DNAJ family-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ family-like protein

Species:

Leishmania mexicana

UniProt:

E9B4A9_LEIMU

TriTrypDb:

LmxM.32.2690

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4A9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.748
CLV_C14_Caspase3-7	238	242	PF00656	0.592
CLV_NRD_NRD_1	254	256	PF00675	0.658
CLV_NRD_NRD_1	81	83	PF00675	0.358
CLV_NRD_NRD_1	85	87	PF00675	0.329
CLV_PCSK_KEX2_1	256	258	PF00082	0.619
CLV_PCSK_KEX2_1	81	83	PF00082	0.358
CLV_PCSK_KEX2_1	85	87	PF00082	0.329
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.619
CLV_PCSK_PC7_1	81	87	PF00082	0.444
CLV_PCSK_SKI1_1	102	106	PF00082	0.416
CLV_PCSK_SKI1_1	172	176	PF00082	0.591
CLV_Separin_Metazoa	211	215	PF03568	0.619
DEG_APCC_KENBOX_2	34	38	PF00400	0.541
DEG_Nend_UBRbox_3	1	3	PF02207	0.498
DEG_SCF_FBW7_1	49	55	PF00400	0.659
DEG_SPOP_SBC_1	6	10	PF00917	0.686
DOC_CKS1_1	201	206	PF01111	0.494
DOC_CKS1_1	49	54	PF01111	0.647
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.644
DOC_MAPK_gen_1	226	233	PF00069	0.517
DOC_MAPK_gen_1	81	91	PF00069	0.348
DOC_MAPK_MEF2A_6	82	91	PF00069	0.444
DOC_PP2B_PxIxI_1	72	78	PF00149	0.557
DOC_USP7_MATH_1	135	139	PF00917	0.767
DOC_USP7_MATH_1	243	247	PF00917	0.733
DOC_USP7_MATH_1	52	56	PF00917	0.662
DOC_USP7_MATH_1	6	10	PF00917	0.714
DOC_USP7_UBL2_3	228	232	PF12436	0.594
DOC_WW_Pin1_4	200	205	PF00397	0.491
DOC_WW_Pin1_4	27	32	PF00397	0.746
DOC_WW_Pin1_4	48	53	PF00397	0.637
LIG_14-3-3_CanoR_1	192	201	PF00244	0.575
LIG_14-3-3_CanoR_1	85	90	PF00244	0.441
LIG_BRCT_BRCA1_1	87	91	PF00533	0.401
LIG_FHA_1	196	202	PF00498	0.489
LIG_FHA_1	225	231	PF00498	0.642
LIG_FHA_1	243	249	PF00498	0.601
LIG_FHA_2	108	114	PF00498	0.375
LIG_FHA_2	125	131	PF00498	0.614
LIG_LIR_Gen_1	203	213	PF02991	0.602
LIG_LIR_Gen_1	39	49	PF02991	0.493
LIG_LIR_Nem_3	39	44	PF02991	0.466
LIG_SH2_CRK	84	88	PF00017	0.444
LIG_SH2_STAT5	124	127	PF00017	0.572
LIG_SH2_STAT5	43	46	PF00017	0.512
LIG_TRAF2_1	141	144	PF00917	0.719
LIG_TRAF2_1	182	185	PF00917	0.547
LIG_WRC_WIRS_1	38	43	PF05994	0.599
MOD_CK1_1	195	201	PF00069	0.590
MOD_CK1_1	9	15	PF00069	0.700
MOD_CK2_1	107	113	PF00069	0.481
MOD_CK2_1	124	130	PF00069	0.552
MOD_CK2_1	5	11	PF00069	0.710
MOD_GlcNHglycan	11	14	PF01048	0.778
MOD_GlcNHglycan	137	140	PF01048	0.716
MOD_GlcNHglycan	238	241	PF01048	0.655
MOD_GlcNHglycan	55	58	PF01048	0.691
MOD_GlcNHglycan	63	66	PF01048	0.732
MOD_GSK3_1	1	8	PF00069	0.706
MOD_GSK3_1	107	114	PF00069	0.429
MOD_GSK3_1	192	199	PF00069	0.630
MOD_GSK3_1	27	34	PF00069	0.643
MOD_GSK3_1	48	55	PF00069	0.583
MOD_N-GLC_1	1	6	PF02516	0.624
MOD_NEK2_1	1	6	PF00069	0.628
MOD_NEK2_1	197	202	PF00069	0.630
MOD_PKA_1	85	91	PF00069	0.444
MOD_PKA_2	85	91	PF00069	0.441
MOD_Plk_4	111	117	PF00069	0.414
MOD_Plk_4	124	130	PF00069	0.494
MOD_ProDKin_1	200	206	PF00069	0.492
MOD_ProDKin_1	27	33	PF00069	0.726
MOD_ProDKin_1	48	54	PF00069	0.647
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.577
TRG_ENDOCYTIC_2	43	46	PF00928	0.416
TRG_ENDOCYTIC_2	84	87	PF00928	0.344
TRG_ER_diArg_1	80	82	PF00400	0.358
TRG_ER_diArg_1	84	86	PF00400	0.329
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Q0	Leptomonas seymouri	62%	100%
A0A1X0NSQ5	Trypanosomatidae	35%	100%
A0A3Q8IH27	Leishmania donovani	89%	99%
A4HLY0	Leishmania braziliensis	78%	100%
A4I9A9	Leishmania infantum	89%	99%
C9ZJB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q3R7	Leishmania major	90%	100%
V5BF66	Trypanosoma cruzi	38%	100%