Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4B6_LEIMU

TriTrypDb:

LmxM.32.2760

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4B6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	419	423	PF00656	0.692
CLV_NRD_NRD_1	257	259	PF00675	0.666
CLV_NRD_NRD_1	439	441	PF00675	0.590
CLV_NRD_NRD_1	447	449	PF00675	0.590
CLV_NRD_NRD_1	49	51	PF00675	0.613
CLV_NRD_NRD_1	555	557	PF00675	0.580
CLV_NRD_NRD_1	611	613	PF00675	0.446
CLV_PCSK_KEX2_1	279	281	PF00082	0.661
CLV_PCSK_KEX2_1	439	441	PF00082	0.511
CLV_PCSK_KEX2_1	447	449	PF00082	0.498
CLV_PCSK_KEX2_1	49	51	PF00082	0.613
CLV_PCSK_KEX2_1	555	557	PF00082	0.580
CLV_PCSK_KEX2_1	610	612	PF00082	0.453
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.625
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.515
CLV_PCSK_SKI1_1	316	320	PF00082	0.668
CLV_PCSK_SKI1_1	348	352	PF00082	0.673
CLV_PCSK_SKI1_1	451	455	PF00082	0.653
CLV_PCSK_SKI1_1	494	498	PF00082	0.605
CLV_PCSK_SKI1_1	501	505	PF00082	0.427
CLV_PCSK_SKI1_1	527	531	PF00082	0.538
CLV_PCSK_SKI1_1	543	547	PF00082	0.607
CLV_PCSK_SKI1_1	618	622	PF00082	0.509
CLV_PCSK_SKI1_1	726	730	PF00082	0.549
DEG_APCC_DBOX_1	571	579	PF00400	0.542
DEG_APCC_DBOX_1	725	733	PF00400	0.482
DEG_COP1_1	144	151	PF00400	0.549
DEG_MDM2_SWIB_1	513	520	PF02201	0.480
DEG_SCF_TRCP1_1	36	41	PF00400	0.695
DEG_SPOP_SBC_1	174	178	PF00917	0.522
DEG_SPOP_SBC_1	232	236	PF00917	0.696
DEG_SPOP_SBC_1	237	241	PF00917	0.654
DOC_CYCLIN_RxL_1	345	355	PF00134	0.638
DOC_CYCLIN_RxL_1	445	455	PF00134	0.511
DOC_CYCLIN_RxL_1	723	731	PF00134	0.480
DOC_MAPK_gen_1	512	520	PF00069	0.408
DOC_MAPK_gen_1	555	561	PF00069	0.494
DOC_USP7_MATH_1	101	105	PF00917	0.573
DOC_USP7_MATH_1	113	117	PF00917	0.524
DOC_USP7_MATH_1	141	145	PF00917	0.584
DOC_USP7_MATH_1	175	179	PF00917	0.673
DOC_USP7_MATH_1	224	228	PF00917	0.639
DOC_USP7_MATH_1	233	237	PF00917	0.699
DOC_USP7_MATH_1	423	427	PF00917	0.741
DOC_USP7_MATH_1	429	433	PF00917	0.645
DOC_USP7_MATH_1	45	49	PF00917	0.542
DOC_USP7_MATH_1	606	610	PF00917	0.654
DOC_USP7_MATH_1	719	723	PF00917	0.481
DOC_USP7_MATH_2	195	201	PF00917	0.671
DOC_USP7_UBL2_3	443	447	PF12436	0.609
DOC_WW_Pin1_4	105	110	PF00397	0.700
DOC_WW_Pin1_4	147	152	PF00397	0.706
DOC_WW_Pin1_4	15	20	PF00397	0.668
DOC_WW_Pin1_4	157	162	PF00397	0.596
DOC_WW_Pin1_4	166	171	PF00397	0.666
DOC_WW_Pin1_4	292	297	PF00397	0.733
DOC_WW_Pin1_4	377	382	PF00397	0.491
DOC_WW_Pin1_4	721	726	PF00397	0.635
DOC_WW_Pin1_4	74	79	PF00397	0.568
LIG_14-3-3_CanoR_1	115	119	PF00244	0.526
LIG_14-3-3_CanoR_1	13	18	PF00244	0.564
LIG_14-3-3_CanoR_1	140	149	PF00244	0.559
LIG_14-3-3_CanoR_1	258	268	PF00244	0.659
LIG_14-3-3_CanoR_1	501	506	PF00244	0.663
LIG_Actin_WH2_2	511	529	PF00022	0.521
LIG_eIF4E_1	706	712	PF01652	0.425
LIG_FHA_1	115	121	PF00498	0.739
LIG_FHA_1	163	169	PF00498	0.677
LIG_FHA_1	20	26	PF00498	0.559
LIG_FHA_1	37	43	PF00498	0.537
LIG_FHA_1	412	418	PF00498	0.701
LIG_FHA_1	505	511	PF00498	0.598
LIG_FHA_1	560	566	PF00498	0.567
LIG_FHA_1	68	74	PF00498	0.537
LIG_FHA_2	185	191	PF00498	0.786
LIG_FHA_2	390	396	PF00498	0.624
LIG_FHA_2	423	429	PF00498	0.567
LIG_FHA_2	480	486	PF00498	0.545
LIG_FHA_2	648	654	PF00498	0.648
LIG_HCF-1_HBM_1	568	571	PF13415	0.546
LIG_LIR_Apic_2	372	376	PF02991	0.579
LIG_LIR_Gen_1	335	341	PF02991	0.622
LIG_LIR_Gen_1	621	629	PF02991	0.558
LIG_LIR_Nem_3	335	339	PF02991	0.623
LIG_LIR_Nem_3	582	588	PF02991	0.534
LIG_LIR_Nem_3	621	626	PF02991	0.528
LIG_LYPXL_S_1	65	69	PF13949	0.511
LIG_MAD2	59	67	PF02301	0.735
LIG_MYND_1	109	113	PF01753	0.680
LIG_MYND_1	219	223	PF01753	0.624
LIG_PCNA_yPIPBox_3	555	565	PF02747	0.465
LIG_PDZ_Class_2	734	739	PF00595	0.620
LIG_Pex14_1	336	340	PF04695	0.442
LIG_Pex14_1	370	374	PF04695	0.670
LIG_Pex14_1	406	410	PF04695	0.510
LIG_Pex14_1	88	92	PF04695	0.526
LIG_Pex14_2	513	517	PF04695	0.588
LIG_Pex14_2	600	604	PF04695	0.625
LIG_SH2_STAP1	11	15	PF00017	0.566
LIG_SH2_STAP1	498	502	PF00017	0.646
LIG_SH2_STAP1	579	583	PF00017	0.481
LIG_SH2_STAP1	97	101	PF00017	0.522
LIG_SH2_STAT3	11	14	PF00017	0.565
LIG_SH2_STAT5	579	582	PF00017	0.369
LIG_SH2_STAT5	97	100	PF00017	0.579
LIG_SH3_1	107	113	PF00018	0.569
LIG_SH3_2	110	115	PF14604	0.536
LIG_SH3_3	103	109	PF00018	0.643
LIG_SH3_3	145	151	PF00018	0.722
LIG_SH3_3	189	195	PF00018	0.569
LIG_SH3_3	290	296	PF00018	0.774
LIG_SH3_3	309	315	PF00018	0.627
LIG_SH3_3	454	460	PF00018	0.669
LIG_SH3_3	657	663	PF00018	0.487
LIG_SUMO_SIM_par_1	116	121	PF11976	0.517
LIG_SUMO_SIM_par_1	164	169	PF11976	0.530
LIG_SUMO_SIM_par_1	413	422	PF11976	0.551
LIG_SUMO_SIM_par_1	501	507	PF11976	0.637
LIG_TRAF2_1	341	344	PF00917	0.613
LIG_TRAF2_1	482	485	PF00917	0.394
LIG_TRAF2_1	638	641	PF00917	0.534
LIG_WRC_WIRS_1	66	71	PF05994	0.513
LIG_WRPW_2	92	95	PF00400	0.511
LIG_WW_2	109	112	PF00397	0.678
MOD_CDK_SPK_2	15	20	PF00069	0.668
MOD_CDK_SPK_2	721	726	PF00069	0.525
MOD_CK1_1	100	106	PF00069	0.679
MOD_CK1_1	236	242	PF00069	0.818
MOD_CK1_1	292	298	PF00069	0.602
MOD_CK1_1	397	403	PF00069	0.731
MOD_CK1_1	418	424	PF00069	0.567
MOD_CK1_1	83	89	PF00069	0.679
MOD_CK2_1	173	179	PF00069	0.626
MOD_CK2_1	184	190	PF00069	0.763
MOD_CK2_1	479	485	PF00069	0.405
MOD_CK2_1	635	641	PF00069	0.567
MOD_CK2_1	647	653	PF00069	0.536
MOD_CK2_1	689	695	PF00069	0.595
MOD_Cter_Amidation	445	448	PF01082	0.592
MOD_Cter_Amidation	449	452	PF01082	0.620
MOD_GlcNHglycan	199	202	PF01048	0.719
MOD_GlcNHglycan	224	227	PF01048	0.699
MOD_GlcNHglycan	228	231	PF01048	0.640
MOD_GlcNHglycan	235	238	PF01048	0.600
MOD_GlcNHglycan	245	249	PF01048	0.694
MOD_GlcNHglycan	265	268	PF01048	0.678
MOD_GlcNHglycan	28	31	PF01048	0.652
MOD_GlcNHglycan	282	285	PF01048	0.591
MOD_GlcNHglycan	309	312	PF01048	0.762
MOD_GlcNHglycan	322	325	PF01048	0.549
MOD_GlcNHglycan	36	39	PF01048	0.661
MOD_GlcNHglycan	431	434	PF01048	0.668
MOD_GlcNHglycan	637	640	PF01048	0.570
MOD_GlcNHglycan	721	724	PF01048	0.642
MOD_GlcNHglycan	99	102	PF01048	0.628
MOD_GSK3_1	114	121	PF00069	0.509
MOD_GSK3_1	147	154	PF00069	0.751
MOD_GSK3_1	15	22	PF00069	0.585
MOD_GSK3_1	162	169	PF00069	0.674
MOD_GSK3_1	222	229	PF00069	0.628
MOD_GSK3_1	231	238	PF00069	0.818
MOD_GSK3_1	259	266	PF00069	0.712
MOD_GSK3_1	316	323	PF00069	0.714
MOD_GSK3_1	34	41	PF00069	0.655
MOD_GSK3_1	396	403	PF00069	0.727
MOD_GSK3_1	411	418	PF00069	0.604
MOD_GSK3_1	423	430	PF00069	0.566
MOD_GSK3_1	79	86	PF00069	0.764
MOD_GSK3_1	97	104	PF00069	0.582
MOD_N-GLC_1	280	285	PF02516	0.667
MOD_NEK2_1	173	178	PF00069	0.606
MOD_NEK2_1	214	219	PF00069	0.608
MOD_NEK2_1	260	265	PF00069	0.684
MOD_NEK2_1	320	325	PF00069	0.540
MOD_NEK2_1	394	399	PF00069	0.675
MOD_NEK2_1	471	476	PF00069	0.606
MOD_NEK2_1	51	56	PF00069	0.640
MOD_NEK2_1	546	551	PF00069	0.548
MOD_NEK2_1	559	564	PF00069	0.430
MOD_NEK2_1	95	100	PF00069	0.520
MOD_OFUCOSY	362	367	PF10250	0.521
MOD_PIKK_1	101	107	PF00454	0.607
MOD_PIKK_1	151	157	PF00454	0.702
MOD_PIKK_1	238	244	PF00454	0.767
MOD_PIKK_1	452	458	PF00454	0.491
MOD_PIKK_1	547	553	PF00454	0.400
MOD_PIKK_1	577	583	PF00454	0.440
MOD_PKA_2	114	120	PF00069	0.525
MOD_PKA_2	19	25	PF00069	0.602
MOD_PKA_2	332	338	PF00069	0.629
MOD_PKA_2	374	380	PF00069	0.702
MOD_PKA_2	5	11	PF00069	0.673
MOD_PKA_2	633	639	PF00069	0.495
MOD_PKB_1	32	40	PF00069	0.553
MOD_Plk_1	118	124	PF00069	0.588
MOD_Plk_1	125	131	PF00069	0.535
MOD_Plk_1	394	400	PF00069	0.549
MOD_Plk_1	423	429	PF00069	0.603
MOD_Plk_1	51	57	PF00069	0.531
MOD_Plk_1	95	101	PF00069	0.555
MOD_Plk_2-3	479	485	PF00069	0.618
MOD_Plk_4	289	295	PF00069	0.672
MOD_Plk_4	316	322	PF00069	0.590
MOD_Plk_4	332	338	PF00069	0.607
MOD_Plk_4	411	417	PF00069	0.653
MOD_Plk_4	471	477	PF00069	0.630
MOD_Plk_4	618	624	PF00069	0.595
MOD_ProDKin_1	105	111	PF00069	0.700
MOD_ProDKin_1	147	153	PF00069	0.708
MOD_ProDKin_1	15	21	PF00069	0.667
MOD_ProDKin_1	157	163	PF00069	0.597
MOD_ProDKin_1	166	172	PF00069	0.664
MOD_ProDKin_1	292	298	PF00069	0.734
MOD_ProDKin_1	377	383	PF00069	0.496
MOD_ProDKin_1	721	727	PF00069	0.630
MOD_ProDKin_1	74	80	PF00069	0.570
MOD_SUMO_for_1	496	499	PF00179	0.538
MOD_SUMO_rev_2	478	488	PF00179	0.400
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.635
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.649
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.650
TRG_DiLeu_BaLyEn_6	724	729	PF01217	0.481
TRG_ENDOCYTIC_2	66	69	PF00928	0.511
TRG_ENDOCYTIC_2	92	95	PF00928	0.511
TRG_ER_diArg_1	31	34	PF00400	0.575
TRG_ER_diArg_1	439	441	PF00400	0.544
TRG_ER_diArg_1	49	51	PF00400	0.506
TRG_ER_diArg_1	555	557	PF00400	0.543
TRG_ER_diArg_1	610	612	PF00400	0.674
TRG_NLS_MonoExtC_3	446	451	PF00514	0.512
TRG_NLS_MonoExtN_4	445	452	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.673
TRG_Pf-PMV_PEXEL_1	726	731	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7V3	Leishmania donovani	76%	81%
A4HLY7	Leishmania braziliensis	52%	100%
A4I9B6	Leishmania infantum	76%	90%
Q4Q3Q9	Leishmania major	76%	98%