DNA replication licensing factor MCM3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

minichromosome maintenance (MCM) complex subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B4B0_LEIMU

TriTrypDb:

LmxM.32.2700

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0032991	protein-containing complex	1	11
GO:0042555	MCM complex	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B4B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4B0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006270	DNA replication initiation	5	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0022402	cell cycle process	2	1
GO:0022616	DNA strand elongation	5	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:1902292	cell cycle DNA replication initiation	3	1
GO:1902315	nuclear cell cycle DNA replication initiation	4	1
GO:1902975	mitotic DNA replication initiation	4	1
GO:1903047	mitotic cell cycle process	3	1
GO:0006260	DNA replication	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.392
CLV_C14_Caspase3-7	251	255	PF00656	0.450
CLV_C14_Caspase3-7	272	276	PF00656	0.370
CLV_C14_Caspase3-7	548	552	PF00656	0.485
CLV_C14_Caspase3-7	567	571	PF00656	0.574
CLV_C14_Caspase3-7	64	68	PF00656	0.575
CLV_C14_Caspase3-7	641	645	PF00656	0.508
CLV_NRD_NRD_1	15	17	PF00675	0.346
CLV_NRD_NRD_1	355	357	PF00675	0.293
CLV_NRD_NRD_1	523	525	PF00675	0.204
CLV_NRD_NRD_1	572	574	PF00675	0.738
CLV_NRD_NRD_1	701	703	PF00675	0.558
CLV_NRD_NRD_1	807	809	PF00675	0.404
CLV_PCSK_KEX2_1	15	17	PF00082	0.346
CLV_PCSK_KEX2_1	523	525	PF00082	0.204
CLV_PCSK_KEX2_1	572	574	PF00082	0.738
CLV_PCSK_KEX2_1	617	619	PF00082	0.282
CLV_PCSK_KEX2_1	727	729	PF00082	0.570
CLV_PCSK_KEX2_1	807	809	PF00082	0.392
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.308
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.570
CLV_PCSK_SKI1_1	16	20	PF00082	0.341
CLV_PCSK_SKI1_1	261	265	PF00082	0.215
CLV_PCSK_SKI1_1	384	388	PF00082	0.215
CLV_PCSK_SKI1_1	431	435	PF00082	0.204
CLV_PCSK_SKI1_1	45	49	PF00082	0.301
CLV_PCSK_SKI1_1	492	496	PF00082	0.204
CLV_PCSK_SKI1_1	5	9	PF00082	0.413
CLV_PCSK_SKI1_1	610	614	PF00082	0.271
DEG_APCC_DBOX_1	182	190	PF00400	0.428
DEG_APCC_DBOX_1	260	268	PF00400	0.415
DEG_APCC_DBOX_1	505	513	PF00400	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.479
DEG_ODPH_VHL_1	722	735	PF01847	0.499
DEG_SCF_TRCP1_1	769	774	PF00400	0.596
DEG_SPOP_SBC_1	393	397	PF00917	0.446
DEG_SPOP_SBC_1	752	756	PF00917	0.438
DOC_CKS1_1	185	190	PF01111	0.404
DOC_CKS1_1	651	656	PF01111	0.508
DOC_CYCLIN_RxL_1	42	52	PF00134	0.334
DOC_MAPK_DCC_7	384	394	PF00069	0.404
DOC_MAPK_gen_1	43	50	PF00069	0.446
DOC_MAPK_gen_1	727	735	PF00069	0.611
DOC_MAPK_gen_1	818	826	PF00069	0.415
DOC_MAPK_MEF2A_6	261	269	PF00069	0.415
DOC_MAPK_MEF2A_6	343	350	PF00069	0.404
DOC_MAPK_MEF2A_6	364	371	PF00069	0.405
DOC_MAPK_MEF2A_6	43	50	PF00069	0.343
DOC_MAPK_MEF2A_6	832	840	PF00069	0.338
DOC_MAPK_MEF2A_6	92	101	PF00069	0.291
DOC_MAPK_NFAT4_5	343	351	PF00069	0.417
DOC_MAPK_NFAT4_5	43	51	PF00069	0.363
DOC_PP1_RVXF_1	490	496	PF00149	0.404
DOC_PP2B_PxIxI_1	835	841	PF00149	0.311
DOC_PP4_FxxP_1	126	129	PF00568	0.358
DOC_PP4_FxxP_1	651	654	PF00568	0.508
DOC_USP7_MATH_1	300	304	PF00917	0.583
DOC_USP7_MATH_1	411	415	PF00917	0.424
DOC_USP7_MATH_1	472	476	PF00917	0.404
DOC_USP7_MATH_1	738	742	PF00917	0.655
DOC_USP7_MATH_1	752	756	PF00917	0.479
DOC_USP7_MATH_1	822	826	PF00917	0.382
DOC_USP7_UBL2_3	176	180	PF12436	0.404
DOC_WW_Pin1_4	132	137	PF00397	0.379
DOC_WW_Pin1_4	184	189	PF00397	0.404
DOC_WW_Pin1_4	617	622	PF00397	0.471
DOC_WW_Pin1_4	650	655	PF00397	0.508
DOC_WW_Pin1_4	670	675	PF00397	0.317
LIG_14-3-3_CanoR_1	142	148	PF00244	0.411
LIG_14-3-3_CanoR_1	156	164	PF00244	0.386
LIG_14-3-3_CanoR_1	356	363	PF00244	0.508
LIG_14-3-3_CanoR_1	419	428	PF00244	0.413
LIG_14-3-3_CanoR_1	473	477	PF00244	0.420
LIG_14-3-3_CanoR_1	5	14	PF00244	0.380
LIG_14-3-3_CanoR_1	531	541	PF00244	0.533
LIG_14-3-3_CanoR_1	662	670	PF00244	0.404
LIG_14-3-3_CanoR_1	689	693	PF00244	0.487
LIG_14-3-3_CanoR_1	821	827	PF00244	0.352
LIG_Actin_WH2_2	656	673	PF00022	0.404
LIG_AP2alpha_1	18	22	PF02296	0.307
LIG_BIR_III_2	783	787	PF00653	0.557
LIG_BRCT_BRCA1_1	275	279	PF00533	0.397
LIG_BRCT_BRCA1_1	604	608	PF00533	0.498
LIG_FHA_1	185	191	PF00498	0.406
LIG_FHA_1	195	201	PF00498	0.441
LIG_FHA_1	235	241	PF00498	0.404
LIG_FHA_1	405	411	PF00498	0.404
LIG_FHA_1	456	462	PF00498	0.404
LIG_FHA_1	508	514	PF00498	0.415
LIG_FHA_1	835	841	PF00498	0.392
LIG_FHA_2	176	182	PF00498	0.444
LIG_FHA_2	202	208	PF00498	0.414
LIG_FHA_2	217	223	PF00498	0.346
LIG_FHA_2	270	276	PF00498	0.355
LIG_FHA_2	4	10	PF00498	0.478
LIG_FHA_2	546	552	PF00498	0.499
LIG_FHA_2	673	679	PF00498	0.404
LIG_Integrin_RGD_1	364	366	PF01839	0.204
LIG_LIR_Apic_2	648	654	PF02991	0.508
LIG_LIR_Gen_1	111	117	PF02991	0.397
LIG_LIR_Gen_1	276	285	PF02991	0.331
LIG_LIR_Gen_1	291	302	PF02991	0.404
LIG_LIR_Gen_1	437	446	PF02991	0.404
LIG_LIR_Gen_1	508	518	PF02991	0.405
LIG_LIR_Gen_1	611	616	PF02991	0.380
LIG_LIR_Nem_3	111	115	PF02991	0.338
LIG_LIR_Nem_3	276	282	PF02991	0.405
LIG_LIR_Nem_3	291	297	PF02991	0.451
LIG_LIR_Nem_3	508	514	PF02991	0.405
LIG_LIR_Nem_3	52	56	PF02991	0.385
LIG_PCNA_PIPBox_1	11	20	PF02747	0.350
LIG_Pex14_2	18	22	PF04695	0.307
LIG_Pex14_2	507	511	PF04695	0.404
LIG_Pex14_2	608	612	PF04695	0.508
LIG_PTB_Apo_2	478	485	PF02174	0.404
LIG_PTB_Phospho_1	478	484	PF10480	0.404
LIG_SH2_CRK	527	531	PF00017	0.450
LIG_SH2_NCK_1	541	545	PF00017	0.632
LIG_SH2_PTP2	56	59	PF00017	0.510
LIG_SH2_PTP2	635	638	PF00017	0.404
LIG_SH2_PTP2	93	96	PF00017	0.345
LIG_SH2_SRC	541	544	PF00017	0.634
LIG_SH2_SRC	56	59	PF00017	0.510
LIG_SH2_STAP1	140	144	PF00017	0.404
LIG_SH2_STAP1	27	31	PF00017	0.351
LIG_SH2_STAT3	487	490	PF00017	0.508
LIG_SH2_STAT5	112	115	PF00017	0.321
LIG_SH2_STAT5	170	173	PF00017	0.404
LIG_SH2_STAT5	271	274	PF00017	0.387
LIG_SH2_STAT5	415	418	PF00017	0.415
LIG_SH2_STAT5	56	59	PF00017	0.510
LIG_SH2_STAT5	635	638	PF00017	0.404
LIG_SH2_STAT5	93	96	PF00017	0.341
LIG_SH3_3	130	136	PF00018	0.353
LIG_SH3_3	264	270	PF00018	0.455
LIG_SH3_3	369	375	PF00018	0.404
LIG_SH3_3	494	500	PF00018	0.404
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.441
LIG_SUMO_SIM_anti_2	281	286	PF11976	0.303
LIG_SUMO_SIM_par_1	146	151	PF11976	0.404
LIG_SUMO_SIM_par_1	368	374	PF11976	0.404
LIG_SUMO_SIM_par_1	390	397	PF11976	0.404
LIG_SUMO_SIM_par_1	46	52	PF11976	0.352
LIG_SUMO_SIM_par_1	601	607	PF11976	0.512
LIG_SUMO_SIM_par_1	836	842	PF11976	0.405
LIG_TRAF2_1	675	678	PF00917	0.508
LIG_TYR_ITIM	525	530	PF00017	0.437
LIG_TYR_ITIM	539	544	PF00017	0.527
LIG_TYR_ITIM	54	59	PF00017	0.504
LIG_UBA3_1	433	441	PF00899	0.254
LIG_WRC_WIRS_1	217	222	PF05994	0.213
LIG_WRC_WIRS_1	609	614	PF05994	0.205
MOD_CDK_SPK_2	132	137	PF00069	0.345
MOD_CDK_SPK_2	650	655	PF00069	0.384
MOD_CK1_1	278	284	PF00069	0.320
MOD_CK1_1	358	364	PF00069	0.384
MOD_CK1_1	502	508	PF00069	0.238
MOD_CK1_1	585	591	PF00069	0.656
MOD_CK1_1	602	608	PF00069	0.318
MOD_CK1_1	679	685	PF00069	0.429
MOD_CK1_1	839	845	PF00069	0.564
MOD_CK2_1	132	138	PF00069	0.333
MOD_CK2_1	175	181	PF00069	0.279
MOD_CK2_1	201	207	PF00069	0.272
MOD_CK2_1	3	9	PF00069	0.432
MOD_CK2_1	554	560	PF00069	0.575
MOD_CK2_1	595	601	PF00069	0.457
MOD_CK2_1	672	678	PF00069	0.254
MOD_CK2_1	706	712	PF00069	0.523
MOD_CK2_1	738	744	PF00069	0.585
MOD_CK2_1	822	828	PF00069	0.519
MOD_Cter_Amidation	570	573	PF01082	0.617
MOD_DYRK1A_RPxSP_1	132	136	PF00069	0.472
MOD_GlcNHglycan	401	404	PF01048	0.238
MOD_GlcNHglycan	421	424	PF01048	0.117
MOD_GlcNHglycan	556	559	PF01048	0.532
MOD_GlcNHglycan	560	564	PF01048	0.543
MOD_GlcNHglycan	584	587	PF01048	0.584
MOD_GlcNHglycan	59	62	PF01048	0.613
MOD_GlcNHglycan	740	743	PF01048	0.682
MOD_GlcNHglycan	769	772	PF01048	0.666
MOD_GlcNHglycan	773	776	PF01048	0.633
MOD_GlcNHglycan	793	796	PF01048	0.402
MOD_GSK3_1	152	159	PF00069	0.254
MOD_GSK3_1	171	178	PF00069	0.238
MOD_GSK3_1	190	197	PF00069	0.409
MOD_GSK3_1	216	223	PF00069	0.213
MOD_GSK3_1	269	276	PF00069	0.381
MOD_GSK3_1	288	295	PF00069	0.476
MOD_GSK3_1	373	380	PF00069	0.242
MOD_GSK3_1	394	401	PF00069	0.238
MOD_GSK3_1	409	416	PF00069	0.264
MOD_GSK3_1	5	12	PF00069	0.405
MOD_GSK3_1	545	552	PF00069	0.497
MOD_GSK3_1	592	599	PF00069	0.469
MOD_GSK3_1	617	624	PF00069	0.332
MOD_GSK3_1	672	679	PF00069	0.279
MOD_GSK3_1	767	774	PF00069	0.522
MOD_GSK3_1	78	85	PF00069	0.444
MOD_GSK3_1	839	846	PF00069	0.561
MOD_N-GLC_1	3	8	PF02516	0.436
MOD_N-GLC_1	596	601	PF02516	0.600
MOD_N-GLC_1	803	808	PF02516	0.609
MOD_NEK2_1	189	194	PF00069	0.265
MOD_NEK2_1	220	225	PF00069	0.253
MOD_NEK2_1	392	397	PF00069	0.243
MOD_NEK2_1	507	512	PF00069	0.254
MOD_NEK2_1	592	597	PF00069	0.485
MOD_NEK2_1	608	613	PF00069	0.235
MOD_NEK2_1	688	693	PF00069	0.354
MOD_NEK2_1	78	83	PF00069	0.520
MOD_NEK2_1	843	848	PF00069	0.469
MOD_PIKK_1	220	226	PF00454	0.238
MOD_PIKK_1	288	294	PF00454	0.473
MOD_PIKK_1	377	383	PF00454	0.238
MOD_PIKK_1	441	447	PF00454	0.303
MOD_PKA_1	572	578	PF00069	0.469
MOD_PKA_2	155	161	PF00069	0.242
MOD_PKA_2	355	361	PF00069	0.384
MOD_PKA_2	472	478	PF00069	0.238
MOD_PKA_2	572	578	PF00069	0.626
MOD_PKA_2	592	598	PF00069	0.472
MOD_PKA_2	661	667	PF00069	0.218
MOD_PKA_2	688	694	PF00069	0.355
MOD_PKA_2	738	744	PF00069	0.512
MOD_PKA_2	771	777	PF00069	0.547
MOD_Plk_1	190	196	PF00069	0.254
MOD_Plk_1	3	9	PF00069	0.432
MOD_Plk_1	417	423	PF00069	0.238
MOD_Plk_1	507	513	PF00069	0.254
MOD_Plk_2-3	545	551	PF00069	0.625
MOD_Plk_4	143	149	PF00069	0.261
MOD_Plk_4	216	222	PF00069	0.213
MOD_Plk_4	278	284	PF00069	0.391
MOD_Plk_4	332	338	PF00069	0.312
MOD_Plk_4	472	478	PF00069	0.238
MOD_Plk_4	499	505	PF00069	0.238
MOD_Plk_4	507	513	PF00069	0.238
MOD_Plk_4	599	605	PF00069	0.465
MOD_Plk_4	761	767	PF00069	0.433
MOD_Plk_4	82	88	PF00069	0.443
MOD_Plk_4	843	849	PF00069	0.435
MOD_Plk_4	9	15	PF00069	0.371
MOD_ProDKin_1	132	138	PF00069	0.380
MOD_ProDKin_1	184	190	PF00069	0.238
MOD_ProDKin_1	617	623	PF00069	0.332
MOD_ProDKin_1	650	656	PF00069	0.384
MOD_ProDKin_1	670	676	PF00069	0.117
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.312
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.332
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.290
TRG_ENDOCYTIC_2	112	115	PF00928	0.261
TRG_ENDOCYTIC_2	271	274	PF00928	0.356
TRG_ENDOCYTIC_2	527	530	PF00928	0.437
TRG_ENDOCYTIC_2	541	544	PF00928	0.538
TRG_ENDOCYTIC_2	56	59	PF00928	0.510
TRG_ENDOCYTIC_2	635	638	PF00928	0.238
TRG_ENDOCYTIC_2	93	96	PF00928	0.341
TRG_ER_diArg_1	117	120	PF00400	0.437
TRG_ER_diArg_1	14	16	PF00400	0.342
TRG_ER_diArg_1	161	164	PF00400	0.239
TRG_ER_diArg_1	523	525	PF00400	0.238
TRG_ER_diArg_1	757	760	PF00400	0.523
TRG_ER_diArg_1	807	809	PF00400	0.412
TRG_NES_CRM1_1	501	515	PF08389	0.238
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	628	633	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P686	Leptomonas seymouri	79%	100%
A0A0N0P860	Leptomonas seymouri	33%	88%
A0A0S4IW18	Bodo saltans	31%	100%
A0A0S4JM41	Bodo saltans	67%	100%
A0A1X0NSY3	Trypanosomatidae	65%	100%
A0A1X0NT66	Trypanosomatidae	33%	100%
A0A1X0NZT6	Trypanosomatidae	32%	92%
A0A3Q8IAX4	Leishmania donovani	32%	90%
A0A3R7K9K0	Trypanosoma rangeli	67%	100%
A0A3R7NBN0	Trypanosoma rangeli	32%	91%
A0A3S5H7S8	Leishmania donovani	34%	100%
A0A3S7WY81	Leishmania donovani	33%	100%
A0A3S7X726	Leishmania donovani	94%	99%
A0A422NDD9	Trypanosoma rangeli	32%	100%
A4FUD9	Bos taurus	40%	100%
A4HGC9	Leishmania braziliensis	32%	100%
A4HKT9	Leishmania braziliensis	34%	100%
A4HLY1	Leishmania braziliensis	87%	99%
A4I0T0	Leishmania infantum	33%	100%
A4I3G2	Leishmania infantum	32%	90%
A4I8B8	Leishmania infantum	34%	100%
A4I9B0	Leishmania infantum	94%	99%
B8AEH3	Oryza sativa subsp. indica	32%	100%
B8AZ14	Oryza sativa subsp. indica	31%	100%
B8AZ99	Oryza sativa subsp. indica	41%	100%
B8BKI8	Oryza sativa subsp. indica	32%	91%
B9FKM7	Oryza sativa subsp. japonica	31%	100%
C9ZJB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
D0A7X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	92%
D0A999	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D3ZVK1	Rattus norvegicus	28%	100%
E9AWT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AZQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	90%
E9B377	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
P24279	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	90%
P25205	Homo sapiens	40%	100%
P25206	Mus musculus	40%	100%
P29458	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	94%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P29496	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P30664	Xenopus laevis	31%	100%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	99%
P33991	Homo sapiens	32%	100%
P33992	Homo sapiens	30%	100%
P33993	Homo sapiens	33%	100%
P40377	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P49717	Mus musculus	31%	100%
P49718	Mus musculus	30%	100%
P49736	Homo sapiens	32%	96%
P49739	Xenopus laevis	42%	100%
P55861	Xenopus laevis	32%	98%
P97310	Mus musculus	31%	96%
Q0DHC4	Oryza sativa subsp. japonica	41%	100%
Q0V8B7	Bos taurus	31%	100%
Q0V9Q6	Xenopus tropicalis	28%	100%
Q21902	Caenorhabditis elegans	32%	100%
Q24849	Entamoeba histolytica	38%	100%
Q28BS0	Xenopus tropicalis	40%	100%
Q29JI9	Drosophila pseudoobscura pseudoobscura	31%	100%
Q2R482	Oryza sativa subsp. japonica	32%	91%
Q43704	Zea mays	41%	100%
Q4Q3R6	Leishmania major	95%	100%
Q4Q8I2	Leishmania major	32%	90%
Q4QAP2	Leishmania major	34%	100%
Q54CP4	Dictyostelium discoideum	30%	100%
Q5F310	Xenopus laevis	28%	100%
Q5JKB0	Oryza sativa subsp. japonica	30%	100%
Q5R8G6	Pongo abelii	40%	100%
Q5XK83	Xenopus laevis	31%	100%
Q5ZMN2	Gallus gallus	41%	100%
Q6DIH3	Xenopus tropicalis	31%	99%
Q6GL41	Xenopus tropicalis	31%	100%
Q6KAJ4	Oryza sativa subsp. japonica	32%	100%
Q7ZXZ0	Xenopus laevis	41%	100%
Q9FL33	Arabidopsis thaliana	41%	100%
Q9LPD9	Arabidopsis thaliana	31%	93%
Q9SF37	Arabidopsis thaliana	30%	100%
Q9SX03	Zea mays	42%	100%
Q9SX04	Zea mays	42%	100%
Q9U1E0	Leishmania major	34%	100%
Q9UJA3	Homo sapiens	28%	100%
Q9V461	Drosophila melanogaster	31%	100%
Q9XYU1	Drosophila melanogaster	40%	100%
V5BAH7	Trypanosoma cruzi	67%	100%
V5BQA9	Trypanosoma cruzi	33%	100%
V5BSG2	Trypanosoma cruzi	34%	100%