LIM zinc-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B4A4_LEIMU

TriTrypDb:

LmxM.32.2640

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B4A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4A4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.652
CLV_C14_Caspase3-7	388	392	PF00656	0.686
CLV_C14_Caspase3-7	78	82	PF00656	0.594
CLV_NRD_NRD_1	247	249	PF00675	0.574
CLV_NRD_NRD_1	268	270	PF00675	0.587
CLV_NRD_NRD_1	333	335	PF00675	0.713
CLV_NRD_NRD_1	370	372	PF00675	0.592
CLV_NRD_NRD_1	411	413	PF00675	0.725
CLV_PCSK_KEX2_1	174	176	PF00082	0.780
CLV_PCSK_KEX2_1	247	249	PF00082	0.574
CLV_PCSK_KEX2_1	268	270	PF00082	0.584
CLV_PCSK_KEX2_1	333	335	PF00082	0.713
CLV_PCSK_KEX2_1	370	372	PF00082	0.618
CLV_PCSK_KEX2_1	86	88	PF00082	0.647
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.720
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.647
CLV_PCSK_SKI1_1	333	337	PF00082	0.526
CLV_PCSK_SKI1_1	83	87	PF00082	0.726
DEG_APCC_DBOX_1	222	230	PF00400	0.561
DEG_Nend_UBRbox_2	1	3	PF02207	0.726
DEG_SPOP_SBC_1	103	107	PF00917	0.754
DOC_CYCLIN_RxL_1	329	341	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.490
DOC_MAPK_gen_1	333	340	PF00069	0.640
DOC_MAPK_gen_1	86	94	PF00069	0.542
DOC_MAPK_MEF2A_6	333	340	PF00069	0.483
DOC_MAPK_NFAT4_5	333	341	PF00069	0.484
DOC_PP2B_LxvP_1	232	235	PF13499	0.356
DOC_PP2B_LxvP_1	336	339	PF13499	0.489
DOC_USP7_MATH_1	104	108	PF00917	0.754
DOC_USP7_MATH_1	250	254	PF00917	0.582
DOC_USP7_MATH_1	283	287	PF00917	0.535
DOC_USP7_MATH_1	33	37	PF00917	0.624
DOC_USP7_UBL2_3	79	83	PF12436	0.648
DOC_WW_Pin1_4	155	160	PF00397	0.729
DOC_WW_Pin1_4	37	42	PF00397	0.556
DOC_WW_Pin1_4	402	407	PF00397	0.669
DOC_WW_Pin1_4	9	14	PF00397	0.745
LIG_14-3-3_CanoR_1	135	142	PF00244	0.568
LIG_14-3-3_CanoR_1	154	159	PF00244	0.689
LIG_14-3-3_CanoR_1	160	168	PF00244	0.601
LIG_14-3-3_CanoR_1	333	339	PF00244	0.595
LIG_14-3-3_CanoR_1	370	380	PF00244	0.661
LIG_BRCT_BRCA1_1	106	110	PF00533	0.724
LIG_BRCT_BRCA1_1	175	179	PF00533	0.663
LIG_BRCT_BRCA1_1	252	256	PF00533	0.547
LIG_CtBP_PxDLS_1	359	363	PF00389	0.616
LIG_FHA_1	103	109	PF00498	0.777
LIG_FHA_1	123	129	PF00498	0.754
LIG_FHA_1	42	48	PF00498	0.665
LIG_FHA_1	59	65	PF00498	0.607
LIG_FHA_1	96	102	PF00498	0.724
LIG_FHA_2	202	208	PF00498	0.632
LIG_FHA_2	310	316	PF00498	0.614
LIG_FHA_2	386	392	PF00498	0.683
LIG_Integrin_isoDGR_2	425	427	PF01839	0.574
LIG_Integrin_RGD_1	313	315	PF01839	0.689
LIG_LIR_Gen_1	144	150	PF02991	0.520
LIG_LIR_Gen_1	184	193	PF02991	0.620
LIG_LIR_Gen_1	315	322	PF02991	0.674
LIG_LIR_Gen_1	377	386	PF02991	0.649
LIG_LIR_Nem_3	144	149	PF02991	0.524
LIG_LIR_Nem_3	184	190	PF02991	0.625
LIG_LIR_Nem_3	315	320	PF02991	0.580
LIG_MLH1_MIPbox_1	252	256	PF16413	0.547
LIG_PTB_Apo_2	216	223	PF02174	0.391
LIG_PTB_Apo_2	422	429	PF02174	0.509
LIG_PTB_Phospho_1	216	222	PF10480	0.387
LIG_PTB_Phospho_1	422	428	PF10480	0.508
LIG_SH2_CRK	146	150	PF00017	0.521
LIG_SH2_CRK	187	191	PF00017	0.624
LIG_SH2_CRK	202	206	PF00017	0.475
LIG_SH2_CRK	222	226	PF00017	0.343
LIG_SH2_GRB2like	146	149	PF00017	0.526
LIG_SH2_NCK_1	146	150	PF00017	0.521
LIG_SH2_NCK_1	187	191	PF00017	0.608
LIG_SH2_NCK_1	317	321	PF00017	0.576
LIG_SH2_STAP1	136	140	PF00017	0.749
LIG_SH2_STAP1	187	191	PF00017	0.608
LIG_SH2_STAP1	293	297	PF00017	0.564
LIG_SH2_STAT3	386	389	PF00017	0.674
LIG_SH2_STAT5	146	149	PF00017	0.526
LIG_SH2_STAT5	227	230	PF00017	0.638
LIG_SH2_STAT5	264	267	PF00017	0.511
LIG_SH2_STAT5	276	279	PF00017	0.429
LIG_SH2_STAT5	387	390	PF00017	0.674
LIG_SH3_2	242	247	PF14604	0.588
LIG_SH3_3	239	245	PF00018	0.517
LIG_SH3_3	51	57	PF00018	0.741
LIG_SH3_3	7	13	PF00018	0.771
LIG_TRAF2_1	298	301	PF00917	0.595
LIG_TRAF2_2	13	18	PF00917	0.709
MOD_CDK_SPK_2	155	160	PF00069	0.716
MOD_CK1_1	111	117	PF00069	0.718
MOD_CK1_1	144	150	PF00069	0.740
MOD_CK1_1	194	200	PF00069	0.651
MOD_CK1_1	374	380	PF00069	0.655
MOD_CK2_1	201	207	PF00069	0.635
MOD_Cter_Amidation	266	269	PF01082	0.507
MOD_Cter_Amidation	410	413	PF01082	0.708
MOD_GlcNHglycan	137	140	PF01048	0.714
MOD_GlcNHglycan	193	196	PF01048	0.671
MOD_GlcNHglycan	30	33	PF01048	0.702
MOD_GlcNHglycan	324	328	PF01048	0.483
MOD_GlcNHglycan	35	38	PF01048	0.645
MOD_GlcNHglycan	373	376	PF01048	0.691
MOD_GlcNHglycan	400	403	PF01048	0.813
MOD_GlcNHglycan	414	417	PF01048	0.579
MOD_GlcNHglycan	98	101	PF01048	0.638
MOD_GSK3_1	104	111	PF00069	0.818
MOD_GSK3_1	14	21	PF00069	0.730
MOD_GSK3_1	155	162	PF00069	0.781
MOD_GSK3_1	23	30	PF00069	0.670
MOD_GSK3_1	33	40	PF00069	0.579
MOD_GSK3_1	334	341	PF00069	0.660
MOD_GSK3_1	370	377	PF00069	0.671
MOD_GSK3_1	398	405	PF00069	0.722
MOD_LATS_1	368	374	PF00433	0.611
MOD_N-GLC_1	185	190	PF02516	0.619
MOD_N-GLC_1	371	376	PF02516	0.671
MOD_N-GLC_2	237	239	PF02516	0.552
MOD_NEK2_1	108	113	PF00069	0.716
MOD_NEK2_1	22	27	PF00069	0.567
MOD_NEK2_2	250	255	PF00069	0.560
MOD_PIKK_1	108	114	PF00454	0.751
MOD_PIKK_1	11	17	PF00454	0.705
MOD_PIKK_1	385	391	PF00454	0.671
MOD_PKA_1	370	376	PF00069	0.533
MOD_PKA_1	412	418	PF00069	0.703
MOD_PKA_2	134	140	PF00069	0.569
MOD_PKA_2	153	159	PF00069	0.754
MOD_PKA_2	267	273	PF00069	0.590
MOD_PKA_2	370	376	PF00069	0.597
MOD_PKA_2	421	427	PF00069	0.686
MOD_Plk_1	185	191	PF00069	0.677
MOD_Plk_4	104	110	PF00069	0.801
MOD_Plk_4	186	192	PF00069	0.737
MOD_Plk_4	250	256	PF00069	0.586
MOD_ProDKin_1	155	161	PF00069	0.724
MOD_ProDKin_1	37	43	PF00069	0.554
MOD_ProDKin_1	402	408	PF00069	0.670
MOD_ProDKin_1	9	15	PF00069	0.746
MOD_SUMO_rev_2	78	85	PF00179	0.553
TRG_ENDOCYTIC_2	146	149	PF00928	0.526
TRG_ENDOCYTIC_2	187	190	PF00928	0.631
TRG_ENDOCYTIC_2	202	205	PF00928	0.470
TRG_ENDOCYTIC_2	276	279	PF00928	0.553
TRG_ENDOCYTIC_2	317	320	PF00928	0.647
TRG_ER_diArg_1	212	215	PF00400	0.572
TRG_ER_diArg_1	246	248	PF00400	0.605
TRG_ER_diArg_1	333	335	PF00400	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X718	Leishmania donovani	85%	100%
A4HLX5	Leishmania braziliensis	65%	100%
A4I9A4	Leishmania infantum	85%	100%
Q4Q3S2	Leishmania major	82%	100%