UDP-N-acetylglucosamine pyrophosphorylase,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-N-acetylglucosamine pyrophosphorylase, putative

Species:

Leishmania mexicana

UniProt:

E9B491_LEIMU

TriTrypDb:

LmxM.32.2520

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B491

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B491

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	1
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	1
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009225	nucleotide-sugar metabolic process	4	1
GO:0009226	nucleotide-sugar biosynthetic process	5	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046349	amino sugar biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003977	UDP-N-acetylglucosamine diphosphorylase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0070569	uridylyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	290	296	PF00089	0.251
CLV_NRD_NRD_1	160	162	PF00675	0.226
CLV_NRD_NRD_1	345	347	PF00675	0.349
CLV_NRD_NRD_1	390	392	PF00675	0.247
CLV_PCSK_FUR_1	426	430	PF00082	0.134
CLV_PCSK_KEX2_1	345	347	PF00082	0.288
CLV_PCSK_KEX2_1	428	430	PF00082	0.144
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.134
CLV_PCSK_SKI1_1	138	142	PF00082	0.187
CLV_PCSK_SKI1_1	150	154	PF00082	0.205
CLV_PCSK_SKI1_1	4	8	PF00082	0.511
CLV_PCSK_SKI1_1	415	419	PF00082	0.265
CLV_PCSK_SKI1_1	540	544	PF00082	0.474
DEG_APCC_DBOX_1	53	61	PF00400	0.463
DEG_SPOP_SBC_1	489	493	PF00917	0.453
DOC_CDC14_PxL_1	89	97	PF14671	0.509
DOC_MAPK_gen_1	277	287	PF00069	0.509
DOC_MAPK_MEF2A_6	183	190	PF00069	0.473
DOC_MAPK_NFAT4_5	183	191	PF00069	0.451
DOC_USP7_MATH_1	125	129	PF00917	0.439
DOC_USP7_MATH_1	239	243	PF00917	0.563
DOC_USP7_MATH_1	258	262	PF00917	0.471
DOC_USP7_MATH_1	316	320	PF00917	0.432
DOC_USP7_MATH_1	488	492	PF00917	0.619
DOC_USP7_MATH_1	521	525	PF00917	0.346
DOC_USP7_MATH_1	542	546	PF00917	0.474
DOC_USP7_UBL2_3	313	317	PF12436	0.405
DOC_WW_Pin1_4	24	29	PF00397	0.560
DOC_WW_Pin1_4	260	265	PF00397	0.390
DOC_WW_Pin1_4	457	462	PF00397	0.492
DOC_WW_Pin1_4	517	522	PF00397	0.309
DOC_WW_Pin1_4	79	84	PF00397	0.385
LIG_14-3-3_CanoR_1	221	226	PF00244	0.526
LIG_14-3-3_CanoR_1	32	41	PF00244	0.279
LIG_14-3-3_CanoR_1	345	352	PF00244	0.513
LIG_14-3-3_CanoR_1	503	510	PF00244	0.465
LIG_BIR_II_1	1	5	PF00653	0.341
LIG_FHA_1	183	189	PF00498	0.451
LIG_FHA_1	230	236	PF00498	0.421
LIG_FHA_1	319	325	PF00498	0.472
LIG_FHA_1	34	40	PF00498	0.406
LIG_FHA_1	352	358	PF00498	0.429
LIG_FHA_1	471	477	PF00498	0.436
LIG_FHA_1	492	498	PF00498	0.412
LIG_FHA_2	189	195	PF00498	0.420
LIG_FHA_2	497	503	PF00498	0.508
LIG_FHA_2	67	73	PF00498	0.383
LIG_LIR_Gen_1	21	28	PF02991	0.461
LIG_LIR_Gen_1	331	342	PF02991	0.465
LIG_LIR_Gen_1	370	381	PF02991	0.429
LIG_LIR_Nem_3	206	212	PF02991	0.462
LIG_LIR_Nem_3	21	26	PF02991	0.461
LIG_LIR_Nem_3	296	302	PF02991	0.416
LIG_LIR_Nem_3	331	337	PF02991	0.441
LIG_LIR_Nem_3	338	342	PF02991	0.429
LIG_LIR_Nem_3	370	376	PF02991	0.429
LIG_LIR_Nem_3	444	450	PF02991	0.433
LIG_REV1ctd_RIR_1	216	225	PF16727	0.528
LIG_SH2_CRK	23	27	PF00017	0.416
LIG_SH2_GRB2like	41	44	PF00017	0.390
LIG_SH2_GRB2like	59	62	PF00017	0.238
LIG_SH2_NCK_1	228	232	PF00017	0.451
LIG_SH2_NCK_1	339	343	PF00017	0.405
LIG_SH2_NCK_1	41	45	PF00017	0.496
LIG_SH2_SRC	228	231	PF00017	0.509
LIG_SH2_SRC	59	62	PF00017	0.241
LIG_SH2_STAP1	254	258	PF00017	0.509
LIG_SH2_STAP1	416	420	PF00017	0.451
LIG_SH2_STAT3	155	158	PF00017	0.451
LIG_SH2_STAT3	498	501	PF00017	0.385
LIG_SH2_STAT3	533	536	PF00017	0.336
LIG_SH2_STAT5	298	301	PF00017	0.509
LIG_SH2_STAT5	339	342	PF00017	0.435
LIG_SH2_STAT5	41	44	PF00017	0.503
LIG_SH2_STAT5	498	501	PF00017	0.440
LIG_SH2_STAT5	533	536	PF00017	0.409
LIG_SH2_STAT5	59	62	PF00017	0.280
LIG_SH3_3	131	137	PF00018	0.451
LIG_SH3_3	291	297	PF00018	0.447
LIG_SUMO_SIM_par_1	185	194	PF11976	0.452
LIG_SUMO_SIM_par_1	283	288	PF11976	0.509
LIG_SUMO_SIM_par_1	467	473	PF11976	0.472
LIG_SUMO_SIM_par_1	545	552	PF11976	0.346
LIG_TRAF2_1	14	17	PF00917	0.442
LIG_TRAF2_1	499	502	PF00917	0.532
LIG_TRFH_1	210	214	PF08558	0.496
LIG_TYR_ITIM	337	342	PF00017	0.405
LIG_UBA3_1	467	474	PF00899	0.412
MOD_CK1_1	148	154	PF00069	0.509
MOD_CK1_1	220	226	PF00069	0.490
MOD_CK1_1	491	497	PF00069	0.649
MOD_CK2_1	11	17	PF00069	0.418
MOD_CK2_1	173	179	PF00069	0.334
MOD_CK2_1	24	30	PF00069	0.383
MOD_CK2_1	316	322	PF00069	0.429
MOD_CK2_1	419	425	PF00069	0.451
MOD_CK2_1	496	502	PF00069	0.424
MOD_GlcNHglycan	115	118	PF01048	0.335
MOD_GlcNHglycan	127	130	PF01048	0.239
MOD_GlcNHglycan	13	16	PF01048	0.406
MOD_GlcNHglycan	147	150	PF01048	0.278
MOD_GlcNHglycan	260	263	PF01048	0.296
MOD_GlcNHglycan	264	267	PF01048	0.235
MOD_GlcNHglycan	318	321	PF01048	0.288
MOD_GlcNHglycan	346	349	PF01048	0.310
MOD_GlcNHglycan	540	543	PF01048	0.474
MOD_GlcNHglycan	544	547	PF01048	0.490
MOD_GSK3_1	217	224	PF00069	0.482
MOD_GSK3_1	258	265	PF00069	0.490
MOD_GSK3_1	26	33	PF00069	0.473
MOD_GSK3_1	363	370	PF00069	0.459
MOD_GSK3_1	517	524	PF00069	0.308
MOD_GSK3_1	538	545	PF00069	0.488
MOD_N-GLC_1	266	271	PF02516	0.134
MOD_NEK2_1	11	16	PF00069	0.401
MOD_NEK2_1	132	137	PF00069	0.480
MOD_NEK2_1	188	193	PF00069	0.419
MOD_NEK2_1	381	386	PF00069	0.500
MOD_NEK2_1	39	44	PF00069	0.540
MOD_NEK2_1	53	58	PF00069	0.286
MOD_PIKK_1	197	203	PF00454	0.377
MOD_PIKK_1	33	39	PF00454	0.455
MOD_PKA_2	182	188	PF00069	0.555
MOD_PKA_2	220	226	PF00069	0.516
MOD_PKA_2	239	245	PF00069	0.559
MOD_PKA_2	344	350	PF00069	0.505
MOD_PKA_2	390	396	PF00069	0.451
MOD_PKA_2	502	508	PF00069	0.474
MOD_PKA_2	53	59	PF00069	0.377
MOD_Plk_1	266	272	PF00069	0.358
MOD_Plk_1	381	387	PF00069	0.557
MOD_Plk_1	441	447	PF00069	0.451
MOD_Plk_4	266	272	PF00069	0.460
MOD_Plk_4	382	388	PF00069	0.517
MOD_Plk_4	85	91	PF00069	0.472
MOD_ProDKin_1	24	30	PF00069	0.556
MOD_ProDKin_1	260	266	PF00069	0.390
MOD_ProDKin_1	457	463	PF00069	0.492
MOD_ProDKin_1	517	523	PF00069	0.309
MOD_ProDKin_1	79	85	PF00069	0.385
MOD_SUMO_for_1	404	407	PF00179	0.405
MOD_SUMO_rev_2	549	555	PF00179	0.312
TRG_DiLeu_BaEn_1	118	123	PF01217	0.509
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.496
TRG_ENDOCYTIC_2	228	231	PF00928	0.481
TRG_ENDOCYTIC_2	23	26	PF00928	0.499
TRG_ENDOCYTIC_2	254	257	PF00928	0.416
TRG_ENDOCYTIC_2	339	342	PF00928	0.411
TRG_ENDOCYTIC_2	516	519	PF00928	0.191
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.205
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG62	Leptomonas seymouri	64%	99%
A0A0S4IVW9	Bodo saltans	39%	100%
A0A1X0P444	Trypanosomatidae	44%	100%
A0A3S7X721	Leishmania donovani	86%	98%
A0A422P028	Trypanosoma rangeli	40%	100%
D0A658	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AHS0	Leishmania infantum	85%	98%
E9AIV6	Leishmania braziliensis	81%	100%
O64765	Arabidopsis thaliana	34%	100%
O74933	Candida albicans	35%	100%
O94617	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P43123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q16222	Homo sapiens	31%	100%
Q18493	Caenorhabditis elegans	29%	100%
Q28CH3	Xenopus tropicalis	32%	100%
Q2FEW1	Staphylococcus aureus (strain USA300)	28%	100%
Q2FW81	Staphylococcus aureus (strain NCTC 8325 / PS 47)	28%	100%
Q2YYH4	Staphylococcus aureus (strain bovine RF122 / ET3-1)	28%	100%
Q3KQV9	Homo sapiens	33%	100%
Q3TW96	Mus musculus	33%	100%
Q49ZB5	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	27%	100%
Q4Q3T5	Leishmania major	87%	100%
Q54GN5	Dictyostelium discoideum	31%	100%
Q5HE34	Staphylococcus aureus (strain COL)	28%	100%
Q5HM59	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	30%	100%
Q6G7E3	Staphylococcus aureus (strain MSSA476)	28%	100%
Q6GEQ8	Staphylococcus aureus (strain MRSA252)	28%	100%
Q7A0A0	Staphylococcus aureus (strain MW2)	28%	100%
Q7A4A4	Staphylococcus aureus (strain N315)	28%	100%
Q7ZWD4	Danio rerio	32%	100%
Q8CNG6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	30%	100%
Q91YN5	Mus musculus	32%	100%
Q940S3	Arabidopsis thaliana	34%	100%
Q99S95	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
V5BYI4	Trypanosoma cruzi	43%	93%