Putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MF, Family M17

Species:

Leishmania mexicana

UniProt:

E9B496_LEIMU

TriTrypDb:

LmxM.32.2570

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

E9B496

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B496

PDB structure(s): 5nth_A

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0019538	protein metabolic process	3	16
GO:0043170	macromolecule metabolic process	3	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004177	aminopeptidase activity	5	16
GO:0005488	binding	1	16
GO:0008233	peptidase activity	3	16
GO:0008235	metalloexopeptidase activity	5	16
GO:0008237	metallopeptidase activity	4	16
GO:0008238	exopeptidase activity	4	16
GO:0016787	hydrolase activity	2	16
GO:0030145	manganese ion binding	6	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16
GO:0046914	transition metal ion binding	5	16
GO:0070006	metalloaminopeptidase activity	6	16
GO:0140096	catalytic activity, acting on a protein	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	170	172	PF00082	0.385
CLV_PCSK_KEX2_1	431	433	PF00082	0.409
CLV_PCSK_KEX2_1	5	7	PF00082	0.611
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.414
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.467
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.611
CLV_PCSK_SKI1_1	288	292	PF00082	0.343
CLV_PCSK_SKI1_1	380	384	PF00082	0.334
CLV_PCSK_SKI1_1	41	45	PF00082	0.581
CLV_PCSK_SKI1_1	63	67	PF00082	0.279
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.365
DOC_MAPK_gen_1	233	241	PF00069	0.438
DOC_MAPK_gen_1	363	372	PF00069	0.374
DOC_MAPK_JIP1_4	193	199	PF00069	0.411
DOC_MAPK_MEF2A_6	235	243	PF00069	0.293
DOC_MAPK_MEF2A_6	363	372	PF00069	0.427
DOC_MAPK_MEF2A_6	94	103	PF00069	0.476
DOC_PP2B_LxvP_1	501	504	PF13499	0.449
DOC_PP2B_PxIxI_1	397	403	PF00149	0.427
DOC_USP7_MATH_1	16	20	PF00917	0.548
DOC_USP7_MATH_1	174	178	PF00917	0.483
DOC_USP7_MATH_1	42	46	PF00917	0.622
DOC_USP7_MATH_1	475	479	PF00917	0.336
DOC_USP7_MATH_2	337	343	PF00917	0.467
DOC_USP7_UBL2_3	466	470	PF12436	0.431
DOC_WW_Pin1_4	281	286	PF00397	0.348
DOC_WW_Pin1_4	394	399	PF00397	0.365
LIG_14-3-3_CanoR_1	380	388	PF00244	0.450
LIG_14-3-3_CanoR_1	41	50	PF00244	0.644
LIG_14-3-3_CanoR_1	8	14	PF00244	0.539
LIG_Actin_WH2_2	219	237	PF00022	0.475
LIG_APCC_ABBA_1	70	75	PF00400	0.477
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BIR_III_4	376	380	PF00653	0.334
LIG_BRCT_BRCA1_1	454	458	PF00533	0.288
LIG_CaM_NSCaTE_8	230	237	PF13499	0.486
LIG_CtBP_PxDLS_1	248	254	PF00389	0.377
LIG_EH1_1	512	520	PF00400	0.238
LIG_FHA_1	213	219	PF00498	0.362
LIG_FHA_1	298	304	PF00498	0.390
LIG_FHA_1	31	37	PF00498	0.449
LIG_FHA_1	367	373	PF00498	0.334
LIG_FHA_1	395	401	PF00498	0.348
LIG_FHA_1	45	51	PF00498	0.595
LIG_FHA_1	94	100	PF00498	0.429
LIG_FHA_2	10	16	PF00498	0.418
LIG_FHA_2	220	226	PF00498	0.334
LIG_FHA_2	373	379	PF00498	0.334
LIG_FHA_2	422	428	PF00498	0.434
LIG_FHA_2	504	510	PF00498	0.449
LIG_FHA_2	82	88	PF00498	0.501
LIG_LIR_Gen_1	175	185	PF02991	0.570
LIG_LIR_Gen_1	220	231	PF02991	0.343
LIG_LIR_Gen_1	493	504	PF02991	0.414
LIG_LIR_Nem_3	175	181	PF02991	0.551
LIG_LIR_Nem_3	2	7	PF02991	0.691
LIG_LIR_Nem_3	220	226	PF02991	0.343
LIG_LIR_Nem_3	253	259	PF02991	0.343
LIG_LIR_Nem_3	442	448	PF02991	0.330
LIG_LIR_Nem_3	493	499	PF02991	0.368
LIG_MAD2	186	194	PF02301	0.271
LIG_PDZ_Class_3	522	527	PF00595	0.518
LIG_SH2_CRK	256	260	PF00017	0.343
LIG_SH2_CRK	4	8	PF00017	0.687
LIG_SH2_GRB2like	178	181	PF00017	0.528
LIG_SH2_GRB2like	423	426	PF00017	0.392
LIG_SH2_NCK_1	13	17	PF00017	0.510
LIG_SH2_NCK_1	74	78	PF00017	0.475
LIG_SH2_SRC	13	16	PF00017	0.544
LIG_SH2_SRC	178	181	PF00017	0.528
LIG_SH2_SRC	74	77	PF00017	0.195
LIG_SH2_STAP1	151	155	PF00017	0.348
LIG_SH2_STAP1	28	32	PF00017	0.463
LIG_SH2_STAP1	74	78	PF00017	0.427
LIG_SH2_STAT5	146	149	PF00017	0.404
LIG_SH2_STAT5	178	181	PF00017	0.489
LIG_SH2_STAT5	396	399	PF00017	0.392
LIG_SH2_STAT5	423	426	PF00017	0.397
LIG_SH2_STAT5	449	452	PF00017	0.375
LIG_SH2_STAT5	482	485	PF00017	0.215
LIG_SH3_3	178	184	PF00018	0.474
LIG_SH3_3	208	214	PF00018	0.334
LIG_SH3_3	445	451	PF00018	0.427
LIG_SUMO_SIM_anti_2	287	293	PF11976	0.467
LIG_SUMO_SIM_anti_2	52	59	PF11976	0.427
LIG_SUMO_SIM_par_1	271	276	PF11976	0.365
LIG_SUMO_SIM_par_1	336	342	PF11976	0.388
LIG_SUMO_SIM_par_1	52	59	PF11976	0.427
LIG_TRAF2_1	12	15	PF00917	0.569
LIG_TRAF2_1	247	250	PF00917	0.449
LIG_UBA3_1	361	365	PF00899	0.377
LIG_WRC_WIRS_1	519	524	PF05994	0.258
MOD_CDK_SPK_2	281	286	PF00069	0.382
MOD_CDK_SPxxK_3	281	288	PF00069	0.342
MOD_CK1_1	108	114	PF00069	0.403
MOD_CK1_1	30	36	PF00069	0.501
MOD_CK1_1	304	310	PF00069	0.288
MOD_CK1_1	366	372	PF00069	0.334
MOD_CK1_1	426	432	PF00069	0.470
MOD_CK1_1	9	15	PF00069	0.319
MOD_CK2_1	146	152	PF00069	0.390
MOD_CK2_1	21	27	PF00069	0.392
MOD_CK2_1	219	225	PF00069	0.334
MOD_CK2_1	372	378	PF00069	0.334
MOD_CK2_1	421	427	PF00069	0.402
MOD_CK2_1	503	509	PF00069	0.409
MOD_CK2_1	8	14	PF00069	0.524
MOD_CK2_1	81	87	PF00069	0.471
MOD_GlcNHglycan	148	151	PF01048	0.377
MOD_GlcNHglycan	18	21	PF01048	0.448
MOD_GlcNHglycan	190	193	PF01048	0.567
MOD_GlcNHglycan	365	368	PF01048	0.334
MOD_GlcNHglycan	454	457	PF01048	0.450
MOD_GlcNHglycan	459	462	PF01048	0.491
MOD_GSK3_1	159	166	PF00069	0.447
MOD_GSK3_1	217	224	PF00069	0.353
MOD_GSK3_1	297	304	PF00069	0.238
MOD_GSK3_1	392	399	PF00069	0.405
MOD_GSK3_1	81	88	PF00069	0.493
MOD_N-GLC_1	16	21	PF02516	0.446
MOD_N-GLC_1	30	35	PF02516	0.470
MOD_N-GLC_1	372	377	PF02516	0.343
MOD_N-GLC_1	486	491	PF02516	0.455
MOD_N-GLC_1	9	14	PF02516	0.328
MOD_NEK2_1	21	26	PF00069	0.375
MOD_NEK2_1	217	222	PF00069	0.334
MOD_NEK2_2	301	306	PF00069	0.353
MOD_NEK2_2	310	315	PF00069	0.424
MOD_NEK2_2	465	470	PF00069	0.460
MOD_PIKK_1	352	358	PF00454	0.394
MOD_PK_1	105	111	PF00069	0.494
MOD_PKB_1	6	14	PF00069	0.542
MOD_Plk_1	151	157	PF00069	0.456
MOD_Plk_1	16	22	PF00069	0.445
MOD_Plk_1	174	180	PF00069	0.503
MOD_Plk_1	239	245	PF00069	0.224
MOD_Plk_1	30	36	PF00069	0.405
MOD_Plk_1	338	344	PF00069	0.449
MOD_Plk_1	392	398	PF00069	0.427
MOD_Plk_1	63	69	PF00069	0.348
MOD_Plk_1	9	15	PF00069	0.473
MOD_Plk_2-3	219	225	PF00069	0.377
MOD_Plk_4	174	180	PF00069	0.498
MOD_Plk_4	339	345	PF00069	0.409
MOD_Plk_4	396	402	PF00069	0.486
MOD_Plk_4	49	55	PF00069	0.428
MOD_ProDKin_1	281	287	PF00069	0.348
MOD_ProDKin_1	394	400	PF00069	0.365
MOD_SUMO_rev_2	460	468	PF00179	0.324
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.475
TRG_ENDOCYTIC_2	178	181	PF00928	0.564
TRG_ENDOCYTIC_2	256	259	PF00928	0.334
TRG_ENDOCYTIC_2	4	7	PF00928	0.698
TRG_NES_CRM1_1	359	371	PF08389	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E6	Leptomonas seymouri	77%	100%
A0A0N1PAS4	Leptomonas seymouri	42%	98%
A0A0S4IQ79	Bodo saltans	55%	100%
A0A1X0NWR5	Trypanosomatidae	49%	100%
A0A1X0P4M9	Trypanosomatidae	48%	100%
A0A3R7JY84	Trypanosoma rangeli	49%	100%
A0A3R7N130	Trypanosoma rangeli	56%	94%
A0A3S7WRP1	Leishmania donovani	43%	99%
A0A3S7X742	Leishmania donovani	91%	100%
A0K9N9	Burkholderia cenocepacia (strain HI2424)	29%	100%
A1JJ31	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	32%	100%
A1SRZ1	Psychromonas ingrahamii (strain 37)	30%	100%
A4H6I8	Leishmania braziliensis	43%	98%
A4HCW4	Leishmania braziliensis	32%	100%
A4HLW7	Leishmania braziliensis	84%	100%
A4HUX3	Leishmania infantum	43%	99%
A4I996	Leishmania infantum	91%	100%
A4JGZ2	Burkholderia vietnamiensis (strain G4 / LMG 22486)	29%	100%
A4TQP6	Yersinia pestis (strain Pestoides F)	31%	100%
A5GN62	Synechococcus sp. (strain WH7803)	31%	100%
A7FML9	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	31%	100%
A8AD60	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	32%	100%
A8LI79	Dinoroseobacter shibae (strain DSM 16493 / NCIMB 14021 / DFL 12)	33%	100%
A9AHG9	Burkholderia multivorans (strain ATCC 17616 / 249)	29%	100%
A9MHK1	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	34%	100%
A9N1Y3	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	34%	100%
A9R5F5	Yersinia pestis bv. Antiqua (strain Angola)	31%	100%
B1JLS9	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	31%	100%
B1JWV2	Burkholderia cenocepacia (strain MC0-3)	29%	100%
B1YUW5	Burkholderia ambifaria (strain MC40-6)	29%	100%
B2JET5	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	28%	100%
B2K3E9	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	31%	100%
B2T146	Paraburkholderia phytofirmans (strain DSM 17436 / LMG 22146 / PsJN)	28%	100%
B3Q9R8	Rhodopseudomonas palustris (strain TIE-1)	31%	100%
B4E8G9	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	29%	100%
B4F2N1	Proteus mirabilis (strain HI4320)	32%	100%
B4T0R5	Salmonella newport (strain SL254)	34%	100%
B5F1B3	Salmonella agona (strain SL483)	34%	100%
B5FR78	Salmonella dublin (strain CT_02021853)	34%	100%
B5R595	Salmonella enteritidis PT4 (strain P125109)	34%	100%
B5RD05	Salmonella gallinarum (strain 287/91 / NCTC 13346)	34%	100%
B5ZWY7	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	32%	100%
B8GTX6	Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)	30%	100%
C0PYL4	Salmonella paratyphi C (strain RKS4594)	34%	100%
C0QC86	Desulforapulum autotrophicum (strain ATCC 43914 / DSM 3382 / VKM B-1955 / HRM2)	30%	100%
C5CCM4	Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)	34%	100%
D0A654	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	93%
D0A7H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ANK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
P47707	Metamycoplasma salivarium	30%	100%
P57823	Pasteurella multocida (strain Pm70)	29%	100%
Q0BCQ2	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	29%	100%
Q0I236	Haemophilus somnus (strain 129Pt)	32%	100%
Q11A96	Trichodesmium erythraeum (strain IMS101)	29%	100%
Q12QW7	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	29%	100%
Q143Y9	Paraburkholderia xenovorans (strain LB400)	28%	100%
Q1BUE7	Burkholderia cenocepacia (strain AU 1054)	29%	100%
Q1C3R8	Yersinia pestis bv. Antiqua (strain Antiqua)	31%	100%
Q1CM01	Yersinia pestis bv. Antiqua (strain Nepal516)	31%	100%
Q1MIZ4	Rhizobium leguminosarum bv. viciae (strain 3841)	32%	100%
Q2T0C0	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	28%	100%
Q39DS5	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	30%	100%
Q488M4	Colwellia psychrerythraea (strain 34H / ATCC BAA-681)	29%	100%
Q4Q3T0	Leishmania major	92%	100%
Q4QH17	Leishmania major	43%	98%
Q57LH5	Salmonella choleraesuis (strain SC-B67)	34%	100%
Q5FFZ5	Ehrlichia ruminantium (strain Gardel)	30%	100%
Q5HAP2	Ehrlichia ruminantium (strain Welgevonden)	29%	100%
Q5QY05	Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)	31%	100%
Q606B9	Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)	27%	100%
Q66F09	Yersinia pseudotuberculosis serotype I (strain IP32953)	31%	100%
Q6A9W5	Cutibacterium acnes (strain DSM 16379 / KPA171202)	34%	100%
Q6N5B9	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	31%	100%
Q6NSR8	Mus musculus	45%	100%
Q7V0D4	Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 / MED4)	28%	100%
Q8Z4N3	Salmonella typhi	34%	100%
Q8ZBH3	Yersinia pestis	31%	100%
Q92QY7	Rhizobium meliloti (strain 1021)	34%	100%
Q984S1	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	33%	100%
Q9RF52	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	34%	100%
V5BTR1	Trypanosoma cruzi	57%	95%
V5BWE3	Trypanosoma cruzi	50%	100%