Putative GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4B9_LEIMU

TriTrypDb:

LmxM.32.2790

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4B9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4B9

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003676	nucleic acid binding	3	8
GO:0003746	translation elongation factor activity	4	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.555
CLV_C14_Caspase3-7	538	542	PF00656	0.437
CLV_NRD_NRD_1	170	172	PF00675	0.415
CLV_NRD_NRD_1	339	341	PF00675	0.525
CLV_NRD_NRD_1	564	566	PF00675	0.241
CLV_NRD_NRD_1	572	574	PF00675	0.231
CLV_NRD_NRD_1	615	617	PF00675	0.412
CLV_NRD_NRD_1	705	707	PF00675	0.374
CLV_NRD_NRD_1	819	821	PF00675	0.548
CLV_NRD_NRD_1	88	90	PF00675	0.542
CLV_PCSK_KEX2_1	153	155	PF00082	0.627
CLV_PCSK_KEX2_1	338	340	PF00082	0.487
CLV_PCSK_KEX2_1	572	574	PF00082	0.252
CLV_PCSK_KEX2_1	701	703	PF00082	0.431
CLV_PCSK_KEX2_1	87	89	PF00082	0.536
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.541
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.445
CLV_PCSK_SKI1_1	117	121	PF00082	0.519
CLV_PCSK_SKI1_1	163	167	PF00082	0.518
CLV_PCSK_SKI1_1	476	480	PF00082	0.249
CLV_PCSK_SKI1_1	488	492	PF00082	0.241
CLV_PCSK_SKI1_1	557	561	PF00082	0.248
CLV_PCSK_SKI1_1	788	792	PF00082	0.306
CLV_Separin_Metazoa	762	766	PF03568	0.437
DEG_SCF_FBW7_2	589	594	PF00400	0.388
DEG_SCF_TRCP1_1	358	363	PF00400	0.437
DEG_SPOP_SBC_1	321	325	PF00917	0.655
DOC_ANK_TNKS_1	794	801	PF00023	0.448
DOC_CYCLIN_yCln2_LP_2	529	535	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	827	833	PF00134	0.543
DOC_MAPK_gen_1	517	527	PF00069	0.437
DOC_MAPK_gen_1	572	579	PF00069	0.448
DOC_MAPK_gen_1	706	712	PF00069	0.439
DOC_MAPK_gen_1	792	801	PF00069	0.504
DOC_MAPK_MEF2A_6	520	529	PF00069	0.437
DOC_MAPK_NFAT4_5	520	528	PF00069	0.448
DOC_MAPK_RevD_3	138	154	PF00069	0.364
DOC_MAPK_RevD_3	601	617	PF00069	0.507
DOC_PP1_RVXF_1	786	792	PF00149	0.555
DOC_PP2B_LxvP_1	529	532	PF13499	0.460
DOC_PP2B_LxvP_1	559	562	PF13499	0.437
DOC_PP2B_LxvP_1	827	830	PF13499	0.535
DOC_USP7_MATH_1	113	117	PF00917	0.642
DOC_USP7_MATH_1	211	215	PF00917	0.716
DOC_USP7_MATH_1	301	305	PF00917	0.653
DOC_USP7_MATH_1	321	325	PF00917	0.641
DOC_USP7_MATH_1	444	448	PF00917	0.531
DOC_USP7_MATH_1	454	458	PF00917	0.483
DOC_USP7_MATH_1	471	475	PF00917	0.469
DOC_USP7_MATH_1	51	55	PF00917	0.441
DOC_USP7_MATH_1	542	546	PF00917	0.414
DOC_USP7_UBL2_3	818	822	PF12436	0.583
DOC_WW_Pin1_4	207	212	PF00397	0.672
DOC_WW_Pin1_4	220	225	PF00397	0.778
DOC_WW_Pin1_4	314	319	PF00397	0.801
DOC_WW_Pin1_4	322	327	PF00397	0.677
DOC_WW_Pin1_4	449	454	PF00397	0.587
DOC_WW_Pin1_4	540	545	PF00397	0.437
DOC_WW_Pin1_4	587	592	PF00397	0.388
DOC_WW_Pin1_4	61	66	PF00397	0.745
DOC_WW_Pin1_4	714	719	PF00397	0.500
LIG_14-3-3_CanoR_1	310	318	PF00244	0.761
LIG_14-3-3_CanoR_1	463	470	PF00244	0.368
LIG_14-3-3_CanoR_1	488	497	PF00244	0.450
LIG_14-3-3_CanoR_1	620	626	PF00244	0.430
LIG_14-3-3_CanoR_1	751	759	PF00244	0.437
LIG_Actin_WH2_2	476	493	PF00022	0.437
LIG_Actin_WH2_2	752	767	PF00022	0.437
LIG_APCC_ABBA_1	105	110	PF00400	0.398
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_BIR_III_2	541	545	PF00653	0.523
LIG_BRCT_BRCA1_1	632	636	PF00533	0.382
LIG_FHA_1	246	252	PF00498	0.447
LIG_FHA_1	325	331	PF00498	0.626
LIG_FHA_1	363	369	PF00498	0.438
LIG_FHA_1	394	400	PF00498	0.450
LIG_FHA_1	42	48	PF00498	0.578
LIG_FHA_1	465	471	PF00498	0.413
LIG_FHA_1	490	496	PF00498	0.437
LIG_FHA_1	632	638	PF00498	0.372
LIG_FHA_1	64	70	PF00498	0.634
LIG_FHA_1	647	653	PF00498	0.361
LIG_FHA_1	656	662	PF00498	0.379
LIG_FHA_1	794	800	PF00498	0.437
LIG_FHA_1	801	807	PF00498	0.437
LIG_FHA_2	421	427	PF00498	0.556
LIG_FHA_2	464	470	PF00498	0.485
LIG_FHA_2	477	483	PF00498	0.392
LIG_FHA_2	536	542	PF00498	0.437
LIG_FHA_2	613	619	PF00498	0.435
LIG_GBD_Chelix_1	166	174	PF00786	0.451
LIG_GBD_Chelix_1	523	531	PF00786	0.339
LIG_LIR_Gen_1	503	511	PF02991	0.459
LIG_LIR_Nem_3	247	252	PF02991	0.378
LIG_LIR_Nem_3	503	507	PF02991	0.459
LIG_LIR_Nem_3	664	669	PF02991	0.393
LIG_LIR_Nem_3	720	724	PF02991	0.450
LIG_LIR_Nem_3	738	744	PF02991	0.562
LIG_MLH1_MIPbox_1	632	636	PF16413	0.382
LIG_Rb_pABgroove_1	475	483	PF01858	0.437
LIG_SH2_CRK	415	419	PF00017	0.504
LIG_SH2_CRK	504	508	PF00017	0.437
LIG_SH2_NCK_1	196	200	PF00017	0.593
LIG_SH2_NCK_1	481	485	PF00017	0.437
LIG_SH2_SRC	196	199	PF00017	0.636
LIG_SH2_SRC	741	744	PF00017	0.437
LIG_SH2_STAP1	504	508	PF00017	0.455
LIG_SH2_STAT3	14	17	PF00017	0.382
LIG_SH2_STAT3	758	761	PF00017	0.462
LIG_SH2_STAT5	489	492	PF00017	0.437
LIG_SH2_STAT5	758	761	PF00017	0.462
LIG_SH3_3	295	301	PF00018	0.608
LIG_SH3_3	313	319	PF00018	0.657
LIG_SH3_3	426	432	PF00018	0.539
LIG_SH3_3	598	604	PF00018	0.528
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.539
LIG_SUMO_SIM_anti_2	727	732	PF11976	0.437
LIG_SUMO_SIM_par_1	474	482	PF11976	0.449
LIG_SUMO_SIM_par_1	670	676	PF11976	0.477
LIG_TRAF2_1	80	83	PF00917	0.415
LIG_TYR_ITIM	413	418	PF00017	0.417
LIG_UBA3_1	558	566	PF00899	0.312
MOD_CDK_SPK_2	714	719	PF00069	0.386
MOD_CK1_1	207	213	PF00069	0.709
MOD_CK1_1	317	323	PF00069	0.748
MOD_CK1_1	324	330	PF00069	0.688
MOD_CK1_1	359	365	PF00069	0.298
MOD_CK1_1	366	372	PF00069	0.325
MOD_CK1_1	397	403	PF00069	0.294
MOD_CK1_1	442	448	PF00069	0.460
MOD_CK1_1	59	65	PF00069	0.696
MOD_CK1_1	596	602	PF00069	0.296
MOD_CK1_1	717	723	PF00069	0.437
MOD_CK2_1	259	265	PF00069	0.431
MOD_CK2_1	395	401	PF00069	0.274
MOD_CK2_1	420	426	PF00069	0.384
MOD_CK2_1	463	469	PF00069	0.481
MOD_CK2_1	88	94	PF00069	0.587
MOD_GlcNHglycan	176	179	PF01048	0.564
MOD_GlcNHglycan	358	361	PF01048	0.309
MOD_GlcNHglycan	406	409	PF01048	0.428
MOD_GlcNHglycan	441	444	PF01048	0.393
MOD_GlcNHglycan	446	449	PF01048	0.379
MOD_GlcNHglycan	456	459	PF01048	0.232
MOD_GlcNHglycan	509	512	PF01048	0.286
MOD_GlcNHglycan	58	61	PF01048	0.684
MOD_GlcNHglycan	702	705	PF01048	0.361
MOD_GlcNHglycan	752	755	PF01048	0.321
MOD_GlcNHglycan	90	93	PF01048	0.471
MOD_GSK3_1	174	181	PF00069	0.313
MOD_GSK3_1	207	214	PF00069	0.750
MOD_GSK3_1	259	266	PF00069	0.536
MOD_GSK3_1	317	324	PF00069	0.792
MOD_GSK3_1	356	363	PF00069	0.324
MOD_GSK3_1	390	397	PF00069	0.277
MOD_GSK3_1	454	461	PF00069	0.367
MOD_GSK3_1	472	479	PF00069	0.291
MOD_GSK3_1	59	66	PF00069	0.677
MOD_GSK3_1	631	638	PF00069	0.410
MOD_GSK3_1	731	738	PF00069	0.391
MOD_GSK3_1	746	753	PF00069	0.303
MOD_GSK3_1	763	770	PF00069	0.286
MOD_N-GLC_1	199	204	PF02516	0.735
MOD_N-GLC_1	308	313	PF02516	0.704
MOD_N-GLC_1	596	601	PF02516	0.289
MOD_N-GLC_1	655	660	PF02516	0.432
MOD_NEK2_1	166	171	PF00069	0.401
MOD_NEK2_1	174	179	PF00069	0.420
MOD_NEK2_1	439	444	PF00069	0.279
MOD_NEK2_1	490	495	PF00069	0.306
MOD_NEK2_1	593	598	PF00069	0.309
MOD_NEK2_1	635	640	PF00069	0.473
MOD_NEK2_1	73	78	PF00069	0.562
MOD_NEK2_1	731	736	PF00069	0.297
MOD_NEK2_2	458	463	PF00069	0.302
MOD_PIKK_1	63	69	PF00454	0.589
MOD_PIKK_1	646	652	PF00454	0.334
MOD_PK_1	395	401	PF00069	0.274
MOD_PKA_1	87	93	PF00069	0.534
MOD_PKA_2	309	315	PF00069	0.548
MOD_PKA_2	394	400	PF00069	0.326
MOD_PKA_2	472	478	PF00069	0.374
MOD_PKA_2	516	522	PF00069	0.274
MOD_PKA_2	750	756	PF00069	0.274
MOD_PKA_2	87	93	PF00069	0.566
MOD_Plk_1	230	236	PF00069	0.529
MOD_Plk_1	548	554	PF00069	0.368
MOD_Plk_1	575	581	PF00069	0.350
MOD_Plk_1	631	637	PF00069	0.360
MOD_Plk_1	655	661	PF00069	0.427
MOD_Plk_1	767	773	PF00069	0.294
MOD_Plk_4	155	161	PF00069	0.526
MOD_Plk_4	245	251	PF00069	0.519
MOD_Plk_4	277	283	PF00069	0.499
MOD_Plk_4	326	332	PF00069	0.621
MOD_Plk_4	363	369	PF00069	0.289
MOD_Plk_4	476	482	PF00069	0.289
MOD_Plk_4	490	496	PF00069	0.251
MOD_Plk_4	631	637	PF00069	0.400
MOD_Plk_4	639	645	PF00069	0.344
MOD_Plk_4	655	661	PF00069	0.424
MOD_Plk_4	717	723	PF00069	0.324
MOD_ProDKin_1	207	213	PF00069	0.674
MOD_ProDKin_1	220	226	PF00069	0.773
MOD_ProDKin_1	314	320	PF00069	0.802
MOD_ProDKin_1	322	328	PF00069	0.660
MOD_ProDKin_1	449	455	PF00069	0.484
MOD_ProDKin_1	540	546	PF00069	0.274
MOD_ProDKin_1	587	593	PF00069	0.205
MOD_ProDKin_1	61	67	PF00069	0.740
MOD_ProDKin_1	714	720	PF00069	0.493
MOD_SUMO_for_1	35	38	PF00179	0.449
MOD_SUMO_for_1	697	700	PF00179	0.393
TRG_DiLeu_BaEn_1	247	252	PF01217	0.433
TRG_DiLeu_BaEn_1	785	790	PF01217	0.350
TRG_DiLeu_BaEn_1	808	813	PF01217	0.522
TRG_DiLeu_BaLyEn_6	554	559	PF01217	0.169
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.548
TRG_DiLeu_LyEn_5	785	790	PF01217	0.350
TRG_ENDOCYTIC_2	415	418	PF00928	0.368
TRG_ENDOCYTIC_2	504	507	PF00928	0.300
TRG_ENDOCYTIC_2	741	744	PF00928	0.418
TRG_ER_diArg_1	337	340	PF00400	0.500
TRG_ER_diArg_1	571	573	PF00400	0.295
TRG_ER_diArg_1	87	89	PF00400	0.407
TRG_NLS_Bipartite_1	153	175	PF00514	0.434
TRG_NLS_MonoExtC_3	819	825	PF00514	0.503
TRG_NLS_MonoExtN_4	818	824	PF00514	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K5	Leptomonas seymouri	69%	100%
A0A0S4JM58	Bodo saltans	52%	100%
A0A1X0NRK6	Trypanosomatidae	46%	96%
A0A3R7MHD3	Trypanosoma rangeli	50%	100%
A0A3S7X775	Leishmania donovani	93%	99%
A4HLZ0	Leishmania braziliensis	83%	100%
A4I9C0	Leishmania infantum	93%	99%
C9ZJA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q4Q3Q6	Leishmania major	91%	100%
V5BF52	Trypanosoma cruzi	50%	98%