Transcription elongation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation factor-like protein

Species:

Leishmania mexicana

UniProt:

E9B4C1_LEIMU

TriTrypDb:

LmxM.32.2810

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

E9B4C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4C1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006351	DNA-templated transcription	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0032774	RNA biosynthetic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0097659	nucleic acid-templated transcription	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003746	translation elongation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.436
CLV_C14_Caspase3-7	58	62	PF00656	0.459
CLV_NRD_NRD_1	322	324	PF00675	0.542
CLV_NRD_NRD_1	352	354	PF00675	0.454
CLV_PCSK_KEX2_1	132	134	PF00082	0.588
CLV_PCSK_KEX2_1	443	445	PF00082	0.346
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.559
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.346
CLV_PCSK_PC7_1	128	134	PF00082	0.582
CLV_PCSK_SKI1_1	153	157	PF00082	0.550
CLV_PCSK_SKI1_1	287	291	PF00082	0.425
CLV_PCSK_SKI1_1	365	369	PF00082	0.377
CLV_PCSK_SKI1_1	462	466	PF00082	0.268
CLV_PCSK_SKI1_1	74	78	PF00082	0.436
DEG_APCC_DBOX_1	185	193	PF00400	0.338
DEG_Nend_UBRbox_2	1	3	PF02207	0.519
DEG_SCF_SKP2-CKS1_1	386	393	PF00560	0.511
DEG_SPOP_SBC_1	337	341	PF00917	0.448
DOC_MAPK_gen_1	362	372	PF00069	0.465
DOC_MAPK_MEF2A_6	365	372	PF00069	0.494
DOC_MAPK_NFAT4_5	365	373	PF00069	0.408
DOC_PP2B_LxvP_1	254	257	PF13499	0.713
DOC_USP7_MATH_1	112	116	PF00917	0.473
DOC_USP7_MATH_1	117	121	PF00917	0.671
DOC_USP7_MATH_1	149	153	PF00917	0.638
DOC_USP7_MATH_1	210	214	PF00917	0.356
DOC_USP7_MATH_1	245	249	PF00917	0.581
DOC_USP7_MATH_1	268	272	PF00917	0.633
DOC_USP7_MATH_1	283	287	PF00917	0.617
DOC_USP7_MATH_1	289	293	PF00917	0.567
DOC_USP7_MATH_1	97	101	PF00917	0.520
DOC_WW_Pin1_4	269	274	PF00397	0.588
DOC_WW_Pin1_4	292	297	PF00397	0.650
DOC_WW_Pin1_4	31	36	PF00397	0.582
DOC_WW_Pin1_4	333	338	PF00397	0.407
DOC_WW_Pin1_4	387	392	PF00397	0.461
LIG_14-3-3_CanoR_1	228	234	PF00244	0.372
LIG_14-3-3_CanoR_1	23	30	PF00244	0.397
LIG_14-3-3_CanoR_1	323	327	PF00244	0.404
LIG_14-3-3_CanoR_1	444	449	PF00244	0.315
LIG_APCC_ABBA_1	10	15	PF00400	0.479
LIG_APCC_ABBAyCdc20_2	9	15	PF00400	0.477
LIG_FHA_1	459	465	PF00498	0.252
LIG_FHA_2	198	204	PF00498	0.510
LIG_FHA_2	323	329	PF00498	0.548
LIG_FHA_2	339	345	PF00498	0.375
LIG_FHA_2	358	364	PF00498	0.441
LIG_FHA_2	402	408	PF00498	0.431
LIG_FHA_2	445	451	PF00498	0.375
LIG_FHA_2	463	469	PF00498	0.119
LIG_FHA_2	50	56	PF00498	0.518
LIG_FHA_2	68	74	PF00498	0.311
LIG_LIR_Gen_1	325	334	PF02991	0.405
LIG_LIR_Gen_1	8	17	PF02991	0.374
LIG_LIR_Nem_3	325	330	PF02991	0.406
LIG_LIR_Nem_3	8	14	PF02991	0.353
LIG_MYND_1	218	222	PF01753	0.485
LIG_PCNA_PIPBox_1	429	438	PF02747	0.357
LIG_RPA_C_Fungi	123	135	PF08784	0.431
LIG_SH2_CRK	327	331	PF00017	0.401
LIG_SH2_GRB2like	327	330	PF00017	0.401
LIG_SH2_NCK_1	327	331	PF00017	0.401
LIG_SH2_SRC	13	16	PF00017	0.534
LIG_SH2_SRC	327	330	PF00017	0.547
LIG_SH2_STAP1	327	331	PF00017	0.547
LIG_SH2_STAP1	343	347	PF00017	0.412
LIG_SH2_STAT3	394	397	PF00017	0.508
LIG_SH2_STAT3	449	452	PF00017	0.290
LIG_SH2_STAT5	13	16	PF00017	0.536
LIG_SH2_STAT5	198	201	PF00017	0.511
LIG_SH2_STAT5	394	397	PF00017	0.508
LIG_SH2_STAT5	4	7	PF00017	0.496
LIG_SH2_STAT5	463	466	PF00017	0.338
LIG_SH3_1	276	282	PF00018	0.494
LIG_SH3_2	282	287	PF14604	0.487
LIG_SH3_3	216	222	PF00018	0.532
LIG_SH3_3	267	273	PF00018	0.683
LIG_SH3_3	276	282	PF00018	0.705
LIG_SH3_3	44	50	PF00018	0.445
LIG_TRAF2_1	26	29	PF00917	0.494
LIG_TRAF2_1	409	412	PF00917	0.501
LIG_TYR_ITSM	323	330	PF00017	0.430
LIG_UBA3_1	429	437	PF00899	0.365
LIG_WRC_WIRS_1	230	235	PF05994	0.477
MOD_CDK_SPK_2	387	392	PF00069	0.509
MOD_CDK_SPxK_1	387	393	PF00069	0.511
MOD_CDK_SPxxK_3	269	276	PF00069	0.717
MOD_CK1_1	213	219	PF00069	0.544
MOD_CK1_1	272	278	PF00069	0.650
MOD_CK1_1	292	298	PF00069	0.595
MOD_CK1_1	336	342	PF00069	0.518
MOD_CK2_1	197	203	PF00069	0.502
MOD_CK2_1	23	29	PF00069	0.394
MOD_CK2_1	401	407	PF00069	0.448
MOD_CK2_1	444	450	PF00069	0.256
MOD_CK2_1	452	458	PF00069	0.233
MOD_CK2_1	49	55	PF00069	0.437
MOD_CK2_1	67	73	PF00069	0.309
MOD_Cter_Amidation	441	444	PF01082	0.336
MOD_GlcNHglycan	114	117	PF01048	0.457
MOD_GlcNHglycan	119	122	PF01048	0.587
MOD_GlcNHglycan	139	145	PF01048	0.652
MOD_GlcNHglycan	174	177	PF01048	0.446
MOD_GlcNHglycan	287	290	PF01048	0.610
MOD_GlcNHglycan	296	299	PF01048	0.591
MOD_GlcNHglycan	314	317	PF01048	0.703
MOD_GlcNHglycan	385	388	PF01048	0.406
MOD_GlcNHglycan	454	457	PF01048	0.279
MOD_GlcNHglycan	99	102	PF01048	0.578
MOD_GSK3_1	167	174	PF00069	0.497
MOD_GSK3_1	245	252	PF00069	0.493
MOD_GSK3_1	268	275	PF00069	0.497
MOD_GSK3_1	285	292	PF00069	0.578
MOD_GSK3_1	318	325	PF00069	0.610
MOD_GSK3_1	333	340	PF00069	0.345
MOD_GSK3_1	383	390	PF00069	0.364
MOD_GSK3_1	458	465	PF00069	0.286
MOD_N-GLC_1	430	435	PF02516	0.411
MOD_N-GLC_2	64	66	PF02516	0.402
MOD_NEK2_1	202	207	PF00069	0.334
MOD_NEK2_1	290	295	PF00069	0.680
MOD_NEK2_1	338	343	PF00069	0.624
MOD_NEK2_1	430	435	PF00069	0.452
MOD_NEK2_1	67	72	PF00069	0.414
MOD_NEK2_1	82	87	PF00069	0.364
MOD_NEK2_2	151	156	PF00069	0.388
MOD_PIKK_1	213	219	PF00454	0.553
MOD_PIKK_1	249	255	PF00454	0.596
MOD_PIKK_1	318	324	PF00454	0.494
MOD_PKA_2	259	265	PF00069	0.626
MOD_PKA_2	322	328	PF00069	0.414
MOD_Plk_1	140	146	PF00069	0.433
MOD_Plk_1	180	186	PF00069	0.444
MOD_Plk_1	343	349	PF00069	0.446
MOD_Plk_1	375	381	PF00069	0.399
MOD_Plk_1	430	436	PF00069	0.395
MOD_Plk_1	82	88	PF00069	0.475
MOD_Plk_4	210	216	PF00069	0.370
MOD_Plk_4	322	328	PF00069	0.514
MOD_Plk_4	343	349	PF00069	0.527
MOD_Plk_4	375	381	PF00069	0.514
MOD_Plk_4	431	437	PF00069	0.343
MOD_Plk_4	444	450	PF00069	0.260
MOD_Plk_4	49	55	PF00069	0.506
MOD_ProDKin_1	269	275	PF00069	0.590
MOD_ProDKin_1	292	298	PF00069	0.650
MOD_ProDKin_1	31	37	PF00069	0.577
MOD_ProDKin_1	333	339	PF00069	0.407
MOD_ProDKin_1	387	393	PF00069	0.463
MOD_SUMO_rev_2	201	207	PF00179	0.485
TRG_DiLeu_BaEn_1	364	369	PF01217	0.412
TRG_DiLeu_BaEn_3	374	380	PF01217	0.405
TRG_ENDOCYTIC_2	158	161	PF00928	0.595
TRG_ENDOCYTIC_2	327	330	PF00928	0.401
TRG_ENDOCYTIC_2	331	334	PF00928	0.365
TRG_ENDOCYTIC_2	44	47	PF00928	0.451
TRG_ER_diArg_1	370	373	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZC4	Leptomonas seymouri	60%	99%
A0A0S4JM53	Bodo saltans	26%	91%
A0A0S4JM77	Bodo saltans	29%	100%
A0A1X0NRX7	Trypanosomatidae	38%	100%
A0A3Q8IGU5	Leishmania donovani	91%	100%
A0A3R7KDK8	Trypanosoma rangeli	39%	100%
A4HLZ2	Leishmania braziliensis	82%	100%
A4I9C2	Leishmania infantum	91%	100%
C9ZJ99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q2KI09	Bos taurus	23%	100%
Q4Q3Q4	Leishmania major	93%	99%
V5BJM3	Trypanosoma cruzi	36%	100%