TMF_TATA_bd domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4A7_LEIMU

TriTrypDb:

LmxM.32.2670

Length:

1232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4A7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.554
CLV_C14_Caspase3-7	897	901	PF00656	0.528
CLV_MEL_PAP_1	367	373	PF00089	0.558
CLV_NRD_NRD_1	1016	1018	PF00675	0.482
CLV_NRD_NRD_1	1054	1056	PF00675	0.531
CLV_NRD_NRD_1	1092	1094	PF00675	0.509
CLV_NRD_NRD_1	1136	1138	PF00675	0.706
CLV_NRD_NRD_1	1140	1142	PF00675	0.644
CLV_NRD_NRD_1	206	208	PF00675	0.608
CLV_NRD_NRD_1	299	301	PF00675	0.370
CLV_NRD_NRD_1	494	496	PF00675	0.410
CLV_NRD_NRD_1	528	530	PF00675	0.497
CLV_NRD_NRD_1	789	791	PF00675	0.715
CLV_NRD_NRD_1	92	94	PF00675	0.717
CLV_PCSK_KEX2_1	1016	1018	PF00082	0.520
CLV_PCSK_KEX2_1	1075	1077	PF00082	0.516
CLV_PCSK_KEX2_1	1136	1138	PF00082	0.697
CLV_PCSK_KEX2_1	1140	1142	PF00082	0.637
CLV_PCSK_KEX2_1	205	207	PF00082	0.611
CLV_PCSK_KEX2_1	494	496	PF00082	0.454
CLV_PCSK_KEX2_1	530	532	PF00082	0.408
CLV_PCSK_KEX2_1	666	668	PF00082	0.596
CLV_PCSK_KEX2_1	711	713	PF00082	0.599
CLV_PCSK_KEX2_1	789	791	PF00082	0.695
CLV_PCSK_KEX2_1	92	94	PF00082	0.717
CLV_PCSK_KEX2_1	990	992	PF00082	0.435
CLV_PCSK_PC1ET2_1	1075	1077	PF00082	0.532
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.391
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.575
CLV_PCSK_PC1ET2_1	711	713	PF00082	0.567
CLV_PCSK_PC1ET2_1	990	992	PF00082	0.435
CLV_PCSK_PC7_1	1136	1142	PF00082	0.746
CLV_PCSK_PC7_1	490	496	PF00082	0.413
CLV_PCSK_SKI1_1	1055	1059	PF00082	0.537
CLV_PCSK_SKI1_1	1141	1145	PF00082	0.731
CLV_PCSK_SKI1_1	347	351	PF00082	0.468
CLV_PCSK_SKI1_1	361	365	PF00082	0.465
CLV_PCSK_SKI1_1	516	520	PF00082	0.443
CLV_PCSK_SKI1_1	590	594	PF00082	0.619
CLV_PCSK_SKI1_1	598	602	PF00082	0.502
CLV_PCSK_SKI1_1	630	634	PF00082	0.612
CLV_PCSK_SKI1_1	893	897	PF00082	0.493
CLV_PCSK_SKI1_1	93	97	PF00082	0.612
DEG_Nend_Nbox_1	1	3	PF02207	0.561
DEG_SCF_FBW7_1	409	416	PF00400	0.692
DEG_SPOP_SBC_1	1192	1196	PF00917	0.681
DEG_SPOP_SBC_1	186	190	PF00917	0.578
DOC_CKS1_1	264	269	PF01111	0.705
DOC_CYCLIN_RxL_1	627	637	PF00134	0.546
DOC_CYCLIN_RxL_1	89	100	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	255	261	PF00134	0.495
DOC_MAPK_gen_1	300	308	PF00069	0.358
DOC_MAPK_gen_1	880	887	PF00069	0.466
DOC_MAPK_MEF2A_6	755	763	PF00069	0.573
DOC_PP1_RVXF_1	1160	1167	PF00149	0.564
DOC_PP2B_LxvP_1	255	258	PF13499	0.663
DOC_PP4_FxxP_1	1211	1214	PF00568	0.771
DOC_PP4_FxxP_1	244	247	PF00568	0.605
DOC_USP7_MATH_1	109	113	PF00917	0.798
DOC_USP7_MATH_1	1129	1133	PF00917	0.638
DOC_USP7_MATH_1	1180	1184	PF00917	0.714
DOC_USP7_MATH_1	1187	1191	PF00917	0.650
DOC_USP7_MATH_1	119	123	PF00917	0.613
DOC_USP7_MATH_1	1192	1196	PF00917	0.606
DOC_USP7_MATH_1	1205	1209	PF00917	0.586
DOC_USP7_MATH_1	1212	1216	PF00917	0.601
DOC_USP7_MATH_1	1225	1229	PF00917	0.502
DOC_USP7_MATH_1	175	179	PF00917	0.692
DOC_USP7_MATH_1	185	189	PF00917	0.629
DOC_USP7_MATH_1	199	203	PF00917	0.699
DOC_USP7_MATH_1	330	334	PF00917	0.539
DOC_USP7_MATH_1	404	408	PF00917	0.465
DOC_USP7_MATH_1	431	435	PF00917	0.522
DOC_USP7_MATH_1	559	563	PF00917	0.662
DOC_USP7_MATH_1	566	570	PF00917	0.485
DOC_USP7_MATH_1	733	737	PF00917	0.681
DOC_USP7_UBL2_3	1056	1060	PF12436	0.544
DOC_WW_Pin1_4	1188	1193	PF00397	0.622
DOC_WW_Pin1_4	1195	1200	PF00397	0.720
DOC_WW_Pin1_4	1210	1215	PF00397	0.635
DOC_WW_Pin1_4	133	138	PF00397	0.750
DOC_WW_Pin1_4	15	20	PF00397	0.597
DOC_WW_Pin1_4	156	161	PF00397	0.602
DOC_WW_Pin1_4	171	176	PF00397	0.781
DOC_WW_Pin1_4	189	194	PF00397	0.577
DOC_WW_Pin1_4	214	219	PF00397	0.746
DOC_WW_Pin1_4	223	228	PF00397	0.654
DOC_WW_Pin1_4	233	238	PF00397	0.477
DOC_WW_Pin1_4	243	248	PF00397	0.450
DOC_WW_Pin1_4	263	268	PF00397	0.551
DOC_WW_Pin1_4	409	414	PF00397	0.758
LIG_14-3-3_CanoR_1	1076	1085	PF00244	0.471
LIG_14-3-3_CanoR_1	25	32	PF00244	0.567
LIG_14-3-3_CanoR_1	382	386	PF00244	0.554
LIG_14-3-3_CanoR_1	40	49	PF00244	0.531
LIG_14-3-3_CanoR_1	425	435	PF00244	0.558
LIG_14-3-3_CanoR_1	516	524	PF00244	0.504
LIG_14-3-3_CanoR_1	598	607	PF00244	0.481
LIG_14-3-3_CanoR_1	65	72	PF00244	0.562
LIG_14-3-3_CanoR_1	768	772	PF00244	0.607
LIG_14-3-3_CterR_2	1229	1232	PF00244	0.727
LIG_Actin_WH2_2	367	384	PF00022	0.552
LIG_BIR_III_4	873	877	PF00653	0.411
LIG_BRCT_BRCA1_1	1207	1211	PF00533	0.783
LIG_deltaCOP1_diTrp_1	4	12	PF00928	0.496
LIG_FAT_LD_1	759	767	PF03623	0.576
LIG_FHA_1	276	282	PF00498	0.464
LIG_FHA_1	4	10	PF00498	0.491
LIG_FHA_1	441	447	PF00498	0.562
LIG_FHA_1	448	454	PF00498	0.521
LIG_FHA_1	518	524	PF00498	0.550
LIG_FHA_1	553	559	PF00498	0.499
LIG_FHA_1	682	688	PF00498	0.435
LIG_FHA_1	756	762	PF00498	0.490
LIG_FHA_1	832	838	PF00498	0.590
LIG_FHA_1	974	980	PF00498	0.346
LIG_FHA_2	1069	1075	PF00498	0.544
LIG_FHA_2	172	178	PF00498	0.727
LIG_FHA_2	363	369	PF00498	0.554
LIG_FHA_2	46	52	PF00498	0.534
LIG_FHA_2	65	71	PF00498	0.573
LIG_FHA_2	657	663	PF00498	0.517
LIG_FHA_2	681	687	PF00498	0.577
LIG_FHA_2	727	733	PF00498	0.649
LIG_FHA_2	920	926	PF00498	0.441
LIG_FHA_2	937	943	PF00498	0.511
LIG_FHA_2	955	961	PF00498	0.347
LIG_GBD_Chelix_1	1082	1090	PF00786	0.339
LIG_HCF-1_HBM_1	615	618	PF13415	0.641
LIG_LIR_Apic_2	1208	1214	PF02991	0.780
LIG_LIR_Apic_2	243	247	PF02991	0.582
LIG_LIR_Gen_1	1161	1168	PF02991	0.501
LIG_LIR_Nem_3	1113	1119	PF02991	0.638
LIG_LIR_Nem_3	1161	1166	PF02991	0.502
LIG_LIR_Nem_3	873	878	PF02991	0.464
LIG_NRBOX	1102	1108	PF00104	0.454
LIG_NRBOX	827	833	PF00104	0.501
LIG_PCNA_yPIPBox_3	905	917	PF02747	0.522
LIG_Pex14_1	853	857	PF04695	0.480
LIG_SH2_NCK_1	118	122	PF00017	0.753
LIG_SH2_NCK_1	618	622	PF00017	0.569
LIG_SH2_PTP2	1116	1119	PF00017	0.595
LIG_SH2_SRC	1085	1088	PF00017	0.325
LIG_SH2_STAP1	317	321	PF00017	0.460
LIG_SH2_STAT5	1085	1088	PF00017	0.325
LIG_SH2_STAT5	1116	1119	PF00017	0.595
LIG_SH3_3	1120	1126	PF00018	0.595
LIG_SH3_3	124	130	PF00018	0.684
LIG_SH3_3	134	140	PF00018	0.513
LIG_SUMO_SIM_anti_2	741	747	PF11976	0.594
LIG_SUMO_SIM_anti_2	758	764	PF11976	0.388
LIG_SUMO_SIM_par_1	905	911	PF11976	0.456
LIG_TRAF2_1	1112	1115	PF00917	0.483
LIG_TRAF2_1	419	422	PF00917	0.557
LIG_TRAF2_1	438	441	PF00917	0.351
LIG_TRAF2_1	571	574	PF00917	0.586
LIG_TRAF2_1	950	953	PF00917	0.609
LIG_TRAF2_1	964	967	PF00917	0.411
LIG_WRC_WIRS_1	9	14	PF05994	0.490
MOD_CK1_1	1069	1075	PF00069	0.641
MOD_CK1_1	1171	1177	PF00069	0.707
MOD_CK1_1	1194	1200	PF00069	0.767
MOD_CK1_1	1210	1216	PF00069	0.556
MOD_CK1_1	122	128	PF00069	0.757
MOD_CK1_1	131	137	PF00069	0.548
MOD_CK1_1	138	144	PF00069	0.615
MOD_CK1_1	188	194	PF00069	0.645
MOD_CK1_1	233	239	PF00069	0.603
MOD_CK1_1	243	249	PF00069	0.524
MOD_CK1_1	407	413	PF00069	0.737
MOD_CK1_1	562	568	PF00069	0.650
MOD_CK1_1	818	824	PF00069	0.502
MOD_CK1_1	972	978	PF00069	0.412
MOD_CK2_1	171	177	PF00069	0.720
MOD_CK2_1	25	31	PF00069	0.637
MOD_CK2_1	362	368	PF00069	0.556
MOD_CK2_1	45	51	PF00069	0.600
MOD_CK2_1	634	640	PF00069	0.575
MOD_CK2_1	656	662	PF00069	0.522
MOD_CK2_1	680	686	PF00069	0.585
MOD_CK2_1	726	732	PF00069	0.645
MOD_CK2_1	8	14	PF00069	0.490
MOD_CK2_1	82	88	PF00069	0.627
MOD_CK2_1	919	925	PF00069	0.428
MOD_CK2_1	936	942	PF00069	0.519
MOD_CK2_1	947	953	PF00069	0.421
MOD_CK2_1	998	1004	PF00069	0.476
MOD_CMANNOS	2	5	PF00535	0.486
MOD_GlcNHglycan	1103	1106	PF01048	0.459
MOD_GlcNHglycan	1130	1134	PF01048	0.586
MOD_GlcNHglycan	1148	1151	PF01048	0.690
MOD_GlcNHglycan	1172	1176	PF01048	0.704
MOD_GlcNHglycan	1214	1217	PF01048	0.550
MOD_GlcNHglycan	122	125	PF01048	0.690
MOD_GlcNHglycan	201	204	PF01048	0.692
MOD_GlcNHglycan	230	233	PF01048	0.612
MOD_GlcNHglycan	237	240	PF01048	0.584
MOD_GlcNHglycan	249	252	PF01048	0.638
MOD_GlcNHglycan	28	31	PF01048	0.612
MOD_GlcNHglycan	332	335	PF01048	0.629
MOD_GlcNHglycan	406	409	PF01048	0.661
MOD_GlcNHglycan	483	487	PF01048	0.577
MOD_GlcNHglycan	559	562	PF01048	0.737
MOD_GlcNHglycan	568	571	PF01048	0.502
MOD_GlcNHglycan	636	639	PF01048	0.442
MOD_GlcNHglycan	690	693	PF01048	0.621
MOD_GlcNHglycan	73	76	PF01048	0.748
MOD_GlcNHglycan	735	738	PF01048	0.614
MOD_GlcNHglycan	817	820	PF01048	0.549
MOD_GlcNHglycan	84	87	PF01048	0.603
MOD_GlcNHglycan	900	903	PF01048	0.550
MOD_GSK3_1	1187	1194	PF00069	0.825
MOD_GSK3_1	119	126	PF00069	0.625
MOD_GSK3_1	1225	1232	PF00069	0.626
MOD_GSK3_1	129	136	PF00069	0.784
MOD_GSK3_1	161	168	PF00069	0.552
MOD_GSK3_1	171	178	PF00069	0.831
MOD_GSK3_1	185	192	PF00069	0.551
MOD_GSK3_1	219	226	PF00069	0.664
MOD_GSK3_1	228	235	PF00069	0.629
MOD_GSK3_1	243	250	PF00069	0.671
MOD_GSK3_1	290	297	PF00069	0.512
MOD_GSK3_1	4	11	PF00069	0.552
MOD_GSK3_1	409	416	PF00069	0.783
MOD_GSK3_1	41	48	PF00069	0.611
MOD_GSK3_1	478	485	PF00069	0.491
MOD_GSK3_1	540	547	PF00069	0.697
MOD_GSK3_1	548	555	PF00069	0.637
MOD_GSK3_1	562	569	PF00069	0.510
MOD_GSK3_1	814	821	PF00069	0.675
MOD_GSK3_1	82	89	PF00069	0.604
MOD_GSK3_1	827	834	PF00069	0.495
MOD_GSK3_1	894	901	PF00069	0.466
MOD_GSK3_1	969	976	PF00069	0.425
MOD_N-GLC_1	1180	1185	PF02516	0.709
MOD_N-GLC_1	738	743	PF02516	0.457
MOD_N-GLC_1	82	87	PF02516	0.508
MOD_N-GLC_1	863	868	PF02516	0.467
MOD_NEK2_1	1058	1063	PF00069	0.571
MOD_NEK2_1	230	235	PF00069	0.534
MOD_NEK2_1	381	386	PF00069	0.485
MOD_NEK2_1	552	557	PF00069	0.673
MOD_NEK2_1	969	974	PF00069	0.480
MOD_NEK2_2	431	436	PF00069	0.463
MOD_PIKK_1	1076	1082	PF00454	0.461
MOD_PIKK_1	1110	1116	PF00454	0.498
MOD_PIKK_1	1200	1206	PF00454	0.788
MOD_PIKK_1	163	169	PF00454	0.619
MOD_PIKK_1	275	281	PF00454	0.514
MOD_PIKK_1	441	447	PF00454	0.527
MOD_PIKK_1	517	523	PF00454	0.508
MOD_PIKK_1	542	548	PF00454	0.527
MOD_PIKK_1	656	662	PF00454	0.495
MOD_PIKK_1	998	1004	PF00454	0.476
MOD_PKA_2	104	110	PF00069	0.565
MOD_PKA_2	24	30	PF00069	0.633
MOD_PKA_2	381	387	PF00069	0.599
MOD_PKA_2	426	432	PF00069	0.530
MOD_PKA_2	634	640	PF00069	0.397
MOD_PKA_2	64	70	PF00069	0.660
MOD_PKA_2	681	687	PF00069	0.401
MOD_PKA_2	726	732	PF00069	0.628
MOD_PKA_2	767	773	PF00069	0.520
MOD_PKB_1	514	522	PF00069	0.451
MOD_PKB_1	790	798	PF00069	0.515
MOD_Plk_1	1042	1048	PF00069	0.492
MOD_Plk_1	1069	1075	PF00069	0.558
MOD_Plk_1	180	186	PF00069	0.724
MOD_Plk_1	290	296	PF00069	0.363
MOD_Plk_1	310	316	PF00069	0.394
MOD_Plk_1	413	419	PF00069	0.594
MOD_Plk_1	501	507	PF00069	0.383
MOD_Plk_1	540	546	PF00069	0.432
MOD_Plk_1	548	554	PF00069	0.471
MOD_Plk_1	738	744	PF00069	0.555
MOD_Plk_1	82	88	PF00069	0.543
MOD_Plk_1	853	859	PF00069	0.481
MOD_Plk_1	863	869	PF00069	0.466
MOD_Plk_1	883	889	PF00069	0.313
MOD_Plk_2-3	883	889	PF00069	0.469
MOD_Plk_2-3	919	925	PF00069	0.417
MOD_Plk_2-3	954	960	PF00069	0.600
MOD_Plk_2-3	995	1001	PF00069	0.475
MOD_Plk_4	123	129	PF00069	0.646
MOD_Plk_4	73	79	PF00069	0.569
MOD_Plk_4	770	776	PF00069	0.655
MOD_Plk_4	838	844	PF00069	0.460
MOD_ProDKin_1	1188	1194	PF00069	0.623
MOD_ProDKin_1	1195	1201	PF00069	0.719
MOD_ProDKin_1	1210	1216	PF00069	0.635
MOD_ProDKin_1	133	139	PF00069	0.751
MOD_ProDKin_1	15	21	PF00069	0.604
MOD_ProDKin_1	156	162	PF00069	0.604
MOD_ProDKin_1	171	177	PF00069	0.785
MOD_ProDKin_1	189	195	PF00069	0.578
MOD_ProDKin_1	214	220	PF00069	0.742
MOD_ProDKin_1	223	229	PF00069	0.655
MOD_ProDKin_1	233	239	PF00069	0.477
MOD_ProDKin_1	243	249	PF00069	0.449
MOD_ProDKin_1	263	269	PF00069	0.554
MOD_ProDKin_1	409	415	PF00069	0.758
MOD_SUMO_for_1	506	509	PF00179	0.548
MOD_SUMO_for_1	748	751	PF00179	0.489
MOD_SUMO_for_1	810	813	PF00179	0.531
MOD_SUMO_for_1	887	890	PF00179	0.601
MOD_SUMO_for_1	964	967	PF00179	0.610
MOD_SUMO_rev_2	462	467	PF00179	0.559
MOD_SUMO_rev_2	730	736	PF00179	0.726
MOD_SUMO_rev_2	747	756	PF00179	0.396
TRG_DiLeu_BaEn_1	1115	1120	PF01217	0.528
TRG_DiLeu_BaEn_1	977	982	PF01217	0.519
TRG_DiLeu_BaEn_4	574	580	PF01217	0.596
TRG_DiLeu_BaEn_4	652	658	PF01217	0.476
TRG_DiLeu_BaEn_4	953	959	PF01217	0.473
TRG_DiLeu_BaLyEn_6	821	826	PF01217	0.574
TRG_ENDOCYTIC_2	1116	1119	PF00928	0.595
TRG_ER_diArg_1	1016	1019	PF00400	0.486
TRG_ER_diArg_1	205	207	PF00400	0.521
TRG_ER_diArg_1	424	427	PF00400	0.470
TRG_ER_diArg_1	576	579	PF00400	0.665
TRG_ER_diArg_1	725	728	PF00400	0.641
TRG_ER_diArg_1	789	792	PF00400	0.615
TRG_ER_diArg_1	92	94	PF00400	0.730
TRG_ER_FFAT_2	238	250	PF00635	0.481
TRG_NES_CRM1_1	751	764	PF08389	0.501
TRG_Pf-PMV_PEXEL_1	1010	1014	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	1016	1020	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	598	602	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	630	634	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXK7	Leptomonas seymouri	44%	91%
A0A3Q8IGT3	Leishmania donovani	82%	100%
A4HLX8	Leishmania braziliensis	55%	97%
A4I9A7	Leishmania infantum	82%	100%
Q4Q3R9	Leishmania major	81%	100%