CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4A6_LEIMU

TriTrypDb:

LmxM.32.2660

Length:

1166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4A6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1106	1110	PF00656	0.608
CLV_C14_Caspase3-7	1161	1165	PF00656	0.693
CLV_C14_Caspase3-7	54	58	PF00656	0.521
CLV_C14_Caspase3-7	609	613	PF00656	0.686
CLV_C14_Caspase3-7	786	790	PF00656	0.546
CLV_C14_Caspase3-7	892	896	PF00656	0.748
CLV_NRD_NRD_1	1012	1014	PF00675	0.787
CLV_NRD_NRD_1	1085	1087	PF00675	0.633
CLV_NRD_NRD_1	1148	1150	PF00675	0.758
CLV_NRD_NRD_1	1152	1154	PF00675	0.767
CLV_NRD_NRD_1	120	122	PF00675	0.549
CLV_NRD_NRD_1	183	185	PF00675	0.530
CLV_NRD_NRD_1	196	198	PF00675	0.643
CLV_NRD_NRD_1	220	222	PF00675	0.622
CLV_NRD_NRD_1	376	378	PF00675	0.695
CLV_NRD_NRD_1	559	561	PF00675	0.566
CLV_NRD_NRD_1	59	61	PF00675	0.530
CLV_NRD_NRD_1	700	702	PF00675	0.552
CLV_NRD_NRD_1	773	775	PF00675	0.727
CLV_NRD_NRD_1	793	795	PF00675	0.513
CLV_NRD_NRD_1	917	919	PF00675	0.642
CLV_NRD_NRD_1	975	977	PF00675	0.691
CLV_NRD_NRD_1	982	984	PF00675	0.670
CLV_PCSK_FUR_1	1149	1153	PF00082	0.704
CLV_PCSK_KEX2_1	1012	1014	PF00082	0.787
CLV_PCSK_KEX2_1	1085	1087	PF00082	0.599
CLV_PCSK_KEX2_1	1148	1150	PF00082	0.766
CLV_PCSK_KEX2_1	1151	1153	PF00082	0.765
CLV_PCSK_KEX2_1	120	122	PF00082	0.549
CLV_PCSK_KEX2_1	183	185	PF00082	0.530
CLV_PCSK_KEX2_1	196	198	PF00082	0.643
CLV_PCSK_KEX2_1	219	221	PF00082	0.662
CLV_PCSK_KEX2_1	376	378	PF00082	0.696
CLV_PCSK_KEX2_1	559	561	PF00082	0.524
CLV_PCSK_KEX2_1	59	61	PF00082	0.530
CLV_PCSK_KEX2_1	700	702	PF00082	0.552
CLV_PCSK_KEX2_1	773	775	PF00082	0.727
CLV_PCSK_KEX2_1	793	795	PF00082	0.513
CLV_PCSK_KEX2_1	917	919	PF00082	0.643
CLV_PCSK_KEX2_1	982	984	PF00082	0.697
CLV_PCSK_PC7_1	1148	1154	PF00082	0.690
CLV_PCSK_SKI1_1	1128	1132	PF00082	0.738
CLV_PCSK_SKI1_1	206	210	PF00082	0.623
CLV_PCSK_SKI1_1	30	34	PF00082	0.485
CLV_PCSK_SKI1_1	473	477	PF00082	0.534
CLV_PCSK_SKI1_1	542	546	PF00082	0.545
CLV_PCSK_SKI1_1	631	635	PF00082	0.556
CLV_PCSK_SKI1_1	819	823	PF00082	0.642
DEG_APCC_DBOX_1	308	316	PF00400	0.676
DEG_APCC_DBOX_1	536	544	PF00400	0.556
DEG_SCF_FBW7_1	1022	1029	PF00400	0.531
DEG_SPOP_SBC_1	898	902	PF00917	0.452
DOC_ANK_TNKS_1	453	460	PF00023	0.555
DOC_ANK_TNKS_1	773	780	PF00023	0.731
DOC_CDC14_PxL_1	640	648	PF14671	0.743
DOC_CYCLIN_RxL_1	537	549	PF00134	0.556
DOC_CYCLIN_RxL_1	861	870	PF00134	0.675
DOC_CYCLIN_yCln2_LP_2	634	640	PF00134	0.647
DOC_MAPK_gen_1	1052	1060	PF00069	0.598
DOC_MAPK_gen_1	1148	1158	PF00069	0.719
DOC_MAPK_gen_1	138	145	PF00069	0.530
DOC_MAPK_gen_1	219	231	PF00069	0.590
DOC_MAPK_gen_1	384	392	PF00069	0.599
DOC_MAPK_gen_1	815	824	PF00069	0.471
DOC_MAPK_MEF2A_6	1052	1060	PF00069	0.598
DOC_MAPK_MEF2A_6	224	233	PF00069	0.491
DOC_MAPK_MEF2A_6	346	355	PF00069	0.513
DOC_MAPK_MEF2A_6	4	11	PF00069	0.586
DOC_MAPK_MEF2A_6	811	820	PF00069	0.563
DOC_PP2B_LxvP_1	355	358	PF13499	0.576
DOC_PP2B_LxvP_1	866	869	PF13499	0.808
DOC_PP4_FxxP_1	316	319	PF00568	0.588
DOC_PP4_FxxP_1	581	584	PF00568	0.592
DOC_PP4_FxxP_1	765	768	PF00568	0.496
DOC_USP7_MATH_1	1004	1008	PF00917	0.670
DOC_USP7_MATH_1	1031	1035	PF00917	0.691
DOC_USP7_MATH_1	1072	1076	PF00917	0.563
DOC_USP7_MATH_1	1112	1116	PF00917	0.580
DOC_USP7_MATH_1	113	117	PF00917	0.462
DOC_USP7_MATH_1	147	151	PF00917	0.324
DOC_USP7_MATH_1	19	23	PF00917	0.658
DOC_USP7_MATH_1	253	257	PF00917	0.654
DOC_USP7_MATH_1	528	532	PF00917	0.722
DOC_USP7_MATH_1	547	551	PF00917	0.509
DOC_USP7_MATH_1	582	586	PF00917	0.575
DOC_USP7_MATH_1	621	625	PF00917	0.655
DOC_USP7_MATH_1	658	662	PF00917	0.716
DOC_USP7_MATH_1	72	76	PF00917	0.777
DOC_USP7_MATH_1	757	761	PF00917	0.556
DOC_USP7_MATH_1	778	782	PF00917	0.817
DOC_USP7_MATH_1	803	807	PF00917	0.647
DOC_USP7_MATH_1	90	94	PF00917	0.467
DOC_USP7_MATH_1	936	940	PF00917	0.760
DOC_USP7_MATH_1	970	974	PF00917	0.687
DOC_USP7_MATH_2	333	339	PF00917	0.545
DOC_WW_Pin1_4	1018	1023	PF00397	0.720
DOC_WW_Pin1_4	1033	1038	PF00397	0.449
DOC_WW_Pin1_4	1108	1113	PF00397	0.672
DOC_WW_Pin1_4	145	150	PF00397	0.487
DOC_WW_Pin1_4	320	325	PF00397	0.706
DOC_WW_Pin1_4	395	400	PF00397	0.642
DOC_WW_Pin1_4	506	511	PF00397	0.725
DOC_WW_Pin1_4	764	769	PF00397	0.642
LIG_14-3-3_CanoR_1	1073	1080	PF00244	0.636
LIG_14-3-3_CanoR_1	1120	1129	PF00244	0.701
LIG_14-3-3_CanoR_1	1138	1146	PF00244	0.791
LIG_14-3-3_CanoR_1	1151	1157	PF00244	0.708
LIG_14-3-3_CanoR_1	183	187	PF00244	0.563
LIG_14-3-3_CanoR_1	24	32	PF00244	0.641
LIG_14-3-3_CanoR_1	259	265	PF00244	0.586
LIG_14-3-3_CanoR_1	350	356	PF00244	0.467
LIG_14-3-3_CanoR_1	376	381	PF00244	0.816
LIG_14-3-3_CanoR_1	384	389	PF00244	0.427
LIG_14-3-3_CanoR_1	393	398	PF00244	0.500
LIG_14-3-3_CanoR_1	471	480	PF00244	0.519
LIG_14-3-3_CanoR_1	627	634	PF00244	0.532
LIG_14-3-3_CanoR_1	724	734	PF00244	0.706
LIG_14-3-3_CanoR_1	993	1002	PF00244	0.648
LIG_Actin_WH2_1	817	833	PF00022	0.436
LIG_Actin_WH2_2	417	433	PF00022	0.584
LIG_Actin_WH2_2	457	475	PF00022	0.528
LIG_Actin_WH2_2	536	554	PF00022	0.652
LIG_BIR_III_2	1109	1113	PF00653	0.547
LIG_BRCT_BRCA1_1	1035	1039	PF00533	0.381
LIG_BRCT_BRCA1_1	235	239	PF00533	0.548
LIG_BRCT_BRCA1_1	327	331	PF00533	0.748
LIG_BRCT_BRCA1_1	388	392	PF00533	0.490
LIG_BRCT_BRCA1_1	510	514	PF00533	0.669
LIG_BRCT_BRCA1_1	943	947	PF00533	0.774
LIG_DLG_GKlike_1	606	614	PF00625	0.398
LIG_FHA_1	1023	1029	PF00498	0.583
LIG_FHA_1	165	171	PF00498	0.435
LIG_FHA_1	228	234	PF00498	0.444
LIG_FHA_1	43	49	PF00498	0.569
LIG_FHA_1	628	634	PF00498	0.616
LIG_FHA_1	94	100	PF00498	0.492
LIG_FHA_2	1104	1110	PF00498	0.629
LIG_FHA_2	410	416	PF00498	0.491
LIG_FHA_2	474	480	PF00498	0.602
LIG_FHA_2	570	576	PF00498	0.508
LIG_FHA_2	75	81	PF00498	0.534
LIG_FHA_2	778	784	PF00498	0.735
LIG_FHA_2	807	813	PF00498	0.729
LIG_FHA_2	898	904	PF00498	0.615
LIG_HP1_1	108	112	PF01393	0.453
LIG_IBAR_NPY_1	210	212	PF08397	0.620
LIG_LIR_Apic_2	763	768	PF02991	0.529
LIG_LIR_Gen_1	1111	1121	PF02991	0.538
LIG_LIR_Nem_3	1111	1116	PF02991	0.669
LIG_LIR_Nem_3	167	171	PF02991	0.436
LIG_LIR_Nem_3	271	277	PF02991	0.609
LIG_LIR_Nem_3	389	395	PF02991	0.500
LIG_PCNA_yPIPBox_3	279	292	PF02747	0.504
LIG_RPA_C_Fungi	959	971	PF08784	0.700
LIG_SH2_CRK	168	172	PF00017	0.419
LIG_SH2_NCK_1	734	738	PF00017	0.579
LIG_SH2_PTP2	109	112	PF00017	0.453
LIG_SH2_SRC	192	195	PF00017	0.490
LIG_SH2_STAP1	562	566	PF00017	0.500
LIG_SH2_STAP1	734	738	PF00017	0.604
LIG_SH2_STAT3	600	603	PF00017	0.524
LIG_SH2_STAT5	1050	1053	PF00017	0.629
LIG_SH2_STAT5	109	112	PF00017	0.394
LIG_SH2_STAT5	212	215	PF00017	0.638
LIG_SH2_STAT5	291	294	PF00017	0.608
LIG_SH2_STAT5	411	414	PF00017	0.309
LIG_SH2_STAT5	436	439	PF00017	0.475
LIG_SH2_STAT5	628	631	PF00017	0.481
LIG_SH2_STAT5	834	837	PF00017	0.608
LIG_SH2_STAT5	989	992	PF00017	0.589
LIG_SH3_3	107	113	PF00018	0.467
LIG_SH3_3	1084	1090	PF00018	0.582
LIG_SH3_3	369	375	PF00018	0.713
LIG_SH3_3	377	383	PF00018	0.624
LIG_SH3_3	478	484	PF00018	0.499
LIG_SH3_3	507	513	PF00018	0.648
LIG_SH3_3	576	582	PF00018	0.584
LIG_SH3_3	727	733	PF00018	0.704
LIG_SH3_3	84	90	PF00018	0.587
LIG_SH3_3	874	880	PF00018	0.745
LIG_SH3_3	882	888	PF00018	0.632
LIG_SH3_3	946	952	PF00018	0.683
LIG_SUMO_SIM_anti_2	851	859	PF11976	0.657
LIG_SUMO_SIM_par_1	393	398	PF11976	0.523
LIG_SUMO_SIM_par_1	563	569	PF11976	0.540
LIG_TRAF2_1	445	448	PF00917	0.481
LIG_TRAF2_1	476	479	PF00917	0.498
LIG_TRAF2_1	737	740	PF00917	0.745
LIG_UBA3_1	1038	1042	PF00899	0.468
LIG_WW_1	731	734	PF00397	0.582
MOD_CDK_SPK_2	395	400	PF00069	0.642
MOD_CK1_1	1021	1027	PF00069	0.727
MOD_CK1_1	22	28	PF00069	0.640
MOD_CK1_1	46	52	PF00069	0.432
MOD_CK1_1	506	512	PF00069	0.683
MOD_CK1_1	530	536	PF00069	0.661
MOD_CK1_1	688	694	PF00069	0.717
MOD_CK1_1	70	76	PF00069	0.717
MOD_CK1_1	749	755	PF00069	0.693
MOD_CK1_1	760	766	PF00069	0.626
MOD_CK1_1	767	773	PF00069	0.574
MOD_CK1_1	806	812	PF00069	0.591
MOD_CK1_1	93	99	PF00069	0.473
MOD_CK1_1	943	949	PF00069	0.698
MOD_CK2_1	1004	1010	PF00069	0.753
MOD_CK2_1	414	420	PF00069	0.482
MOD_CK2_1	473	479	PF00069	0.512
MOD_CK2_1	569	575	PF00069	0.600
MOD_CK2_1	700	706	PF00069	0.782
MOD_CK2_1	74	80	PF00069	0.543
MOD_CK2_1	777	783	PF00069	0.732
MOD_CK2_1	806	812	PF00069	0.760
MOD_Cter_Amidation	57	60	PF01082	0.521
MOD_Cter_Amidation	698	701	PF01082	0.543
MOD_GlcNHglycan	1029	1032	PF01048	0.746
MOD_GlcNHglycan	1033	1036	PF01048	0.747
MOD_GlcNHglycan	1045	1048	PF01048	0.564
MOD_GlcNHglycan	1074	1077	PF01048	0.752
MOD_GlcNHglycan	21	24	PF01048	0.679
MOD_GlcNHglycan	235	238	PF01048	0.586
MOD_GlcNHglycan	25	28	PF01048	0.641
MOD_GlcNHglycan	251	254	PF01048	0.587
MOD_GlcNHglycan	301	304	PF01048	0.677
MOD_GlcNHglycan	316	319	PF01048	0.494
MOD_GlcNHglycan	327	330	PF01048	0.649
MOD_GlcNHglycan	37	40	PF01048	0.470
MOD_GlcNHglycan	473	476	PF01048	0.528
MOD_GlcNHglycan	48	51	PF01048	0.433
MOD_GlcNHglycan	53	56	PF01048	0.601
MOD_GlcNHglycan	530	533	PF01048	0.729
MOD_GlcNHglycan	534	537	PF01048	0.635
MOD_GlcNHglycan	654	657	PF01048	0.636
MOD_GlcNHglycan	662	665	PF01048	0.567
MOD_GlcNHglycan	687	690	PF01048	0.707
MOD_GlcNHglycan	70	73	PF01048	0.760
MOD_GlcNHglycan	74	77	PF01048	0.677
MOD_GlcNHglycan	936	939	PF01048	0.751
MOD_GlcNHglycan	943	946	PF01048	0.639
MOD_GSK3_1	1017	1024	PF00069	0.723
MOD_GSK3_1	1027	1034	PF00069	0.798
MOD_GSK3_1	11	18	PF00069	0.703
MOD_GSK3_1	1108	1115	PF00069	0.743
MOD_GSK3_1	1158	1165	PF00069	0.702
MOD_GSK3_1	19	26	PF00069	0.686
MOD_GSK3_1	192	199	PF00069	0.614
MOD_GSK3_1	240	247	PF00069	0.670
MOD_GSK3_1	249	256	PF00069	0.600
MOD_GSK3_1	409	416	PF00069	0.594
MOD_GSK3_1	42	49	PF00069	0.565
MOD_GSK3_1	504	511	PF00069	0.634
MOD_GSK3_1	524	531	PF00069	0.721
MOD_GSK3_1	547	554	PF00069	0.543
MOD_GSK3_1	622	629	PF00069	0.619
MOD_GSK3_1	63	70	PF00069	0.731
MOD_GSK3_1	742	749	PF00069	0.649
MOD_GSK3_1	760	767	PF00069	0.468
MOD_GSK3_1	789	796	PF00069	0.760
MOD_GSK3_1	889	896	PF00069	0.719
MOD_GSK3_1	936	943	PF00069	0.681
MOD_LATS_1	1150	1156	PF00433	0.521
MOD_LATS_1	194	200	PF00433	0.469
MOD_LATS_1	374	380	PF00433	0.662
MOD_LATS_1	65	71	PF00433	0.684
MOD_NEK2_1	298	303	PF00069	0.676
MOD_NEK2_1	503	508	PF00069	0.487
MOD_NEK2_1	566	571	PF00069	0.529
MOD_NEK2_1	622	627	PF00069	0.649
MOD_NEK2_1	690	695	PF00069	0.770
MOD_NEK2_1	889	894	PF00069	0.695
MOD_NEK2_1	940	945	PF00069	0.783
MOD_NEK2_2	547	552	PF00069	0.520
MOD_PIKK_1	1103	1109	PF00454	0.824
MOD_PIKK_1	1114	1120	PF00454	0.639
MOD_PIKK_1	291	297	PF00454	0.500
MOD_PIKK_1	337	343	PF00454	0.663
MOD_PIKK_1	43	49	PF00454	0.486
MOD_PIKK_1	678	684	PF00454	0.772
MOD_PIKK_1	690	696	PF00454	0.593
MOD_PK_1	1152	1158	PF00069	0.698
MOD_PK_1	376	382	PF00069	0.814
MOD_PKA_1	1152	1158	PF00069	0.697
MOD_PKA_1	196	202	PF00069	0.480
MOD_PKA_1	376	382	PF00069	0.814
MOD_PKA_1	700	706	PF00069	0.535
MOD_PKA_1	793	799	PF00069	0.553
MOD_PKA_2	1072	1078	PF00069	0.725
MOD_PKA_2	1137	1143	PF00069	0.830
MOD_PKA_2	1152	1158	PF00069	0.658
MOD_PKA_2	182	188	PF00069	0.426
MOD_PKA_2	196	202	PF00069	0.464
MOD_PKA_2	23	29	PF00069	0.630
MOD_PKA_2	375	381	PF00069	0.815
MOD_PKA_2	551	557	PF00069	0.375
MOD_PKA_2	626	632	PF00069	0.523
MOD_PKA_2	700	706	PF00069	0.721
MOD_PKA_2	783	789	PF00069	0.790
MOD_PKA_2	793	799	PF00069	0.718
MOD_PKA_2	806	812	PF00069	0.655
MOD_PKB_1	471	479	PF00069	0.532
MOD_PKB_1	604	612	PF00069	0.594
MOD_Plk_1	227	233	PF00069	0.559
MOD_Plk_1	676	682	PF00069	0.681
MOD_Plk_1	757	763	PF00069	0.511
MOD_Plk_2-3	783	789	PF00069	0.543
MOD_Plk_4	114	120	PF00069	0.452
MOD_Plk_4	1152	1158	PF00069	0.709
MOD_Plk_4	498	504	PF00069	0.459
MOD_Plk_4	760	766	PF00069	0.648
MOD_Plk_4	767	773	PF00069	0.702
MOD_Plk_4	889	895	PF00069	0.691
MOD_Plk_4	90	96	PF00069	0.523
MOD_Plk_4	936	942	PF00069	0.507
MOD_ProDKin_1	1018	1024	PF00069	0.723
MOD_ProDKin_1	1033	1039	PF00069	0.432
MOD_ProDKin_1	1108	1114	PF00069	0.672
MOD_ProDKin_1	145	151	PF00069	0.482
MOD_ProDKin_1	320	326	PF00069	0.712
MOD_ProDKin_1	395	401	PF00069	0.647
MOD_ProDKin_1	506	512	PF00069	0.724
MOD_ProDKin_1	764	770	PF00069	0.636
TRG_DiLeu_BaEn_1	491	496	PF01217	0.592
TRG_DiLeu_BaEn_1	857	862	PF01217	0.562
TRG_DiLeu_BaEn_4	478	484	PF01217	0.499
TRG_DiLeu_BaEn_4	825	831	PF01217	0.607
TRG_DiLeu_BaLyEn_6	539	544	PF01217	0.508
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.644
TRG_DiLeu_BaLyEn_6	949	954	PF01217	0.782
TRG_ENDOCYTIC_2	109	112	PF00928	0.394
TRG_ENDOCYTIC_2	168	171	PF00928	0.420
TRG_ENDOCYTIC_2	562	565	PF00928	0.525
TRG_ER_diArg_1	1084	1086	PF00400	0.630
TRG_ER_diArg_1	1148	1151	PF00400	0.761
TRG_ER_diArg_1	119	121	PF00400	0.534
TRG_ER_diArg_1	219	221	PF00400	0.662
TRG_ER_diArg_1	309	312	PF00400	0.579
TRG_ER_diArg_1	375	377	PF00400	0.696
TRG_ER_diArg_1	559	561	PF00400	0.566
TRG_ER_diArg_1	59	61	PF00400	0.530
TRG_ER_diArg_1	700	702	PF00400	0.552
TRG_ER_diArg_1	772	774	PF00400	0.722
TRG_ER_diArg_1	793	795	PF00400	0.553
TRG_ER_diArg_1	814	817	PF00400	0.507
TRG_ER_diArg_1	916	918	PF00400	0.672
TRG_ER_diArg_1	982	984	PF00400	0.703
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	700	704	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P548	Leptomonas seymouri	46%	100%
A0A3S7X755	Leishmania donovani	85%	100%
A4HLX7	Leishmania braziliensis	70%	99%
A4I9A6	Leishmania infantum	85%	100%
Q4Q3S0	Leishmania major	88%	100%