Signal recognition particle receptor subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle receptor beta subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B4A2_LEIMU

TriTrypDb:

LmxM.32.2620

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	6
GO:0016020	membrane	2	7
GO:0031090	organelle membrane	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0005785	signal recognition particle receptor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

E9B4A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4A2

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.546
CLV_C14_Caspase3-7	394	398	PF00656	0.535
CLV_C14_Caspase3-7	425	429	PF00656	0.734
CLV_NRD_NRD_1	218	220	PF00675	0.422
CLV_NRD_NRD_1	230	232	PF00675	0.498
CLV_NRD_NRD_1	350	352	PF00675	0.419
CLV_NRD_NRD_1	370	372	PF00675	0.330
CLV_NRD_NRD_1	418	420	PF00675	0.589
CLV_PCSK_KEX2_1	218	220	PF00082	0.440
CLV_PCSK_KEX2_1	229	231	PF00082	0.497
CLV_PCSK_KEX2_1	350	352	PF00082	0.372
CLV_PCSK_KEX2_1	358	360	PF00082	0.316
CLV_PCSK_KEX2_1	418	420	PF00082	0.597
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.346
CLV_PCSK_SKI1_1	108	112	PF00082	0.728
CLV_PCSK_SKI1_1	18	22	PF00082	0.658
CLV_PCSK_SKI1_1	218	222	PF00082	0.331
CLV_PCSK_SKI1_1	246	250	PF00082	0.385
CLV_PCSK_SKI1_1	350	354	PF00082	0.349
CLV_PCSK_SKI1_1	371	375	PF00082	0.346
CLV_PCSK_SKI1_1	419	423	PF00082	0.602
DEG_SPOP_SBC_1	232	236	PF00917	0.619
DOC_CKS1_1	93	98	PF01111	0.538
DOC_CYCLIN_RxL_1	348	357	PF00134	0.546
DOC_CYCLIN_RxL_1	368	375	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.623
DOC_MAPK_gen_1	229	239	PF00069	0.545
DOC_MAPK_gen_1	281	290	PF00069	0.411
DOC_MAPK_gen_1	418	424	PF00069	0.799
DOC_MAPK_MEF2A_6	233	241	PF00069	0.552
DOC_MAPK_MEF2A_6	246	253	PF00069	0.564
DOC_PP1_RVXF_1	217	224	PF00149	0.572
DOC_PP1_RVXF_1	348	355	PF00149	0.549
DOC_PP2B_LxvP_1	459	462	PF13499	0.635
DOC_USP7_MATH_1	120	124	PF00917	0.510
DOC_USP7_MATH_1	63	67	PF00917	0.528
DOC_USP7_MATH_1	98	102	PF00917	0.528
DOC_USP7_UBL2_3	368	372	PF12436	0.530
DOC_WW_Pin1_4	148	153	PF00397	0.537
DOC_WW_Pin1_4	177	182	PF00397	0.530
DOC_WW_Pin1_4	340	345	PF00397	0.546
DOC_WW_Pin1_4	92	97	PF00397	0.564
LIG_14-3-3_CanoR_1	108	117	PF00244	0.528
LIG_14-3-3_CanoR_1	190	195	PF00244	0.477
LIG_14-3-3_CanoR_1	230	239	PF00244	0.549
LIG_14-3-3_CanoR_1	263	267	PF00244	0.549
LIG_14-3-3_CanoR_1	305	314	PF00244	0.466
LIG_14-3-3_CanoR_1	419	425	PF00244	0.701
LIG_14-3-3_CanoR_1	450	455	PF00244	0.559
LIG_14-3-3_CanoR_1	97	106	PF00244	0.463
LIG_Actin_WH2_2	114	131	PF00022	0.455
LIG_Actin_WH2_2	209	224	PF00022	0.249
LIG_BIR_II_1	1	5	PF00653	0.523
LIG_BIR_III_2	172	176	PF00653	0.489
LIG_BRCT_BRCA1_1	342	346	PF00533	0.546
LIG_BRCT_BRCA1_1	452	456	PF00533	0.707
LIG_deltaCOP1_diTrp_1	198	201	PF00928	0.419
LIG_EH1_1	346	354	PF00400	0.546
LIG_eIF4E_1	347	353	PF01652	0.546
LIG_FHA_1	149	155	PF00498	0.522
LIG_FHA_1	203	209	PF00498	0.513
LIG_FHA_1	232	238	PF00498	0.549
LIG_FHA_2	10	16	PF00498	0.493
LIG_FHA_2	319	325	PF00498	0.619
LIG_FHA_2	355	361	PF00498	0.546
LIG_FHA_2	480	486	PF00498	0.594
LIG_FHA_2	66	72	PF00498	0.413
LIG_GBD_Chelix_1	333	341	PF00786	0.346
LIG_HCF-1_HBM_1	476	479	PF13415	0.663
LIG_Integrin_RGD_1	35	37	PF01839	0.622
LIG_LIR_Gen_1	122	132	PF02991	0.510
LIG_LIR_Gen_1	196	207	PF02991	0.355
LIG_LIR_Gen_1	247	254	PF02991	0.594
LIG_LIR_Gen_1	453	464	PF02991	0.634
LIG_LIR_Nem_3	122	128	PF02991	0.507
LIG_LIR_Nem_3	196	202	PF02991	0.355
LIG_LIR_Nem_3	247	253	PF02991	0.529
LIG_LIR_Nem_3	343	349	PF02991	0.546
LIG_LIR_Nem_3	453	459	PF02991	0.635
LIG_MAD2	289	297	PF02301	0.619
LIG_NRBOX	332	338	PF00104	0.520
LIG_REV1ctd_RIR_1	212	223	PF16727	0.340
LIG_SH2_STAP1	365	369	PF00017	0.530
LIG_SH2_STAP1	479	483	PF00017	0.702
LIG_SH2_STAT5	210	213	PF00017	0.389
LIG_SH2_STAT5	24	27	PF00017	0.596
LIG_SH3_3	288	294	PF00018	0.546
LIG_SUMO_SIM_anti_2	480	486	PF11976	0.692
LIG_SUMO_SIM_par_1	312	319	PF11976	0.546
LIG_SUMO_SIM_par_1	420	425	PF11976	0.707
LIG_TRAF2_1	41	44	PF00917	0.532
LIG_TYR_ITIM	208	213	PF00017	0.411
LIG_UBA3_1	238	246	PF00899	0.546
LIG_WRC_WIRS_1	191	196	PF05994	0.538
MOD_CDK_SPK_2	92	97	PF00069	0.477
MOD_CK1_1	123	129	PF00069	0.581
MOD_CK1_1	130	136	PF00069	0.474
MOD_CK1_1	180	186	PF00069	0.457
MOD_CK1_1	244	250	PF00069	0.546
MOD_CK1_1	262	268	PF00069	0.611
MOD_CK1_1	364	370	PF00069	0.530
MOD_CK1_1	381	387	PF00069	0.546
MOD_CK2_1	192	198	PF00069	0.527
MOD_CK2_1	262	268	PF00069	0.530
MOD_CK2_1	38	44	PF00069	0.514
MOD_CK2_1	479	485	PF00069	0.555
MOD_CK2_1	65	71	PF00069	0.406
MOD_CK2_1	9	15	PF00069	0.493
MOD_GlcNHglycan	100	103	PF01048	0.767
MOD_GlcNHglycan	130	133	PF01048	0.783
MOD_GlcNHglycan	195	198	PF01048	0.644
MOD_GlcNHglycan	202	205	PF01048	0.421
MOD_GlcNHglycan	243	246	PF01048	0.346
MOD_GlcNHglycan	273	276	PF01048	0.370
MOD_GlcNHglycan	31	34	PF01048	0.770
MOD_GlcNHglycan	408	411	PF01048	0.545
MOD_GlcNHglycan	413	416	PF01048	0.539
MOD_GlcNHglycan	49	52	PF01048	0.694
MOD_GSK3_1	119	126	PF00069	0.369
MOD_GSK3_1	148	155	PF00069	0.585
MOD_GSK3_1	391	398	PF00069	0.483
MOD_GSK3_1	402	409	PF00069	0.688
MOD_GSK3_1	65	72	PF00069	0.521
MOD_N-GLC_1	108	113	PF02516	0.713
MOD_N-GLC_1	9	14	PF02516	0.694
MOD_NEK2_1	1	6	PF00069	0.384
MOD_NEK2_1	128	133	PF00069	0.423
MOD_NEK2_1	202	207	PF00069	0.513
MOD_NEK2_1	259	264	PF00069	0.506
MOD_NEK2_1	354	359	PF00069	0.552
MOD_PK_1	391	397	PF00069	0.535
MOD_PKA_2	128	134	PF00069	0.382
MOD_PKA_2	232	238	PF00069	0.552
MOD_PKA_2	262	268	PF00069	0.555
MOD_PKA_2	395	401	PF00069	0.483
MOD_PKA_2	69	75	PF00069	0.422
MOD_PKB_1	229	237	PF00069	0.660
MOD_Plk_1	108	114	PF00069	0.497
MOD_Plk_1	9	15	PF00069	0.493
MOD_Plk_2-3	318	324	PF00069	0.546
MOD_Plk_4	120	126	PF00069	0.505
MOD_Plk_4	202	208	PF00069	0.458
MOD_Plk_4	233	239	PF00069	0.546
MOD_Plk_4	9	15	PF00069	0.489
MOD_ProDKin_1	148	154	PF00069	0.536
MOD_ProDKin_1	177	183	PF00069	0.528
MOD_ProDKin_1	340	346	PF00069	0.546
MOD_ProDKin_1	92	98	PF00069	0.560
MOD_SUMO_rev_2	405	409	PF00179	0.629
MOD_SUMO_rev_2	41	48	PF00179	0.447
MOD_SUMO_rev_2	470	480	PF00179	0.669
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.546
TRG_ENDOCYTIC_2	210	213	PF00928	0.411
TRG_ENDOCYTIC_2	300	303	PF00928	0.411
TRG_ER_diArg_1	217	219	PF00400	0.537
TRG_ER_diArg_1	229	231	PF00400	0.698
TRG_ER_diArg_1	349	351	PF00400	0.619
TRG_ER_diArg_1	418	420	PF00400	0.761
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X6	Leptomonas seymouri	54%	100%
A0A3S7X750	Leishmania donovani	87%	100%
A4HLX3	Leishmania braziliensis	69%	100%
A4I9A2	Leishmania infantum	87%	100%
Q4Q3S4	Leishmania major	84%	100%