2	428	433	PF11976	0.501
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.561
LIG_SUMO_SIM_par_1	451	456	PF11976	0.515
LIG_SUMO_SIM_par_1	488	495	PF11976	0.551
LIG_TRAF2_1	108	111	PF00917	0.714
LIG_TRAF2_1	122	125	PF00917	0.774
LIG_TRAF2_1	418	421	PF00917	0.484
LIG_TRAF2_1	93	96	PF00917	0.525
LIG_TRFH_1	259	263	PF08558	0.757
LIG_UBA3_1	322	330	PF00899	0.448
MOD_CDK_SPK_2	267	272	PF00069	0.675
MOD_CDK_SPxxK_3	540	547	PF00069	0.770
MOD_CK1_1	120	126	PF00069	0.687
MOD_CK1_1	173	179	PF00069	0.622
MOD_CK1_1	2	8	PF00069	0.708
MOD_CK1_1	217	223	PF00069	0.548
MOD_CK1_1	240	246	PF00069	0.640
MOD_CK1_1	267	273	PF00069	0.684
MOD_CK1_1	392	398	PF00069	0.592
MOD_CK1_1	415	421	PF00069	0.608
MOD_CK1_1	509	515	PF00069	0.635
MOD_CK1_1	520	526	PF00069	0.681
MOD_CK1_1	535	541	PF00069	0.743
MOD_CK1_1	566	572	PF00069	0.617
MOD_CK1_1	86	92	PF00069	0.598
MOD_CK2_1	104	110	PF00069	0.743
MOD_CK2_1	205	211	PF00069	0.678
MOD_CK2_1	251	257	PF00069	0.639
MOD_CK2_1	287	293	PF00069	0.659
MOD_CK2_1	415	421	PF00069	0.469
MOD_GlcNHglycan	1	4	PF01048	0.709
MOD_GlcNHglycan	119	122	PF01048	0.748
MOD_GlcNHglycan	131	134	PF01048	0.806
MOD_GlcNHglycan	154	157	PF01048	0.613
MOD_GlcNHglycan	176	179	PF01048	0.757
MOD_GlcNHglycan	19	22	PF01048	0.266
MOD_GlcNHglycan	217	220	PF01048	0.678
MOD_GlcNHglycan	242	245	PF01048	0.630
MOD_GlcNHglycan	309	312	PF01048	0.599
MOD_GlcNHglycan	382	385	PF01048	0.602
MOD_GlcNHglycan	455	458	PF01048	0.553
MOD_GlcNHglycan	5	8	PF01048	0.619
MOD_GlcNHglycan	51	54	PF01048	0.347
MOD_GlcNHglycan	61	64	PF01048	0.328
MOD_GSK3_1	100	107	PF00069	0.757
MOD_GSK3_1	113	120	PF00069	0.805
MOD_GSK3_1	170	177	PF00069	0.620
MOD_GSK3_1	236	243	PF00069	0.682
MOD_GSK3_1	285	292	PF00069	0.601
MOD_GSK3_1	303	310	PF00069	0.435
MOD_GSK3_1	49	56	PF00069	0.501
MOD_GSK3_1	509	516	PF00069	0.701
MOD_GSK3_1	533	540	PF00069	0.729
MOD_GSK3_1	547	554	PF00069	0.518
MOD_GSK3_1	585	592	PF00069	0.396
MOD_LATS_1	168	174	PF00433	0.618
MOD_N-GLC_1	173	178	PF02516	0.750
MOD_N-GLC_1	222	227	PF02516	0.664
MOD_N-GLC_1	589	594	PF02516	0.425
MOD_NEK2_1	1	6	PF00069	0.729
MOD_NEK2_1	339	344	PF00069	0.501
MOD_NEK2_1	453	458	PF00069	0.544
MOD_NEK2_1	492	497	PF00069	0.555
MOD_NEK2_1	503	508	PF00069	0.736
MOD_OFUCOSY	391	396	PF10250	0.725
MOD_PIKK_1	295	301	PF00454	0.605
MOD_PIKK_1	375	381	PF00454	0.478
MOD_PIKK_1	509	515	PF00454	0.709
MOD_PKA_1	170	176	PF00069	0.748
MOD_PKA_2	170	176	PF00069	0.619
MOD_PKA_2	188	194	PF00069	0.758
MOD_PKA_2	251	257	PF00069	0.651
MOD_PKA_2	285	291	PF00069	0.500
MOD_PKA_2	389	395	PF00069	0.615
MOD_PKA_2	546	552	PF00069	0.656
MOD_Plk_1	332	338	PF00069	0.521
MOD_Plk_2-3	207	213	PF00069	0.648
MOD_Plk_2-3	222	228	PF00069	0.685
MOD_Plk_2-3	389	395	PF00069	0.667
MOD_Plk_4	10	16	PF00069	0.339
MOD_Plk_4	347	353	PF00069	0.608
MOD_Plk_4	53	59	PF00069	0.585
MOD_ProDKin_1	104	110	PF00069	0.755
MOD_ProDKin_1	113	119	PF00069	0.787
MOD_ProDKin_1	267	273	PF00069	0.691
MOD_ProDKin_1	353	359	PF00069	0.550
MOD_ProDKin_1	506	512	PF00069	0.713
MOD_ProDKin_1	517	523	PF00069	0.632
MOD_ProDKin_1	526	532	PF00069	0.561
MOD_ProDKin_1	535	541	PF00069	0.745
MOD_SUMO_for_1	248	251	PF00179	0.662
TRG_DiLeu_BaEn_1	76	81	PF01217	0.515
TRG_DiLeu_BaEn_2	299	305	PF01217	0.602
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.580
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.307
TRG_ENDOCYTIC_2	279	282	PF00928	0.639
TRG_ENDOCYTIC_2	525	528	PF00928	0.733
TRG_ER_diArg_1	468	470	PF00400	0.453
TRG_ER_diArg_1	493	496	PF00400	0.570
TRG_ER_diArg_1	498	500	PF00400	0.641
TRG_NLS_Bipartite_1	160	174	PF00514	0.705
TRG_NLS_Bipartite_1	234	250	PF00514	0.675
TRG_NLS_MonoCore_2	168	173	PF00514	0.655
TRG_NLS_MonoExtC_3	159	164	PF00514	0.703
TRG_NLS_MonoExtC_3	188	193	PF00514	0.707
TRG_NLS_MonoExtC_3	245	251	PF00514	0.680
TRG_NLS_MonoExtN_4	166	173	PF00514	0.751
TRG_NLS_MonoExtN_4	188	193	PF00514	0.722
TRG_Pf-PMV_PEXEL_1	469	474	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Y6	Leptomonas seymouri	55%	100%
A0A1X0NRB1	Trypanosomatidae	31%	100%
A0A3Q8IKG6	Leishmania donovani	91%	100%
A0A422NKE1	Trypanosoma rangeli	33%	100%
A4HLZ3	Leishmania braziliensis	78%	99%
A4I9C3	Leishmania infantum	91%	100%
Q4Q3Q3	Leishmania major	91%	100%