Putative enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-CoA hydratase/Enoyl-CoA isomerase/3- hydroxyacyl-CoA dehydrogenase, putative

Species:

Leishmania mexicana

UniProt:

E9B4A0_LEIMU

TriTrypDb:

LmxM.32.2600

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B4A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B4A0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006629	lipid metabolic process	3	11
GO:0006631	fatty acid metabolic process	4	11
GO:0006635	fatty acid beta-oxidation	6	10
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	10
GO:0009062	fatty acid catabolic process	5	10
GO:0009987	cellular process	1	11
GO:0016042	lipid catabolic process	4	10
GO:0016054	organic acid catabolic process	4	10
GO:0019395	fatty acid oxidation	5	10
GO:0019752	carboxylic acid metabolic process	5	11
GO:0030258	lipid modification	4	10
GO:0032787	monocarboxylic acid metabolic process	6	11
GO:0034440	lipid oxidation	5	10
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044242	cellular lipid catabolic process	4	10
GO:0044248	cellular catabolic process	3	10
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	10
GO:0046395	carboxylic acid catabolic process	5	10
GO:0071704	organic substance metabolic process	2	11
GO:0072329	monocarboxylic acid catabolic process	6	10
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	7
GO:0004300	enoyl-CoA hydratase activity	5	6
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	11
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	11
GO:0016829	lyase activity	2	6
GO:0016835	carbon-oxygen lyase activity	3	6
GO:0016836	hydro-lyase activity	4	6
GO:0016853	isomerase activity	2	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0051287	NAD binding	4	11
GO:0070403	NAD+ binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.314
CLV_NRD_NRD_1	21	23	PF00675	0.488
CLV_NRD_NRD_1	255	257	PF00675	0.374
CLV_NRD_NRD_1	454	456	PF00675	0.382
CLV_NRD_NRD_1	633	635	PF00675	0.358
CLV_NRD_NRD_1	717	719	PF00675	0.483
CLV_NRD_NRD_1	764	766	PF00675	0.637
CLV_NRD_NRD_1	827	829	PF00675	0.429
CLV_NRD_NRD_1	831	833	PF00675	0.379
CLV_NRD_NRD_1	897	899	PF00675	0.383
CLV_PCSK_KEX2_1	185	187	PF00082	0.468
CLV_PCSK_KEX2_1	2	4	PF00082	0.569
CLV_PCSK_KEX2_1	21	23	PF00082	0.409
CLV_PCSK_KEX2_1	254	256	PF00082	0.386
CLV_PCSK_KEX2_1	454	456	PF00082	0.382
CLV_PCSK_KEX2_1	525	527	PF00082	0.373
CLV_PCSK_KEX2_1	678	680	PF00082	0.687
CLV_PCSK_KEX2_1	764	766	PF00082	0.577
CLV_PCSK_KEX2_1	825	827	PF00082	0.432
CLV_PCSK_KEX2_1	831	833	PF00082	0.366
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.657
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.362
CLV_PCSK_PC1ET2_1	678	680	PF00082	0.687
CLV_PCSK_PC1ET2_1	825	827	PF00082	0.527
CLV_PCSK_PC7_1	827	833	PF00082	0.515
CLV_PCSK_SKI1_1	263	267	PF00082	0.337
CLV_PCSK_SKI1_1	333	337	PF00082	0.362
CLV_PCSK_SKI1_1	55	59	PF00082	0.342
CLV_PCSK_SKI1_1	607	611	PF00082	0.356
CLV_PCSK_SKI1_1	641	645	PF00082	0.393
CLV_PCSK_SKI1_1	701	705	PF00082	0.469
CLV_PCSK_SKI1_1	726	730	PF00082	0.427
CLV_PCSK_SKI1_1	827	831	PF00082	0.450
CLV_PCSK_SKI1_1	842	846	PF00082	0.215
CLV_PCSK_SKI1_1	898	902	PF00082	0.220
CLV_PCSK_SKI1_1	925	929	PF00082	0.323
DEG_APCC_DBOX_1	193	201	PF00400	0.412
DEG_APCC_DBOX_1	409	417	PF00400	0.380
DEG_APCC_DBOX_1	606	614	PF00400	0.404
DEG_APCC_DBOX_1	798	806	PF00400	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.580
DEG_SPOP_SBC_1	70	74	PF00917	0.392
DOC_CDC14_PxL_1	590	598	PF14671	0.396
DOC_CKS1_1	222	227	PF01111	0.572
DOC_CKS1_1	727	732	PF01111	0.509
DOC_CYCLIN_RxL_1	330	338	PF00134	0.477
DOC_CYCLIN_RxL_1	635	648	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.392
DOC_MAPK_FxFP_2	149	152	PF00069	0.281
DOC_MAPK_FxFP_2	874	877	PF00069	0.417
DOC_MAPK_gen_1	18	27	PF00069	0.443
DOC_MAPK_gen_1	380	388	PF00069	0.423
DOC_MAPK_gen_1	797	805	PF00069	0.410
DOC_MAPK_HePTP_8	545	557	PF00069	0.334
DOC_MAPK_MEF2A_6	292	301	PF00069	0.480
DOC_MAPK_MEF2A_6	382	390	PF00069	0.544
DOC_MAPK_MEF2A_6	548	557	PF00069	0.334
DOC_MAPK_MEF2A_6	797	805	PF00069	0.491
DOC_PP1_RVXF_1	840	846	PF00149	0.313
DOC_PP2B_LxvP_1	340	343	PF13499	0.490
DOC_PP2B_LxvP_1	45	48	PF13499	0.370
DOC_PP4_FxxP_1	149	152	PF00568	0.261
DOC_PP4_FxxP_1	557	560	PF00568	0.278
DOC_PP4_FxxP_1	874	877	PF00568	0.484
DOC_PP4_FxxP_1	912	915	PF00568	0.329
DOC_SPAK_OSR1_1	155	159	PF12202	0.285
DOC_USP7_MATH_1	101	105	PF00917	0.349
DOC_USP7_MATH_1	113	117	PF00917	0.292
DOC_USP7_MATH_1	531	535	PF00917	0.454
DOC_USP7_MATH_1	658	662	PF00917	0.412
DOC_USP7_MATH_1	669	673	PF00917	0.436
DOC_USP7_MATH_1	742	746	PF00917	0.603
DOC_USP7_MATH_1	784	788	PF00917	0.587
DOC_USP7_MATH_1	790	794	PF00917	0.716
DOC_USP7_MATH_1	801	805	PF00917	0.402
DOC_USP7_MATH_1	906	910	PF00917	0.531
DOC_USP7_UBL2_3	895	899	PF12436	0.433
DOC_WW_Pin1_4	156	161	PF00397	0.349
DOC_WW_Pin1_4	218	223	PF00397	0.666
DOC_WW_Pin1_4	224	229	PF00397	0.566
DOC_WW_Pin1_4	561	566	PF00397	0.292
DOC_WW_Pin1_4	685	690	PF00397	0.590
DOC_WW_Pin1_4	726	731	PF00397	0.509
LIG_14-3-3_CanoR_1	254	261	PF00244	0.410
LIG_14-3-3_CanoR_1	29	35	PF00244	0.485
LIG_14-3-3_CanoR_1	353	360	PF00244	0.481
LIG_14-3-3_CanoR_1	55	61	PF00244	0.387
LIG_14-3-3_CanoR_1	571	580	PF00244	0.349
LIG_14-3-3_CanoR_1	607	617	PF00244	0.364
LIG_14-3-3_CanoR_1	659	663	PF00244	0.421
LIG_14-3-3_CanoR_1	77	85	PF00244	0.330
LIG_BIR_III_2	281	285	PF00653	0.299
LIG_BRCT_BRCA1_1	526	530	PF00533	0.235
LIG_BRCT_BRCA1_1	74	78	PF00533	0.392
LIG_BRCT_BRCA1_1	908	912	PF00533	0.452
LIG_Clathr_ClatBox_1	643	647	PF01394	0.404
LIG_eIF4E_1	603	609	PF01652	0.332
LIG_FHA_1	107	113	PF00498	0.276
LIG_FHA_1	247	253	PF00498	0.287
LIG_FHA_1	255	261	PF00498	0.373
LIG_FHA_1	406	412	PF00498	0.598
LIG_FHA_1	465	471	PF00498	0.292
LIG_FHA_1	604	610	PF00498	0.307
LIG_FHA_1	638	644	PF00498	0.378
LIG_FHA_1	658	664	PF00498	0.126
LIG_FHA_1	711	717	PF00498	0.370
LIG_FHA_1	784	790	PF00498	0.732
LIG_FHA_2	454	460	PF00498	0.422
LIG_FHA_2	727	733	PF00498	0.498
LIG_HP1_1	801	805	PF01393	0.464
LIG_LIR_Apic_2	359	365	PF02991	0.432
LIG_LIR_Apic_2	693	699	PF02991	0.439
LIG_LIR_Apic_2	909	915	PF02991	0.343
LIG_LIR_Gen_1	13	20	PF02991	0.467
LIG_LIR_Gen_1	837	848	PF02991	0.438
LIG_LIR_Gen_1	928	933	PF02991	0.470
LIG_LIR_Nem_3	13	19	PF02991	0.521
LIG_LIR_Nem_3	591	596	PF02991	0.400
LIG_LIR_Nem_3	611	617	PF02991	0.240
LIG_LIR_Nem_3	722	728	PF02991	0.423
LIG_LIR_Nem_3	815	821	PF02991	0.458
LIG_LIR_Nem_3	837	843	PF02991	0.445
LIG_LYPXL_SIV_4	327	335	PF13949	0.474
LIG_LYPXL_yS_3	593	596	PF13949	0.396
LIG_PCNA_TLS_4	454	461	PF02747	0.396
LIG_Pex14_2	88	92	PF04695	0.392
LIG_Pex14_2	929	933	PF04695	0.379
LIG_PTB_Apo_2	691	698	PF02174	0.235
LIG_SH2_CRK	203	207	PF00017	0.428
LIG_SH2_CRK	725	729	PF00017	0.474
LIG_SH2_SRC	886	889	PF00017	0.420
LIG_SH2_STAP1	188	192	PF00017	0.392
LIG_SH2_STAP1	261	265	PF00017	0.299
LIG_SH2_STAP1	814	818	PF00017	0.487
LIG_SH2_STAP1	886	890	PF00017	0.328
LIG_SH2_STAT5	328	331	PF00017	0.415
LIG_SH2_STAT5	460	463	PF00017	0.396
LIG_SH2_STAT5	603	606	PF00017	0.332
LIG_SH2_STAT5	727	730	PF00017	0.500
LIG_SH3_3	169	175	PF00018	0.392
LIG_SH3_3	219	225	PF00018	0.521
LIG_SH3_3	284	290	PF00018	0.413
LIG_SH3_3	387	393	PF00018	0.703
LIG_SH3_3	487	493	PF00018	0.407
LIG_SH3_3	671	677	PF00018	0.663
LIG_SH3_3	681	687	PF00018	0.679
LIG_SH3_3	696	702	PF00018	0.368
LIG_SH3_3	97	103	PF00018	0.307
LIG_SUMO_SIM_anti_2	426	432	PF11976	0.312
LIG_SUMO_SIM_anti_2	436	442	PF11976	0.281
LIG_SUMO_SIM_par_1	439	444	PF11976	0.310
LIG_SUMO_SIM_par_1	594	599	PF11976	0.445
LIG_SUMO_SIM_par_1	67	75	PF11976	0.365
LIG_SUMO_SIM_par_1	801	807	PF11976	0.443
LIG_TRAF2_1	240	243	PF00917	0.396
LIG_TRAF2_1	729	732	PF00917	0.462
LIG_TYR_ITIM	816	821	PF00017	0.392
LIG_UBA3_1	516	525	PF00899	0.404
LIG_UBA3_1	586	592	PF00899	0.401
LIG_WW_3	34	38	PF00397	0.513
MOD_CK1_1	106	112	PF00069	0.230
MOD_CK1_1	355	361	PF00069	0.521
MOD_CK1_1	685	691	PF00069	0.534
MOD_CK1_1	793	799	PF00069	0.638
MOD_CK1_1	804	810	PF00069	0.330
MOD_CK1_1	94	100	PF00069	0.350
MOD_CK2_1	101	107	PF00069	0.326
MOD_CK2_1	315	321	PF00069	0.646
MOD_CK2_1	433	439	PF00069	0.338
MOD_CK2_1	460	466	PF00069	0.434
MOD_CK2_1	658	664	PF00069	0.157
MOD_CK2_1	685	691	PF00069	0.542
MOD_CK2_1	726	732	PF00069	0.484
MOD_CMANNOS	271	274	PF00535	0.485
MOD_Cter_Amidation	183	186	PF01082	0.369
MOD_Cter_Amidation	716	719	PF01082	0.446
MOD_GlcNHglycan	203	206	PF01048	0.522
MOD_GlcNHglycan	32	35	PF01048	0.492
MOD_GlcNHglycan	381	385	PF01048	0.681
MOD_GlcNHglycan	394	397	PF01048	0.553
MOD_GlcNHglycan	534	537	PF01048	0.319
MOD_GlcNHglycan	750	753	PF01048	0.616
MOD_GlcNHglycan	760	763	PF01048	0.638
MOD_GlcNHglycan	765	768	PF01048	0.613
MOD_GlcNHglycan	786	789	PF01048	0.608
MOD_GlcNHglycan	792	795	PF01048	0.614
MOD_GlcNHglycan	80	83	PF01048	0.323
MOD_GlcNHglycan	862	865	PF01048	0.307
MOD_GSK3_1	352	359	PF00069	0.529
MOD_GSK3_1	397	404	PF00069	0.569
MOD_GSK3_1	420	427	PF00069	0.409
MOD_GSK3_1	460	467	PF00069	0.157
MOD_GSK3_1	525	532	PF00069	0.341
MOD_GSK3_1	742	749	PF00069	0.620
MOD_GSK3_1	768	775	PF00069	0.707
MOD_GSK3_1	778	785	PF00069	0.673
MOD_GSK3_1	789	796	PF00069	0.674
MOD_GSK3_1	817	824	PF00069	0.478
MOD_N-GLC_1	561	566	PF02516	0.404
MOD_N-GLC_1	669	674	PF02516	0.476
MOD_N-GLC_1	812	817	PF02516	0.466
MOD_N-GLC_1	86	91	PF02516	0.393
MOD_NEK2_1	126	131	PF00069	0.312
MOD_NEK2_1	30	35	PF00069	0.519
MOD_NEK2_1	307	312	PF00069	0.462
MOD_NEK2_1	335	340	PF00069	0.417
MOD_NEK2_1	352	357	PF00069	0.310
MOD_NEK2_1	424	429	PF00069	0.349
MOD_NEK2_1	596	601	PF00069	0.501
MOD_NEK2_1	608	613	PF00069	0.338
MOD_NEK2_1	637	642	PF00069	0.387
MOD_NEK2_1	657	662	PF00069	0.126
MOD_NEK2_1	690	695	PF00069	0.534
MOD_NEK2_1	704	709	PF00069	0.348
MOD_NEK2_1	71	76	PF00069	0.348
MOD_NEK2_1	710	715	PF00069	0.287
MOD_NEK2_1	78	83	PF00069	0.327
MOD_NEK2_1	780	785	PF00069	0.550
MOD_PIKK_1	342	348	PF00454	0.483
MOD_PIKK_1	352	358	PF00454	0.542
MOD_PIKK_1	543	549	PF00454	0.387
MOD_PK_1	256	262	PF00069	0.291
MOD_PKA_1	254	260	PF00069	0.413
MOD_PKA_1	525	531	PF00069	0.396
MOD_PKA_1	827	833	PF00069	0.515
MOD_PKA_2	254	260	PF00069	0.444
MOD_PKA_2	352	358	PF00069	0.450
MOD_PKA_2	453	459	PF00069	0.457
MOD_PKA_2	468	474	PF00069	0.284
MOD_PKA_2	525	531	PF00069	0.387
MOD_PKA_2	658	664	PF00069	0.396
MOD_PKA_2	717	723	PF00069	0.467
MOD_PKA_2	763	769	PF00069	0.591
MOD_PKA_2	827	833	PF00069	0.531
MOD_PKB_1	254	262	PF00069	0.288
MOD_PKB_1	462	470	PF00069	0.157
MOD_Plk_1	731	737	PF00069	0.502
MOD_Plk_1	812	818	PF00069	0.387
MOD_Plk_1	866	872	PF00069	0.345
MOD_Plk_2-3	401	407	PF00069	0.598
MOD_Plk_2-3	817	823	PF00069	0.531
MOD_Plk_4	256	262	PF00069	0.438
MOD_Plk_4	525	531	PF00069	0.355
MOD_Plk_4	628	634	PF00069	0.457
MOD_Plk_4	658	664	PF00069	0.396
MOD_Plk_4	742	748	PF00069	0.623
MOD_Plk_4	804	810	PF00069	0.525
MOD_Plk_4	867	873	PF00069	0.329
MOD_Plk_4	928	934	PF00069	0.477
MOD_ProDKin_1	156	162	PF00069	0.349
MOD_ProDKin_1	218	224	PF00069	0.678
MOD_ProDKin_1	561	567	PF00069	0.292
MOD_ProDKin_1	685	691	PF00069	0.579
MOD_ProDKin_1	726	732	PF00069	0.510
TRG_DiLeu_BaEn_1	337	342	PF01217	0.474
TRG_DiLeu_BaEn_2	840	846	PF01217	0.356
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.356
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.262
TRG_ENDOCYTIC_2	272	275	PF00928	0.451
TRG_ENDOCYTIC_2	593	596	PF00928	0.462
TRG_ENDOCYTIC_2	617	620	PF00928	0.293
TRG_ENDOCYTIC_2	725	728	PF00928	0.474
TRG_ENDOCYTIC_2	818	821	PF00928	0.369
TRG_ER_diArg_1	185	187	PF00400	0.468
TRG_ER_diArg_1	254	256	PF00400	0.464
TRG_ER_diArg_1	461	464	PF00400	0.356
TRG_ER_diArg_1	481	484	PF00400	0.390
TRG_ER_diArg_1	737	740	PF00400	0.629
TRG_ER_diArg_1	797	800	PF00400	0.410
TRG_ER_diArg_1	826	828	PF00400	0.446
TRG_ER_diArg_1	831	833	PF00400	0.386
TRG_NES_CRM1_1	837	850	PF08389	0.366
TRG_NLS_MonoCore_2	824	829	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	455	459	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	905	910	PF00026	0.440
TRG_PTS2	1	11	PF00400	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX9	Leptomonas seymouri	58%	100%
A0A0N1PD28	Leptomonas seymouri	23%	100%
A0A0S4JJU7	Bodo saltans	25%	100%
A0A1X0NSP5	Trypanosomatidae	30%	100%
A0A3R7KS65	Trypanosoma rangeli	31%	100%
A0A3S7X716	Leishmania donovani	88%	100%
A4HF10	Leishmania braziliensis	24%	100%
A4HLX1	Leishmania braziliensis	77%	100%
A4I9A0	Leishmania infantum	87%	100%
A4WCW6	Enterobacter sp. (strain 638)	26%	100%
A8A2L0	Escherichia coli O9:H4 (strain HS)	26%	100%
B5XVW2	Klebsiella pneumoniae (strain 342)	25%	100%
C9ZJC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
P07896	Rattus norvegicus	27%	100%
P40939	Homo sapiens	24%	100%
P55100	Cavia porcellus	28%	100%
Q08426	Homo sapiens	27%	100%
Q29554	Sus scrofa	24%	100%
Q4Q3S6	Leishmania major	87%	100%
Q5R5M8	Pongo abelii	27%	100%
Q64428	Rattus norvegicus	24%	100%
Q6NYL3	Danio rerio	29%	100%
Q8BMS1	Mus musculus	24%	100%
Q9DBM2	Mus musculus	27%	100%
Q9ZPI6	Arabidopsis thaliana	24%	100%
V5BN63	Trypanosoma cruzi	30%	100%