Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4A8_LEIMU

TriTrypDb:

LmxM.32.2680

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.484
CLV_C14_Caspase3-7	23	27	PF00656	0.585
CLV_C14_Caspase3-7	244	248	PF00656	0.484
CLV_C14_Caspase3-7	509	513	PF00656	0.566
CLV_C14_Caspase3-7	738	742	PF00656	0.481
CLV_NRD_NRD_1	233	235	PF00675	0.592
CLV_NRD_NRD_1	240	242	PF00675	0.604
CLV_NRD_NRD_1	305	307	PF00675	0.620
CLV_NRD_NRD_1	429	431	PF00675	0.439
CLV_NRD_NRD_1	443	445	PF00675	0.517
CLV_NRD_NRD_1	486	488	PF00675	0.697
CLV_NRD_NRD_1	489	491	PF00675	0.709
CLV_NRD_NRD_1	50	52	PF00675	0.710
CLV_NRD_NRD_1	567	569	PF00675	0.499
CLV_NRD_NRD_1	629	631	PF00675	0.656
CLV_NRD_NRD_1	709	711	PF00675	0.748
CLV_NRD_NRD_1	724	726	PF00675	0.531
CLV_NRD_NRD_1	766	768	PF00675	0.619
CLV_NRD_NRD_1	769	771	PF00675	0.609
CLV_NRD_NRD_1	83	85	PF00675	0.696
CLV_NRD_NRD_1	95	97	PF00675	0.591
CLV_PCSK_FUR_1	238	242	PF00082	0.534
CLV_PCSK_FUR_1	487	491	PF00082	0.675
CLV_PCSK_FUR_1	767	771	PF00082	0.680
CLV_PCSK_FUR_1	93	97	PF00082	0.615
CLV_PCSK_KEX2_1	233	235	PF00082	0.592
CLV_PCSK_KEX2_1	240	242	PF00082	0.604
CLV_PCSK_KEX2_1	305	307	PF00082	0.620
CLV_PCSK_KEX2_1	429	431	PF00082	0.440
CLV_PCSK_KEX2_1	443	445	PF00082	0.515
CLV_PCSK_KEX2_1	486	488	PF00082	0.716
CLV_PCSK_KEX2_1	489	491	PF00082	0.732
CLV_PCSK_KEX2_1	50	52	PF00082	0.710
CLV_PCSK_KEX2_1	629	631	PF00082	0.656
CLV_PCSK_KEX2_1	709	711	PF00082	0.744
CLV_PCSK_KEX2_1	723	725	PF00082	0.573
CLV_PCSK_KEX2_1	769	771	PF00082	0.663
CLV_PCSK_KEX2_1	83	85	PF00082	0.623
CLV_PCSK_KEX2_1	87	89	PF00082	0.637
CLV_PCSK_KEX2_1	95	97	PF00082	0.668
CLV_PCSK_PC1ET2_1	769	771	PF00082	0.634
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.587
CLV_PCSK_PC7_1	765	771	PF00082	0.616
CLV_PCSK_PC7_1	83	89	PF00082	0.653
CLV_PCSK_SKI1_1	136	140	PF00082	0.560
CLV_PCSK_SKI1_1	19	23	PF00082	0.493
CLV_PCSK_SKI1_1	345	349	PF00082	0.543
CLV_PCSK_SKI1_1	433	437	PF00082	0.444
CLV_PCSK_SKI1_1	72	76	PF00082	0.499
DEG_APCC_DBOX_1	389	397	PF00400	0.621
DEG_SPOP_SBC_1	124	128	PF00917	0.535
DEG_SPOP_SBC_1	40	44	PF00917	0.514
DEG_SPOP_SBC_1	505	509	PF00917	0.630
DEG_SPOP_SBC_1	613	617	PF00917	0.574
DOC_ANK_TNKS_1	109	116	PF00023	0.589
DOC_CYCLIN_RxL_1	427	439	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	597	603	PF00134	0.587
DOC_MAPK_gen_1	131	139	PF00069	0.532
DOC_MAPK_gen_1	429	436	PF00069	0.422
DOC_MAPK_gen_1	486	496	PF00069	0.576
DOC_MAPK_gen_1	563	573	PF00069	0.353
DOC_PIKK_1	731	739	PF02985	0.681
DOC_PP1_RVXF_1	17	23	PF00149	0.491
DOC_PP4_FxxP_1	659	662	PF00568	0.509
DOC_USP7_MATH_1	124	128	PF00917	0.633
DOC_USP7_MATH_1	151	155	PF00917	0.757
DOC_USP7_MATH_1	161	165	PF00917	0.787
DOC_USP7_MATH_1	281	285	PF00917	0.705
DOC_USP7_MATH_1	38	42	PF00917	0.520
DOC_USP7_MATH_1	450	454	PF00917	0.595
DOC_USP7_MATH_1	482	486	PF00917	0.549
DOC_USP7_MATH_1	505	509	PF00917	0.676
DOC_USP7_MATH_1	649	653	PF00917	0.744
DOC_USP7_MATH_1	654	658	PF00917	0.581
DOC_USP7_MATH_1	668	672	PF00917	0.420
DOC_USP7_MATH_1	747	751	PF00917	0.651
DOC_USP7_MATH_1	776	780	PF00917	0.772
DOC_USP7_MATH_1	794	798	PF00917	0.525
DOC_USP7_UBL2_3	433	437	PF12436	0.520
DOC_WW_Pin1_4	153	158	PF00397	0.647
DOC_WW_Pin1_4	277	282	PF00397	0.724
DOC_WW_Pin1_4	59	64	PF00397	0.640
DOC_WW_Pin1_4	596	601	PF00397	0.572
DOC_WW_Pin1_4	614	619	PF00397	0.735
DOC_WW_Pin1_4	658	663	PF00397	0.548
DOC_WW_Pin1_4	9	14	PF00397	0.497
LIG_14-3-3_CanoR_1	143	153	PF00244	0.650
LIG_14-3-3_CanoR_1	197	206	PF00244	0.628
LIG_14-3-3_CanoR_1	240	250	PF00244	0.620
LIG_14-3-3_CanoR_1	282	287	PF00244	0.674
LIG_14-3-3_CanoR_1	340	344	PF00244	0.563
LIG_14-3-3_CanoR_1	345	355	PF00244	0.557
LIG_14-3-3_CanoR_1	37	47	PF00244	0.698
LIG_14-3-3_CanoR_1	404	410	PF00244	0.610
LIG_14-3-3_CanoR_1	718	722	PF00244	0.662
LIG_14-3-3_CanoR_1	775	781	PF00244	0.682
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_BRCT_BRCA1_1	189	193	PF00533	0.705
LIG_BRCT_BRCA1_1	206	210	PF00533	0.566
LIG_BRCT_BRCA1_1	655	659	PF00533	0.550
LIG_CtBP_PxDLS_1	621	625	PF00389	0.615
LIG_deltaCOP1_diTrp_1	439	448	PF00928	0.509
LIG_EH1_1	819	827	PF00400	0.505
LIG_FHA_1	15	21	PF00498	0.502
LIG_FHA_1	154	160	PF00498	0.607
LIG_FHA_1	186	192	PF00498	0.554
LIG_FHA_1	257	263	PF00498	0.489
LIG_FHA_1	319	325	PF00498	0.645
LIG_FHA_1	371	377	PF00498	0.545
LIG_FHA_1	523	529	PF00498	0.646
LIG_FHA_1	547	553	PF00498	0.385
LIG_FHA_1	750	756	PF00498	0.567
LIG_FHA_2	198	204	PF00498	0.502
LIG_FHA_2	409	415	PF00498	0.458
LIG_FHA_2	676	682	PF00498	0.592
LIG_FHA_2	73	79	PF00498	0.493
LIG_Integrin_RGD_1	539	541	PF01839	0.431
LIG_Integrin_RGD_1	630	632	PF01839	0.594
LIG_Integrin_RGD_1	772	774	PF01839	0.607
LIG_LIR_Apic_2	656	662	PF02991	0.525
LIG_LIR_Gen_1	2	8	PF02991	0.517
LIG_LIR_Gen_1	458	469	PF02991	0.458
LIG_LIR_Gen_1	678	688	PF02991	0.657
LIG_LIR_Nem_3	190	196	PF02991	0.591
LIG_LIR_Nem_3	2	7	PF02991	0.521
LIG_LIR_Nem_3	354	358	PF02991	0.530
LIG_LIR_Nem_3	458	464	PF02991	0.495
LIG_LIR_Nem_3	602	606	PF02991	0.537
LIG_LIR_Nem_3	678	683	PF02991	0.647
LIG_LIR_Nem_3	828	834	PF02991	0.502
LIG_MLH1_MIPbox_1	655	659	PF16413	0.550
LIG_MYND_1	359	363	PF01753	0.535
LIG_Pex14_2	816	820	PF04695	0.368
LIG_REV1ctd_RIR_1	66	76	PF16727	0.565
LIG_SH2_STAP1	4	8	PF00017	0.505
LIG_SH2_STAP1	735	739	PF00017	0.628
LIG_SH2_STAT3	45	48	PF00017	0.691
LIG_SH2_STAT5	125	128	PF00017	0.543
LIG_SH2_STAT5	331	334	PF00017	0.600
LIG_SH3_3	154	160	PF00018	0.517
LIG_SH3_3	353	359	PF00018	0.529
LIG_SH3_3	615	621	PF00018	0.796
LIG_SH3_3	790	796	PF00018	0.603
LIG_SUMO_SIM_par_1	362	367	PF11976	0.609
LIG_TRAF2_1	309	312	PF00917	0.536
LIG_TRAF2_1	411	414	PF00917	0.587
LIG_WRC_WIRS_1	655	660	PF05994	0.619
LIG_WRC_WIRS_1	817	822	PF05994	0.501
MOD_CDK_SPK_2	277	282	PF00069	0.555
MOD_CK1_1	109	115	PF00069	0.585
MOD_CK1_1	123	129	PF00069	0.666
MOD_CK1_1	408	414	PF00069	0.518
MOD_CK1_1	41	47	PF00069	0.612
MOD_CK1_1	507	513	PF00069	0.623
MOD_CK1_1	522	528	PF00069	0.766
MOD_CK1_1	535	541	PF00069	0.510
MOD_CK1_1	559	565	PF00069	0.562
MOD_CK1_1	599	605	PF00069	0.697
MOD_CK1_1	620	626	PF00069	0.643
MOD_CK1_1	749	755	PF00069	0.621
MOD_CK1_1	82	88	PF00069	0.644
MOD_CK1_1	89	95	PF00069	0.643
MOD_CK2_1	408	414	PF00069	0.633
MOD_CK2_1	526	532	PF00069	0.565
MOD_CK2_1	559	565	PF00069	0.525
MOD_CK2_1	675	681	PF00069	0.655
MOD_CK2_1	72	78	PF00069	0.495
MOD_Cter_Amidation	487	490	PF01082	0.575
MOD_GlcNHglycan	104	107	PF01048	0.586
MOD_GlcNHglycan	111	114	PF01048	0.812
MOD_GlcNHglycan	122	125	PF01048	0.610
MOD_GlcNHglycan	162	166	PF01048	0.649
MOD_GlcNHglycan	169	172	PF01048	0.662
MOD_GlcNHglycan	179	183	PF01048	0.587
MOD_GlcNHglycan	211	214	PF01048	0.716
MOD_GlcNHglycan	227	230	PF01048	0.499
MOD_GlcNHglycan	393	396	PF01048	0.592
MOD_GlcNHglycan	480	483	PF01048	0.647
MOD_GlcNHglycan	608	611	PF01048	0.808
MOD_GlcNHglycan	63	66	PF01048	0.731
MOD_GlcNHglycan	634	637	PF01048	0.577
MOD_GlcNHglycan	645	648	PF01048	0.599
MOD_GlcNHglycan	651	654	PF01048	0.580
MOD_GlcNHglycan	670	673	PF01048	0.442
MOD_GlcNHglycan	711	714	PF01048	0.751
MOD_GlcNHglycan	749	752	PF01048	0.602
MOD_GSK3_1	102	109	PF00069	0.543
MOD_GSK3_1	113	120	PF00069	0.663
MOD_GSK3_1	151	158	PF00069	0.648
MOD_GSK3_1	163	170	PF00069	0.687
MOD_GSK3_1	185	192	PF00069	0.656
MOD_GSK3_1	205	212	PF00069	0.707
MOD_GSK3_1	225	232	PF00069	0.653
MOD_GSK3_1	236	243	PF00069	0.589
MOD_GSK3_1	277	284	PF00069	0.710
MOD_GSK3_1	339	346	PF00069	0.601
MOD_GSK3_1	370	377	PF00069	0.576
MOD_GSK3_1	399	406	PF00069	0.613
MOD_GSK3_1	408	415	PF00069	0.694
MOD_GSK3_1	451	458	PF00069	0.562
MOD_GSK3_1	478	485	PF00069	0.569
MOD_GSK3_1	504	511	PF00069	0.608
MOD_GSK3_1	519	526	PF00069	0.569
MOD_GSK3_1	542	549	PF00069	0.433
MOD_GSK3_1	55	62	PF00069	0.570
MOD_GSK3_1	613	620	PF00069	0.675
MOD_GSK3_1	645	652	PF00069	0.639
MOD_GSK3_1	654	661	PF00069	0.705
MOD_GSK3_1	690	697	PF00069	0.697
MOD_GSK3_1	74	81	PF00069	0.633
MOD_GSK3_1	745	752	PF00069	0.605
MOD_GSK3_1	82	89	PF00069	0.743
MOD_LATS_1	99	105	PF00433	0.533
MOD_N-GLC_1	326	331	PF02516	0.443
MOD_N-GLC_1	38	43	PF02516	0.693
MOD_N-GLC_1	690	695	PF02516	0.691
MOD_N-GLC_1	89	94	PF02516	0.611
MOD_N-GLC_2	235	237	PF02516	0.570
MOD_NEK2_1	102	107	PF00069	0.570
MOD_NEK2_1	117	122	PF00069	0.559
MOD_NEK2_1	196	201	PF00069	0.707
MOD_NEK2_1	209	214	PF00069	0.514
MOD_NEK2_1	534	539	PF00069	0.558
MOD_NEK2_1	542	547	PF00069	0.461
MOD_NEK2_1	553	558	PF00069	0.383
MOD_NEK2_1	816	821	PF00069	0.468
MOD_NEK2_2	326	331	PF00069	0.443
MOD_NEK2_2	654	659	PF00069	0.515
MOD_OFUCOSY	255	260	PF10250	0.466
MOD_PIKK_1	399	405	PF00454	0.556
MOD_PIKK_1	409	415	PF00454	0.453
MOD_PIKK_1	542	548	PF00454	0.405
MOD_PK_1	282	288	PF00069	0.609
MOD_PK_1	548	554	PF00069	0.453
MOD_PKA_1	240	246	PF00069	0.599
MOD_PKA_1	709	715	PF00069	0.698
MOD_PKA_1	83	89	PF00069	0.610
MOD_PKA_2	109	115	PF00069	0.716
MOD_PKA_2	145	151	PF00069	0.629
MOD_PKA_2	196	202	PF00069	0.620
MOD_PKA_2	240	246	PF00069	0.751
MOD_PKA_2	281	287	PF00069	0.666
MOD_PKA_2	339	345	PF00069	0.547
MOD_PKA_2	403	409	PF00069	0.485
MOD_PKA_2	505	511	PF00069	0.670
MOD_PKA_2	55	61	PF00069	0.527
MOD_PKA_2	709	715	PF00069	0.754
MOD_PKA_2	717	723	PF00069	0.626
MOD_PKA_2	776	782	PF00069	0.726
MOD_PKA_2	82	88	PF00069	0.650
MOD_PKB_1	238	246	PF00069	0.597
MOD_PKB_1	54	62	PF00069	0.707
MOD_PKB_1	723	731	PF00069	0.615
MOD_Plk_1	523	529	PF00069	0.587
MOD_Plk_1	542	548	PF00069	0.435
MOD_Plk_1	587	593	PF00069	0.386
MOD_Plk_4	163	169	PF00069	0.635
MOD_Plk_4	205	211	PF00069	0.545
MOD_Plk_4	249	255	PF00069	0.478
MOD_Plk_4	282	288	PF00069	0.560
MOD_Plk_4	548	554	PF00069	0.453
MOD_Plk_4	654	660	PF00069	0.545
MOD_Plk_4	694	700	PF00069	0.627
MOD_Plk_4	776	782	PF00069	0.676
MOD_Plk_4	816	822	PF00069	0.476
MOD_ProDKin_1	153	159	PF00069	0.644
MOD_ProDKin_1	277	283	PF00069	0.725
MOD_ProDKin_1	59	65	PF00069	0.637
MOD_ProDKin_1	596	602	PF00069	0.573
MOD_ProDKin_1	614	620	PF00069	0.735
MOD_ProDKin_1	658	664	PF00069	0.543
MOD_ProDKin_1	9	15	PF00069	0.496
MOD_SUMO_for_1	436	439	PF00179	0.520
MOD_SUMO_rev_2	414	422	PF00179	0.368
MOD_SUMO_rev_2	562	571	PF00179	0.535
MOD_SUMO_rev_2	732	742	PF00179	0.627
TRG_ENDOCYTIC_2	134	137	PF00928	0.534
TRG_ENDOCYTIC_2	4	7	PF00928	0.509
TRG_ENDOCYTIC_2	431	434	PF00928	0.441
TRG_ER_diArg_1	130	133	PF00400	0.565
TRG_ER_diArg_1	238	241	PF00400	0.615
TRG_ER_diArg_1	305	307	PF00400	0.613
TRG_ER_diArg_1	429	431	PF00400	0.444
TRG_ER_diArg_1	442	444	PF00400	0.510
TRG_ER_diArg_1	486	489	PF00400	0.704
TRG_ER_diArg_1	496	499	PF00400	0.609
TRG_ER_diArg_1	628	630	PF00400	0.779
TRG_ER_diArg_1	723	725	PF00400	0.622
TRG_ER_diArg_1	93	96	PF00400	0.616
TRG_NES_CRM1_1	811	823	PF08389	0.686
TRG_NLS_MonoCore_2	766	771	PF00514	0.682
TRG_NLS_MonoExtC_3	766	771	PF00514	0.606
TRG_NLS_MonoExtN_4	765	772	PF00514	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I487	Leptomonas seymouri	39%	95%
A0A3Q8IKF4	Leishmania donovani	82%	100%
A4HLX9	Leishmania braziliensis	61%	99%
A4I9A8	Leishmania infantum	82%	100%
Q4Q3R8	Leishmania major	82%	100%