Beta-ketoacyl-[acyl-carrier-protein] synthase I

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-ketoacyl synthase family protein, putative

Species:

Leishmania mexicana

UniProt:

E9B4B2_LEIMU

TriTrypDb:

LmxM.32.2720

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4B2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006633	fatty acid biosynthetic process	5	3
GO:0008152	metabolic process	1	3
GO:0008610	lipid biosynthetic process	4	3
GO:0009058	biosynthetic process	2	3
GO:0009987	cellular process	1	3
GO:0016053	organic acid biosynthetic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046394	carboxylic acid biosynthetic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072330	monocarboxylic acid biosynthetic process	6	3
GO:1901576	organic substance biosynthetic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004312	fatty acid synthase activity	5	11
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	317	319	PF00675	0.313
CLV_PCSK_KEX2_1	317	319	PF00082	0.313
DEG_SCF_FBW7_1	361	367	PF00400	0.149
DEG_SPOP_SBC_1	440	444	PF00917	0.269
DOC_CKS1_1	1	6	PF01111	0.469
DOC_CKS1_1	361	366	PF01111	0.149
DOC_MAPK_gen_1	213	221	PF00069	0.267
DOC_MAPK_MEF2A_6	125	132	PF00069	0.253
DOC_PP4_FxxP_1	66	69	PF00568	0.269
DOC_USP7_MATH_1	190	194	PF00917	0.248
DOC_USP7_MATH_1	385	389	PF00917	0.248
DOC_USP7_MATH_1	433	437	PF00917	0.481
DOC_WW_Pin1_4	227	232	PF00397	0.248
DOC_WW_Pin1_4	247	252	PF00397	0.127
DOC_WW_Pin1_4	360	365	PF00397	0.344
DOC_WW_Pin1_4	41	46	PF00397	0.268
LIG_Actin_WH2_2	346	362	PF00022	0.313
LIG_AP2alpha_2	88	90	PF02296	0.362
LIG_BRCT_BRCA1_1	254	258	PF00533	0.222
LIG_BRCT_BRCA1_1	441	445	PF00533	0.270
LIG_FHA_1	341	347	PF00498	0.248
LIG_FHA_1	404	410	PF00498	0.381
LIG_FHA_1	450	456	PF00498	0.285
LIG_FHA_2	343	349	PF00498	0.248
LIG_FHA_2	395	401	PF00498	0.392
LIG_FHA_2	6	12	PF00498	0.313
LIG_FHA_2	91	97	PF00498	0.291
LIG_LIR_Nem_3	11	16	PF02991	0.267
LIG_LIR_Nem_3	444	450	PF02991	0.311
LIG_NRBOX	378	384	PF00104	0.291
LIG_PDZ_Class_1	454	459	PF00595	0.298
LIG_Pex14_2	32	36	PF04695	0.381
LIG_SH2_CRK	161	165	PF00017	0.248
LIG_SH2_GRB2like	337	340	PF00017	0.248
LIG_SH2_NCK_1	161	165	PF00017	0.300
LIG_SH2_SRC	337	340	PF00017	0.248
LIG_SH2_STAT5	337	340	PF00017	0.248
LIG_SH3_3	303	309	PF00018	0.327
LIG_SH3_3	358	364	PF00018	0.201
LIG_SH3_3	64	70	PF00018	0.307
LIG_SH3_3	86	92	PF00018	0.354
LIG_SUMO_SIM_anti_2	348	354	PF11976	0.313
LIG_SUMO_SIM_par_1	272	277	PF11976	0.227
LIG_SUMO_SIM_par_1	394	400	PF11976	0.313
LIG_TRAF2_1	106	109	PF00917	0.278
LIG_TRAF2_1	153	156	PF00917	0.149
LIG_TYR_ITIM	159	164	PF00017	0.248
MOD_CDK_SPxxK_3	41	48	PF00069	0.303
MOD_CK1_1	252	258	PF00069	0.316
MOD_CK1_1	362	368	PF00069	0.188
MOD_CK2_1	394	400	PF00069	0.392
MOD_CK2_1	90	96	PF00069	0.267
MOD_DYRK1A_RPxSP_1	360	364	PF00069	0.149
MOD_GlcNHglycan	20	23	PF01048	0.274
MOD_GlcNHglycan	252	255	PF01048	0.402
MOD_GlcNHglycan	373	376	PF01048	0.458
MOD_GSK3_1	141	148	PF00069	0.397
MOD_GSK3_1	359	366	PF00069	0.335
MOD_GSK3_1	403	410	PF00069	0.311
MOD_GSK3_1	5	12	PF00069	0.340
MOD_N-GLC_1	247	252	PF02516	0.316
MOD_N-GLC_1	407	412	PF02516	0.486
MOD_NEK2_1	258	263	PF00069	0.313
MOD_NEK2_1	370	375	PF00069	0.267
MOD_NEK2_1	454	459	PF00069	0.292
MOD_NEK2_1	5	10	PF00069	0.319
MOD_PKA_2	359	365	PF00069	0.381
MOD_Plk_1	141	147	PF00069	0.288
MOD_Plk_4	207	213	PF00069	0.289
MOD_Plk_4	391	397	PF00069	0.374
MOD_ProDKin_1	227	233	PF00069	0.248
MOD_ProDKin_1	247	253	PF00069	0.127
MOD_ProDKin_1	360	366	PF00069	0.344
MOD_ProDKin_1	41	47	PF00069	0.268
TRG_DiLeu_BaEn_2	27	33	PF01217	0.313
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.269
TRG_ENDOCYTIC_2	161	164	PF00928	0.263
TRG_ENDOCYTIC_2	291	294	PF00928	0.381
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Z2	Leptomonas seymouri	70%	93%
A0A1X0NR83	Trypanosomatidae	52%	91%
A0A3Q8IDZ5	Leishmania donovani	93%	100%
A0A3R7KVG4	Trypanosoma rangeli	56%	99%
A4HLY3	Leishmania braziliensis	86%	100%
A4I9B2	Leishmania infantum	93%	100%
C9ZJB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	92%
O34340	Bacillus subtilis (strain 168)	39%	100%
O94297	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P04683	Rhizobium leguminosarum bv. viciae	34%	100%
P04684	Rhizobium leguminosarum bv. trifolii	34%	100%
P06230	Rhizobium meliloti (strain 1021)	32%	100%
P06231	Rhizobium meliloti	33%	100%
P16538	Streptomyces glaucescens	32%	100%
P16540	Streptomyces violaceoruber	33%	100%
P23155	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	34%	100%
P23902	Hordeum vulgare	34%	99%
P39525	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P43678	Streptomyces rimosus	35%	100%
P43710	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	35%	100%
P52410	Arabidopsis thaliana	38%	97%
P55338	Vibrio harveyi	38%	100%
P56902	Rhizobium meliloti (strain 1021)	44%	100%
P57193	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	33%	100%
P73283	Synechocystis sp. (strain PCC 6803 / Kazusa)	37%	100%
Q02578	Streptomyces cyaneus	36%	100%
Q02K94	Pseudomonas aeruginosa (strain UCBPP-PA14)	33%	100%
Q05356	Streptomyces halstedii	34%	100%
Q0CZH1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	69%
Q0VCA7	Bos taurus	39%	100%
Q4Q3R4	Leishmania major	92%	100%
Q5HHA1	Staphylococcus aureus (strain COL)	40%	100%
Q5TKS0	Staphylococcus aureus	40%	100%
Q6GAU2	Staphylococcus aureus (strain MSSA476)	40%	100%
Q6GIA3	Staphylococcus aureus (strain MRSA252)	40%	100%
Q7A6F8	Staphylococcus aureus (strain N315)	40%	100%
Q83E37	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	36%	100%
Q8KA28	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	31%	100%
Q8L3X9	Arabidopsis thaliana	39%	100%
Q8NXE1	Staphylococcus aureus (strain MW2)	40%	100%
Q99VA6	Staphylococcus aureus (strain Mu50 / ATCC 700699)	40%	100%
Q9C9P4	Arabidopsis thaliana	39%	85%
Q9D404	Mus musculus	39%	100%
Q9HU15	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	22%	72%
Q9KQH9	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	38%	100%
Q9NWU1	Homo sapiens	39%	100%
V5AV31	Trypanosoma cruzi	54%	98%