Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B498_LEIMU

TriTrypDb:

LmxM.32.2585

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B498

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B498

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	500	504	PF00656	0.487
CLV_NRD_NRD_1	221	223	PF00675	0.488
CLV_NRD_NRD_1	49	51	PF00675	0.828
CLV_NRD_NRD_1	504	506	PF00675	0.661
CLV_PCSK_KEX2_1	221	223	PF00082	0.488
CLV_PCSK_KEX2_1	49	51	PF00082	0.828
CLV_PCSK_SKI1_1	215	219	PF00082	0.665
CLV_PCSK_SKI1_1	354	358	PF00082	0.613
CLV_PCSK_SKI1_1	365	369	PF00082	0.429
CLV_PCSK_SKI1_1	433	437	PF00082	0.578
CLV_PCSK_SKI1_1	506	510	PF00082	0.668
CLV_PCSK_SKI1_1	539	543	PF00082	0.496
CLV_PCSK_SKI1_1	71	75	PF00082	0.506
CLV_PCSK_SKI1_1	80	84	PF00082	0.478
DEG_APCC_DBOX_1	451	459	PF00400	0.649
DEG_Nend_UBRbox_1	1	4	PF02207	0.681
DEG_SPOP_SBC_1	371	375	PF00917	0.507
DEG_SPOP_SBC_1	485	489	PF00917	0.678
DOC_CYCLIN_yCln2_LP_2	255	261	PF00134	0.467
DOC_MAPK_MEF2A_6	535	542	PF00069	0.516
DOC_PP2B_LxvP_1	27	30	PF13499	0.736
DOC_PP4_MxPP_1	51	54	PF00568	0.606
DOC_USP7_MATH_1	113	117	PF00917	0.705
DOC_USP7_MATH_1	15	19	PF00917	0.547
DOC_USP7_MATH_1	185	189	PF00917	0.634
DOC_USP7_MATH_1	224	228	PF00917	0.469
DOC_USP7_MATH_1	276	280	PF00917	0.699
DOC_USP7_MATH_1	356	360	PF00917	0.515
DOC_USP7_MATH_1	371	375	PF00917	0.620
DOC_USP7_MATH_1	418	422	PF00917	0.815
DOC_USP7_MATH_1	484	488	PF00917	0.689
DOC_USP7_MATH_1	563	567	PF00917	0.559
DOC_WW_Pin1_4	188	193	PF00397	0.605
DOC_WW_Pin1_4	265	270	PF00397	0.581
DOC_WW_Pin1_4	284	289	PF00397	0.652
DOC_WW_Pin1_4	377	382	PF00397	0.564
DOC_WW_Pin1_4	49	54	PF00397	0.781
DOC_WW_Pin1_4	97	102	PF00397	0.628
LIG_14-3-3_CanoR_1	184	194	PF00244	0.419
LIG_14-3-3_CanoR_1	2	8	PF00244	0.685
LIG_14-3-3_CanoR_1	277	281	PF00244	0.685
LIG_14-3-3_CanoR_1	283	289	PF00244	0.650
LIG_14-3-3_CanoR_1	365	370	PF00244	0.616
LIG_14-3-3_CanoR_1	376	380	PF00244	0.570
LIG_14-3-3_CanoR_1	505	514	PF00244	0.787
LIG_14-3-3_CanoR_1	562	568	PF00244	0.562
LIG_14-3-3_CanoR_1	57	65	PF00244	0.775
LIG_14-3-3_CanoR_1	71	78	PF00244	0.457
LIG_BIR_III_4	263	267	PF00653	0.602
LIG_BIR_III_4	394	398	PF00653	0.764
LIG_BRCT_BRCA1_1	255	259	PF00533	0.758
LIG_BRCT_BRCA1_1	3	7	PF00533	0.769
LIG_BRCT_BRCA1_1	342	346	PF00533	0.554
LIG_FHA_1	107	113	PF00498	0.722
LIG_FHA_1	148	154	PF00498	0.547
LIG_FHA_1	203	209	PF00498	0.467
LIG_FHA_1	226	232	PF00498	0.472
LIG_FHA_1	265	271	PF00498	0.466
LIG_FHA_1	33	39	PF00498	0.804
LIG_FHA_1	463	469	PF00498	0.450
LIG_FHA_2	42	48	PF00498	0.771
LIG_FHA_2	467	473	PF00498	0.518
LIG_FHA_2	477	483	PF00498	0.648
LIG_LIR_Gen_1	256	264	PF02991	0.679
LIG_LIR_Gen_1	343	351	PF02991	0.588
LIG_LIR_Nem_3	256	262	PF02991	0.679
LIG_LIR_Nem_3	343	349	PF02991	0.578
LIG_LIR_Nem_3	377	382	PF02991	0.748
LIG_LIR_Nem_3	546	552	PF02991	0.493
LIG_MYND_1	54	58	PF01753	0.530
LIG_RPA_C_Fungi	155	167	PF08784	0.564
LIG_SH2_STAP1	197	201	PF00017	0.443
LIG_SH2_STAP1	360	364	PF00017	0.609
LIG_SH2_STAT5	330	333	PF00017	0.491
LIG_SH2_STAT5	337	340	PF00017	0.460
LIG_SH2_STAT5	467	470	PF00017	0.522
LIG_SH3_1	28	34	PF00018	0.505
LIG_SH3_1	425	431	PF00018	0.706
LIG_SH3_2	428	433	PF14604	0.684
LIG_SH3_3	26	32	PF00018	0.515
LIG_SH3_3	425	431	PF00018	0.722
LIG_SH3_3	434	440	PF00018	0.626
LIG_SH3_CIN85_PxpxPR_1	428	433	PF14604	0.684
LIG_SUMO_SIM_par_1	442	449	PF11976	0.617
LIG_TRAF2_1	103	106	PF00917	0.796
LIG_TRFH_1	436	440	PF08558	0.524
LIG_TYR_ITIM	195	200	PF00017	0.483
LIG_UBA3_1	531	535	PF00899	0.479
LIG_WRC_WIRS_1	490	495	PF05994	0.621
LIG_WW_3	430	434	PF00397	0.664
MOD_CDC14_SPxK_1	287	290	PF00782	0.501
MOD_CDK_SPxK_1	284	290	PF00069	0.502
MOD_CK1_1	114	120	PF00069	0.772
MOD_CK1_1	175	181	PF00069	0.649
MOD_CK1_1	188	194	PF00069	0.459
MOD_CK1_1	203	209	PF00069	0.379
MOD_CK1_1	359	365	PF00069	0.422
MOD_CK1_1	374	380	PF00069	0.734
MOD_CK1_1	460	466	PF00069	0.553
MOD_CK1_1	488	494	PF00069	0.767
MOD_CK1_1	60	66	PF00069	0.725
MOD_CK2_1	466	472	PF00069	0.531
MOD_CK2_1	491	497	PF00069	0.707
MOD_Cter_Amidation	503	506	PF01082	0.707
MOD_GlcNHglycan	113	116	PF01048	0.702
MOD_GlcNHglycan	120	123	PF01048	0.671
MOD_GlcNHglycan	17	20	PF01048	0.716
MOD_GlcNHglycan	272	275	PF01048	0.645
MOD_GlcNHglycan	3	6	PF01048	0.682
MOD_GlcNHglycan	300	303	PF01048	0.696
MOD_GlcNHglycan	382	385	PF01048	0.751
MOD_GlcNHglycan	394	398	PF01048	0.602
MOD_GlcNHglycan	425	428	PF01048	0.642
MOD_GlcNHglycan	493	496	PF01048	0.696
MOD_GlcNHglycan	509	512	PF01048	0.748
MOD_GlcNHglycan	565	568	PF01048	0.565
MOD_GlcNHglycan	9	12	PF01048	0.690
MOD_GSK3_1	111	118	PF00069	0.681
MOD_GSK3_1	298	305	PF00069	0.654
MOD_GSK3_1	3	10	PF00069	0.714
MOD_GSK3_1	370	377	PF00069	0.569
MOD_GSK3_1	385	392	PF00069	0.593
MOD_GSK3_1	457	464	PF00069	0.579
MOD_GSK3_1	484	491	PF00069	0.669
MOD_GSK3_1	57	64	PF00069	0.751
MOD_GSK3_1	97	104	PF00069	0.769
MOD_N-GLC_1	175	180	PF02516	0.646
MOD_N-GLC_2	284	286	PF02516	0.620
MOD_N-GLC_2	545	547	PF02516	0.602
MOD_NEK2_1	1	6	PF00069	0.681
MOD_NEK2_1	146	151	PF00069	0.494
MOD_NEK2_1	202	207	PF00069	0.275
MOD_NEK2_1	270	275	PF00069	0.487
MOD_NEK2_1	507	512	PF00069	0.705
MOD_NEK2_1	7	12	PF00069	0.690
MOD_PIKK_1	101	107	PF00454	0.691
MOD_PKA_2	1	7	PF00069	0.682
MOD_PKA_2	276	282	PF00069	0.686
MOD_PKA_2	375	381	PF00069	0.626
MOD_PKA_2	563	569	PF00069	0.489
MOD_PKB_1	57	65	PF00069	0.529
MOD_Plk_1	147	153	PF00069	0.477
MOD_Plk_1	313	319	PF00069	0.491
MOD_Plk_4	3	9	PF00069	0.713
MOD_Plk_4	385	391	PF00069	0.593
MOD_ProDKin_1	188	194	PF00069	0.596
MOD_ProDKin_1	265	271	PF00069	0.583
MOD_ProDKin_1	284	290	PF00069	0.655
MOD_ProDKin_1	377	383	PF00069	0.565
MOD_ProDKin_1	49	55	PF00069	0.779
MOD_ProDKin_1	97	103	PF00069	0.628
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.463
TRG_ENDOCYTIC_2	197	200	PF00928	0.444
TRG_ER_diArg_1	212	215	PF00400	0.449
TRG_ER_diArg_1	49	51	PF00400	0.821
TRG_ER_diArg_1	559	562	PF00400	0.648
TRG_ER_diArg_1	56	59	PF00400	0.709
TRG_ER_diArg_1	65	68	PF00400	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA9	Leptomonas seymouri	30%	96%
A0A3Q8IF25	Leishmania donovani	82%	98%
A4HLW9	Leishmania braziliensis	61%	100%
A4I998	Leishmania infantum	82%	98%
Q4Q3S8	Leishmania major	80%	100%