Eukaryotic translation initiation factor 5B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor IF-2, putative

Species:

Leishmania mexicana

UniProt:

E9B4B4_LEIMU

TriTrypDb:

LmxM.32.2740

Length:

818

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 3
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4B4

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.692
CLV_NRD_NRD_1	180	182	PF00675	0.573
CLV_NRD_NRD_1	197	199	PF00675	0.546
CLV_NRD_NRD_1	207	209	PF00675	0.533
CLV_NRD_NRD_1	49	51	PF00675	0.553
CLV_NRD_NRD_1	61	63	PF00675	0.596
CLV_NRD_NRD_1	623	625	PF00675	0.260
CLV_NRD_NRD_1	724	726	PF00675	0.515
CLV_NRD_NRD_1	83	85	PF00675	0.560
CLV_NRD_NRD_1	86	88	PF00675	0.586
CLV_PCSK_FUR_1	342	346	PF00082	0.337
CLV_PCSK_KEX2_1	180	182	PF00082	0.573
CLV_PCSK_KEX2_1	206	208	PF00082	0.591
CLV_PCSK_KEX2_1	344	346	PF00082	0.319
CLV_PCSK_KEX2_1	49	51	PF00082	0.556
CLV_PCSK_KEX2_1	612	614	PF00082	0.252
CLV_PCSK_KEX2_1	622	624	PF00082	0.257
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.591
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.337
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.257
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.257
CLV_PCSK_PC7_1	202	208	PF00082	0.554
CLV_PCSK_SKI1_1	180	184	PF00082	0.717
CLV_PCSK_SKI1_1	461	465	PF00082	0.438
CLV_PCSK_SKI1_1	499	503	PF00082	0.257
CLV_PCSK_SKI1_1	520	524	PF00082	0.257
CLV_PCSK_SKI1_1	562	566	PF00082	0.565
CLV_PCSK_SKI1_1	596	600	PF00082	0.271
CLV_PCSK_SKI1_1	792	796	PF00082	0.489
CLV_PCSK_SKI1_1	811	815	PF00082	0.463
DEG_MDM2_SWIB_1	384	391	PF02201	0.537
DEG_SCF_FBW7_2	297	304	PF00400	0.457
DEG_SPOP_SBC_1	580	584	PF00917	0.457
DOC_CKS1_1	298	303	PF01111	0.457
DOC_CKS1_1	501	506	PF01111	0.457
DOC_CKS1_1	717	722	PF01111	0.412
DOC_CKS1_1	749	754	PF01111	0.542
DOC_CYCLIN_RxL_1	496	503	PF00134	0.457
DOC_MAPK_DCC_7	287	297	PF00069	0.498
DOC_MAPK_DCC_7	682	691	PF00069	0.388
DOC_MAPK_gen_1	25	32	PF00069	0.636
DOC_MAPK_gen_1	284	292	PF00069	0.488
DOC_MAPK_gen_1	342	352	PF00069	0.464
DOC_MAPK_gen_1	409	417	PF00069	0.457
DOC_MAPK_gen_1	520	530	PF00069	0.457
DOC_MAPK_gen_1	622	634	PF00069	0.488
DOC_MAPK_gen_1	647	653	PF00069	0.471
DOC_MAPK_gen_1	678	686	PF00069	0.428
DOC_MAPK_gen_1	725	734	PF00069	0.565
DOC_MAPK_gen_1	98	106	PF00069	0.682
DOC_MAPK_MEF2A_6	523	530	PF00069	0.457
DOC_MAPK_MEF2A_6	627	634	PF00069	0.450
DOC_PP1_RVXF_1	37	43	PF00149	0.360
DOC_PP2B_LxvP_1	290	293	PF13499	0.457
DOC_PP2B_LxvP_1	813	816	PF13499	0.446
DOC_PP4_FxxP_1	570	573	PF00568	0.528
DOC_PP4_FxxP_1	634	637	PF00568	0.537
DOC_USP7_MATH_1	271	275	PF00917	0.536
DOC_USP7_MATH_1	601	605	PF00917	0.451
DOC_USP7_UBL2_3	128	132	PF12436	0.694
DOC_USP7_UBL2_3	25	29	PF12436	0.348
DOC_USP7_UBL2_3	446	450	PF12436	0.418
DOC_USP7_UBL2_3	7	11	PF12436	0.642
DOC_USP7_UBL2_3	795	799	PF12436	0.557
DOC_USP7_UBL2_3	814	818	PF12436	0.617
DOC_USP7_UBL2_3	88	92	PF12436	0.601
DOC_WW_Pin1_4	225	230	PF00397	0.390
DOC_WW_Pin1_4	297	302	PF00397	0.457
DOC_WW_Pin1_4	500	505	PF00397	0.448
DOC_WW_Pin1_4	716	721	PF00397	0.400
DOC_WW_Pin1_4	748	753	PF00397	0.553
LIG_14-3-3_CanoR_1	312	317	PF00244	0.448
LIG_14-3-3_CanoR_1	412	418	PF00244	0.537
LIG_14-3-3_CanoR_1	548	556	PF00244	0.286
LIG_14-3-3_CanoR_1	680	685	PF00244	0.503
LIG_14-3-3_CanoR_1	736	741	PF00244	0.482
LIG_14-3-3_CanoR_1	785	789	PF00244	0.556
LIG_Actin_WH2_2	677	694	PF00022	0.547
LIG_Actin_WH2_2	703	718	PF00022	0.474
LIG_Clathr_ClatBox_1	295	299	PF01394	0.457
LIG_Clathr_ClatBox_1	431	435	PF01394	0.457
LIG_CtBP_PxDLS_1	753	759	PF00389	0.563
LIG_EH1_1	467	475	PF00400	0.509
LIG_FAT_LD_1	588	596	PF03623	0.457
LIG_FHA_1	240	246	PF00498	0.457
LIG_FHA_1	260	266	PF00498	0.325
LIG_FHA_1	277	283	PF00498	0.449
LIG_FHA_1	467	473	PF00498	0.522
LIG_FHA_1	540	546	PF00498	0.536
LIG_FHA_1	699	705	PF00498	0.488
LIG_FHA_2	158	164	PF00498	0.689
LIG_FHA_2	184	190	PF00498	0.677
LIG_FHA_2	446	452	PF00498	0.408
LIG_FHA_2	454	460	PF00498	0.354
LIG_GBD_Chelix_1	322	330	PF00786	0.257
LIG_LIR_Apic_2	534	540	PF02991	0.457
LIG_LIR_Apic_2	569	573	PF02991	0.537
LIG_LIR_Gen_1	168	175	PF02991	0.591
LIG_LIR_Gen_1	386	395	PF02991	0.528
LIG_LIR_Gen_1	625	636	PF02991	0.537
LIG_LIR_LC3C_4	542	547	PF02991	0.394
LIG_LIR_Nem_3	168	174	PF02991	0.610
LIG_LIR_Nem_3	304	309	PF02991	0.457
LIG_LIR_Nem_3	386	391	PF02991	0.537
LIG_LIR_Nem_3	625	631	PF02991	0.537
LIG_LIR_Nem_3	664	669	PF02991	0.513
LIG_NRBOX	587	593	PF00104	0.457
LIG_Pex14_2	384	388	PF04695	0.537
LIG_Rb_pABgroove_1	353	361	PF01858	0.488
LIG_Rb_pABgroove_1	657	665	PF01858	0.457
LIG_SH2_CRK	628	632	PF00017	0.488
LIG_SH2_GRB2like	405	408	PF00017	0.511
LIG_SH2_GRB2like	669	672	PF00017	0.481
LIG_SH2_PTP2	537	540	PF00017	0.509
LIG_SH2_SRC	516	519	PF00017	0.457
LIG_SH2_SRC	537	540	PF00017	0.537
LIG_SH2_STAP1	628	632	PF00017	0.488
LIG_SH2_STAT5	516	519	PF00017	0.471
LIG_SH2_STAT5	537	540	PF00017	0.509
LIG_SH3_3	714	720	PF00018	0.428
LIG_SH3_4	128	135	PF00018	0.683
LIG_Sin3_3	320	327	PF02671	0.457
LIG_SUMO_SIM_anti_2	318	323	PF11976	0.457
LIG_SUMO_SIM_anti_2	430	435	PF11976	0.459
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.537
LIG_SUMO_SIM_anti_2	542	548	PF11976	0.402
LIG_SUMO_SIM_anti_2	728	735	PF11976	0.489
LIG_SUMO_SIM_anti_2	801	808	PF11976	0.537
LIG_SUMO_SIM_par_1	294	300	PF11976	0.457
LIG_SUMO_SIM_par_1	320	325	PF11976	0.457
LIG_SUMO_SIM_par_1	430	435	PF11976	0.459
LIG_SUMO_SIM_par_1	706	711	PF11976	0.537
LIG_SUMO_SIM_par_1	745	751	PF11976	0.557
LIG_SUMO_SIM_par_1	801	808	PF11976	0.537
LIG_TRAF2_1	144	147	PF00917	0.704
LIG_TRAF2_1	162	165	PF00917	0.736
LIG_TRAF2_1	278	281	PF00917	0.408
LIG_TRAF2_1	35	38	PF00917	0.559
LIG_TRAF2_1	44	47	PF00917	0.523
LIG_UBA3_1	22	29	PF00899	0.539
LIG_UBA3_1	591	599	PF00899	0.457
LIG_UBA3_1	658	665	PF00899	0.505
LIG_UBA3_1	805	814	PF00899	0.417
LIG_WRC_WIRS_1	591	596	PF05994	0.488
MOD_CK1_1	274	280	PF00069	0.505
MOD_CK1_1	311	317	PF00069	0.457
MOD_CK1_1	421	427	PF00069	0.457
MOD_CK1_1	500	506	PF00069	0.528
MOD_CK1_1	579	585	PF00069	0.537
MOD_CK1_1	697	703	PF00069	0.575
MOD_CK1_1	762	768	PF00069	0.466
MOD_CK1_1	781	787	PF00069	0.402
MOD_CK2_1	157	163	PF00069	0.670
MOD_CK2_1	183	189	PF00069	0.676
MOD_CK2_1	274	280	PF00069	0.500
MOD_CK2_1	453	459	PF00069	0.367
MOD_DYRK1A_RPxSP_1	716	720	PF00069	0.534
MOD_GlcNHglycan	276	279	PF01048	0.370
MOD_GlcNHglycan	394	398	PF01048	0.351
MOD_GlcNHglycan	420	423	PF01048	0.257
MOD_GlcNHglycan	530	533	PF01048	0.351
MOD_GlcNHglycan	721	724	PF01048	0.499
MOD_GlcNHglycan	761	764	PF01048	0.465
MOD_GSK3_1	221	228	PF00069	0.503
MOD_GSK3_1	236	243	PF00069	0.410
MOD_GSK3_1	304	311	PF00069	0.446
MOD_GSK3_1	379	386	PF00069	0.488
MOD_GSK3_1	413	420	PF00069	0.457
MOD_GSK3_1	493	500	PF00069	0.528
MOD_GSK3_1	576	583	PF00069	0.497
MOD_GSK3_1	694	701	PF00069	0.578
MOD_NEK2_1	453	458	PF00069	0.369
MOD_NEK2_1	576	581	PF00069	0.529
MOD_NEK2_1	805	810	PF00069	0.397
MOD_PIKK_1	259	265	PF00454	0.457
MOD_PIKK_1	493	499	PF00454	0.457
MOD_PK_1	680	686	PF00069	0.572
MOD_PK_1	727	733	PF00069	0.557
MOD_PKA_1	180	186	PF00069	0.682
MOD_PKA_1	198	204	PF00069	0.645
MOD_PKA_2	180	186	PF00069	0.637
MOD_PKA_2	248	254	PF00069	0.457
MOD_PKA_2	271	277	PF00069	0.515
MOD_PKA_2	311	317	PF00069	0.453
MOD_PKA_2	334	340	PF00069	0.455
MOD_PKA_2	547	553	PF00069	0.282
MOD_PKA_2	784	790	PF00069	0.408
MOD_PKB_1	310	318	PF00069	0.457
MOD_Plk_1	727	733	PF00069	0.592
MOD_Plk_4	240	246	PF00069	0.457
MOD_Plk_4	265	271	PF00069	0.457
MOD_Plk_4	413	419	PF00069	0.457
MOD_Plk_4	453	459	PF00069	0.370
MOD_Plk_4	590	596	PF00069	0.488
MOD_Plk_4	727	733	PF00069	0.590
MOD_Plk_4	805	811	PF00069	0.407
MOD_ProDKin_1	225	231	PF00069	0.387
MOD_ProDKin_1	297	303	PF00069	0.457
MOD_ProDKin_1	500	506	PF00069	0.448
MOD_ProDKin_1	716	722	PF00069	0.396
MOD_ProDKin_1	748	754	PF00069	0.550
MOD_SUMO_for_1	28	31	PF00179	0.632
MOD_SUMO_for_1	391	394	PF00179	0.471
MOD_SUMO_for_1	794	797	PF00179	0.475
MOD_SUMO_rev_2	194	201	PF00179	0.686
MOD_SUMO_rev_2	796	800	PF00179	0.535
MOD_SUMO_rev_2	80	90	PF00179	0.646
TRG_DiLeu_BaEn_1	336	341	PF01217	0.457
TRG_DiLeu_LyEn_5	336	341	PF01217	0.457
TRG_ENDOCYTIC_2	628	631	PF00928	0.488
TRG_ENDOCYTIC_2	660	663	PF00928	0.457
TRG_ER_diArg_1	207	209	PF00400	0.509
TRG_ER_diArg_1	309	312	PF00400	0.457
TRG_ER_diArg_1	39	42	PF00400	0.510
TRG_ER_diArg_1	49	52	PF00400	0.509
TRG_ER_diArg_1	510	513	PF00400	0.457
TRG_NES_CRM1_1	679	690	PF08389	0.516
TRG_NES_CRM1_1	729	743	PF08389	0.321
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P688	Leptomonas seymouri	78%	99%
A0A1X0NR88	Trypanosomatidae	70%	99%
A0A3Q8IHQ5	Leishmania donovani	98%	100%
A0A3R7NFT4	Trypanosoma rangeli	68%	98%
A0B8Q6	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	36%	100%
A0KTZ6	Shewanella sp. (strain ANA-3)	27%	92%
A1RUX2	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	33%	100%
A1RXH6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	36%	100%
A1TSK3	Acidovorax citrulli (strain AAC00-1)	27%	87%
A1VXL9	Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176)	26%	94%
A1W8Z4	Acidovorax sp. (strain JS42)	26%	87%
A2BJZ8	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	36%	100%
A2STM8	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	36%	100%
A3CSP4	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	36%	100%
A3DMS0	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	38%	100%
A3MTU7	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	34%	100%
A4FZQ3	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	36%	100%
A4G7S7	Herminiimonas arsenicoxydans	28%	87%
A4HLY5	Leishmania braziliensis	92%	100%
A4I9B4	Leishmania infantum	98%	100%
A4VXH3	Streptococcus suis (strain 05ZYH33)	27%	87%
A4W3R7	Streptococcus suis (strain 98HAH33)	27%	87%
A4WIK2	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	33%	100%
A4YCQ5	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	36%	100%
A5UJM9	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	31%	100%
A6MVX8	Rhodomonas salina	26%	100%
A6URS1	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	35%	100%
A6UVG0	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	34%	100%
A6VIS4	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	36%	100%
A7GZZ3	Campylobacter curvus (strain 525.92)	29%	91%
A7H1L5	Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)	26%	96%
A7IAP7	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	36%	100%
A8A8D3	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	37%	100%
A8FJU1	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)	26%	94%
A8MBV9	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	36%	100%
A9A813	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	36%	100%
B0R6U5	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	37%	100%
B1YCQ7	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	34%	100%
B2GUV7	Rattus norvegicus	48%	67%
B4RXT8	Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)	26%	94%
B6YWH3	Thermococcus onnurineus (strain NA1)	36%	100%
B8GP02	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	25%	96%
B9KEV0	Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)	27%	93%
B9LQL7	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	34%	100%
C6A1V3	Thermococcus sibiricus (strain DSM 12597 / MM 739)	35%	100%
C9ZJA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	98%
G0S8G9	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	52%	73%
O26359	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	36%	100%
O29490	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	38%	100%
O58822	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	34%	78%
O60841	Homo sapiens	48%	67%
P18311	Enterococcus faecium	27%	100%
P39730	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	82%
P95691	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	34%	100%
Q05D44	Mus musculus	48%	67%
Q0HLG1	Shewanella sp. (strain MR-4)	27%	92%
Q0HXR5	Shewanella sp. (strain MR-7)	27%	92%
Q0VSS1	Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2)	26%	91%
Q0W8X2	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	37%	100%
Q10251	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	76%
Q12Z93	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	34%	100%
Q18FT0	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	34%	100%
Q2FU48	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	37%	100%
Q2NGM6	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	33%	100%
Q3IMS5	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	33%	100%
Q466D5	Methanosarcina barkeri (strain Fusaro / DSM 804)	34%	100%
Q4Q3R1	Leishmania major	95%	100%
Q54XP6	Dictyostelium discoideum	47%	78%
Q57710	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	35%	71%
Q5HX30	Campylobacter jejuni (strain RM1221)	26%	94%
Q5JGR9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	35%	72%
Q5QTY8	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	26%	91%
Q5RDE1	Pongo abelii	47%	67%
Q5UXU6	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	35%	100%
Q609C0	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	26%	94%
Q6FF40	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	29%	91%
Q6M0I6	Methanococcus maripaludis (strain S2 / LL)	36%	100%
Q835U8	Enterococcus faecalis (strain ATCC 700802 / V583)	26%	100%
Q8EHL5	Shewanella oneidensis (strain MR-1)	27%	92%
Q8PU78	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	34%	100%
Q8TQL5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	34%	100%
Q8TV06	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	36%	100%
Q8U1R8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	34%	83%
Q8ZX20	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	34%	100%
Q976A1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	100%
Q97BK4	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	31%	100%
Q980Q8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	35%	100%
Q98R05	Mycoplasmopsis pulmonis (strain UAB CTIP)	25%	100%
Q9HJ60	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	31%	100%
Q9HNQ2	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	37%	100%
Q9PIZ1	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	27%	94%
Q9UZK7	Pyrococcus abyssi (strain GE5 / Orsay)	35%	82%
Q9Y9B3	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	35%	100%
V5AV36	Trypanosoma cruzi	70%	92%