Mitochondrial guide RNA binding complex subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guide RNA associated protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9B4B3_LEIMU

TriTrypDb:

LmxM.32.2730

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9B4B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4B3

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	2
GO:0000963	mitochondrial RNA processing	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	2
GO:0010467	gene expression	4	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0140053	mitochondrial gene expression	5	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.517
CLV_C14_Caspase3-7	390	394	PF00656	0.485
CLV_NRD_NRD_1	160	162	PF00675	0.605
CLV_NRD_NRD_1	232	234	PF00675	0.483
CLV_NRD_NRD_1	325	327	PF00675	0.445
CLV_NRD_NRD_1	40	42	PF00675	0.516
CLV_NRD_NRD_1	414	416	PF00675	0.352
CLV_NRD_NRD_1	433	435	PF00675	0.468
CLV_PCSK_KEX2_1	160	162	PF00082	0.588
CLV_PCSK_KEX2_1	232	234	PF00082	0.483
CLV_PCSK_KEX2_1	325	327	PF00082	0.460
CLV_PCSK_KEX2_1	376	378	PF00082	0.368
CLV_PCSK_KEX2_1	40	42	PF00082	0.507
CLV_PCSK_KEX2_1	433	435	PF00082	0.398
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.418
CLV_PCSK_SKI1_1	257	261	PF00082	0.458
DOC_MAPK_gen_1	160	168	PF00069	0.584
DOC_MAPK_gen_1	266	274	PF00069	0.472
DOC_MAPK_gen_1	433	439	PF00069	0.412
DOC_MAPK_MEF2A_6	358	366	PF00069	0.378
DOC_MAPK_MEF2A_6	420	429	PF00069	0.421
DOC_PP1_RVXF_1	231	238	PF00149	0.428
DOC_PP1_RVXF_1	255	261	PF00149	0.477
DOC_SPAK_OSR1_1	350	354	PF12202	0.386
DOC_SPAK_OSR1_1	365	369	PF12202	0.372
DOC_USP7_MATH_1	100	104	PF00917	0.409
DOC_USP7_MATH_1	207	211	PF00917	0.519
DOC_USP7_MATH_1	291	295	PF00917	0.385
DOC_USP7_MATH_1	316	320	PF00917	0.427
DOC_USP7_MATH_1	498	502	PF00917	0.655
DOC_USP7_MATH_1	88	92	PF00917	0.585
DOC_WW_Pin1_4	26	31	PF00397	0.629
DOC_WW_Pin1_4	397	402	PF00397	0.422
DOC_WW_Pin1_4	432	437	PF00397	0.409
LIG_14-3-3_CanoR_1	18	23	PF00244	0.689
LIG_14-3-3_CanoR_1	269	273	PF00244	0.450
LIG_14-3-3_CanoR_1	325	331	PF00244	0.560
LIG_14-3-3_CanoR_1	40	48	PF00244	0.655
LIG_Actin_WH2_2	159	174	PF00022	0.562
LIG_Actin_WH2_2	376	391	PF00022	0.516
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	90	94	PF00533	0.497
LIG_deltaCOP1_diTrp_1	150	157	PF00928	0.532
LIG_deltaCOP1_diTrp_1	236	243	PF00928	0.409
LIG_deltaCOP1_diTrp_1	58	64	PF00928	0.468
LIG_FHA_1	269	275	PF00498	0.580
LIG_FHA_1	31	37	PF00498	0.727
LIG_FHA_1	352	358	PF00498	0.460
LIG_FHA_1	424	430	PF00498	0.374
LIG_FHA_1	433	439	PF00498	0.403
LIG_FHA_1	54	60	PF00498	0.567
LIG_FHA_1	72	78	PF00498	0.348
LIG_FHA_1	91	97	PF00498	0.638
LIG_FHA_2	131	137	PF00498	0.641
LIG_FHA_2	139	145	PF00498	0.635
LIG_FHA_2	197	203	PF00498	0.486
LIG_GBD_Chelix_1	304	312	PF00786	0.442
LIG_LIR_Gen_1	164	173	PF02991	0.578
LIG_LIR_Gen_1	450	461	PF02991	0.367
LIG_LIR_Nem_3	164	168	PF02991	0.589
LIG_LIR_Nem_3	175	180	PF02991	0.538
LIG_LIR_Nem_3	450	456	PF02991	0.366
LIG_LIR_Nem_3	475	479	PF02991	0.435
LIG_SH2_CRK	177	181	PF00017	0.467
LIG_SH2_CRK	185	189	PF00017	0.433
LIG_SH2_CRK	261	265	PF00017	0.477
LIG_SH2_CRK	476	480	PF00017	0.472
LIG_SH2_SRC	282	285	PF00017	0.428
LIG_SH2_SRC	382	385	PF00017	0.381
LIG_SH2_STAP1	451	455	PF00017	0.312
LIG_SH2_STAT3	80	83	PF00017	0.405
LIG_SH2_STAT5	216	219	PF00017	0.495
LIG_SH2_STAT5	287	290	PF00017	0.453
LIG_SH2_STAT5	356	359	PF00017	0.365
LIG_SH2_STAT5	382	385	PF00017	0.522
LIG_SH2_STAT5	408	411	PF00017	0.358
LIG_SH2_STAT5	80	83	PF00017	0.412
LIG_SH3_1	176	182	PF00018	0.502
LIG_SH3_3	176	182	PF00018	0.502
LIG_SH3_3	341	347	PF00018	0.500
LIG_SH3_3	395	401	PF00018	0.446
LIG_SH3_3	452	458	PF00018	0.365
LIG_SH3_3	92	98	PF00018	0.679
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.487
LIG_SUMO_SIM_par_1	435	440	PF11976	0.444
LIG_TYR_ITIM	259	264	PF00017	0.455
LIG_TYR_ITIM	449	454	PF00017	0.377
MOD_CK1_1	190	196	PF00069	0.461
MOD_CK1_1	21	27	PF00069	0.675
MOD_CK1_1	394	400	PF00069	0.420
MOD_CK1_1	53	59	PF00069	0.495
MOD_CK1_1	71	77	PF00069	0.395
MOD_CK2_1	138	144	PF00069	0.703
MOD_CK2_1	293	299	PF00069	0.410
MOD_CK2_1	70	76	PF00069	0.420
MOD_CMANNOS	61	64	PF00535	0.413
MOD_GlcNHglycan	1	4	PF01048	0.762
MOD_GlcNHglycan	113	116	PF01048	0.506
MOD_GlcNHglycan	191	195	PF01048	0.558
MOD_GlcNHglycan	44	47	PF01048	0.667
MOD_GlcNHglycan	469	472	PF01048	0.410
MOD_GSK3_1	126	133	PF00069	0.755
MOD_GSK3_1	17	24	PF00069	0.644
MOD_GSK3_1	26	33	PF00069	0.711
MOD_GSK3_1	387	394	PF00069	0.428
MOD_GSK3_1	490	497	PF00069	0.574
MOD_GSK3_1	71	78	PF00069	0.483
MOD_LATS_1	16	22	PF00433	0.539
MOD_N-GLC_1	30	35	PF02516	0.775
MOD_N-GLC_1	50	55	PF02516	0.425
MOD_NEK2_1	1	6	PF00069	0.670
MOD_NEK2_1	242	247	PF00069	0.411
MOD_NEK2_1	260	265	PF00069	0.561
MOD_NEK2_1	339	344	PF00069	0.404
MOD_NEK2_1	351	356	PF00069	0.359
MOD_NEK2_1	36	41	PF00069	0.767
MOD_NEK2_1	429	434	PF00069	0.370
MOD_NEK2_1	437	442	PF00069	0.461
MOD_NEK2_1	492	497	PF00069	0.517
MOD_NEK2_1	70	75	PF00069	0.368
MOD_PIKK_1	356	362	PF00454	0.364
MOD_PIKK_1	418	424	PF00454	0.519
MOD_PKA_1	101	107	PF00069	0.581
MOD_PKA_1	325	331	PF00069	0.546
MOD_PKA_2	17	23	PF00069	0.779
MOD_PKA_2	268	274	PF00069	0.588
MOD_PKA_2	324	330	PF00069	0.532
MOD_PKA_2	388	394	PF00069	0.497
MOD_Plk_1	138	144	PF00069	0.684
MOD_Plk_1	50	56	PF00069	0.488
MOD_Plk_1	75	81	PF00069	0.524
MOD_Plk_4	101	107	PF00069	0.460
MOD_Plk_4	394	400	PF00069	0.420
MOD_Plk_4	75	81	PF00069	0.456
MOD_Plk_4	90	96	PF00069	0.669
MOD_ProDKin_1	26	32	PF00069	0.629
MOD_ProDKin_1	397	403	PF00069	0.416
MOD_ProDKin_1	432	438	PF00069	0.411
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.414
TRG_ENDOCYTIC_2	165	168	PF00928	0.637
TRG_ENDOCYTIC_2	177	180	PF00928	0.383
TRG_ENDOCYTIC_2	185	188	PF00928	0.391
TRG_ENDOCYTIC_2	261	264	PF00928	0.452
TRG_ENDOCYTIC_2	287	290	PF00928	0.386
TRG_ENDOCYTIC_2	451	454	PF00928	0.346
TRG_ENDOCYTIC_2	476	479	PF00928	0.474
TRG_ER_diArg_1	231	233	PF00400	0.395
TRG_ER_diArg_1	324	326	PF00400	0.419
TRG_ER_diArg_1	368	371	PF00400	0.386
TRG_ER_diArg_1	40	42	PF00400	0.555
TRG_NES_CRM1_1	186	202	PF08389	0.493
TRG_NES_CRM1_1	299	314	PF08389	0.530
TRG_NLS_MonoExtC_3	374	380	PF00514	0.406
TRG_NLS_MonoExtN_4	373	379	PF00514	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK37	Leptomonas seymouri	28%	100%
A0A0N1IKX3	Leptomonas seymouri	80%	92%
A0A0S4IN88	Bodo saltans	29%	94%
A0A0S4JQR1	Bodo saltans	55%	93%
A0A1X0NRA1	Trypanosomatidae	68%	98%
A0A1X0NTQ0	Trypanosomatidae	30%	100%
A0A3Q8II17	Leishmania donovani	94%	100%
A0A3S7WX47	Leishmania donovani	28%	100%
A0A422NDT8	Trypanosoma rangeli	29%	100%
A0A422NKD3	Trypanosoma rangeli	68%	100%
A4HCA9	Leishmania braziliensis	26%	100%
A4HLY4	Leishmania braziliensis	88%	100%
A4HZU2	Leishmania infantum	28%	100%
A4I9B3	Leishmania infantum	94%	100%
C9ZJB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
C9ZRN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AVP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q3R2	Leishmania major	94%	100%
Q4QBT2	Leishmania major	28%	100%
V5BAI0	Trypanosoma cruzi	67%	100%
V5BVS4	Trypanosoma cruzi	30%	100%