LeishMANIAdb
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Putative dynein intermediate chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative dynein intermediate chain
Gene product:
dynein intermediate chain, putative
Species:
Leishmania mexicana
UniProt:
E9B4A3_LEIMU
TriTrypDb:
LmxM.32.2630
Length:
1040

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005858 axonemal dynein complex 4 1
GO:0005875 microtubule associated complex 2 1
GO:0005930 axoneme 2 1
GO:0030286 dynein complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 2
GO:1902494 catalytic complex 2 1
GO:0016020 membrane 2 1

Expansion

Sequence features

E9B4A3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4A3

Function

Biological processes
Term Name Level Count
GO:0003341 cilium movement 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0045503 dynein light chain binding 3 1
GO:0045504 dynein heavy chain binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 336 340 PF00656 0.385
CLV_C14_Caspase3-7 559 563 PF00656 0.553
CLV_C14_Caspase3-7 966 970 PF00656 0.445
CLV_MEL_PAP_1 589 595 PF00089 0.428
CLV_NRD_NRD_1 117 119 PF00675 0.650
CLV_NRD_NRD_1 149 151 PF00675 0.666
CLV_NRD_NRD_1 189 191 PF00675 0.600
CLV_NRD_NRD_1 232 234 PF00675 0.586
CLV_NRD_NRD_1 31 33 PF00675 0.562
CLV_NRD_NRD_1 313 315 PF00675 0.538
CLV_NRD_NRD_1 611 613 PF00675 0.536
CLV_NRD_NRD_1 818 820 PF00675 0.686
CLV_NRD_NRD_1 925 927 PF00675 0.421
CLV_NRD_NRD_1 983 985 PF00675 0.420
CLV_PCSK_KEX2_1 117 119 PF00082 0.650
CLV_PCSK_KEX2_1 149 151 PF00082 0.635
CLV_PCSK_KEX2_1 188 190 PF00082 0.596
CLV_PCSK_KEX2_1 30 32 PF00082 0.590
CLV_PCSK_KEX2_1 611 613 PF00082 0.543
CLV_PCSK_KEX2_1 647 649 PF00082 0.605
CLV_PCSK_KEX2_1 983 985 PF00082 0.424
CLV_PCSK_PC1ET2_1 647 649 PF00082 0.605
CLV_PCSK_PC7_1 26 32 PF00082 0.475
CLV_PCSK_SKI1_1 16 20 PF00082 0.590
CLV_PCSK_SKI1_1 233 237 PF00082 0.588
CLV_PCSK_SKI1_1 503 507 PF00082 0.607
DEG_SPOP_SBC_1 696 700 PF00917 0.382
DOC_ANK_TNKS_1 36 43 PF00023 0.658
DOC_CKS1_1 321 326 PF01111 0.443
DOC_CKS1_1 476 481 PF01111 0.486
DOC_CYCLIN_yCln2_LP_2 663 669 PF00134 0.352
DOC_MAPK_gen_1 188 194 PF00069 0.602
DOC_MAPK_gen_1 233 241 PF00069 0.582
DOC_MAPK_gen_1 314 322 PF00069 0.504
DOC_MAPK_gen_1 611 619 PF00069 0.441
DOC_MAPK_gen_1 926 932 PF00069 0.437
DOC_MAPK_gen_1 983 990 PF00069 0.396
DOC_MAPK_MEF2A_6 664 673 PF00069 0.413
DOC_PP1_RVXF_1 586 592 PF00149 0.398
DOC_PP1_RVXF_1 755 762 PF00149 0.348
DOC_PP1_RVXF_1 896 902 PF00149 0.329
DOC_PP2B_PxIxI_1 780 786 PF00149 0.398
DOC_PP4_FxxP_1 593 596 PF00568 0.445
DOC_PP4_FxxP_1 688 691 PF00568 0.386
DOC_USP7_MATH_1 270 274 PF00917 0.458
DOC_USP7_MATH_1 301 305 PF00917 0.522
DOC_USP7_MATH_1 422 426 PF00917 0.558
DOC_USP7_MATH_1 493 497 PF00917 0.555
DOC_USP7_MATH_1 528 532 PF00917 0.558
DOC_USP7_MATH_1 546 550 PF00917 0.485
DOC_USP7_MATH_1 572 576 PF00917 0.559
DOC_USP7_MATH_1 637 641 PF00917 0.532
DOC_USP7_MATH_1 695 699 PF00917 0.374
DOC_USP7_UBL2_3 811 815 PF12436 0.647
DOC_USP7_UBL2_3 820 824 PF12436 0.643
DOC_WW_Pin1_4 241 246 PF00397 0.558
DOC_WW_Pin1_4 320 325 PF00397 0.456
DOC_WW_Pin1_4 475 480 PF00397 0.478
DOC_WW_Pin1_4 494 499 PF00397 0.760
DOC_WW_Pin1_4 51 56 PF00397 0.591
DOC_WW_Pin1_4 518 523 PF00397 0.627
DOC_WW_Pin1_4 531 536 PF00397 0.806
DOC_WW_Pin1_4 592 597 PF00397 0.456
DOC_WW_Pin1_4 899 904 PF00397 0.336
LIG_14-3-3_CanoR_1 117 122 PF00244 0.681
LIG_14-3-3_CanoR_1 173 181 PF00244 0.767
LIG_14-3-3_CanoR_1 188 193 PF00244 0.511
LIG_14-3-3_CanoR_1 233 241 PF00244 0.582
LIG_14-3-3_CanoR_1 271 278 PF00244 0.642
LIG_14-3-3_CanoR_1 419 426 PF00244 0.510
LIG_14-3-3_CanoR_1 582 590 PF00244 0.490
LIG_14-3-3_CanoR_1 61 65 PF00244 0.673
LIG_14-3-3_CanoR_1 625 629 PF00244 0.568
LIG_14-3-3_CanoR_1 636 644 PF00244 0.556
LIG_14-3-3_CanoR_1 931 936 PF00244 0.404
LIG_14-3-3_CanoR_1 983 990 PF00244 0.347
LIG_APCC_ABBA_1 249 254 PF00400 0.415
LIG_BIR_III_2 577 581 PF00653 0.479
LIG_BIR_III_4 359 363 PF00653 0.532
LIG_BRCT_BRCA1_1 164 168 PF00533 0.625
LIG_FHA_1 234 240 PF00498 0.549
LIG_FHA_1 242 248 PF00498 0.484
LIG_FHA_1 291 297 PF00498 0.574
LIG_FHA_1 426 432 PF00498 0.680
LIG_FHA_1 444 450 PF00498 0.352
LIG_FHA_1 518 524 PF00498 0.676
LIG_FHA_1 698 704 PF00498 0.387
LIG_FHA_1 728 734 PF00498 0.385
LIG_FHA_1 86 92 PF00498 0.600
LIG_FHA_1 915 921 PF00498 0.397
LIG_FHA_1 946 952 PF00498 0.412
LIG_FHA_1 993 999 PF00498 0.439
LIG_FHA_2 1021 1027 PF00498 0.488
LIG_FHA_2 223 229 PF00498 0.656
LIG_FHA_2 343 349 PF00498 0.566
LIG_FHA_2 365 371 PF00498 0.559
LIG_FHA_2 557 563 PF00498 0.556
LIG_FHA_2 964 970 PF00498 0.448
LIG_GBD_Chelix_1 439 447 PF00786 0.487
LIG_Integrin_RGD_1 1019 1021 PF01839 0.492
LIG_LIR_Apic_2 687 691 PF02991 0.374
LIG_LIR_Gen_1 246 256 PF02991 0.396
LIG_LIR_Gen_1 273 282 PF02991 0.666
LIG_LIR_Gen_1 952 958 PF02991 0.382
LIG_LIR_Gen_1 963 973 PF02991 0.365
LIG_LIR_LC3C_4 995 1000 PF02991 0.405
LIG_LIR_Nem_3 246 251 PF02991 0.396
LIG_LIR_Nem_3 273 278 PF02991 0.648
LIG_LIR_Nem_3 952 956 PF02991 0.406
LIG_PCNA_yPIPBox_3 961 974 PF02747 0.274
LIG_RPA_C_Fungi 266 278 PF08784 0.360
LIG_RPA_C_Fungi 606 618 PF08784 0.393
LIG_SH2_CRK 218 222 PF00017 0.555
LIG_SH2_CRK 466 470 PF00017 0.430
LIG_SH2_NCK_1 218 222 PF00017 0.555
LIG_SH2_NCK_1 275 279 PF00017 0.606
LIG_SH2_NCK_1 904 908 PF00017 0.397
LIG_SH2_SRC 218 221 PF00017 0.572
LIG_SH2_SRC 889 892 PF00017 0.338
LIG_SH2_STAP1 331 335 PF00017 0.456
LIG_SH2_STAP1 885 889 PF00017 0.384
LIG_SH2_STAP1 904 908 PF00017 0.338
LIG_SH2_STAT3 250 253 PF00017 0.555
LIG_SH2_STAT3 706 709 PF00017 0.426
LIG_SH2_STAT5 250 253 PF00017 0.440
LIG_SH2_STAT5 621 624 PF00017 0.446
LIG_SH2_STAT5 674 677 PF00017 0.460
LIG_SH2_STAT5 865 868 PF00017 0.329
LIG_SH2_STAT5 908 911 PF00017 0.315
LIG_SH2_STAT5 979 982 PF00017 0.307
LIG_SH3_3 217 223 PF00018 0.610
LIG_SH3_3 306 312 PF00018 0.593
LIG_SH3_3 505 511 PF00018 0.637
LIG_SH3_3 521 527 PF00018 0.618
LIG_SH3_3 663 669 PF00018 0.352
LIG_SH3_3 709 715 PF00018 0.466
LIG_SH3_4 820 827 PF00018 0.565
LIG_SUMO_SIM_anti_2 994 1004 PF11976 0.425
LIG_SUMO_SIM_par_1 236 244 PF11976 0.525
LIG_SUMO_SIM_par_1 512 517 PF11976 0.478
LIG_SUMO_SIM_par_1 692 700 PF11976 0.401
LIG_SUMO_SIM_par_1 994 1004 PF11976 0.425
LIG_TRAF2_1 277 280 PF00917 0.521
LIG_TRAF2_1 345 348 PF00917 0.600
LIG_TRAF2_1 840 843 PF00917 0.606
LIG_TRAF2_1 991 994 PF00917 0.457
LIG_TYR_ITIM 464 469 PF00017 0.406
LIG_WRC_WIRS_1 471 476 PF05994 0.506
MOD_CK1_1 116 122 PF00069 0.630
MOD_CK1_1 134 140 PF00069 0.655
MOD_CK1_1 158 164 PF00069 0.593
MOD_CK1_1 175 181 PF00069 0.513
MOD_CK1_1 304 310 PF00069 0.535
MOD_CK1_1 4 10 PF00069 0.675
MOD_CK1_1 425 431 PF00069 0.547
MOD_CK1_1 517 523 PF00069 0.597
MOD_CK1_1 531 537 PF00069 0.623
MOD_CK1_1 570 576 PF00069 0.509
MOD_CK1_1 638 644 PF00069 0.511
MOD_CK1_1 77 83 PF00069 0.578
MOD_CK1_1 902 908 PF00069 0.341
MOD_CK2_1 1020 1026 PF00069 0.443
MOD_CK2_1 222 228 PF00069 0.487
MOD_CK2_1 342 348 PF00069 0.560
MOD_CK2_1 364 370 PF00069 0.558
MOD_CK2_1 696 702 PF00069 0.406
MOD_CK2_1 729 735 PF00069 0.404
MOD_CK2_1 80 86 PF00069 0.670
MOD_CK2_1 877 883 PF00069 0.410
MOD_Cter_Amidation 147 150 PF01082 0.629
MOD_Cter_Amidation 812 815 PF01082 0.617
MOD_GlcNHglycan 144 147 PF01048 0.666
MOD_GlcNHglycan 272 275 PF01048 0.340
MOD_GlcNHglycan 316 319 PF01048 0.545
MOD_GlcNHglycan 331 334 PF01048 0.426
MOD_GlcNHglycan 416 419 PF01048 0.687
MOD_GlcNHglycan 529 533 PF01048 0.525
MOD_GlcNHglycan 548 551 PF01048 0.597
MOD_GlcNHglycan 569 572 PF01048 0.622
MOD_GlcNHglycan 752 755 PF01048 0.349
MOD_GlcNHglycan 76 79 PF01048 0.615
MOD_GlcNHglycan 80 83 PF01048 0.631
MOD_GlcNHglycan 811 814 PF01048 0.616
MOD_GlcNHglycan 824 827 PF01048 0.560
MOD_GlcNHglycan 904 907 PF01048 0.361
MOD_GlcNHglycan 912 915 PF01048 0.303
MOD_GSK3_1 1 8 PF00069 0.602
MOD_GSK3_1 112 119 PF00069 0.567
MOD_GSK3_1 131 138 PF00069 0.624
MOD_GSK3_1 155 162 PF00069 0.601
MOD_GSK3_1 177 184 PF00069 0.620
MOD_GSK3_1 188 195 PF00069 0.646
MOD_GSK3_1 235 242 PF00069 0.602
MOD_GSK3_1 281 288 PF00069 0.631
MOD_GSK3_1 290 297 PF00069 0.586
MOD_GSK3_1 394 401 PF00069 0.669
MOD_GSK3_1 402 409 PF00069 0.627
MOD_GSK3_1 414 421 PF00069 0.557
MOD_GSK3_1 439 446 PF00069 0.540
MOD_GSK3_1 493 500 PF00069 0.515
MOD_GSK3_1 514 521 PF00069 0.605
MOD_GSK3_1 566 573 PF00069 0.528
MOD_GSK3_1 592 599 PF00069 0.447
MOD_GSK3_1 638 645 PF00069 0.470
MOD_GSK3_1 73 80 PF00069 0.623
MOD_GSK3_1 809 816 PF00069 0.578
MOD_GSK3_1 866 873 PF00069 0.353
MOD_GSK3_1 875 882 PF00069 0.389
MOD_GSK3_1 910 917 PF00069 0.330
MOD_GSK3_1 941 948 PF00069 0.390
MOD_GSK3_1 97 104 PF00069 0.644
MOD_LATS_1 982 988 PF00433 0.257
MOD_N-GLC_1 113 118 PF02516 0.488
MOD_N-GLC_1 493 498 PF02516 0.666
MOD_N-GLC_1 51 56 PF02516 0.652
MOD_NEK2_1 1 6 PF00069 0.676
MOD_NEK2_1 1012 1017 PF00069 0.545
MOD_NEK2_1 102 107 PF00069 0.573
MOD_NEK2_1 112 117 PF00069 0.573
MOD_NEK2_1 159 164 PF00069 0.601
MOD_NEK2_1 192 197 PF00069 0.541
MOD_NEK2_1 290 295 PF00069 0.629
MOD_NEK2_1 400 405 PF00069 0.552
MOD_NEK2_1 414 419 PF00069 0.715
MOD_NEK2_1 439 444 PF00069 0.433
MOD_NEK2_1 556 561 PF00069 0.520
MOD_NEK2_1 642 647 PF00069 0.492
MOD_NEK2_1 74 79 PF00069 0.624
MOD_NEK2_1 748 753 PF00069 0.343
MOD_NEK2_1 803 808 PF00069 0.548
MOD_NEK2_1 875 880 PF00069 0.438
MOD_NEK2_1 909 914 PF00069 0.299
MOD_NEK2_2 1005 1010 PF00069 0.345
MOD_NEK2_2 294 299 PF00069 0.527
MOD_NEK2_2 659 664 PF00069 0.344
MOD_PIKK_1 129 135 PF00454 0.685
MOD_PIKK_1 285 291 PF00454 0.595
MOD_PIKK_1 342 348 PF00454 0.571
MOD_PIKK_1 556 562 PF00454 0.556
MOD_PIKK_1 813 819 PF00454 0.618
MOD_PIKK_1 85 91 PF00454 0.633
MOD_PIKK_1 877 883 PF00454 0.410
MOD_PK_1 177 183 PF00069 0.597
MOD_PK_1 931 937 PF00069 0.446
MOD_PKA_1 117 123 PF00069 0.658
MOD_PKA_1 188 194 PF00069 0.602
MOD_PKA_1 233 239 PF00069 0.580
MOD_PKA_1 314 320 PF00069 0.514
MOD_PKA_1 611 617 PF00069 0.409
MOD_PKA_1 983 989 PF00069 0.408
MOD_PKA_2 116 122 PF00069 0.659
MOD_PKA_2 172 178 PF00069 0.663
MOD_PKA_2 188 194 PF00069 0.460
MOD_PKA_2 270 276 PF00069 0.566
MOD_PKA_2 418 424 PF00069 0.493
MOD_PKA_2 581 587 PF00069 0.468
MOD_PKA_2 60 66 PF00069 0.682
MOD_PKA_2 611 617 PF00069 0.518
MOD_PKA_2 624 630 PF00069 0.529
MOD_PKA_2 635 641 PF00069 0.653
MOD_PKA_2 8 14 PF00069 0.748
MOD_PKA_2 983 989 PF00069 0.372
MOD_Plk_1 1005 1011 PF00069 0.342
MOD_Plk_1 159 165 PF00069 0.703
MOD_Plk_1 175 181 PF00069 0.625
MOD_Plk_1 278 284 PF00069 0.586
MOD_Plk_1 638 644 PF00069 0.531
MOD_Plk_1 679 685 PF00069 0.388
MOD_Plk_1 941 947 PF00069 0.401
MOD_Plk_1 993 999 PF00069 0.384
MOD_Plk_2-3 155 161 PF00069 0.642
MOD_Plk_2-3 381 387 PF00069 0.557
MOD_Plk_2-3 963 969 PF00069 0.364
MOD_Plk_4 1005 1011 PF00069 0.342
MOD_Plk_4 102 108 PF00069 0.605
MOD_Plk_4 122 128 PF00069 0.494
MOD_Plk_4 235 241 PF00069 0.529
MOD_Plk_4 243 249 PF00069 0.510
MOD_Plk_4 395 401 PF00069 0.670
MOD_Plk_4 439 445 PF00069 0.431
MOD_Plk_4 60 66 PF00069 0.672
MOD_Plk_4 689 695 PF00069 0.358
MOD_Plk_4 729 735 PF00069 0.412
MOD_Plk_4 870 876 PF00069 0.388
MOD_Plk_4 984 990 PF00069 0.244
MOD_Plk_4 993 999 PF00069 0.374
MOD_ProDKin_1 241 247 PF00069 0.556
MOD_ProDKin_1 320 326 PF00069 0.450
MOD_ProDKin_1 475 481 PF00069 0.480
MOD_ProDKin_1 494 500 PF00069 0.762
MOD_ProDKin_1 51 57 PF00069 0.591
MOD_ProDKin_1 518 524 PF00069 0.626
MOD_ProDKin_1 531 537 PF00069 0.807
MOD_ProDKin_1 592 598 PF00069 0.453
MOD_ProDKin_1 899 905 PF00069 0.334
TRG_DiLeu_BaEn_1 585 590 PF01217 0.455
TRG_DiLeu_BaEn_1 689 694 PF01217 0.364
TRG_DiLeu_BaEn_1 994 999 PF01217 0.437
TRG_DiLeu_BaEn_2 743 749 PF01217 0.423
TRG_DiLeu_BaLyEn_6 208 213 PF01217 0.495
TRG_DiLeu_BaLyEn_6 593 598 PF01217 0.297
TRG_DiLeu_LyEn_5 585 590 PF01217 0.417
TRG_ENDOCYTIC_2 275 278 PF00928 0.447
TRG_ENDOCYTIC_2 466 469 PF00928 0.417
TRG_ER_diArg_1 187 190 PF00400 0.596
TRG_ER_diArg_1 29 32 PF00400 0.578
TRG_ER_diArg_1 897 900 PF00400 0.338
TRG_ER_diArg_1 983 985 PF00400 0.424

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P550 Leptomonas seymouri 56% 100%
A0A3S7X748 Leishmania donovani 86% 96%
A4HLX4 Leishmania braziliensis 72% 100%
A4I9A3 Leishmania infantum 86% 96%
C9ZJC3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
Q4Q3S3 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS